Abstract
The benefits of honey have been recognized since ancient times for treating numerous
diseases. However, in today's modern era, the use of traditional remedies has been rapidly
diminishing due to the complexities of modern lifestyles. While antibiotics are commonly used and
effective in treating pathogenic infections, their inappropriate use can lead to the development of
resistance among microorganisms, resulting in their widespread prevalence. Therefore, new
approaches are constantly required to combat drug-resistant microorganisms, and one practical and
useful approach is the use of drug combination treatments.
Manuka honey, derived from the manuka tree (Leptospermum scoparium) found exclusively in New
Zealand, has garnered significant attention for its biological potential, particularly due to its
antioxidant and antimicrobial properties. Moreover, when combined with antibiotics, it has
demonstrated the ability to enhance their effectiveness. In this review, we delve into the chemical
markers of manuka honey that are currently known, as well as detail the impact of manuka honey on
the management of infectious diseases up to the present.
Graphical Abstract
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