Abstract

Introduction: Cancer and diabetes are proving to be lethal to human society and have attracted attention of researchers around the world. Synthesis of mixed ligand complexes is a challenging area owing to their potential applications as drugs against various diseases.

Methods: Synthesis and biological evaluation of mixed ligand complexes of Vanadium(IV) with heterocyclic bidentate molecule 8-hydroxyquinoline as primary ligand and L-Amino acids such as L-cysteine, L-alanine, L-phenylalanine, L-threonine and L-serine as secondary ligands is reported here. All the complexes were characterized using IR, electronic, Mass, TGA/DTA method, powder XRD analysis, molar conductance and magnetic susceptibility measurements and were screened for their biological activities.

Results: The synthesized mixed ligand complexes were screened for their antibacterial activity against E. coli and antifungal activity against C. albicans. They were also evaluated for in vitro antidibetic activity, anticancer activity against HepG2 (human liver cancer cell line) by MTT assay.

Conclusion: The synthesized mixed ligand complexes were thermally stable, paramagnetic, nonelectrolytic in nature and proposed to have square pyramidal geometry. They also exhibited potential as antibacterial, anticancer and antidibetic agents.

Keywords: Anticancer, Antidibetic, α-amylase, Powder XRD, HePG2, Square pyramidal.