Pharmacological Attributes of Fenugreek with Special Reference to Alzheimer’s Disease

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Abstract

Background: An annual plant, Fenugreek (Trigonellafoenum-graecum L.) has well-known health care benefits in Ayurvedic and Chinese medicine. Its leaves and seeds have alkaloids, amino acids, caumarins, flavonoids, saponins, and other bioactive components. Various pharmacological properties such as antioxidants, hypoglycemic, and hypolipidemic have been attributed to fenugreek. Trigonelline, diosgenin, and 4- hydroxyisoleucine have shown neuroprotection against Alzheimer’s disease, and the extract have also been reported to act as an anti-depressant, anti-anxiety, and also regulate cognitive functions. This review highlights various studies carried out on animals as well as on humans for the protective effect against Alzheimer’s disease.

Methods: The data presented in this review is taken from popular search engines, viz, Google Scholar, PubMed, and Scopus. This review highlights the studies and clinical trials performed to show the protective effect of Fenugreek on neurodegenerative diseases with special reference to AD from 2005 to 2023.

Results: Fenugreek improves cognitive deficits by Nrf2-mediated antioxidative pathway and provides neuroprotection against amyloid-beta-induced mitochondria dysfunction. It enhances SOD and catalase activities and scavenges reactive oxygen species to protect the cellular organelle from oxidative stress. It normalizes the tubulin protein and improved axonal growth by regulating nerve growth factors. Fenugreek can also influence metabolism.

Discussion: Fenugreek significantly improves the pathological symptoms of neurodegenerative disease, especially AD and can be used as a therapeutic agent to control disease conditions as evidenced by the review of the literature.

[1]
Khalil, W.; Roshdy, H.; Kassem, S. The potential therapeutic role of Fenugreek saponin against Alzheimers disease: Evaluation of apoptotic and acetylcholinesterase inhibitory activities. J. Appl. Pharm. Sci., 2016, 6, 166-173.
[http://dx.doi.org/10.7324/JAPS.2016.60925]
[2]
Prema, A.; Justin Thenmozhi, A.; Manivasagam, T.; Mohamed Essa, M.; Guillemin, G.J. Fenugreek seed powder attenuated aluminum chloride-induced tau pathology, oxidative stress, and inflammation in a rat model of Alzheimer’s disease. J. Alzheimers Dis., 2017, 60(s1), S209-S220.
[http://dx.doi.org/10.3233/JAD-161103] [PMID: 28269780]
[3]
Farid, MM.; Yang, X.; Kuboyama, T.; Tohda, C. Trigonelline recovers memory function in Alzheimer’s disease model mice: Evidence of brain penetration and target molecule. Sci. Rep., 2020, 2(10), 16424.
[http://dx.doi.org/10.1038/s41598-020-73514-1]
[4]
Olaiya, C.O.; Soetan, K.O. A review of the health benefits of fenugreek (Trigonella foenum-graecum L.): Nutritional, Biochemical and pharmaceutical perspectives. Int. J. Adv. Social. Sci. Humanit, 2014, 3-12.
[5]
Gaddam, A.; Galla, C.; Thummisetti, S.; Marikanty, R.K.; Palanisamy, U.D.; Rao, P.V. Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes. J. Diabetes Metab. Disord., 2015, 14(1), 74.
[http://dx.doi.org/10.1186/s40200-015-0208-4] [PMID: 26436069]
[6]
Gaur, V.; Bodhankar, S.L.; Mohan, V.; Thakurdesai, P.A. Neurobehavioral assessment of hydroalcoholic extract of Trigonella foenum-graecum seeds in rodent models of Parkinson’s disease. Pharm. Biol., 2013, 51(5), 550-557.
[http://dx.doi.org/10.3109/13880209.2012.747547] [PMID: 23368940]
[7]
Baliga, M.S.; Palatty, P.L.; Adnan, M.; Naik, T.S.; Kamble, P.S.; George, T.; D’souza, J.J. Anti-diabetic effects of leaves of Trigonella foenum-graecum L. (Fenugreek): Leads from preclinical studies. Journal of Food Chemistry and Nanotechnology, 2017, 3(2), 67-71.
[http://dx.doi.org/10.17756/jfcn.2017-039]
[8]
Prema, A.; Thenmozhi, A.J.; Manivasagam, T.; Essa, M.M.; Akbar, M.D.; Akbar, M. Fenugreek seed powder nullified aluminium chloride induced memory loss, biochemical changes, Aβ burden and apoptosis via regulating Akt/GSK3β signaling pathway. PLoS One, 2016, 11(11), e0165955.
[http://dx.doi.org/10.1371/journal.pone.0165955] [PMID: 27893738]
[9]
Nathan, J.; Panjwani, S.; Mohan, V.; Joshi, V.; Thakurdesai, P.A. Efficacy and safety of standardized extract of Trigonella foenum-graecum L seeds as an adjuvant to L-Dopa in the management of patients with Parkinson’s disease. Phytother. Res., 2014, 28(2), 172-178.
[http://dx.doi.org/10.1002/ptr.4969] [PMID: 23512705]
[10]
Mirzaie, M.; Khalili, M.; Kiasalari, Z.; Roghani, M. Neuroprotective and antiapoptotic potential of trigonelline in a striatal 6-hydroxydopamine rat model of Parkinson’s disease. Neurophysiology, 2016, 48(3), 176-183.
[http://dx.doi.org/10.1007/s11062-016-9586-6]
[11]
Pujari, R.; Thakurdesai, P. Fenugreek in Management of Neurological and Psychological Disorders; Fenugreek, 2022, pp. 229-257.
[http://dx.doi.org/10.1201/9781003082767-20]
[12]
Zameer, S.; Najmi, A.K.; Vohora, D.; Akhtar, M. A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its hypolipidemic, hypoglycemic, and antioxidant potential. Nutr. Neurosci., 2018, 21(8), 539-545.
[http://dx.doi.org/10.1080/1028415X.2017.1327200] [PMID: 28504078]
[13]
Zhou, J.; Chan, L.; Zhou, S. Trigonelline: A plant alkaloid with therapeutic potential for diabetes and central nervous system disease. Curr. Med. Chem., 2012, 19(21), 3523-3531.
[http://dx.doi.org/10.2174/092986712801323171] [PMID: 22680628]
[14]
Anjomshoa, M.; Boroujeni, S.N.; Bagheri, E.; Lorigooini, Z.; Amini-Khoei, H. Possible involvement of N-methyl-D-aspartate receptor (NMDA-R) in the antidepressant-like effect of trigonelline in male mice. Curr. Pharm. Des., 2020, 26(39), 5067-5071.
[http://dx.doi.org/10.2174/1381612826666200610181259] [PMID: 32520677]
[15]
Fahanik-Babaei, J.; Baluchnejadmojarad, T.; Nikbakht, F.; Roghani, M. Trigonelline ameliorates learning and memory and synaptic plasticity impairment in intrahippocampal amyloid beta (1-40) rat model of alzheimer’s disease. Acta Med. Iran., 2018, 625-634.
[16]
Farid, M.M.; Nagase, T.; Yang, X.; Nomoto, K.; Kuboyama, T.; Inada, Y.; Tohda, C. Effects of Trigonellafoenum-graecum seeds extract on Alzheimer’s disease transgenic model mouse and its potential active compound transferred to the brain. Japanese J Food Chem Safety., 2021, 28, 63-70.
[17]
Tohda, C.; Urano, T.; Umezaki, M.; Nemere, I.; Kuboyama, T. Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice. Sci. Rep., 2012, 2(1), 535.
[http://dx.doi.org/10.1038/srep00535] [PMID: 22837815]
[18]
Li, B.; Xu, P.; Wu, S.; Jiang, Z.; Huang, Z.; Li, Q.; Chen, D. Diosgenin attenuates lipopolysaccharide-induced Parkinson’s disease by inhibiting the TLR/NF-κB pathway. J. Alzheimers Dis., 2018, 64(3), 943-955.
[http://dx.doi.org/10.3233/JAD-180330] [PMID: 29966203]
[19]
Chiu, C.S.; Chiu, Y.J.; Wu, L.Y.; Lu, T.C.; Huang, T.H.; Hsieh, M.T.; Lu, C.Y.; Peng, W.H. Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose. Am. J. Chin. Med., 2011, 39(3), 551-563.
[http://dx.doi.org/10.1142/S0192415X11009020] [PMID: 21598421]
[20]
Cai, B.; Zhang, Y.; Wang, Z.; Xu, D.; Jia, Y.; Guan, Y.; Liao, A.; Liu, G.; Chun, C.; Li, J. Therapeutic potential of diosgenin and its major derivatives against neurological diseases: recent advances. Oxid. Med. Cell. Longev., 2020, 2020, 1-16.
[http://dx.doi.org/10.1155/2020/3153082] [PMID: 32215172]
[21]
Koh, E.K.; Yun, W.B.; Kim, J.E.; Song, S.H.; Sung, J.E.; Lee, H.A.; Seo, E.J.; Jee, S.W.; Bae, C.J.; Hwang, D.Y. Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection. Lab. Anim. Res., 2016, 32(2), 105-115.
[http://dx.doi.org/10.5625/lar.2016.32.2.105] [PMID: 27382379]
[22]
Yang, X.; Tohda, C. Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70). Sci. Rep., 2018, 8(1), 11707.
[http://dx.doi.org/10.1038/s41598-018-30102-8] [PMID: 30076345]
[23]
Gaur, V.; Bodhankar, S.L.; Mohan, V.; Thakurdesai, P. Antidepressant-like effect of 4-hydroxyisoleucine from Trigonella foenum graecum L. seeds in mice. Biomed. Aging Pathol., 2012, 2(3), 121-125.
[http://dx.doi.org/10.1016/j.biomag.2012.07.002]
[24]
Syed, Q.A.; Rashid, Z.; Ahmad, M.H.; Shukat, R.; Ishaq, A.; Muhammad, N.; Rahman, H.U.U. Nutritional and therapeutic properties of fenugreek ( Trigonella foenum-graecum ): a review. Int. J. Food Prop., 2020, 23(1), 1777-1791.
[http://dx.doi.org/10.1080/10942912.2020.1825482]
[25]
Assad, T.; Khan, R.A.; Rajput, M.A. Effect of Trigonella foenum-graecum Linn. seeds methanol extract on learning and memory. Metab. Brain Dis., 2018, 33(4), 1275-1280.
[http://dx.doi.org/10.1007/s11011-018-0235-1] [PMID: 29681009]
[26]
Beg, T.; Jyoti, S.; Naz, F. Rahul, ; Ali, F.; Ali, S.K.; Reyad, A.M.; Siddique, Y.H. Protective effect of kaempferol on the transgenic Drosophila model of Alzheimer’s disease. CNS Neurol. Disord. Drug Targets, 2018, 17(6), 421-429.
[http://dx.doi.org/10.2174/1871527317666180508123050] [PMID: 29745345]
[27]
Ali, F. Rahul, ; Naz, F.; Jyoti, S.; Siddique, Y.H. Health functionality of apigenin: A review. Int. J. Food Prop., 2017, 20(6), 1197-1238.
[http://dx.doi.org/10.1080/10942912.2016.1207188]
[28]
Thillaivanan, S.; Samraj, K. Challenges, constraints and opportunities in herbal medicines-a review. Int. J. Herb. Med., 2014, 2, 21-24.
[29]
Sharma, P.; Manchanda, R.; Goswami, R.; Chawla, S. Biodiversity and therapeutic potential of medicinal plants. In: Environmental Concerns and Sustainable Development; Shukla, V.; Kumar, N., Eds.; 27-44.
[http://dx.doi.org/10.1007/978-981-13-6358-0_2]
[30]
Elkordy, AA.; Haj-Ahmad, RR.; Awaad, AS.; Zaki, RM. An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future. J. Drug. Del. Sci. Tech., 2021, 1(63), 102459.
[31]
Saklani, A.; Kutty, S. Plant-derived compounds in clinical trials. Drug Discov. Today, 2008, 13(3-4), 161-171.
[http://dx.doi.org/10.1016/j.drudis.2007.10.010] [PMID: 18275914]
[32]
Foroumandi, E.; Javan, R.; Moayed, L.; Fahimi, H.; Kheirabadi, F.; Neamatshahi, M.; Shogofteh, F.; Zarghi, A. The effects of fenugreek seed extract supplementation in patients with Alzheimer’s disease: A randomized, double‐blind, placebo‐controlled trial. Phytother. Res., 2023, 37(1), 285-294.
[http://dx.doi.org/10.1002/ptr.7612] [PMID: 36199177]
[33]
Fridlender, M.; Kapulnik, Y.; Koltai, H. Plant derived substances with anti-cancer activity: From folklore to practice. Front. Plant Sci., 2015, 6, 799.
[http://dx.doi.org/10.3389/fpls.2015.00799] [PMID: 26483815]
[34]
Rai, K.S.; Bhat, K.M. Therapeutic Efficacy of Fenugreek Extract or/and Choline with Docosahexaenoic Acid in Attenuating Learning and Memory Deficits in Ovariectomized Rats. J Krishna Institute Med Sci, 2018, 1, 7.
[35]
Chowdhury, A.A.; Gawali, N.B.; Munshi, R.; Juvekar, A.R. Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice. Metab. Brain Dis., 2018, 33(3), 681-691.
[http://dx.doi.org/10.1007/s11011-017-0147-5] [PMID: 29277879]
[36]
Chowdhury, A.A.; Gawali, N.B.; Bulani, V.D.; Kothavade, P.S.; Mestry, S.N.; Deshpande, P.S.; Juvekar, A.R. In vitro antiglycating effect and in vivo neuroprotective activity of Trigonelline in d -galactose induced cognitive impairment. Pharmacol. Rep., 2018, 70(2), 372-377.
[http://dx.doi.org/10.1016/j.pharep.2017.09.006] [PMID: 29477946]
[37]
Nasiri, L.; Zardooz, H.; Reineh, Z.K.; Roghani, M. The effect of fenugreek methanolic extract on learning and memory in experimental model of Alzheimer’s disease in rat. J. Basic Clin Pathophysiol, 2019, 7, 486.
[38]
Nikbakht, F.; Roghani, M.; Fahanik-Babaei, J.; Baluchnejadmojarad, T. Trigonelline protects hippocampus against intracerebral A?(1–40) as a model of Alzheimer’s disease in the rat: Insights into underlying mechanisms. Metab. Brain Dis., 2019, 1, 34.
[http://dx.doi.org/10.1007/s11011-018-0338-8]
[39]
Algridi, M.A.; Azab, A.E. Ameliorating effects of fenugreek seeds powder against hematotoxicity induced by aluminum chloride in male rabbits. J. Biotechnology and Bioprocessing., 2021, 2, 2766-314.
[40]
Zeng, W.Y.; Tan, L.; Han, C.; Zheng, Z.Y.; Wu, G.S.; Luo, H.R.; Li, S.L. Trigonelline extends the lifespan of C. Elegans and delays the progression of age-related diseases by activating AMPK, DAF-16, and HSF-1. Oxid. Med. Cell. Longev., 2021, 2021, 1-11.
[http://dx.doi.org/10.1155/2021/7656834] [PMID: 34616504]
[41]
Cheng, S.M.; Ho, Y.J.; Yu, S.H.; Liu, Y.F.; Lin, Y.Y.; Huang, C.Y.; Ou, H.C.; Huang, H.L.; Lee, S.D. Anti-apoptotic effects of diosgenin in D-galactose-induced aging brain. Am. J. Chin. Med., 2020, 48(2), 391-406.
[http://dx.doi.org/10.1142/S0192415X20500202] [PMID: 32138534]
[42]
Hussain, SM.; Almutairi, N.; Alrakaf, F.; Aljameli, M.; Alshammari, M.; Alnasser, S. Nootropic effect of fenugreek seed extract against scopolamine induced cognitive decline in experimental mice. Psychology, 2020.
[43]
Roghani, M.; Sanaeierad, A.; Reineh, Z.K.; Mahmoudi, N.; Kiasalari, Z.; Rahmani, T. Diosgenin attenuates cognitive impairment in streptozotocin-induced diabetic rats: Underlying mechanisms. Neuropsychobiology, 2021, 80(1), 25-35.
[PMID: 32526752]
[44]
Belaïd-Nouira, Y.; Bakhta, H.; Bouaziz, M.; Flehi-Slim, I.; Haouas, Z.; Ben Cheikh, H. Study of lipid profile and parieto-temporal lipid peroxidation in AlCl3 mediated neurotoxicity. modulatory effect of fenugreek seeds. Lipids Health Dis., 2012, 11(1), 16.
[http://dx.doi.org/10.1186/1476-511X-11-16] [PMID: 22280491]
[45]
Moghadam, F.H.; Vakili-Zarch, B.; Shafiee, M.; Mirjalili, A. Fenugreek seed extract treats peripheral neuropathy in pyridoxine induced neuropathic mice. EXCLI J., 2013, 12, 282-290.
[PMID: 26417231]
[46]
Ahmed, S.I.; Hayat, M.Q.; Zahid, S.; Tahir, M.; Mansoor, Q.; Ismail, M.; Keck, K.; Bates, R. Isolation and identification of flavonoids from anticancer and neuroprotective extracts of <i>Trigonella foenum</i> graecum. Trop. J. Pharm. Res., 2017, 16(6), 1391-1398.
[http://dx.doi.org/10.4314/tjpr.v16i6.25]
[47]
Yousef nasab, F.; Hajinezhad, M.R.; Hashemi, H.; Miri, A. Comparison the effects of Trigonella foenum-graecum L. Seed and Cordia myxa fruit extracts on diabetes induced memory impairment in rats. International Journal of Basic Science in Medicine, 2017, 2(4), 184-188.
[http://dx.doi.org/10.15171/ijbsm.2017.34]
[48]
Khalili, M.; Alavi, M.; Esmaeil-Jamaat, E.; Baluchnejadmojarad, T.; Roghani, M. Trigonelline mitigates lipopolysaccharide-induced learning and memory impairment in the rat due to its anti-oxidative and anti-inflammatory effect. Int. Immunopharmacol., 2018, 61(61), 355-362.
[http://dx.doi.org/10.1016/j.intimp.2018.06.019] [PMID: 29935483]
[49]
Bafadam, S.; Beheshti, F.; Khodabakhshi, T.; Asghari, A.; Ebrahimi, B.; Sadeghnia, H.R.; Mahmoudabady, M.; Niazmand, S.; Hosseini, M. Trigonella foenum-graceum seed (Fenugreek) hydroalcoholic extract improved the oxidative stress status in a rat model of diabetes-induced memory impairment. Horm. Mol. Biol. Clin. Investig., 2019, 39(2), 20180074.
[http://dx.doi.org/10.1515/hmbci-2018-0074] [PMID: 31188777]
[50]
Varshney, V.; Garabadu, D. Ang(1–7) exerts Nrf2-mediated neuroprotection against amyloid beta-induced cognitive deficits in rodents. Mol. Biol. Rep., 2021, 48(5), 4319-4331.
[http://dx.doi.org/10.1007/s11033-021-06447-1] [PMID: 34075536]
[51]
Som, S.; Antony, J.; Dhanabal, S.P.; Ponnusankar, S. Neuroprotective role of Diosgenin, a NGF stimulator, against Aβ (1–42) induced neurotoxicity in animal model of Alzheimer’s disease. Metab. Brain Dis., 2022, 37(2), 359-372.
[http://dx.doi.org/10.1007/s11011-021-00880-8] [PMID: 35023028]
[52]
Tohda, C.; Lee, Y.A.; Goto, Y.; Nemere, I. Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS. Sci. Rep., 2013, 3(1), 3395.
[http://dx.doi.org/10.1038/srep03395] [PMID: 24292207]
[53]
Fernandes, F; Barroso, MF De Simone, A Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease. J. Ethnopharmacol., 2022, 23(290), 115107.2022.
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    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59234415 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59234415) limit 1
      3.76msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59234415
      • 1: 59234415
      • 2: 59234415
      • 3: 59234415
      • 4: 59234415
      • 5: 59234415
      • 6: 59234415
      • 7: 59234415
      • 8: 59234415
      • 9: 59234415
      • 10: 59234415
      • 11: 59234415
      • 12: 59234415
      • 13: 59234415
      • 14: 59234415
      • 15: 59234415
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:63
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=132090
      620μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 66 limit 1
      760μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 66
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=66) and sj.journal_id!=66 group by `j`.`nid`) as `aggregate_table`
      780μsalphaeurekaselec_live_10_06_2022Subject.php#198
      Backtrace
      • 16. app/Models/Subject.php:198
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=66) and sj.journal_id!=66 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      670μsalphaeurekaselec_live_10_06_2022Subject.php#198
      Backtrace
      • 14. app/Models/Subject.php:198
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=66) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      4.6msalphaeurekaselec_live_10_06_2022Subject.php#218
      Backtrace
      • 16. app/Models/Subject.php:218
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=66) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      3.74msalphaeurekaselec_live_10_06_2022Subject.php#218
      Backtrace
      • 14. app/Models/Subject.php:218
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '132090'
      190μsalphaeurekaselec_live_10_06_2022Keywords.php#85
      Bindings
      • 0: 132090
      Backtrace
      • 13. app/Models/Keywords.php:85
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '132090'
      1.63msalphaeurekaselec_live_10_06_2022Article.php#1569
      Bindings
      • 0: 132090
      Backtrace
      • 13. app/Models/Article.php:1569
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs , `au`.*, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '132090' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.44msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 132090
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      250μsalphaeurekaselec_live_10_06_2022BundleOffer.php#113
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:113
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      440μsalphaeurekaselec_live_10_06_2022Article.php#1959
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1959
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 66 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      20.49msalphaeurekaselec_live_10_06_2022Issue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 66 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
      7.78msalphaeurekaselec_live_10_06_2022Article.php#527
      Backtrace
      • 13. app/Models/Article.php:527
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 66 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
      6.66msalphaeurekaselec_live_10_06_2022Article.php#527
      Backtrace
      • 13. app/Models/Article.php:527
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 132090 limit 1
      220μsalphaeurekaselec_live_10_06_2022Article.php#743
      Bindings
      • 0: 132090
      Backtrace
      • 14. app/Models/Article.php:743
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 132090 and content_type = 'article' order by status desc limit 1
      250μsalphaeurekaselec_live_10_06_2022Article.php#750
      Backtrace
      • 11. app/Models/Article.php:750
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 217360 limit 1
      200μsalphaeurekaselec_live_10_06_2022Meta.php#59
      Bindings
      • 0: 217360
      Backtrace
      • 14. app/Models/Meta.php:59
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      230μsalphaeurekaselec_live_10_06_2022BundleOffer.php#113
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:113
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CAR' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      320μsalphaeurekaselec_live_10_06_2022Article.php#2024
      Bindings
      • 0: CAR
      Backtrace
      • 13. app/Models/Article.php:2024
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '132090' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      320μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12621' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      300μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3346' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      270μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3346) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3346) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3346)
      640μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12621) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12621) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12621)
      540μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 132090) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 132090) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59234415 and j.to_ip >=59234415 )) and ((j.from_date <= 1736991043 and j.to_date >= 1736991043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 132090)
      580μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '71' and is_uploaded = 1 and issue_id = 12621 order by cast(first_page as SIGNED) desc limit 1
      480μsalphaeurekaselec_live_10_06_2022Article.php#1818
      Bindings
      • 0: 71
      Backtrace
      • 14. app/Models/Article.php:1818
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '79' and is_uploaded = 1 and issue_id = 12621 order by cast(first_page as SIGNED) asc limit 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1830
      Bindings
      • 0: 79
      Backtrace
      • 14. app/Models/Article.php:1830
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      170μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      200μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 132090 limit 1
      2.38msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 132090
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 66 and `b`.`banner_from_date` <= 1736991043 and `b`.`banner_to_date` >= 1736991043 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.09msalphaeurekaselec_live_10_06_2022Banner.php#189
      Bindings
      • 0: 1
      • 1: J
      • 2: 66
      • 3: 1736991043
      • 4: 1736991043
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:189
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='65a8dc55daf5c62766b5e22365562b4e'
      180μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._main_menu:13
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        C8Yb46Qb9UKyw61whTiJcbVQZsJc0zPMaRzP5WVC
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        array:1 [ "url" => "https://beta.benthamscience.com/article/132090" ]
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        array:2 [ "old" => [] "new" => [] ]
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        []
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        request_headers
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        request_cookies
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        response_headers
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        ClearShow all
        Date ↕MethodURLData
        #12025-01-16 01:30:43GET/article/13209058351