Abstract

The application describes compounds, such as compounds of general Formula, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and synthetic methods of various compounds with warheads are included. The compounds are inhibitors of proteases, such as the 3C, CL- or 3CL-like protease.

Keywords: Cysteine protease inhibitors, COVID-19, cysteine proteases, 3C-like protease, paxlovid, molnupiravir.