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Current Organocatalysis

Author(s): Ram Naresh Yadav, Taoufik Rohand and Bimal Krishna Banik*

DOI: 10.2174/2213337210666230516151722

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Rice Malt: A Solvent-Catalyst for the Synthesis of N-Substituted Pyrroles

Page: [276 - 282] Pages: 7

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Abstract

Aim: The synthesis of diverse N-substituted pyrroles utilizing rice malt is identified. The reaction of hexane-2,5-dione with various primary amines develops the intriguing pyrrole scaffold in moderate to good yields.

Methods: The reaction was carried out at room to ambient temperature in an extremely environmentally benign condition, without the need for any additional solvents or catalysts.

Results: In the synthesis of N-derivatized pyrroles, several 1 amines, both cyclic and acyclic residue, have been accomplished.

Conclusion: To the best of my knowledge, no study has been reported so far based on Paal- Knorr pyrrole synthesis utilizing rice malt as a catalyst and solvent.

Keywords: Rice malt, polysaccharides, polyhydroxy-sugar, paal-knorr, pyrrole, chemotherapeutics, hexane-2, 5-dione, amine, cyclodehydration, cyclo-condensation, aromatization.

Graphical Abstract

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