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Anti-Cancer Agents in Medicinal Chemistry

Author(s): Neha Srivastava, Yachana Mishra, Vijay Mishra*, Abhigyan Ranjan and Murtaza M. Tambuwala

DOI: 10.2174/1871520623666230510094850

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Carbon Nanotubes in Breast Cancer Treatment: An Insight into Properties, Functionalization, and Toxicity

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Abstract

Breast cancer is the most common cancer among women worldwide. It is the main reason why women die from cancer. Early diagnosis due to increased public awareness and better screening helps to tackle the disease through surgical resection and curative therapies. Chemotherapies are frequently used for cancer treatment, but these have severe adverse effects due to a lack of target specificity. Formulation development scientists and clinicians are now particularly concerned with developing safe and efficient drug delivery systems for breast cancer treatment. Potentially relevant literature to get the latest developments and updated information related to properties, functionalization, toxicity and application of carbon nanotubes in breast cancer treatment has been obtained from Web of Science, Scopus, and PubMed portals. Nanomedicine has emerged as a novel tool for target-specific delivery systems and other biomedical applications. Carbon nanotubes (CNTs) are gaining popularity due to their unique mechanical and physiochemical properties for the diagnosis and treatment of cancer. It is a promising carrier that can deliver micro and macromolecules to the cancer cell. CNTs can be functionalized at the surface with different functional groups, which helps in targeting the drugs to target cancer cells. The present review has elaborated on different functionalization approaches and toxicity aspects of CNTs.

Keywords: Breast cancer, carbon nanotubes, toxicity, functionalization, aptamer, antibodies.

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