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Letters in Organic Chemistry

Author(s): Le Thi Loan Chi* and Seiji Iwasa

DOI: 10.2174/1570178620666230502154058

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A Scope of Chiral Cyclopropanations of Various α-functionalized Diazoketone Derivatives with Styrene Catalyzed by p-Nitro Ru(II)-diphenyl- Pheox Complex

Page: [1055 - 1061] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Following the success of the first intermolecular cyclopropanations of diazo acetoxy acetone with olefins using a novel p-nitro-Ru(II)-diphenyl-Pheox catalyst, other α-functionalized diazoketones have synthesized using the same reaction conditions. Consequently, chiral cyclopropyl products were formed with excellent yield (up to 87% yield), high diastereoselectivity (up to 99:1), and high enantioselectivity (up to 90% ee).

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