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Drug Metabolism and Bioanalysis Letters

Author(s): Manu Singhai and Sankha Bhattacharya*

DOI: 10.2174/2949681016666230501172824

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Bigels; A Charismatic Drug Delivery Formulation

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Abstract

Bigels are a novel concept in contrast to previous gel formulations. To look like one gel, bigels are made by merging two gel phases at high shear rates. Colloidal gels can be the same (as in water-in-water bigels, which are phase-separated systems), the same but different, or a combination of a hydrogel and an oleogel. These colloidal gels are utilized to construct bigels (oleogel-in-hydrogel bigels or hydrogel-in-oleogel bigels). Bigels have appealing qualities like hydrophilic and hydrophobic properties, improved spreadability, improved drug penetration, higher stratum corneum hydration, and the capacity to control the drug release rate. Bigels' mechanical, structural, thermal, physical, rheological, and electrical properties are crucial to their practical and successful use in a variety of commercial applications. In this compilation, we have talked about the convenience and interest of bigels as a formulation for novel applications in the pharmaceutical, cosmetic, and food industries. The use of several notable bigels is also discussed in the paper. The Bigels are widely utilized in the food and pharmaceutical industries as well. The Bigels are now being researched as possible drug delivery matrices.

Keywords: Bigel, viscous formulation, hydrogel, organogel, controlled drug delivery, pharmaceutical applications.

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