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Current Drug Therapy

Author(s): Kamal Uddin Zaidi*, Fatema Shah and Firoz Naem Khan

DOI: 10.2174/1574885518666230428153035

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Potential Synergistic Effect of F.carica Against P. aeruginosa Intended for the Management of Nosocomial Infection

Page: [81 - 87] Pages: 7

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Abstract

Background: Multi-drug resistance of Pseudomonas aeruginosa comprises the most vital obstacles in the antibacterial fight worldwide. The innovation of novel and effective antibacterial and/or resistance modulators is crucial to variance the extent of resistance or to reverse multidrug resistance.

Objective: This study aimed to determine the in vitro antibacterial activity of the F.carica against the Pseudomonas aeruginosa associated with nosocomial infection.

Methods: We studied different extracts of F.carica in methanol, benzene and water with antibiotics and their synergistic effect against P. aeruginosa using minimum inhibitory concentration and fraction inhibitory concentration index.

Results: Our results revealed that the methanol extract of leaves possessed maximum phyto constituents and were active against P. aeruginosa. Methanol extracts of leaves alone and in combination with antibiotics showed a higher zone of inhibition and were synergistic (<0.5) compared to other extracts. Moreover, the combination of ofloxacin with all solvent extracts enhanced the synergistic antibacterial activity with respect to other antibiotics used.

Conclusion: We explored the synergistic effects of F. carica methanol extracts alone and with antibiotics was the most potential against P. aeruginosa.

Keywords: Synergism, antibacterial, drug, extract, resistance, nosocomial infection.

Graphical Abstract

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