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Recent Advances in Anti-Infective Drug Discovery

Author(s): Inas M. Abou El-Enain, Nermine N. Abed, Eman E. Helal, Eman S. Abdelkhalek, Waleed Suleiman, Nesreen A. Safwat and Mohammed Yosri*

DOI: 10.2174/2772434418666230427165013

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Eco-friendly Biosynthesis of Ag-NPs by Streptomyces griseus with Anti-Candida albicans and Antitumor Activity

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Abstract

Background: The most significant sexually transmissible fungal disease, semen candidiasis, is caused by Candida albicans and impacts male reproductive potential. Actinomycetes are a group of microorganisms that could be isolated from various habitats and used for the biosynthesis of various nanoparticles with biomedical applications.

Objective: Testing antifungal activity of biosynthesized Ag nanoparticles versus isolated C. albicans from semen as well as its anticancer activity versus the CaCO2 cell line.

Methods: Screening 17 isolated actinomycetes for the biosynthesis of Ag nanoparticle biosynthesis. Characterization of biosynthesized nanoparticles, testing its anti-Candida albicans, and antitumor activity.

Results: Streptomyces griseus was the isolate that identified silver nanoparticles using UV, FTIR, XRD and TEM. Biosynthesized nanoparticles have promising anti-Candida albicans with MIC (125 ± 0.8) μg/ml and accelerate apoptotic rate versus CaCO2 cells (IC50 = 7.30 ± 0.54 μg/ml) with minimal toxicity (CC50 = 142.74 ± 4.71 μg/ml) versus Vero cells.

Conclusion: Certain actinomycetes could be used for the biosynthesis of nanoparticles with successive antifungal and anticancer activity to be verified by in vivo studies.

Keywords: Streptomyces griseus, Candida albicans, nanoparticles, antifungal action, antitumor impact, Ag-NPs.

Graphical Abstract

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