Applications of Silver Nanoparticles in Patent Research

Ana Paula   G.B.   Azevedo; Nathalia      Müller; Celso      Sant´Anna

Abstract

Background: Silver nanoparticles (AgNPs) have been widely applied in research and industrial fields, finding applications in nanomedicine, drug delivery, biomedical devices, electronics, the energy sector, and environmental protection. Patents provide information on the industrial viability of product technologies, and the number of patent documents provides an estimate of the evolution of a specific technological field.

Aims: The present work aims to describe the current trends in AgNPs patent applications. In addition, a retrospective study of published patents in Brazil is presented.

Methods: Analyses of AgNPs-related patents were conducted using the free platform for patent search Lens® in 2010-2019 and articles published in same period using the Scholar® base. The patent applications and their evolution over time, major depositors and holders, and the main technological areas associated with AgNP applications have been described.

Results: China and United States are the major patent applicants for nanotechnologies. The worldwide distribution of publications of journal articles shows that China, India, and the United States are the leading countries in the total number of articles published, in that order.

Conclusion: Our study of patent applications and published articles confirmed the growing global increase in new technologies involving NPs and AgNPs, particularly in the biotechnology area, in the fields of medicine and agriculture.

Keywords: Silver nanoparticles, patent, nanotechnology, bionanotechnology, nanoparticles, patent application.

Graphical Abstract

[1]
Modi S, Prajapati R, Inwati GK, et al. Recent trends in fascinating applications of nanotechnology in allied health sciences. Crystals  2021; 12(1): 39.
 [http://dx.doi.org/10.3390/cryst12010039]

[2]
Kowalczyk P, Szymczak M, Maciejewska M, et al. All that glitters is not silver-A new look at microbiological and medical applications of silver nanoparticles. Int J Mol Sci  2021; 22(2): 854.
 [http://dx.doi.org/10.3390/ijms22020854] [PMID: 33467032]

[3]
Naganthran A, Verasoundarapandian G, Khalid FE, et al. Synthesis, characterization and biomedical application of silver nanoparticles. Materials  2022; 15(2): 427.
 [http://dx.doi.org/10.3390/ma15020427] [PMID: 35057145]

[4]
Ealias AM, Saravanakumar MP. A review on the classification, characterisation, synthesis of nanoparticles and their application. IOP Conference Series. Mater Sci Eng  2017; 263(3): 032019. Available from: https://iopscience.iop.org/article/10.1088/1757-899X/263/3/032019

[5]
Pryshchepa O, Pomastowski P, Buszewski B. Silver nanoparticles: Synthesis, investigation techniques, and properties Advances in Colloid and Interface Science.  Amsterdam: Elsevier B.V. 2020; p. 284.

[6]
Lee S, Jun BH. Silver nanoparticles: Synthesis and application for nanomedicine. Int J Mol Sci  2019; 20(4): 865.
 [http://dx.doi.org/10.3390/ijms20040865] [PMID: 30781560]

[7]
Pandey G, Jain P. Assessing the nanotechnology on the grounds of costs, benefits, and risks Beni-Suef University Journal of Basic and Applied Sciences Springer Science and Business Media Deutschland GmbH.   2020; Vol. 9. Available from: https://bjbas.springeropen.com/articles/10.1186/s43088-020-00085-5

[8]
Grand View Research. Nanomaterials market size, share & trends analysis report by product (Carbon Nanotubes, Titanium Dioxide), by application (Medical, Electronics, Paints & Coatings), By Region, And Segment Forecasts, 2020 - 2027.  2020; p. 113.

[9]
Mikhailov O, Mikhailova EO. Elemental silver nanoparticles: Biosynthesis and bio applications. Materials  2019; 12(19): 3177.

[10]
 Organisation for Economic Co-operation and Development. OECD patent statistics manual. OECD 2009. Available from: https://www.oecd.org/sti/inno/oecdpatentstatisticsmanual.htm

[11]
 WIPO. Global Innovation Index. World Intellectual Property Organization. 2020. Available from: https://www.globalinnovationindex.org/gii-2016-report#

[12]
Krishnan PD, Banas D, Durai RD, et al. Silver nanomaterials for wound dressing applications. Pharmaceutics. MDPI AG  2020; 12: 1-27.

[13]
Singh N, Dhanya BS, Verma ML. Nano-immobilized biocatalysts and their potential biotechnological applications in bioenergy production. Mater Sci Energy Technol  2020; 3: 808-24.
 [http://dx.doi.org/10.1016/j.mset.2020.09.006]

[14]
Tortella GR, Rubilar O, Durán N, Diez MC, Martínez M, Parada J. Silver nanoparticles: Toxicity in model organisms as an overview of its hazard for human health and the environment. J Hazard Mater  2020; 390: 121974.

[15]
 OECD. Oslo Manual 2018: Guidelines for collecting, reporting and using data on innovation. (The Measurement of Scientific, Technological and Innovation Activities). 2018. Available from: https://www.oecd-ilibrary.org/science-and-technology/oslo-manual-2018_9789264304604-en

[16]
Durán N, Nakazato G, Seabra AB. Antimicrobial activity of biogenic silver nanoparticles, and silver chloride nanoparticles: An overview and comments. Appl Microbiol Biotechnol  2016; 100(15): 6555-70.
 [http://dx.doi.org/10.1007/s00253-016-7657-7] [PMID: 27289481]

[17]
Husain S, Nandi A, Simnani FZ, et al. Emerging trends in advanced translational applications of silver nanoparticles: A progressing dawn of nanotechnology. J Funct Biomater  2023; 14(1): 47.
 [http://dx.doi.org/10.3390/jfb14010047] [PMID: 36662094]

[18]
Yuan D, He H, Wu Y, Fan J, Cao Y. Physiologically based pharmacokinetic modeling of nanoparticles. J Pharm Sci  2019; 108(1): 58-72.
 [http://dx.doi.org/10.1016/j.xphs.2018.10.037] [PMID: 30385282]

[19]
Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The history of nanoscience and nanotechnology: From chemical-physical applications to nanomedicine. Molecules  2019; 25(1): 112.
 [http://dx.doi.org/10.3390/molecules25010112] [PMID: 31892180]

[20]
Bruna T, Maldonado-Bravo F, Jara P, Caro N. Silver nanoparticles and their antibacterial applications. Int J Mol Sci. MDPI  2021; 22(13): 7202.

[21]
Sharma NK, Vishwakarma J, Rai S, Alomar TS, Almasoud N, Bhattarai A. Green route synthesis and characterization techniques of silver nanoparticles and their biological adeptness. ACS Omega  2022; 7(31): 27004-20.
 [http://dx.doi.org/10.1021/acsomega.2c01400]

[22]
Sampath G, Chen YY, Rameshkumar N, Krishnan M, Nagarajan K, Shyu DJH. Biologically synthesized silver nanoparticles and their diverse applications. Nanomaterials. MDPI  2022; 12(18): 3126.

[23]
Tariq M, Mohammad KN, Ahmed B, Siddiqui MA, Lee J. Biological synthesis of silver nanoparticles and prospects in plant disease management. Molecules. MDPI  2022; 27(15): 4754.

[24]
Xu L, Wang YY, Huang J, Chen CY, Wang ZX, Xie H. Silver nanoparticles: Synthesis, medical applications and biosafety. Theranostics.  Ivyspring International Publisher 2020; 10: p. 8996-9031.

[25]
Ali J, Ali N, Wang L, Waseem H, Pan G. Revisiting the mechanistic pathways for bacterial mediated synthesis of noble metal nanoparticles. J Microbiol Methods  2019; 159(159): 18-25.
 [http://dx.doi.org/10.1016/j.mimet.2019.02.010] [PMID: 30797020]

[26]
Mikhailova EO. Silver Nanoparticles: Mechanism of action and probable bio-application. J Funct Biomater  2020; 11(4): 84.
 [http://dx.doi.org/10.3390/jfb11040084] [PMID: 33255874]

[27]
Gherasim O, Puiu RA, Bîrca AC. Burduşel AC, Grumezescu AM. An updated review on silver nanoparticles in biomedicine. Nanomaterials. MDPI AG  2020; 10(11): 1-44.

[28]
Devasahayam S. Nanotechnology and Nanomedicine in Market: A Global Perspective on Regulatory Issues. A Global Perspective on Regulatory Issues. Characterization and Biology of Nanomaterials for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery.  Amsterdam: Elsevier Inc. 2018; pp. 477-522.
 [http://dx.doi.org/10.1016/B978-0-12-814031-4.00017-9]

[29]
Salamanca-Buentello F, Daar AS. Nanotechnology, equity and global health. Nature Nanotechnology. Nat Resour  2021; 16(4): 358-61.

[30]
Kaningini AG, Nelwamondo AM, Azizi S, Maaza M, Mohale KC. Metal Nanoparticles in Agriculture: A Review of Possible Use. Coatings. MDPI  2022; 12(10): 1880.

[31]
Rajput VD, Singh A, Minkina T, Rawat S, Mandzhieva S, Sushkova S, et al. Nano-enabled products: Challenges and opportunities for sustainable agriculture. Plants. MDPI  2021; 10(12): 2728.

[32]
Thakur M, Wang B, Verma ML. Development and applications of nanobiosensors for sustainable agricultural and food industries: Recent developments, challenges and perspectives. Environmen Technol Innov  2022; 26: 102371.

[33]
a) Shanmuganathan R, Karuppusamy I, Saravanan M, et al. Synthesis of silver nanoparticles and their biomedical applications-a comprehensive review. Curr Pharm Des  2019; 25(24): 2650-60.
 [http://dx.doi.org/10.2174/1381612825666190708185506] [PMID: 31298154]; 
b) Geckeler KE, Debnath D, Kim C, Kim SH. Solid state synthesis method of silver nanoparticles and silver nanoparticles synthesized thereby. WO2011059215A2, 2011.

[34]
Chugh H, Sood D, Chandra I, Tomar V, Dhawan G, Chandra R. Role of gold and silver nanoparticles in cancer nano-medicine. Artif Cells Nanomed Biotechnol  2018; 46(sup1): 1210-20.
 [http://dx.doi.org/10.1080/21691401.2018.1449118]

[35]
Abass Sofi M, Sunitha S, Ashaq Sofi M, Khadheer Pasha SK, Choi D. An overview of antimicrobial and anticancer potential of silver nanoparticles. J King Saud University-Science  2022; 34(2): 101767.
 [http://dx.doi.org/10.1016/j.jksus.2021.101791]

Cite As

Recent Patents on Nanotechnology

Applications of Silver Nanoparticles in Patent Research

Abstract

Graphical Abstract