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Current Pediatric Reviews

Author(s): Raffaele Falsaperla*, Marco Simone Vaccalluzzo, Ausilia Desiree Collotta, Martino Ruggieri and Salvatore Agati

DOI: 10.2174/1573396320666230417103203

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Extracorporeal Membrane Oxygenation (ECMO) in an Infant with COVID-19: A Case Report with Literature Review

Page: [370 - 374] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

Background: SARS-CoV-2 infection tends to be lethal to the elderly population. However, sometimes children are also involved.

Case Presentation: We present the case of a female infant with a corrected gestational age of 39 weeks and 4 days with severe COVID-19 pneumonia and co-infection of Klebsiella pneumoniae that was supported with extracorporeal membrane oxygenation (ECMO).

Results: We reported the clinical case and reviewed the literature articles on ECMO and Covid-19 in infants and children up to two years of age.

Conclusion: It is crucial to be aware of certain risk factors (severe prematurity, coinfection), which, when linked to SARS-CoV-2 infection, must immediately alert us to the possible criticality of the clinical condition of patients, as highlighted by our own clinical case.

Graphical Abstract

[1]
WHO. Coronavirus disease (COVID-19) Available From: https://www.who.int/news-room/q-a-detail/coronavirus-disease-covid-19
[2]
World Health Organization. COVID-19 disease in children and adolescents. Sci Br 2021; (September): 1-10.
[3]
Hu B, Huang S, Yin L. The cytokine storm and COVID‐19. J Med Virol 2021; 93(1): 250-6. Available From: http://www.ncbi.nlm.nih.gov/pubmed/32592501
[http://dx.doi.org/10.1002/jmv.26232] [PMID: 32592501]
[4]
Singh AK, Oks M, Husk G, et al. Impact of timing of tocilizumab use in hospitalized patients with SARS-CoV-2 infection. Respir Care 2021; 66(12): 1805-14. Available From: https://rc.rcjournal.com/lookup/doi/10.4187/respcare.08779
[http://dx.doi.org/10.4187/respcare.08779] [PMID: 34548407]
[5]
Mallalieu NL, Wimalasundera S, Hsu JC, et al. Intravenous dosing of tocilizumab in patients younger than two years of age with systemic juvenile idiopathic arthritis: Results from an open-label phase 1 clinical trial. Pediatr Rheumatol Online J 2019; 17(1): 57. Available From: https://www.ncbi.nlm.nih.gov/pubmed/31438986
[http://dx.doi.org/10.1186/s12969-019-0364-z] [PMID: 31438986]
[6]
Velasco Puyó P, Moreno L, Díaz de Heredia C, Rivière JG, Soler Palacín P. Tocilizumab in a child with acute lymphoblastic leukemia and cytokine release syndrome associated with COVID-19. Ann Pediatr 2020; 93(2): 132-3. Available From: https://www.linkinghub.elsevier.com/retrieve/pii/S1695403320301806
[http://dx.doi.org/10.1016/j.anpedi.2020.05.002]
[7]
Murphy DA, Hockings LE, Andrews RK, et al. Extracorporeal membrane oxygenation-hemostatic complications. Transfus Med Rev 2015; 29(2): 90-101. Available From: http://www.ncbi.nlm.nih.gov/pubmed/25595476
[http://dx.doi.org/10.1016/j.tmrv.2014.12.001] [PMID: 25595476]
[8]
Thomas J, Kostousov V, Teruya J. Bleeding and Thrombotic Complications in the Use of Extracorporeal Membrane Oxygenation Semin Thromb Hemost 2018; 44(1): 020-9. Available From: https://www.ncbi.nlm.nih.gov/pubmed/28898902
[http://dx.doi.org/10.1055/s-0037-1606179] [PMID: 28898902]
[9]
Cavayas YA, del Sorbo L, Fan E. Intracranial hemorrhage in adults on ECMO. Perfusion 2018; 33 (Suppl. 1): 42-50. Available From: https://www.ncbi.nlm.nih.gov/pubmed/29788836
[http://dx.doi.org/10.1177/0267659118766435] [PMID: 29788836]
[10]
ELSO. Registry Dashboard of ECMO-Supported COVID-19 Patient Data.. Available From: https://www.elso.org/Registry/FullCOVID-19RegistryDashboard.aspx
[11]
Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Calò Carducci FI, et al. COVID-19 in children and adolescents in Europe: A multinational, multicentre cohort study. Lancet Child Adolesc Heal Lancet Child Adolesc Heal 2020; 4(9): 653-61. Available From: http://www.ncbi.nlm.nih.gov/pubmed/32593339
[12]
Meyts I, Bucciol G, Quinti I, et al. Coronavirus disease 2019 in patients with inborn errors of immunity: An international study. J Allergy Clin Immunol 2021; 147(2): 520-31. Available From: http://www.ncbi.nlm.nih.gov/pubmed/32980424
[http://dx.doi.org/10.1016/j.jaci.2020.09.010] [PMID: 32980424]
[13]
Cura Yayla BC, Özsürekçi Y, Aykaç K, et al. Characteristics and management of children with COVID-19 in Turkey. Balkan Med J 2020; 37(6): 341-7. Available From: http://www.ncbi.nlm.nih.gov/pubmed/32865382
[http://dx.doi.org/10.4274/balkanmedj.galenos.2020.2020.7.52] [PMID: 32865382]
[14]
Cicek M, Onalan MA, Yurtseven N. COVID-19 and ECMO support after neonatal congenital heart surgery: A case report. Cardiol Young 2022; 32(1): 150-3. Available From: http://www.ncbi.nlm.nih.gov/pubmed/34112275
[http://dx.doi.org/10.1017/S1047951121002511] [PMID: 34112275]
[15]
Di Nardo M, Hoskote A, Thiruchelvam T, et al. Extracorporeal membrane oxygenation in children with coronavirus disease 2019: Preliminary report from the collaborative European chapter of the extracorporeal life support organization prospective survey. ASAIO J 2021; 67(2): 121-4. Available From: http://www.ncbi.nlm.nih.gov/pubmed/33009172
[http://dx.doi.org/10.1097/MAT.0000000000001309] [PMID: 33009172]
[16]
Sainathan S, Heal ME, Frantz E, Johnston P, Smith R, Sharma M. Use of VA ECMO and percutaneous palliation of ductal dependent co-arctation in a neonate with trisomy 21 and COVID-19 pneumonia. Indian J Thorac Cardiovasc Surg 2021; 37(6): 698-701. Available From: http://www.ncbi.nlm.nih.gov/pubmed/34054231
[17]
Oualha M, Bendavid M, Berteloot L, et al. Severe and fatal forms of COVID-19 in children. Arch Pediatr 2020; 27(5): 235-8. Available From: http://www.ncbi.nlm.nih.gov/pubmed/32518045
[http://dx.doi.org/10.1016/j.arcped.2020.05.010] [PMID: 32518045]
[18]
Nabialek TJ, Puppala NK, Riordan A, Ramaraj R, Duong P, Guerrero R. Successful Management of a COVID-19 Positive Infant With Transposition of the Great Arteries. World J Pediatr Congenit Heart Surg 2021; 12(4): 554-6. Available From: http://www.ncbi.nlm.nih.gov/pubmed/33736537
[http://dx.doi.org/10.1177/21501351211000687] [PMID: 33736537]
[19]
Lee H, Choi S, Park JY, et al. Analysis of Critical COVID-19 Cases Among Children in Korea. J Korean Med Sci 2022; 37(1): e13. Available From: http://www.ncbi.nlm.nih.gov/pubmed/34981683
[http://dx.doi.org/10.3346/jkms.2022.37.e13] [PMID: 34981683]
[20]
Alfraij A, Bin Alamir AA, Al-Otaibi AM, et al. Characteristics and outcomes of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients admitted to the intensive care unit: A multicenter retrospective cohort study. J Infect Public Health 2021; 14(2): 193-200. Available From: http://www.ncbi.nlm.nih.gov/pubmed/33486375
[http://dx.doi.org/10.1016/j.jiph.2020.12.010] [PMID: 33486375]
[21]
Otto WR, Geoghegan S, Posch LC, et al. The Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Healthcare Network in the United States. J Pediatric Infect Dis Soc 2020; 9(5): 523-9. Available From: http://www.ncbi.nlm.nih.gov/pubmed/32559282
[http://dx.doi.org/10.1093/jpids/piaa074] [PMID: 32559282]
[22]
Derespina KR, Kaushik S, Plichta A, et al. Clinical manifestations and outcomes of critically ill children and adolescents with coronavirus disease 2019 in New York City. J Pediatr 2020; 226: 55-63. e2. Available From: http://www.ncbi.nlm.nih.gov/pubmed/32681989
[http://dx.doi.org/10.1016/j.jpeds.2020.07.039] [PMID: 32681989]
[23]
Burger M, Moore M, Wilburn J. Case Report: Pediatric patient with COVID-19 and multisystem inflammatory syndrome in children. Clin Pract Cases Emerg Med 2020; 4(4): 513-6. Available From: http://www.ncbi.nlm.nih.gov/pubmed/33217259
[http://dx.doi.org/10.5811/cpcem.2020.8.48376] [PMID: 33217259]
[24]
Ebach F, Hainmann I, Eis-Hübinger AM, et al. Successful ECMO therapy in a child with COVID‐19‐associated ARDS and acute lymphoblastic leukemia. Pediatr Blood Cancer 2021; 68(9): e29100. Available From: http://www.ncbi.nlm.nih.gov/pubmed/34022118
[http://dx.doi.org/10.1002/pbc.29100] [PMID: 34022118]