An Investigation into the Effects of Chemical, Pharmaceutical, and
Herbal Compounds on Neuroglobin: A Literature Review

Sahar   Golpour   Hamedani; Makan      Pourmasoumi; Gholamreza      Askari; Mohammad      Bagherniya; Thozhukat      Sathyapalan; Amirhossein      Sahebkar
Abstract

Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors have been increasingly studied over the last decade due to their neuroprotective role in neurological disorders and hypoxia. Studies have shown that a number of chemicals, pharmaceuticals, and herbal compounds can modulate the expression of Ngb at different dose levels, indicating a protective role against neurodegenerative diseases. Iron chelators, hormones, antidiabetic drugs, anticoagulants, antidepressants, plant derivatives and short-chain fatty acids are among these compounds. Therefore, this study aimed to review the literature focused on the possible effects and mechanisms of chemical, pharmaceutical, and herbal compounds on Ngbs.
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Cite As
Current Medicinal Chemistry

An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review

Abstract
