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Current Green Chemistry

Author(s): Thaisa Alves Celedonio da Silva, João Roberto da Silva Júnior and Ana Carolina Kogawa*

DOI: 10.2174/2213346110666230331085433

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A New, Ecological and Stability-indicating Method by HPLC for the Quantification of Moxifloxacin in Tablets

Page: [165 - 173] Pages: 9

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Abstract

Introduction: A new, ecological, and stability-indicating method by HPLC was developed for the quantification of moxifloxacin in tablets. A C18 column at 33°C, purified water acidified with 0.2% phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin-1, injection volume of 5 µL, and detection at 290 nm was used.

Method: The method was linear (2-12 µgmL-1), selective, accurate (100.86%), precise (RSD<2%), and robust.

Result: The retention time for moxifloxacin in tablets was approximately 4.4 minutes.

Conclusion: To sum up, a method based on the principles of green analytical chemistry was successfully developed and validated for the quantification of moxifloxacin in tablets.

Keywords: HPLC, green analytical chemistry, method validation, tablets, fluoroquinolone, moxifloxacin.

Graphical Abstract

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