Abstract

A simple and efficient synthesis of pyrrolo[1,2-a]pyrazine using Schiff base formation, intramolecular cyclization (or N-alkylation), and Pictet–Spengler type reaction (hetero-aromatisation) has been developed. In this chemistry, metal-free, cost and time-effective processes have been highlighted to afford the complex nitrogenous scaffold using simple starting materials.

Keywords: Pyrrolyl-ethanamine, halo-aldehyde, Pyrrolo[1, 2-a]pyrazines, cascade reaction, Pictet-Spengler reaction, heteroaromatization.