Abstract
Statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma
cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative
stress. The effect of statins on the central nervous system (CNS), particularly on cognition
and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS),
and Alzheimer’s disease (AD), has received increasing attention in recent years, both
within the scientific community and in the media. This review aims to provide an updated
discussion on the effects of statins on the differentiation and function of various nervous
system cells, including neurons and glial cells. Additionally, the mechanisms of action
and how different types of statins enter the CNS will be discussed.
Keywords:
Statins, neurodegeneration, pleiotropic effect, central nervous system, inflammation, plasma cholesterol.
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