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Current Traditional Medicine

Author(s): Vikrant Verma*

DOI: 10.2174/2215083809666230308093244

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The Herbal Treatment of Osteoarthritis

Article ID: e080323214447 Pages: 18

  • * (Excluding Mailing and Handling)

Abstract

Osteoarthritis is widely acknowledged as the most common, devastating, and diverse ailment that wreaks havoc on people's lives across the world. In the elderly, it is estimated that 10% of males and 18% of women over the age of 60 are affected and its frequency and incidence are increasing in the present scenario. Herbal medicines appear to be safe and effective with antiosteoarthritic effects that help in increased alleviation of symptoms and/or impairment and consist of numerous phytochemicals that have been scientifically verified and confirmed with antiosteoarthritic activity. Currently, there is no definitive cure for osteoarthritis, and there are no effective therapies that can stop or halt the progression of the disease. However, there are a variety of therapies available, ranging from new to old. Intra-articular injections, topical treatments, and oral medicines are altogether FDA-approved replacements for surgery. These all modes of treatment may prove fatal sometimes and are not always successful. Herbal medicines have been utilized worldwide for the treatment of osteoarthritis. This review mainly focuses on the treatment approach of osteoarthritis with the herbal medicines available, because of the side effects and toxicities, and unwanted symptoms of the present treatments.

Graphical Abstract

[1]
Maksimović Z, Samardžić S. Herbal Medicinal Products in the Treatment of Osteoarthritis. In: Osteoarthritis Biomarkers and Treatments IntechOpen;. 2019; pp. 1-2.
[http://dx.doi.org/10.5772/intechopen.80593]
[2]
Malemud CJ. The medical therapy of osteoarthritis: Thinking outside the box. J Ostheoathritis 2016; 1(1): 1-2.
[3]
Desai H, Shah R, Shah H, Thakkar K. Prevalence and medicinal practices for osteoarthritis in Western India. Natl J Physiol Pharm Pharmacol 2020; 11: 1.
[http://dx.doi.org/10.5455/njppp.2021.11.10289202006112020]
[4]
Panda SK, Kumari KL, Adhikari L, Sahu PK, Pal A. A review on clinical efficacy of traditional plants on osteoarthritis. Int J Pharm Sci Res 2019; 10(9): 4040-53.
[5]
Wang M, Liu L, Zhang CS, et al. Mechanism of traditional Chinese medicine in treating knee osteoarthritis. J Pain Res 2020; 13: 1421-9.
[http://dx.doi.org/10.2147/JPR.S247827] [PMID: 32606908]
[6]
Henrotin Y, Mobasheri A. Natural products for promoting joint health and managing osteoarthritis. Curr Rheumatol Rep 2018; 20(11): 72.
[http://dx.doi.org/10.1007/s11926-018-0782-9] [PMID: 30232562]
[7]
Ansaripour S, Dehghan M. Efficacy of some herbal medicines in osteoarthritis with a focus on topical agents: a systematic review. Curr Pharm Des 2020; 26(22): 2676-81.
[http://dx.doi.org/10.2174/1381612826666200429013728] [PMID: 32348208]
[8]
Unusan N. Proanthocyanidins in grape seeds: An updated review of their health benefits and potential uses in the food industry. J Funct Foods 2020; 67: 103861.
[http://dx.doi.org/10.1016/j.jff.2020.103861]
[9]
Prakash V, Jaiswal N, Srivastava M. A review on medicinal properties of Centella asiatica. Asian J Pharm Clin Res 2017; 10(10): 69-74.
[http://dx.doi.org/10.22159/ajpcr.2017.v10i10.20760]
[10]
Moqbel SAA, He Y, Xu L, et al. Rat chondrocyte inflammation and osteoarthritis are ameliorated by madecassoside Oxid Med Cell Longev 2020; 7540197.
[http://dx.doi.org/10.1155/2020/7540197]
[11]
Anvari M, Dortaj H, Hashemibeni B, Pourentezari M. Application of some herbal medicine used for the treatment of osteoarthritis and chondrogenesis. Trad Integrat Med 2020; 5(3): 126-49.
[http://dx.doi.org/10.18502/tim.v5i3.4321]
[12]
Qin Z, Liao D, Chen Y, et al. A widely metabolomic analysis revealed metabolic alterations of epimedium pubescens leaves at different growth stages. Molecules 2019; 25(1): 137.
[http://dx.doi.org/10.3390/molecules25010137] [PMID: 31905759]
[13]
Hashemibeni B, Pourentezari M, Valiani A, Zamani M, Mardani M. Effect of icariin on the chondrogenesis of human adipose derived stem cells on poly (lactic-co-glycolic) acid/fibrin composite scaffold abstract. Introduction 2017; (2): 595-605.
[14]
Luo Y, Zhang Y, Huang Y. Icariin reduces cartilage degeneration in a mouse model of osteoarthritis and is associated with the changes in expression of indian hedgehog and parathyroid hormone-related protein. Med Sci Monit 2018; 24: 6695-706.
[http://dx.doi.org/10.12659/MSM.910983] [PMID: 30244259]
[15]
Samarghandian S, Farkhondeh T, Azimi-Nezhad M. Protective effects of chrysin against drugs and toxic agents. Dose-Response 2017; 15(2): 1559325817711782.
[http://dx.doi.org/10.1177/1559325817711782]
[16]
Aziz N, Kim MY, Cho JY. Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies. J Ethnopharmacol 2018; 225: 342-58.
[http://dx.doi.org/10.1016/j.jep.2018.05.019] [PMID: 29801717]
[17]
Fei J, Liang B, Jiang C, Ni H, Wang L. Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model. Biomed Pharmacother 2019; 109: 1586-92.
[http://dx.doi.org/10.1016/j.biopha.2018.09.161] [PMID: 30551412]
[18]
Xu T, Wang L, Tao Y, Ji Y, Deng F, Wu XH. The function of naringin in inducing secretion of osteoprotegerin and inhibiting formation of osteoclasts. Evid-based Compl Altern Med 2016; 2016: 8981650.
[http://dx.doi.org/10.1155/2016/8981650]
[19]
Mancuso C, Santangelo R. Panax ginseng and Panax quinquefolius: From pharmacology to toxicology. Food Chem Toxicol 2017; 107((Pt A)): 362-72.
[http://dx.doi.org/10.1016/j.fct.2017.07.019] [PMID: 28698154]
[20]
Cheng W, Jing J, Wang Z, Wu D, Huang Y. Chondroprotective effects of ginsenoside Rg1 in human osteoarthritis chondrocytes and a rat model of anterior cruciate ligament transection. Nutrients 2017; 9(3): 263.
[http://dx.doi.org/10.3390/nu9030263] [PMID: 28287423]
[21]
Zhang P. Ginsenoside-Rg5 treatment inhibits apoptosis of chondrocytes and degradation of cartilage matrix in a rat model of osteoarthritis. Oncol Rep 2017; 37(3): 1497-502.
[http://dx.doi.org/10.3892/or.2017.5392] [PMID: 28112382]
[22]
Fattori V, Hohmann M, Rossaneis A, Pinho-Ribeiro F, Verri W. Capsaicin: Current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses. Molecules 2016; 21(7): 844.
[http://dx.doi.org/10.3390/molecules21070844] [PMID: 27367653]
[23]
Basith S, Cui M, Hong S, Choi S. Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases. Molecules 2016; 21(8): 966.
[http://dx.doi.org/10.3390/molecules21080966] [PMID: 27455231]
[24]
Tan BH, Ong CE. The use of natural remedies to treat osteoarthritis. Humanitas Med 2016; 6(1): 1-9.
[http://dx.doi.org/10.5667/tang.2015.0023]
[25]
Ren J, Lu Y, Qian Y, Chen B, Wu T, Ji G. Recent progress regarding kaempferol for the treatment of various diseases (Review). Exp Ther Med 2019; 18(4): 2759-76.
[http://dx.doi.org/10.3892/etm.2019.7886] [PMID: 31572524]
[26]
Zhuang Z, Ye G, Huang B. Kaempferol alleviates the interleukin-1β-induced inflammation in rat osteoarthritis chondrocytes via suppression of NF-κB. Med Sci Monit 2017; 23: 3925-31.
[http://dx.doi.org/10.12659/MSM.902491] [PMID: 28806392]
[27]
Wong SK, Chin KY, Ima-Nirwana S. Berberine and musculoskeletal disorders: The therapeutic potential and underlying molecular mechanisms. Phytomedicine 2020; 73: 152892.
[http://dx.doi.org/10.1016/j.phymed.2019.152892] [PMID: 30902523]
[28]
Zhou Y, Tao H, Li Y, et al. Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt/β-catenin pathway. Eur J Pharmacol 2016; 789: 109-18.
[http://dx.doi.org/10.1016/j.ejphar.2016.07.027] [PMID: 27445236]
[29]
Zhou Y, Ming J, Deng M, et al. Berberine-mediated up-regulation of surfactant protein D facilitates cartilage repair by modulating immune responses via the inhibition of TLR4/NF-ĸB signaling. Pharmacol Res 2020; 155: 104690.
[http://dx.doi.org/10.1016/j.phrs.2020.104690]
[30]
Salehi B, Rescigno A, Dettori T, et al. Avocado-soybean unsaponifiables: A panoply of potentialities to be exploited. Biomolecules 2020; 10(1): 130.
[http://dx.doi.org/10.3390/biom10010130] [PMID: 31940989]
[31]
Riaz A, Rasul A, Hussain G, et al. Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Adv Pharmacol Sci 2018; 2018: 9794625.
[http://dx.doi.org/10.1155/2018/9794625]
[32]
Liu L, Wang D, Qin Y, et al. Astragalin promotes osteoblastic differentiation in MC3T3-E1 cells and bone formation in vivo. Front Endocrinol 2019; 10: 228.
[http://dx.doi.org/10.3389/fendo.2019.00228] [PMID: 31040823]
[33]
Jia Q, Wang T, Wang X, et al. Astragalin suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis and in human fibroblast-like synoviocytes. Front Pharmacol 2019; 10(2): 94.
[http://dx.doi.org/10.3389/fphar.2019.00094] [PMID: 30809149]
[34]
Tuna HI, Babadag B, Ozkaraman A, Balci Alparslan G. Investigation of the effect of black cumin oil on pain in osteoarthritis geriatric individuals. Complement Ther Clin Pract 2018; 31(3): 290-4.
[http://dx.doi.org/10.1016/j.ctcp.2018.03.013] [PMID: 29705470]
[35]
Savaş BB, Alparslan GB, Korkmaz C. Effect of flaxseed poultice compress application on pain and hand functions of patients with hand osteoarthritis. Clin Rheumatol 2019; 38(7): 1961-9.
[http://dx.doi.org/10.1007/s10067-019-04484-7] [PMID: 30806856]
[36]
Park YJ, Cho YR, Oh JS, Ahn EK. Effects of Tribulus terrestris on monosodium iodoacetate-induced osteoarthritis pain in rats. Mol Med Rep 2017; 16(4): 5303-11.
[http://dx.doi.org/10.3892/mmr.2017.7296] [PMID: 28849084]
[37]
Sowndhararajan K, Deepa P, Kim M, Park SJ, Kim S. Baicalein as a potent neuroprotective agent: A review. Biomed Pharmacother 2017; 95: 1021-32.
[http://dx.doi.org/10.1016/j.biopha.2017.08.135] [PMID: 28922719]
[38]
Bie B, Sun J, Guo Y, et al. Baicalein: A review of its anti-cancer effects and mechanisms in hepatocellular carcinoma. Biomed Pharmacother 2017; 93: 1285-91.
[http://dx.doi.org/10.1016/j.biopha.2017.07.068] [PMID: 28747003]
[39]
Hostetler GL, Ralston RA, Schwartz SJ. Flavones: Food sources, bioavailability, metabolism, and bioactivity. Adv Nutr 2017; 8(3): 423-35.
[http://dx.doi.org/10.3945/an.116.012948] [PMID: 28507008]
[40]
Hamidpour R. Frankincense (Boswellia species): The novel phytotherapy for drug targeting in cancer. Arch Cancer Res 2016; 4(1): 1-5.
[http://dx.doi.org/10.21767/2254-6081.100046]
[41]
Mannino G, Occhipinti A, Maffei M. Quantitative determination of 3-O-Acetyl-11-Keto-Boswellic acid (AKBA) and other boswellic acids in Boswellia sacra flueck (syn. B. Carteri Birdw) and Boswellia serrata roxb. Molecules 2016; 21(10): 1329.
[http://dx.doi.org/10.3390/molecules21101329] [PMID: 27782055]
[42]
Mony RS, Baskaran SK, Perumalsamy M, Kannappan P. Effect of hydro alcoholic extracts of Boswellia serrata and Terminalia bellerica against cyclo-oxygenase and lipoxygenase enzymes- an in vitro approach. Int J Pharmacogn Phytochem Res 2017; 9(08): 1067-73.
[http://dx.doi.org/10.25258/phyto.v9i08.9613]
[43]
Dhanik J, Arya N, Nand V, Jyotsna Dhanik C. A review on Zingiber officinale. J Pharmacogn Phytochem 2017; 6(3): 174-84.
[44]
Alipour Z, Asadizaker M, Fayazi S, Yegane N, Kochak M, Haghighi Zadeh MH. The effect of ginger on pain and satisfaction of patients with knee osteoarthritis. Jundishapur J Chronic Dis Care 6(1)2016;
[http://dx.doi.org/10.17795/jjcdc-34798]
[45]
Heidari-Beni M, Moravejolahkami AR, Gorgian P, Askari G, Tarrahi MJ, Bahreini-Esfahani N. Herbal formulation “turmeric extract, black pepper, and ginger” versus Naproxen for chronic knee osteoarthritis: A randomized, double‐blind, controlled clinical trial. Phytother Res 2020; 34(8): 2067-73.
[http://dx.doi.org/10.1002/ptr.6671] [PMID: 32180294]
[46]
Bai Z, Guo XH, Tang C, Yue ST, Shi L, Qiang B. Effects of artesunate on the expressions of insulin-like growth factor-1, osteopontin and C-telopeptides of type II collagen in a rat model of osteoarthritis. Pharmacology 2018; 101(1-2): 1-8.
[http://dx.doi.org/10.1159/000479160] [PMID: 28898893]
[47]
González-Rodríguez ML, Fernández-Romero AM, Rabasco AM. Towards the antioxidant therapy in osteoarthritis: Contribution of nanotechnology. J Drug Deliv Sci Technol 2017; 42: 94-106.
[http://dx.doi.org/10.1016/j.jddst.2017.04.032]
[48]
Lai YL, Lin YY, Sadhasivam S, et al. Efficacy of Bletilla striata polysaccharide on hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes. J Polym Res 2018; 25(2): 49.
[http://dx.doi.org/10.1007/s10965-018-1448-z]
[49]
Lee SA, Moon SM, Han SH, et al. Chondroprotective effects of aqueous extract of Anthriscus sylvestris leaves on osteoarthritis in vitroand in vivo through MAPKs and NF-κB signaling inhibition. Biomed Pharmacother 2018; 103: 1202-11.
[http://dx.doi.org/10.1016/j.biopha.2018.04.183] [PMID: 29864899]
[50]
Xu X, Lv H, Li X, Su H, Zhang X, Yang J. Danshen attenuates cartilage injuries in osteoarthritis in vivo and in vitro by activating JAK2/STAT3 and AKT pathways. Exp Anim 2018; 67(2): 127-37.
[http://dx.doi.org/10.1538/expanim.17-0062] [PMID: 29093428]
[51]
Xu X, Lv H, Li X, Su H, Zhang X, Yang J. Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro. Biochem Cell Biol 2017; 95(6): 644-51.
[http://dx.doi.org/10.1139/bcb-2017-0025] [PMID: 28662337]
[52]
Kamarudin N, Hisamuddin N, Ong H, et al. Analgesic effect of 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one in experimental animal models of nociception. Molecules 2018; 23(9): 2099.
[http://dx.doi.org/10.3390/molecules23092099] [PMID: 30134576]
[53]
Takooree H, Aumeeruddy MZ, Rengasamy KR, et al. A systematic review on black pepper (Piper nigrum L.): From folk uses to pharmacological applications. Critcal reviews in Food Science and nutrition 2019.
[54]
Shah MMR, Liang Y, Cheng JJ, Daroch M. Astaxanthinproducing green microalga Haematococcus pluvialis: From single cell to high value commercial products Front Plant Sci 7: APR2016.2016;
[55]
Hwang YH, Kim KJ, Kim SJ, et al. Suppression effect of astaxanthin on osteoclast formation in vitro and bone loss in vivo. Int J Mol Sci 2018; 19(3): 912.
[http://dx.doi.org/10.3390/ijms19030912] [PMID: 29562730]
[56]
Razavi E, Karimi M, Kamalinejad M. The efficacy of topical oliban oil (Boswellia certerii B.) in relieving the symptoms of knee osteoarthritis. Phys Med Rehabil Electrodiagnosis 2019; 1(1): 7-13.
[57]
Wang W, Ha C, Lin T, Wang D, Wang Y, Gong M. Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. J Pharm Pharmacol 2017; 70(1): 81-8.
[http://dx.doi.org/10.1111/jphp.12835] [PMID: 28994112]
[58]
Feng K, Chen H, Xu C. Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF-κB signaling pathway inhibition. Inflamm Res 2020; 69(4): 385-400.
[http://dx.doi.org/10.1007/s00011-020-01327-z] [PMID: 32112120]
[59]
Ma D, Yu T, Peng L, Wang L, Liao Z, Xu W. PIM1, CYP1B1, and HSPA2 targeted by quercetin play important roles in osteoarthritis treatment by Achyranthes bidentata. Evidence-based Complement Altern Med 2019; p. 1205942.
[http://dx.doi.org/10.1155/2019/1205942]
[60]
Zhang D, Wang C, Hou X, Yan C. Structural characterization and osteoprotective effects of a polysaccharide purified from Achyranthes bidentata. Int J Biol Macromol 2019; 139: 1063-73.
[http://dx.doi.org/10.1016/j.ijbiomac.2019.08.013] [PMID: 31381922]
[61]
Salehi B, Venditti A, Sharifi-Rad M, et al. The therapeutic potential of Apigenin. Int J Mol Sci 2019; 20(6): 1305.
[http://dx.doi.org/10.3390/ijms20061305] [PMID: 30875872]
[62]
Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytother Res 2019; 33(6): 1627-38.
[http://dx.doi.org/10.1002/ptr.6361] [PMID: 31069872]
[63]
Ashkavand Z, Malekinejad H, Amniattalab A, Rezaei-Golmisheh A, Vishwanath BS. Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. Phytomedicine 2012; 19(13): 1200-5.
[http://dx.doi.org/10.1016/j.phymed.2012.07.008] [PMID: 22925727]
[64]
Pérez-Lozano ML, Cesaro A, Mazor M, et al. Emerging natural-product-based treatments for the management of osteoarthritis. Antioxidants 2021; 10(2): 265.
[http://dx.doi.org/10.3390/antiox10020265] [PMID: 33572126]
[65]
Del GMM, Lopes LC, Biavatti MW, et al. Oral herbal medicines marketed in Brazil for the treatment of osteoarthritis: A systematic review and meta-analysis. Phytother Res 2017; 31(11): 1676-85.
[http://dx.doi.org/10.1002/ptr.5910] [PMID: 28872719]
[66]
Guedes V, Castro JP, Brito I. Topical capsaicin for pain in osteoarthritis: A literature review. Reumatología Clínica 2018; 14(1): 40-5.
[http://dx.doi.org/10.1016/j.reumae.2016.07.013] [PMID: 27575891]
[67]
Sharifi-Rad M, Varoni EM, Salehi B, et al. Plants of the genus zingiber as a source of bioactive phytochemicals: From tradition to pharmacy. Mol 2017; 22(12): 2145.
[68]
Rasheed Z. Intake of pomegranate prevents the onset of osteoarthritis: molecular evidences. Int J Health Sci 2016; 10(2): v-viii.
[http://dx.doi.org/10.12816/0048807] [PMID: 27103912]
[69]
Lv H, Jiang L, Zhu M, et al. The genus Tripterygium: A phytochemistry and pharmacological review. Fitoterapia 2019; 137: 104190.
[http://dx.doi.org/10.1016/j.fitote.2019.104190] [PMID: 31163199]
[70]
Baumgardner DJ. Stinging nettle: the bad, the good, the unknown. J Patient Cent Res Rev 2016; 3(1): 48-53.
[http://dx.doi.org/10.17294/2330-0698.1216]
[71]
Ramakanth GSH, Uday Kumar C, Kishan PV, Usharani P. A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. J Ayurveda Integr Med 2016; 7(3): 151-7.
[http://dx.doi.org/10.1016/j.jaim.2016.05.003] [PMID: 27647541]
[72]
Oliviero F, Scanu A, Zamudio-Cuevas Y, Punzi L, Spinella P. Anti-inflammatory effects of polyphenols in arthritis. J Sci Food Agric 2018; 98(5): 1653-9.
[http://dx.doi.org/10.1002/jsfa.8664] [PMID: 28886220]
[73]
Spagnuolo C, Moccia S, Russo GL. Anti-inflammatory effects of flavonoids in neurodegenerative disorders. Eur J Med Chem 2018; 153: 105-15.
[http://dx.doi.org/10.1016/j.ejmech.2017.09.001] [PMID: 28923363]
[74]
Huang TL, Yang SH, Chen YR, Liao JY, Tang Y, Yang KC. The therapeutic effect of aucubin-supplemented hyaluronic acid on interleukin-1beta-stimulated human articular chondrocytes. Phytomedicine 2019; 53: 1-8.
[http://dx.doi.org/10.1016/j.phymed.2018.09.233] [PMID: 30668389]
[75]
Wang L, Shan H, Wang B, et al. Puerarin attenuates osteoarthritis via upregulating amp-activated protein kinase/proliferator-activated receptor-γ coactivator-1 signaling pathway in osteoarthritis rats. Pharmacology 2018; 102(3-4): 117-25.
[http://dx.doi.org/10.1159/000490418] [PMID: 29961054]
[76]
Mussard E, Cesaro A, Lespessailles E, Legrain B, Berteina-Raboin S, Toumi H. Andrographolide, a natural antioxidant: An update. Antioxidants 2019; 8(12): 571.
[http://dx.doi.org/10.3390/antiox8120571] [PMID: 31756965]
[77]
Gorzynik-Debicka M, Przychodzen P, Cappello F, et al. Potential health benefits of olive oil and plant polyphenols. Int J Mol Sci 2018; 19(3): 686.
[http://dx.doi.org/10.3390/ijms19030686] [PMID: 29495598]
[78]
Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health benefits and molecular mechanisms of resveratrol: A narrative review. Foods 2020; 9(3): 340.
[http://dx.doi.org/10.3390/foods9030340] [PMID: 32183376]
[79]
Zeddou M. Osteoarthritis is a low-grade inflammatory disease: Obesity’s involvement and herbal treatment. Evidence-based Complement Altern Med 2019; p. 2037484.
[http://dx.doi.org/10.1155/2019/2037484]
[80]
Pour SM, Hakimi S, Delazar A, Zadeh YJ, Mallah F. Eremostachys laciniata as effective as rectal diclofenac suppository in cesarean section pain relief: A triple-blind controlled clinical trial 2020; 12(1): 26-34.
[http://dx.doi.org/10.1177/2284026519899010]
[81]
Kang YH, Lee HJ, Lee CJ, Park JS. Natural products as sources of novel drug candidates for the pharmacological management of osteoarthritis: A narrative review. Biomol Ther 2019; 27(6): 503-13.
[http://dx.doi.org/10.4062/biomolther.2019.139] [PMID: 31646842]
[82]
Shah SM, Akram M, Rashid A, et al. Epidemiology and herbal treatment of osteoarthritis. Pak J Med Biol Sci 2017; 1(2): 48-57.
[83]
Shen C, Wang A, Xu J, et al. Recent advances in the catalytic synthesis of 4-quinolones. Chem 2019; 5(5): 1059-107.
[http://dx.doi.org/10.1016/j.chempr.2019.01.006]
[84]
Wei Y, Jia J, Jin X, Tong W, Tian H. Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Mol Med Rep 2018; 17(1): 1493-8.
[PMID: 29138829]
[85]
Hancke JL, Srivastav S, Cáceres DD, Burgos RA. A double‐blind, randomized, placebo‐controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. Phytother Res 2019; 33(5): 1469-79.
[http://dx.doi.org/10.1002/ptr.6339] [PMID: 30968986]
[86]
Chin KY, Pang KL. Therapeutic effects of olive and its derivatives on osteoarthritis: From bench to bedside. Nutrients 2017; 9(10): 1060.
[http://dx.doi.org/10.3390/nu9101060] [PMID: 28954409]
[87]
Young IC, Chuang ST, Hsu CH, et al. Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus. BMC Complement Altern Med 2017; 17(1): 91.
[http://dx.doi.org/10.1186/s12906-017-1581-y] [PMID: 28153003]
[88]
Xu X, Wan Y, Gong L, Ma Z, Xu T. Chinese herbal medicine Yanghe decoction for knee osteoarthritis: A protocol for systematic review and meta-analysis. Medicine 2020; 99(34): e21877.
[http://dx.doi.org/10.1097/MD.0000000000021877] [PMID: 32846845]