Abstract

Time-restricted feeding (TRF) is a special lifestyle intervention that improves glucose metabolism, regulates lipid metabolism, increases gut micro richness, and strengthens circadian rhythm. Diabetes is a remarkable component of metabolic syndrome, and individuals with diabetes can benefit from TRF. Melatonin and agomelatine can strengthen circadian rhythm, which is a crucial mechanism of TRF. New drug designs can be inspired by the related mechanisms and influences of TRF on glucose metabolism, and more researches are needed to clarify the specific diet-related mechanisms and apply this knowledge to further drug design.

Keywords: Drug design, glucose metabolism, metabolic syndrome, time-restricted feeding, melatonin, agomelatine.