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Current Organocatalysis

Author(s): Vanam Shekhar*, Chithaluri Sudhakar* and Nagireddy Veerareddy

DOI: 10.2174/2213337210666230228105711

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Stereospecific Total Synthesis of Putaminoxin 1 by Ring Closing Metathesis and Enantioselective Epoxidation

Page: [128 - 132] Pages: 5

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Abstract

The stereoselective synthesis of putaminoxin 1, a biologically active natural phototoxic lactone has been synthesized from (R)-2-Propyloxirane and Hex-5-en-1-ol. The synthesis involves Jacobsen’s hydrolytic kinetic resolution and ring-closing metathesis as the key steps.

Keywords: Putaminoxin 1, stereoselective synthesis, epoxide opening, Jacobsen’s catalyst, ring-closing metathesis, phototoxic lactone.

Graphical Abstract

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