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Mini-Reviews in Medicinal Chemistry

Author(s): Devyani Rajput, Mandeep Singh, Prashant Sahu, Dharmendra Jain, Sushil Kumar Kashaw* and Umesh Kumar Patil*

DOI: 10.2174/1389557523666230222124438

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Advances in Nanogel as Drug Delivery System for Cancer Therapeutics: An Overview

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Abstract

Nanogels have gotten much attention as nanoscopic drug carriers, especially for delivering bioactive mediators to specific sites or at certain times. The versatility of polymer systems and the ease with which their physicochemical properties can be changed have resulted in versatile nano gel formulations. Nanogels offer exceptional stability, drug-loading capacity, biological consistency, strong penetration ability, and the ability to respond to environmental stimuli. Nanogels have shown great promise in various sectors, including gene delivery, chemotherapeutic medication delivery, diagnostics, organ targeting, and many more. This review focuses on various types of nanogels, preparation methods, including drug loading methods, various modes of biodegradation mechanisms, and primary mechanisms of drug release from nanogels. The article also focuses on the historical data for herb-related nanogels that are used to treat various disorders with great patient compliance, delivery rate, and efficacy.

Keywords: Nanogel, hydrogel materials, evaluation parameters, herbal nanogels, in vivo drug delivery, gene delivery.

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