Abstract
Background: Green strategy involves the design, synthesis, processing, and use of chemical
substances by eliminating the generation of chemical hazards. This approach focuses on atom
economy, use of safer solvents or chemicals, consumption of energy, and decomposition of the chemical
substances to non-toxic materials which are eco-friendly.
Objective: So, the microwave irradiated heating method is considered a green and sustainable technique
for the development of novel heterocyclic scaffold-like isoxazole derivatives via chalcones.
Isoxazole derivatives play a vital role due to their diverse pharmacological activities such as antibiotic
(Sulfamethoxazole, Cloxacillin, Flucloxacillin, Cycloserine), anti-fungal (Drazoxolon), Antirheumatic
(Leflunomide), antidepressant (Isocarboxazid), antineoplastic (Acivicin), anticonvulsant (Zonisamide),
antipsychotic (Risperidone) and anti-inflammatory drugs (Valdecoxib), etc.
Methods: The isoxazole derivatives were synthesized with the help of microwave irradiation that follows
green chemistry protocol.
Results: The titled compounds were subjected to antiepileptic evaluation to determine their therapeutic
potential.
Conclusion: The use of microwave radiation enhances the rate of the reaction which leads to high selectivity
with improved product yields in comparison with the traditional heating methods. The tested
compounds exhibited promising antiepileptic activity as compared to the standard drug (Phenytoin).
Keywords:
Epilepsy, isoxazole, chalcone, pharmacological activities, cloxacillin, heterocyclic compounds.
Graphical Abstract
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Ravi Kumar Venkata Varaha Bera
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