Vos, T.; Lim, S.S.; Abbafati, C.; Abbas, K.M.; Abbasi, M.; Abbasifard, M.; Abbasi-Kangevari, M.; Abbastabar, H.; Abd-Allah, F.; Abdelalim, A.; Abdollahi, M.; Abdollahpour, I.; Abolhassani, H.; Aboyans, V.; Abrams, E.M.; Abreu, L.G.; Abrigo, M.R.M.; Abu-Raddad, L.J.; Abushouk, A.I.; Acebedo, A.; Ackerman, I.N.; Adabi, M.; Adamu, A.A.; Adebayo, O.M.; Adekanmbi, V.; Adelson, J.D.; Adetokunboh, O.O.; Adham, D.; Afshari, M.; Afshin, A.; Agardh, E.E.; Agarwal, G.; Agesa, K.M.; Aghaali, M.; Aghamir, S.M.K.; Agrawal, A.; Ahmad, T.; Ahmadi, A.; Ahmadi, M.; Ahmadieh, H.; Ahmadpour, E.; Akalu, T.Y.; Akinyemi, R.O.; Akinyemiju, T.; Akombi, B.; Al-Aly, Z.; Alam, K.; Alam, N.; Alam, S.; Alam, T.; Alanzi, T.M.; Albertson, S.B.; Alcalde-Rabanal, J.E.; Alema, N.M.; Ali, M.; Ali, S.; Alicandro, G.; Alijanzadeh, M.; Alinia, C.; Alipour, V.; Aljunid, S.M.; Alla, F.; Allebeck, P.; Almasi-Hashiani, A.; Alonso, J.; Al-Raddadi, R.M.; Altirkawi, K.A.; Alvis-Guzman, N.; Alvis-Zakzuk, N.J.; Amini, S.; Amini-Rarani, M.; Aminorroaya, A.; Amiri, F.; Amit, A.M.L.; Amugsi, D.A.; Amul, G.G.H.; Anderlini, D.; Andrei, C.L.; Andrei, T.; Anjomshoa, M.; Ansari, F.; Ansari, I.; Ansari-Moghaddam, A.; Antonio, C.A.T.; Antony, C.M.; Antriyandarti, E.; Anvari, D.; Anwer, R.; Arabloo, J.; Arab-Zozani, M.; Aravkin, A.Y.; Ariani, F.; Ärnlöv, J.; Aryal, K.K.; Arzani, A.; Asadi-Aliabadi, M.; Asadi-Pooya, A.A.; Asghari, B.; Ashbaugh, C.; Atnafu, D.D.; Atre, S.R.; Ausloos, F.; Ausloos, M.; Ayala Quintanilla, B.P.; Ayano, G.; Ayanore, M.A.; Aynalem, Y.A.; Azari, S.; Azarian, G.; Azene, Z.N.; Babaee, E.; Badawi, A.; Bagherzadeh, M.; Bakhshaei, M.H.; Bakhtiari, A.; Balakrishnan, S.; Balalla, S.; Balassyano, S.; Banach, M.; Banik, P.C.; Bannick, M.S.; Bante, A.B.; Baraki, A.G.; Barboza, M.A.; Barker-Collo, S.L.; Barthelemy, C.M.; Barua, L.; Barzegar, A.; Basu, S.; Baune, B.T.; Bayati, M.; Bazmandegan, G.; Bedi, N.; Beghi, E.; Béjot, Y.; Bello, A.K.; Bender, R.G.; Bennett, D.A.; Bennitt, F.B.; Bensenor, I.M.; Benziger, C.P.; Berhe, K.; Bernabe, E.; Bertolacci, G.J.; Bhageerathy, R.; Bhala, N.; Bhandari, D.; Bhardwaj, P.; Bhattacharyya, K.; Bhutta, Z.A.; Bibi, S.; Biehl, M.H.; Bikbov, B.; Bin Sayeed, M.S.; Biondi, A.; Birihane, B.M.; Bisanzio, D.; Bisignano, C.; Biswas, R.K.; Bohlouli, S.; Bohluli, M.; Bolla, S.R.R.; Boloor, A.; Boon-Dooley, A.S.; Borges, G.; Borzì, A.M.; Bourne, R.; Brady, O.J.; Brauer, M.; Brayne, C.; Breitborde, N.J.K.; Brenner, H.; Briant, P.S.; Briggs, A.M.; Briko, N.I.; Britton, G.B.; Bryazka, D.; Buchbinder, R.; Bumgarner, B.R.; Busse, R.; Butt, Z.A.; Caetano dos Santos, F.L.; Cámera, L.L.A.A.; Campos-Nonato, I.R.; Car, J.; Cárdenas, R.; Carreras, G.; Carrero, J.J.; Carvalho, F.; Castaldelli-Maia, J.M.; Castañeda-Orjuela, C.A.; Castelpietra, G.; Castle, C.D.; Castro, F.; Catalá-López, F.; Causey, K.; Cederroth, C.R.; Cercy, K.M.; Cerin, E.; Chandan, J.S.; Chang, A.R.; Charlson, F.J.; Chattu, V.K.; Chaturvedi, S.; Chimed-Ochir, O.; Chin, K.L.; Cho, D.Y.; Christensen, H.; Chu, D-T.; Chung, M.T.; Cicuttini, F.M.; Ciobanu, L.G.; Cirillo, M.; Collins, E.L.; Compton, K.; Conti, S.; Cortesi, P.A.; Costa, V.M.; Cousin, E.; Cowden, R.G.; Cowie, B.C.; Cromwell, E.A.; Cross, D.H.; Crowe, C.S.; Cruz, J.A.; Cunningham, M.; Dahlawi, S.M.A.; Damiani, G.; Dandona, L.; Dandona, R.; Darwesh, A.M.; Daryani, A.; Das, J.K.; Das Gupta, R.; das Neves, J.; Dávila-Cervantes, C.A.; Davletov, K.; De Leo, D.; Dean, F.E.; DeCleene, N.K.; Deen, A.; Degenhardt, L.; Dellavalle, R.P.; Demeke, F.M.; Demsie, D.G.; Denova-Gutiérrez, E.; Dereje, N.D.; Dervenis, N.; Desai, R.; Desalew, A.; Dessie, G.A.; Dharmaratne, S.D.; Dhungana, G.P.; Dianatinasab, M.; Diaz, D.; Dibaji, F.Z.S.; Dingels, Z.V.; Dirac, M.A.; Djalalinia, S.; Do, H.T.; Dokova, K.; Dorostkar, F.; Doshi, C.P.; Doshmangir, L.; Douiri, A.; Doxey, M.C.; Driscoll, T.R.; Dunachie, S.J.; Duncan, B.B.; Duraes, A.R.; Eagan, A.W.; Ebrahimi Kalan, M.; Edvardsson, D.; Ehrlich, J.R.; El Nahas, N.; El Sayed, I.; El Tantawi, M.; Elbarazi, I.; Elgendy, I.Y.; Elhabashy, H.R.; El-Jaafary, S.I.; Elyazar, I.R.F.; Emamian, M.H.; Emmons-Bell, S.; Erskine, H.E.; Eshrati, B.; Eskandarieh, S.; Esmaeilnejad, S.; Esmaeilzadeh, F.; Esteghamati, A.; Estep, K.; Etemadi, A.; Etisso, A.E.; Farahmand, M.; Faraj, A.; Fareed, M.; Faridnia, R.; Farinha, C.S.S.; Farioli, A.; Faro, A.; Faruque, M.; Farzadfar, F.; Fattahi, N.; Fazlzadeh, M.; Feigin, V.L.; Feldman, R.; Fereshtehnejad, S-M.; Fernandes, E.; Ferrari, A.J.; Ferreira, M.L.; Filip, I.; Fischer, F.; Fisher, J.L.; Fitzgerald, R.; Flohr, C.; Flor, L.S.; Foigt, N.A.; Folayan, M.O.; Force, L.M.; Fornari, C.; Foroutan, M.; Fox, J.T.; Freitas, M.; Fu, W.; Fukumoto, T.; Furtado, J.M.; Gad, M.M.; Gakidou, E.; Galles, N.C.; Gallus, S.; Gamkrelidze, A.; Garcia-Basteiro, A.L.; Gardner, W.M.; Geberemariyam, B.S.; Gebrehiwot, A.M.; Gebremedhin, K.B.; Gebreslassie, A.A.A.A.; Gershberg Hayoon, A.; Gething, P.W.; Ghadimi, M.; Ghadiri, K.; Ghafourifard, M.; Ghajar, A.; Ghamari, F.; Ghashghaee, A.; Ghiasvand, H.; Ghith, N.; Gholamian, A.; Gilani, S.A.; Gill, P.S.; Gitimoghaddam, M.; Giussani, G.; Goli, S.; Gomez, R.S.; Gopalani, S.V.; Gorini, G.; Gorman, T.M.; Gottlich, H.C.; Goudarzi, H.; Goulart, A.C.; Goulart, B.N.G.; Grada, A.; Grivna, M.; Grosso, G.; Gubari, M.I.M.; Gugnani, H.C.; Guimaraes, A.L.S.; Guimarães, R.A.; Guled, R.A.; Guo, G.; Guo, Y.; Gupta, R.; Haagsma, J.A.; Haddock, B.; Hafezi-Nejad, N.; Hafiz, A.; Hagins, H.; Haile, L.M.; Hall, B.J.; Halvaei, I.; Hamadeh, R.R.; Hamagharib Abdullah, K.; Hamilton, E.B.; Han, C.; Han, H.; Hankey, G.J.; Haro, J.M.; Harvey, J.D.; Hasaballah, A.I.; Hasanzadeh, A.; Hashemian, M.; Hassanipour, S.; Hassankhani, H.; Havmoeller, R.J.; Hay, R.J.; Hay, S.I.; Hayat, K.; Heidari, B.; Heidari, G.; Heidari-Soureshjani, R.; Hendrie, D.; Henrikson, H.J.; Henry, N.J.; Herteliu, C.; Heydarpour, F.; Hird, T.R.; Hoek, H.W.; Hole, M.K.; Holla, R.; Hoogar, P.; Hosgood, H.D.; Hosseinzadeh, M.; Hostiuc, M.; Hostiuc, S.; Househ, M.; Hoy, D.G.; Hsairi, M.; Hsieh, V.C.; Hu, G.; Huda, T.M.; Hugo, F.N.; Huynh, C.K.; Hwang, B-F.; Iannucci, V.C.; Ibitoye, S.E.; Ikuta, K.S.; Ilesanmi, O.S.; Ilic, I.M.; Ilic, M.D.; Inbaraj, L.R.; Ippolito, H.; Irvani, S.S.N.; Islam, M.M.; Islam, M.M.; Islam, S.M.S.; Islami, F.; Iso, H.; Ivers, R.Q.; Iwu, C.C.D.; Iyamu, I.O.; Jaafari, J.; Jacobsen, K.H.; Jadidi-Niaragh, F.; Jafari, H.; Jafarinia, M.; Jahagirdar, D.; Jahani, M.A.; Jahanmehr, N.; Jakovljevic, M.; Jalali, A.; Jalilian, F.; James, S.L.; Janjani, H.; Janodia, M.D.; Jayatilleke, A.U.; Jeemon, P.; Jenabi, E.; Jha, R.P.; Jha, V.; Ji, J.S.; Jia, P.; John, O.; John-Akinola, Y.O.; Johnson, C.O.; Johnson, S.C.; Jonas, J.B.; Joo, T.; Joshi, A.; Jozwiak, J.J.; Jürisson, M.; Kabir, A.; Kabir, Z.; Kalani, H.; Kalani, R.; Kalankesh, L.R.; Kalhor, R.; Kamiab, Z.; Kanchan, T.; Karami Matin, B.; Karch, A.; Karim, M.A.; Karimi, S.E.; Kassa, G.M.; Kassebaum, N.J.; Katikireddi, S.V.; Kawakami, N.; Kayode, G.A.; Keddie, S.H.; Keller, C.; Kereselidze, M.; Khafaie, M.A.; Khalid, N.; Khan, M.; Khatab, K.; Khater, M.M.; Khatib, M.N.; Khayamzadeh, M.; Khodayari, M.T.; Khundkar, R.; Kianipour, N.; Kieling, C.; Kim, D.; Kim, Y-E.; Kim, Y.J.; Kimokoti, R.W.; Kisa, A.; Kisa, S.; Kissimova-Skarbek, K.; Kivimäki, M.; Kneib, C.J.; Knudsen, A.K.S.; Kocarnik, J.M.; Kolola, T.; Kopec, J.A.; Kosen, S.; Koul, P.A.; Koyanagi, A.; Kravchenko, M.A.; Krishan, K.; Krohn, K.J.; Kuate Defo, B.; Kucuk Bicer, B.; Kumar, G.A.; Kumar, M.; Kumar, P.; Kumar, V.; Kumaresh, G.; Kurmi, O.P.; Kusuma, D.; Kyu, H.H.; La Vecchia, C.; Lacey, B.; Lal, D.K.; Lalloo, R.; Lam, J.O.; Lami, F.H.; Landires, I.; Lang, J.J.; Lansingh, V.C.; Larson, S.L.; Larsson, A.O.; Lasrado, S.; Lassi, Z.S.; Lau, K.M-M.; Lavados, P.M.; Lazarus, J.V.; Ledesma, J.R.; Lee, P.H.; Lee, S.W.H.; LeGrand, K.E.; Leigh, J.; Leonardi, M.; Lescinsky, H.; Leung, J.; Levi, M.; Lewington, S.; Li, S.; Lim, L-L.; Lin, C.; Lin, R-T.; Linehan, C.; Linn, S.; Liu, H-C.; Liu, S.; Liu, Z.; Looker, K.J.; Lopez, A.D.; Lopukhov, P.D.; Lorkowski, S.; Lotufo, P.A.; Lucas, T.C.D.; Lugo, A.; Lunevicius, R.; Lyons, R.A.; Ma, J.; MacLachlan, J.H.; Maddison, E.R.; Maddison, R.; Madotto, F.; Mahasha, P.W.; Mai, H.T.; Majeed, A.; Maled, V.; Maleki, S.; Malekzadeh, R.; Malta, D.C.; Mamun, A.A.; Manafi, A.; Manafi, N.; Manguerra, H.; Mansouri, B.; Mansournia, M.A.; Mantilla Herrera, A.M.; Maravilla, J.C.; Marks, A.; Martins-Melo, F.R.; Martopullo, I.; Masoumi, S.Z.; Massano, J.; Massenburg, B.B.; Mathur, M.R.; Maulik, P.K.; McAlinden, C.; McGrath, J.J.; McKee, M.; Mehndiratta, M.M.; Mehri, F.; Mehta, K.M.; Meitei, W.B.; Memiah, P.T.N.; Mendoza, W.; Menezes, R.G.; Mengesha, E.W.; Mengesha, M.B.; Mereke, A.; Meretoja, A.; Meretoja, T.J.; Mestrovic, T.; Miazgowski, B.; Miazgowski, T.; Michalek, I.M.; Mihretie, K.M.; Miller, T.R.; Mills, E.J.; Mirica, A.; Mirrakhimov, E.M.; Mirzaei, H.; Mirzaei, M.; Mirzaei-Alavijeh, M.; Misganaw, A.T.; Mithra, P.; Moazen, B.; Moghadaszadeh, M.; Mohamadi, E.; Mohammad, D.K.; Mohammad, Y.; Mohammad Gholi Mezerji, N.; Mohammadian-Hafshejani, A.; Mohammadifard, N.; Mohammadpourhodki, R.; Mohammed, S.; Mokdad, A.H.; Molokhia, M.; Momen, N.C.; Monasta, L.; Mondello, S.; Mooney, M.D.; Moosazadeh, M.; Moradi, G.; Moradi, M.; Moradi-Lakeh, M.; Moradzadeh, R.; Moraga, P.; Morales, L.; Morawska, L.; Moreno Velásquez, I.; Morgado-da-Costa, J.; Morrison, S.D.; Mosser, J.F.; Mouodi, S.; Mousavi, S.M.; Mousavi Khaneghah, A.; Mueller, U.O.; Munro, S.B.; Muriithi, M.K.; Musa, K.I.; Muthupandian, S.; Naderi, M.; Nagarajan, A.J.; Nagel, G.; Naghshtabrizi, B.; Nair, S.; Nandi, A.K.; Nangia, V.; Nansseu, J.R.; Nayak, V.C.; Nazari, J.; Negoi, I.; Negoi, R.I.; Netsere, H.B.N.; Ngunjiri, J.W.; Nguyen, C.T.; Nguyen, J.; Nguyen, M.; Nguyen, M.; Nichols, E.; Nigatu, D.; Nigatu, Y.T.; Nikbakhsh, R.; Nixon, M.R.; Nnaji, C.A.; Nomura, S.; Norrving, B.; Noubiap, J.J.; Nowak, C.; Nunez-Samudio, V.; Oţoiu, A.; Oancea, B.; Odell, C.M.; Ogbo, F.A.; Oh, I-H.; Okunga, E.W.; Oladnabi, M.; Olagunju, A.T.; Olusanya, B.O.; Olusanya, J.O.; Oluwasanu, M.M.; Omar Bali, A.; Omer, M.O.; Ong, K.L.; Onwujekwe, O.E.; Orji, A.U.; Orpana, H.M.; Ortiz, A.; Ostroff, S.M.; Otstavnov, N.; Otstavnov, S.S.; Øverland, S.; Owolabi, M.O.; P A, M.; Padubidri, J.R.; Pakhare, A.P.; Palladino, R.; Pana, A.; Panda-Jonas, S.; Pandey, A.; Park, E-K.; Parmar, P.G.K.; Pasupula, D.K.; Patel, S.K.; Paternina-Caicedo, A.J.; Pathak, A.; Pathak, M.; Patten, S.B.; Patton, G.C.; Paudel, D.; Pazoki Toroudi, H.; Peden, A.E.; Pennini, A.; Pepito, V.C.F.; Peprah, E.K.; Pereira, A.; Pereira, D.M.; Perico, N.; Pham, H.Q.; Phillips, M.R.; Pigott, D.M.; Pilgrim, T.; Pilz, T.M.; Pirsaheb, M.; Plana-Ripoll, O.; Plass, D.; Pokhrel, K.N.; Polibin, R.V.; Polinder, S.; Polkinghorne, K.R.; Postma, M.J.; Pourjafar, H.; Pourmalek, F.; Pourmirza Kalhori, R.; Pourshams, A.; Poznańska, A.; Prada, S.I.; Prakash, V.; Pribadi, D.R.A.; Pupillo, E.; Quazi Syed, Z.; Rabiee, M.; Rabiee, N.; Radfar, A.; Rafiee, A.; Rafiei, A.; Raggi, A.; Rahimi-Movaghar, A.; Rahman, M.A.; Rajabpour-Sanati, A.; Rajati, F.; Ramezanzadeh, K.; Ranabhat, C.L.; Rao, P.C.; Rao, S.J.; Rasella, D.; Rastogi, P.; Rathi, P.; Rawaf, D.L.; Rawaf, S.; Rawal, L.; Razo, C.; Redford, S.B.; Reiner, R.C., Jr; Reinig, N.; Reitsma, M.B.; Remuzzi, G.; Renjith, V.; Renzaho, A.M.N.; Resnikoff, S.; Rezaei, N.; Rezai, M.; Rezapour, A.; Rhinehart, P-A.; Riahi, S.M.; Ribeiro, A.L.P.; Ribeiro, D.C.; Ribeiro, D.; Rickard, J.; Roberts, N.L.S.; Roberts, S.; Robinson, S.R.; Roever, L.; Rolfe, S.; Ronfani, L.; Roshandel, G.; Roth, G.A.; Rubagotti, E.; Rumisha, S.F.; Sabour, S.; Sachdev, P.S.; Saddik, B.; Sadeghi, E.; Sadeghi, M.; Saeidi, S.; Safi, S.; Safiri, S.; Sagar, R.; Sahebkar, A.; Sahraian, M.A.; Sajadi, S.M.; Salahshoor, M.R.; Salamati, P.; Salehi Zahabi, S.; Salem, H.; Salem, M.R.R.; Salimzadeh, H.; Salomon, J.A.; Salz, I.; Samad, Z.; Samy, A.M.; Sanabria, J.; Santomauro, D.F.; Santos, I.S.; Santos, J.V.; Santric-Milicevic, M.M.; Saraswathy, S.Y.I.; Sarmiento-Suárez, R.; Sarrafzadegan, N.; Sartorius, B.; Sarveazad, A.; Sathian, B.; Sathish, T.; Sattin, D.; Sbarra, A.N.; Schaeffer, L.E.; Schiavolin, S.; Schmidt, M.I.; Schutte, A.E.; Schwebel, D.C.; Schwendicke, F.; Senbeta, A.M.; Senthilkumaran, S.; Sepanlou, S.G.; Shackelford, K.A.; Shadid, J.; Shahabi, S.; Shaheen, A.A.; Shaikh, M.A.; Shalash, A.S.; Shams-Beyranvand, M.; Shamsizadeh, M.; Shannawaz, M.; Sharafi, K.; Sharara, F.; Sheena, B.S.; Sheikhtaheri, A.; Shetty, R.S.; Shibuya, K.; Shiferaw, W.S.; Shigematsu, M.; Shin, J.I.; Shiri, R.; Shirkoohi, R.; Shrime, M.G.; Shuval, K.; Siabani, S.; Sigfusdottir, I.D.; Sigurvinsdottir, R.; Silva, J.P.; Simpson, K.E.; Singh, A.; Singh, J.A.; Skiadaresi, E.; Skou, S.T.; Skryabin, V.Y.; Sobngwi, E.; Sokhan, A.; Soltani, S.; Sorensen, R.J.D.; Soriano, J.B.; Sorrie, M.B.; Soyiri, I.N.; Sreeramareddy, C.T.; Stanaway, J.D.; Stark, B.A.; Ştefan, S.C.; Stein, C.; Steiner, C.; Steiner, T.J.; Stokes, M.A.; Stovner, L.J.; Stubbs, J.L.; Sudaryanto, A.; Sufiyan, M.B.; Sulo, G.; Sultan, I.; Sykes, B.L.; Sylte, D.O.; Szócska, M.; Tabarés-Seisdedos, R.; Tabb, K.M.; Tadakamadla, S.K.; Taherkhani, A.; Tajdini, M.; Takahashi, K.; Taveira, N.; Teagle, W.L.; Teame, H.; Tehrani-Banihashemi, A.; Teklehaimanot, B.F.; Terrason, S.; Tessema, Z.T.; Thankappan, K.R.; Thomson, A.M.; Tohidinik, H.R.; Tonelli, M.; Topor-Madry, R.; Torre, A.E.; Touvier, M.; Tovani-Palone, M.R.R.; Tran, B.X.; Travillian, R.; Troeger, C.E.; Truelsen, T.C.; Tsai, A.C.; Tsatsakis, A.; Tudor Car, L.; Tyrovolas, S.; Uddin, R.; Ullah, S.; Undurraga, E.A.; Unnikrishnan, B.; Vacante, M.; Vakilian, A.; Valdez, P.R.; Varughese, S.; Vasankari, T.J.; Vasseghian, Y.; Venketasubramanian, N.; Violante, F.S.; Vlassov, V.; Vollset, S.E.; Vongpradith, A.; Vukovic, A.; Vukovic, R.; Waheed, Y.; Walters, M.K.; Wang, J.; Wang, Y.; Wang, Y-P.; Ward, J.L.; Watson, A.; Wei, J.; Weintraub, R.G.; Weiss, D.J.; Weiss, J.; Westerman, R.; Whisnant, J.L.; Whiteford, H.A.; Wiangkham, T.; Wiens, K.E.; Wijeratne, T.; Wilner, L.B.; Wilson, S.; Wojtyniak, B.; Wolfe, C.D.A.; Wool, E.E.; Wu, A-M.; Wulf Hanson, S.; Wunrow, H.Y.; Xu, G.; Xu, R.; Yadgir, S.; Yahyazadeh Jabbari, S.H.; Yamagishi, K.; Yaminfirooz, M.; Yano, Y.; Yaya, S.; Yazdi-Feyzabadi, V.; Yearwood, J.A.; Yeheyis, T.Y.; Yeshitila, Y.G.; Yip, P.; Yonemoto, N.; Yoon, S-J.; Yoosefi Lebni, J.; Younis, M.Z.; Younker, T.P.; Yousefi, Z.; Yousefifard, M.; Yousefinezhadi, T.; Yousuf, A.Y.; Yu, C.; Yusefzadeh, H.; Zahirian Moghadam, T.; Zaki, L.; Zaman, S.B.; Zamani, M.; Zamanian, M.; Zandian, H.; Zangeneh, A.; Zastrozhin, M.S.; Zewdie, K.A.; Zhang, Y.; Zhang, Z-J.; Zhao, J.T.; Zhao, Y.; Zheng, P.; Zhou, M.; Ziapour, A.; Zimsen, S.R.M.; Naghavi, M.; Murray, C.J.L. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: A systematic analysis for the global burden of disease study 2019. Lancet, 2020, 396(10258), 1204-1222.
[http://dx.doi.org/10.1016/S0140-6736(20)30925-9] [PMID: 33069326]

Feigin, V.L.; Nguyen, G.; Cercy, K.; Johnson, C.O.; Alam, T.; Parmar, P.G.; Abajobir, A.A.; Abate, K.H.; Abd-Allah, F.; Abejie, A.N.; Abyu, G.Y.; Ademi, Z.; Agarwal, G.; Ahmed, M.B.; Akinyemi, R.O.; Al-Raddadi, R.; Aminde, L.N.; Amlie-Lefond, C.; Ansari, H.; Asayesh, H.; Asgedom, S.W.; Atey, T.M.; Ayele, H.T.; Banach, M.; Banerjee, A.; Barac, A.; Barker-Collo, S.L.; Bärnighausen, T.; Barregard, L.; Basu, S.; Bedi, N.; Behzadifar, M.; Béjot, Y.; Bennett, D.A.; Bensenor, I.M.; Berhe, D.F.; Boneya, D.J.; Brainin, M.; Campos-Nonato, I.R.; Caso, V.; Castañeda-Orjuela, C.A.; Rivas, J.C.; Catalá-López, F.; Christensen, H.; Criqui, M.H.; Damasceno, A.; Dandona, L.; Dandona, R.; Davletov, K.; de Courten, B.; deVeber, G.; Dokova, K.; Edessa, D.; Endres, M.; Faraon, E.J.A.; Farvid, M.S.; Fischer, F.; Foreman, K.; Forouzanfar, M.H.; Gall, S.L.; Gebrehiwot, T.T.; Geleijnse, J.M.; Gillum, R.F.; Giroud, M.; Goulart, A.C.; Gupta, R.; Gupta, R.; Hachinski, V.; Hamadeh, R.R.; Hankey, G.J.; Hareri, H.A.; Havmoeller, R.; Hay, S.I.; Hegazy, M.I.; Hibstu, D.T.; James, S.L.; Jeemon, P.; John, D.; Jonas, J.B.; Jóźwiak, J.; Kalani, R.; Kandel, A.; Kasaeian, A.; Kengne, A.P.; Khader, Y.S.; Khan, A.R.; Khang, Y.H.; Khubchandani, J.; Kim, D.; Kim, Y.J.; Kivimaki, M.; Kokubo, Y.; Kolte, D.; Kopec, J.A.; Kosen, S.; Kravchenko, M.; Krishnamurthi, R.; Kumar, G.A.; Lafranconi, A.; Lavados, P.M.; Legesse, Y.; Li, Y.; Liang, X.; Lo, W.D.; Lorkowski, S.; Lotufo, P.A.; Loy, C.T.; Mackay, M.T.; Abd El Razek, H.M.; Mahdavi, M.; Majeed, A.; Malekzadeh, R.; Malta, D.C.; Mamun, A.A.; Mantovani, L.G.; Martins, S.C.O.; Mate, K.K.; Mazidi, M.; Mehata, S.; Meier, T.; Melaku, Y.A.; Mendoza, W.; Mensah, G.A.; Meretoja, A.; Mezgebe, H.B.; Miazgowski, T.; Miller, T.R.; Ibrahim, N.M.; Mohammed, S.; Mokdad, A.H.; Moosazadeh, M.; Moran, A.E.; Musa, K.I.; Negoi, R.I.; Nguyen, M.; Nguyen, Q.L.; Nguyen, T.H.; Tran, T.T.; Nguyen, T.T.; Anggraini, N.D.N.; Norrving, B.; Noubiap, J.J.; O’Donnell, M.J.; Olagunju, A.T.; Onuma, O.K.; Owolabi, M.O.; Parsaeian, M.; Patton, G.C.; Piradov, M.; Pletcher, M.A.; Pourmalek, F.; Prakash, V.; Qorbani, M.; Rahman, M.; Rahman, M.A.; Rai, R.K.; Ranta, A.; Rawaf, D.; Rawaf, S.; Renzaho, A.M.; Robinson, S.R.; Sahathevan, R.; Sahebkar, A.; Salomon, J.A.; Santalucia, P.; Santos, I.S.; Sartorius, B.; Schutte, A.E.; Sepanlou, S.G.; Shafieesabet, A.; Shaikh, M.A.; Shamsizadeh, M.; Sheth, K.N.; Sisay, M.; Shin, M.J.; Shiue, I.; Silva, D.A.S.; Sobngwi, E.; Soljak, M.; Sorensen, R.J.D.; Sposato, L.A.; Stranges, S.; Suliankatchi, R.A.; Tabarés-Seisdedos, R.; Tanne, D.; Nguyen, C.T.; Thakur, J.S.; Thrift, A.G.; Tirschwell, D.L.; Topor-Madry, R.; Tran, B.X.; Nguyen, L.T.; Truelsen, T.; Tsilimparis, N.; Tyrovolas, S.; Ukwaja, K.N.; Uthman, O.A.; Varakin, Y.; Vasankari, T.; Venketasubramanian, N.; Vlassov, V.V.; Wang, W.; Werdecker, A.; Wolfe, C.D.A.; Xu, G.; Yano, Y.; Yonemoto, N.; Yu, C.; Zaidi, Z.; El Sayed, Z.M.; Zhou, M.; Ziaeian, B.; Zipkin, B.; Vos, T.; Naghavi, M.; Murray, C.J.L.; Roth, G.A. Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016. N. Engl. J. Med., 2018, 379(25), 2429-2437.
[http://dx.doi.org/10.1056/NEJMoa1804492] [PMID: 30575491]

Kalluri, R.; LeBleu, V.S. The biology, function, and biomedical applications of exosomes. Science, 2020, 367(6478), eaau6977.
[http://dx.doi.org/10.1126/science.aau6977] [PMID: 32029601]

Burkova, E.E.; Sedykh, S.E.; Nevinsky, G.A. Human placenta exosomes: Biogenesis, isolation, composition, and prospects for use in diagnostics. Int. J. Mol. Sci., 2021, 22(4), 2158.
[http://dx.doi.org/10.3390/ijms22042158] [PMID: 33671527]

Mathieu, M.; Martin-Jaular, L.; Lavieu, G.; Théry, C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat. Cell Biol., 2019, 21(1), 9-17.
[http://dx.doi.org/10.1038/s41556-018-0250-9] [PMID: 30602770]

van Niel, G.; D’Angelo, G.; Raposo, G. Shedding light on the cell biology of extracellular vesicles. Nat. Rev. Mol. Cell Biol., 2018, 19(4), 213-228.
[http://dx.doi.org/10.1038/nrm.2017.125] [PMID: 29339798]

Cocucci, E.; Meldolesi, J. Ectosomes and exosomes: Shedding the confusion between extracellular vesicles. Trends Cell Biol., 2015, 25(6), 364-372.
[http://dx.doi.org/10.1016/j.tcb.2015.01.004] [PMID: 25683921]

Théry, C.; Witwer, K.W.; Aikawa, E.; Alcaraz, M.J.; Anderson, J.D.; Andriantsitohaina, R.; Antoniou, A.; Arab, T.; Archer, F.; Atkin-Smith, G.K.; Ayre, D.C.; Bach, J.M.; Bachurski, D.; Baharvand, H.; Balaj, L.; Baldacchino, S.; Bauer, N.N.; Baxter, A.A.; Bebawy, M.; Beckham, C.; Bedina Zavec, A.; Benmoussa, A.; Berardi, A.C.; Bergese, P.; Bielska, E.; Blenkiron, C.; Bobis-Wozowicz, S.; Boilard, E.; Boireau, W.; Bongiovanni, A.; Borràs, F.E.; Bosch, S.; Boulanger, C.M.; Breakefield, X.; Breglio, A.M.; Brennan, M.Á.; Brigstock, D.R.; Brisson, A.; Broekman, M.L.D.; Bromberg, J.F.; Bryl-Górecka, P.; Buch, S.; Buck, A.H.; Burger, D.; Busatto, S.; Buschmann, D.; Bussolati, B.; Buzás, E.I.; Byrd, J.B.; Camussi, G.; Carter, D.R.F.; Caruso, S.; Chamley, L.W.; Chang, Y.T.; Chen, C.; Chen, S.; Cheng, L.; Chin, A.R.; Clayton, A.; Clerici, S.P.; Cocks, A.; Cocucci, E.; Coffey, R.J.; Cordeiro-da-Silva, A.; Couch, Y.; Coumans, F.A.W.; Coyle, B.; Crescitelli, R.; Criado, M.F.; D’Souza-Schorey, C.; Das, S.; Datta Chaudhuri, A.; de Candia, P.; De Santana, E.F.; De Wever, O.; del Portillo, H.A.; Demaret, T.; Deville, S.; Devitt, A.; Dhondt, B.; Di Vizio, D.; Dieterich, L.C.; Dolo, V.; Dominguez, R.A.P.; Dominici, M.; Dourado, M.R.; Driedonks, T.A.P.; Duarte, F.V.; Duncan, H.M.; Eichenberger, R.M.; Ekström, K.; EL Andaloussi, S.; Elie-Caille, C.; Erdbrügger, U.; Falcón-Pérez, J.M.; Fatima, F.; Fish, J.E.; Flores-Bellver, M.; Försönits, A.; Frelet-Barrand, A.; Fricke, F.; Fuhrmann, G.; Gabrielsson, S.; Gámez-Valero, A.; Gardiner, C.; Gärtner, K.; Gaudin, R.; Gho, Y.S.; Giebel, B.; Gilbert, C.; Gimona, M.; Giusti, I.; Goberdhan, D.C.I.; Görgens, A.; Gorski, S.M.; Greening, D.W.; Gross, J.C.; Gualerzi, A.; Gupta, G.N.; Gustafson, D.; Handberg, A.; Haraszti, R.A.; Harrison, P.; Hegyesi, H.; Hendrix, A.; Hill, A.F.; Hochberg, F.H.; Hoffmann, K.F.; Holder, B.; Holthofer, H.; Hosseinkhani, B.; Hu, G.; Huang, Y.; Huber, V.; Hunt, S.; Ibrahim, A.G.E.; Ikezu, T.; Inal, J.M.; Isin, M.; Ivanova, A.; Jackson, H.K.; Jacobsen, S.; Jay, S.M.; Jayachandran, M.; Jenster, G.; Jiang, L.; Johnson, S.M.; Jones, J.C.; Jong, A.; Jovanovic-Talisman, T.; Jung, S.; Kalluri, R.; Kano, S.; Kaur, S.; Kawamura, Y.; Keller, E.T.; Khamari, D.; Khomyakova, E.; Khvorova, A.; Kierulf, P.; Kim, K.P.; Kislinger, T.; Klingeborn, M.; Klinke, D.J., II; Kornek, M.; Kosanović, M.M.; Kovács, Á.F.; Krämer-Albers, E.M.; Krasemann, S.; Krause, M.; Kurochkin, I.V.; Kusuma, G.D.; Kuypers, S.; Laitinen, S.; Langevin, S.M.; Languino, L.R.; Lannigan, J.; Lässer, C.; Laurent, L.C.; Lavieu, G.; Lázaro-Ibáñez, E.; Le Lay, S.; Lee, M.S.; Lee, Y.X.F.; Lemos, D.S.; Lenassi, M.; Leszczynska, A.; Li, I.T.S.; Liao, K.; Libregts, S.F.; Ligeti, E.; Lim, R.; Lim, S.K.; Linē, A.; Linnemannstöns, K.; Llorente, A.; Lombard, C.A.; Lorenowicz, M.J.; Lörincz, Á.M.; Lötvall, J.; Lovett, J.; Lowry, M.C.; Loyer, X.; Lu, Q.; Lukomska, B.; Lunavat, T.R.; Maas, S.L.N.; Malhi, H.; Marcilla, A.; Mariani, J.; Mariscal, J.; Martens-Uzunova, E.S.; Martin-Jaular, L.; Martinez, M.C.; Martins, V.R.; Mathieu, M.; Mathivanan, S.; Maugeri, M.; McGinnis, L.K.; McVey, M.J.; Meckes, D.G., Jr; Meehan, K.L.; Mertens, I.; Minciacchi, V.R.; Möller, A.; Møller Jørgensen, M.; Morales-Kastresana, A.; Morhayim, J.; Mullier, F.; Muraca, M.; Musante, L.; Mussack, V.; Muth, D.C.; Myburgh, K.H.; Najrana, T.; Nawaz, M.; Nazarenko, I.; Nejsum, P.; Neri, C.; Neri, T.; Nieuwland, R.; Nimrichter, L.; Nolan, J.P.; Nolte-’t Hoen, E.N.M.; Noren Hooten, N.; O’Driscoll, L.; O’Grady, T.; O’Loghlen, A.; Ochiya, T.; Olivier, M.; Ortiz, A.; Ortiz, L.A.; Osteikoetxea, X.; Østergaard, O.; Ostrowski, M.; Park, J.; Pegtel, D.M.; Peinado, H.; Perut, F.; Pfaffl, M.W.; Phinney, D.G.; Pieters, B.C.H.; Pink, R.C.; Pisetsky, D.S.; Pogge von Strandmann, E.; Polakovicova, I.; Poon, I.K.H.; Powell, B.H.; Prada, I.; Pulliam, L.; Quesenberry, P.; Radeghieri, A.; Raffai, R.L.; Raimondo, S.; Rak, J.; Ramirez, M.I.; Raposo, G.; Rayyan, M.S.; Regev-Rudzki, N.; Ricklefs, F.L.; Robbins, P.D.; Roberts, D.D.; Rodrigues, S.C.; Rohde, E.; Rome, S.; Rouschop, K.M.A.; Rughetti, A.; Russell, A.E.; Saá, P.; Sahoo, S.; Salas-Huenuleo, E.; Sánchez, C.; Saugstad, J.A.; Saul, M.J.; Schiffelers, R.M.; Schneider, R.; Schøyen, T.H.; Scott, A.; Shahaj, E.; Sharma, S.; Shatnyeva, O.; Shekari, F.; Shelke, G.V.; Shetty, A.K.; Shiba, K.; Siljander, P.R.M.; Silva, A.M.; Skowronek, A.; Snyder, O.L., II; Soares, R.P.; Sódar, B.W.; Soekmadji, C.; Sotillo, J.; Stahl, P.D.; Stoorvogel, W.; Stott, S.L.; Strasser, E.F.; Swift, S.; Tahara, H.; Tewari, M.; Timms, K.; Tiwari, S.; Tixeira, R.; Tkach, M.; Toh, W.S.; Tomasini, R.; Torrecilhas, A.C.; Tosar, J.P.; Toxavidis, V.; Urbanelli, L.; Vader, P.; van Balkom, B.W.M.; van der Grein, S.G.; Van Deun, J.; van Herwijnen, M.J.C.; Van Keuren-Jensen, K.; van Niel, G.; van Royen, M.E.; van Wijnen, A.J.; Vasconcelos, M.H.; Vechetti, I.J., Jr; Veit, T.D.; Vella, L.J.; Velot, É.; Verweij, F.J.; Vestad, B.; Viñas, J.L.; Visnovitz, T.; Vukman, K.V.; Wahlgren, J.; Watson, D.C.; Wauben, M.H.M.; Weaver, A.; Webber, J.P.; Weber, V.; Wehman, A.M.; Weiss, D.J.; Welsh, J.A.; Wendt, S.; Wheelock, A.M.; Wiener, Z.; Witte, L.; Wolfram, J.; Xagorari, A.; Xander, P.; Xu, J.; Yan, X.; Yáñez-Mó, M.; Yin, H.; Yuana, Y.; Zappulli, V.; Zarubova, J.; Žėkas, V.; Zhang, J.; Zhao, Z.; Zheng, L.; Zheutlin, A.R.; Zickler, A.M.; Zimmermann, P.; Zivkovic, A.M.; Zocco, D.; Zuba-Surma, E.K. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J. Extracell. Vesicles, 2018, 7(1), 1535750.
[http://dx.doi.org/10.1080/20013078.2018.1535750] [PMID: 30637094]

Morel, O.; Toti, F.; Hugel, B.; Freyssinet, J.M. Cellular microparticles: A disseminated storage pool of bioactive vascular effectors. Curr. Opin. Hematol., 2004, 11(3), 156-164.
[http://dx.doi.org/10.1097/01.moh.0000131441.10020.87] [PMID: 15257014]

Janowska-Wieczorek, A.; Majka, M.; Kijowski, J.; Baj-Krzyworzeka, M.; Reca, R.; Turner, A.R.; Ratajczak, J.; Emerson, S.G.; Kowalska, M.A.; Ratajczak, M.Z. Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Blood, 2001, 98(10), 3143-3149.
[http://dx.doi.org/10.1182/blood.V98.10.3143] [PMID: 11698303]

Rozmyslowicz, T.; Majka, M.; Kijowski, J.; Murphy, S.L.; Conover, D.O.; Poncz, M.; Ratajczak, J.; Gaulton, G.N.; Ratajczak, M.Z. Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIVE. AIDS, 2003, 17(1), 33-42.
[http://dx.doi.org/10.1097/00002030-200301030-00006] [PMID: 12478067]

Janowska-Wieczorek, A.; Wysoczynski, M.; Kijowski, J.; Marquez-Curtis, L.; Machalinski, B.; Ratajczak, J.; Ratajczak, M.Z. Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int. J. Cancer, 2005, 113(5), 752-760.
[http://dx.doi.org/10.1002/ijc.20657] [PMID: 15499615]

Xu, R.; Rai, A.; Chen, M.; Suwakulsiri, W.; Greening, D.W.; Simpson, R.J. Extracellular vesicles in cancer — implications for future improvements in cancer care. Nat. Rev. Clin. Oncol., 2018, 15(10), 617-638.
[http://dx.doi.org/10.1038/s41571-018-0036-9] [PMID: 29795272]

Yang, J.; Cao, L.L.; Wang, X.P.; Guo, W.; Guo, R.B.; Sun, Y.Q.; Xue, T.F.; Cai, Z.Y.; Ji, J.; Cheng, H.; Sun, X.L. Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke. Cell Death Dis., 2021, 12(1), 23.
[http://dx.doi.org/10.1038/s41419-020-03310-2] [PMID: 33414461]

Piffoux, M.; Nicolás-Boluda, A.; Mulens-Arias, V.; Richard, S.; Rahmi, G.; Gazeau, F.; Wilhelm, C.; Silva, A.K.A. Extracellular vesicles for personalized medicine: The input of physically triggered production, loading and theranostic properties. Adv. Drug Deliv. Rev., 2019, 138, 247-258.
[http://dx.doi.org/10.1016/j.addr.2018.12.009] [PMID: 30553953]

Chung, J.; Kim, K.H.; Yu, N.; An, S.H.; Lee, S.; Kwon, K. Fluid shear stress regulates the landscape of microRNAs in endothelial cell-derived small extracellular vesicles and modulates the function of endothelial cells. Int. J. Mol. Sci., 2022, 23(3), 1314.
[http://dx.doi.org/10.3390/ijms23031314] [PMID: 35163238]

Pan, W.; Liang, J.; Tang, H.; Fang, X.; Wang, F.; Ding, Y.; Huang, H.; Zhang, H. Differentially expressed microRNA profiles in exosomes from vascular smooth muscle cells associated with coronary artery calcification. Int. J. Biochem. Cell Biol., 2020, 118, 105645.
[http://dx.doi.org/10.1016/j.biocel.2019.105645] [PMID: 31733402]

Zhu, J.; Liu, B.; Wang, Z.; Wang, D.; Ni, H.; Zhang, L.; Wang, Y. Exosomes from nicotine-stimulated macrophages accelerate atherosclerosis through miR-21-3p/PTEN-mediated VSMC migration and proliferation. Theranostics, 2019, 9(23), 6901-6919.
[http://dx.doi.org/10.7150/thno.37357] [PMID: 31660076]

Yao, Y.; Sun, W.; Sun, Q.; Jing, B.; Liu, S.; Liu, X.; Shen, G.; Chen, R.; Wang, H. Platelet-derived exosomal MicroRNA-25-3p inhibits coronary vascular endothelial cell inflammation through adam10 via the NF-κB signaling pathway in ApoE−/− mice. Front. Immunol., 2019, 10, 2205.
[http://dx.doi.org/10.3389/fimmu.2019.02205] [PMID: 31632389]

Valadi, H.; Ekström, K.; Bossios, A.; Sjöstrand, M.; Lee, J.J.; Lötvall, J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol., 2007, 9(6), 654-659.
[http://dx.doi.org/10.1038/ncb1596] [PMID: 17486113]

Nolte-’t Hoen, E.N.M.; Buermans, H.P.J.; Waasdorp, M.; Stoorvogel, W.; Wauben, M.H.M.; ’t Hoen, P.A.C. Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions. Nucleic Acids Res., 2012, 40(18), 9272-9285.
[http://dx.doi.org/10.1093/nar/gks658] [PMID: 22821563]

Wei, Z.; Batagov, A.O.; Schinelli, S.; Wang, J.; Wang, Y.; El Fatimy, R.; Rabinovsky, R.; Balaj, L.; Chen, C.C.; Hochberg, F.; Carter, B.; Breakefield, X.O.; Krichevsky, A.M. Coding and noncoding landscape of extracellular RNA released by human glioma stem cells. Nat. Commun., 2017, 8(1), 1145.
[http://dx.doi.org/10.1038/s41467-017-01196-x] [PMID: 29074968]

Mao, Q.; Liang, X.L.; Zhang, C.L.; Pang, Y.H.; Lu, Y.X. LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis. Stem Cell Res. Ther., 2019, 10(1), 393.
[http://dx.doi.org/10.1186/s13287-019-1522-4] [PMID: 31847890]

Li, Y.; Zheng, Q.; Bao, C.; Li, S.; Guo, W.; Zhao, J.; Chen, D.; Gu, J.; He, X.; Huang, S. Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res., 2015, 25(8), 981-984.
[http://dx.doi.org/10.1038/cr.2015.82] [PMID: 26138677]

Thakur, B.K.; Zhang, H.; Becker, A.; Matei, I.; Huang, Y.; Costa-Silva, B.; Zheng, Y.; Hoshino, A.; Brazier, H.; Xiang, J.; Williams, C.; Rodriguez-Barrueco, R.; Silva, J.M.; Zhang, W.; Hearn, S.; Elemento, O.; Paknejad, N.; Manova-Todorova, K.; Welte, K.; Bromberg, J.; Peinado, H.; Lyden, D. Double-stranded DNA in exosomes: A novel biomarker in cancer detection. Cell Res., 2014, 24(6), 766-769.
[http://dx.doi.org/10.1038/cr.2014.44] [PMID: 24710597]

Chen, X.; Jiang, M.; Li, H.; Wang, Y.; Shen, H.; Li, X.; Zhang, Y.; Wu, J.; Yu, Z.; Chen, G. CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage. J. Neuroinflammation, 2020, 17(1), 209.
[http://dx.doi.org/10.1186/s12974-020-01882-6] [PMID: 32664984]

Zhou, S.; Gao, B.; Sun, C.; Bai, Y.; Cheng, D.; Zhang, Y.; Li, X.; Zhao, J.; Xu, D. Vascular endothelial cell-derived exosomes protect neural stem cells against ischemia/reperfusion injury. Neuroscience, 2020, 441, 184-196.
[http://dx.doi.org/10.1016/j.neuroscience.2020.05.046] [PMID: 32502570]

Cremer, S.; Michalik, K.M.; Fischer, A.; Pfisterer, L.; Jaé, N.; Winter, C.; Boon, R.A.; Muhly-Reinholz, M.; John, D.; Uchida, S.; Weber, C.; Poller, W.; Günther, S.; Braun, T.; Li, D.Y.; Maegdefessel, L.; Perisic Matic, L.; Hedin, U.; Soehnlein, O.; Zeiher, A.; Dimmeler, S. Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation. Circulation, 2019, 139(10), 1320-1334.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029015] [PMID: 30586743]

Ji, Q.; Ji, Y.; Peng, J.; Zhou, X.; Chen, X.; Zhao, H.; Xu, T.; Chen, L.; Xu, Y. Increased brain-specific MiR-9 and MiR-124 in the serum exosomes of acute ischemic stroke patients. PLoS One, 2016, 11(9), e0163645.
[http://dx.doi.org/10.1371/journal.pone.0163645] [PMID: 27661079]

Liao, B.; Zhou, M.; Zhou, F.; Luo, X.; Zhong, S.; Zhou, Y.; Qin, Y.; Li, P.; Qin, C. Exosome-derived MiRNAs as biomarkers of the development and progression of intracranial aneurysms. J. Atheroscler. Thromb., 2020, 27(6), 545-610.
[http://dx.doi.org/10.5551/jat.51102] [PMID: 31597886]

Zhang, Y.; Tang, Y.; Dammer, E.; Liu, J.; Zhao, Y.; Zhu, L.; Ren, R.; Chen, H.; Wang, G.; Cheng, Q. Dysregulated urinary arginine metabolism in older adults with amnestic mild cognitive impairment. Front. Aging Neurosci., 2019, 11, 90.
[http://dx.doi.org/10.3389/fnagi.2019.00090] [PMID: 31105552]

Arroyo, J.D.; Chevillet, J.R.; Kroh, E.M.; Ruf, I.K.; Pritchard, C.C.; Gibson, D.F.; Mitchell, P.S.; Bennett, C.F.; Pogosova-Agadjanyan, E.L.; Stirewalt, D.L.; Tait, J.F.; Tewari, M. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl. Acad. Sci. USA, 2011, 108(12), 5003-5008.
[http://dx.doi.org/10.1073/pnas.1019055108] [PMID: 21383194]

Wang, K.; Zhang, S.; Weber, J.; Baxter, D.; Galas, D.J. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res., 2010, 38(20), 7248-7259.
[http://dx.doi.org/10.1093/nar/gkq601] [PMID: 20615901]

Vickers, K.C.; Palmisano, B.T.; Shoucri, B.M.; Shamburek, R.D.; Remaley, A.T. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat. Cell Biol., 2011, 13(4), 423-433.
[http://dx.doi.org/10.1038/ncb2210] [PMID: 21423178]

Kim, S.H.; Lim, K.H.; Yang, S.; Joo, J.Y. Long non-coding RNAs in brain tumors: Roles and potential as therapeutic targets. J. Hematol. Oncol., 2021, 14(1), 77.
[http://dx.doi.org/10.1186/s13045-021-01088-0] [PMID: 33980320]

He, X.; Wang, S.; Li, M.; Zhong, L.; Zheng, H.; Sun, Y.; Lai, Y.; Chen, X.; Wei, G.; Si, X.; Han, Y.; Huang, S.; Li, X.; Liao, W.; Liao, Y.; Bin, J. Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis. Theranostics, 2019, 9(19), 5558-5576.
[http://dx.doi.org/10.7150/thno.34463] [PMID: 31534503]

Hu, Y.W.; Guo, F.X.; Xu, Y.J.; Li, P.; Lu, Z.F.; McVey, D.G.; Zheng, L.; Wang, Q.; Ye, J.H.; Kang, C.M.; Wu, S.G.; Zhao, J.J.; Ma, X.; Yang, Z.; Fang, F.C.; Qiu, Y.R.; Xu, B.M.; Xiao, L.; Wu, Q.; Wu, L.M.; Ding, L.; Webb, T.R.; Samani, N.J.; Ye, S. Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN. J. Clin. Invest., 2019, 129(3), 1115-1128.
[http://dx.doi.org/10.1172/JCI98230] [PMID: 30589415]

Li, Z.; Huang, C.; Bao, C.; Chen, L.; Lin, M.; Wang, X.; Zhong, G.; Yu, B.; Hu, W.; Dai, L.; Zhu, P.; Chang, Z.; Wu, Q.; Zhao, Y.; Jia, Y.; Xu, P.; Liu, H.; Shan, G. Exon-intron circular RNAs regulate transcription in the nucleus. Nat. Struct. Mol. Biol., 2015, 22(3), 256-264.
[http://dx.doi.org/10.1038/nsmb.2959] [PMID: 25664725]

Conn, V.M.; Hugouvieux, V.; Nayak, A.; Conos, S.A.; Capovilla, G.; Cildir, G.; Jourdain, A.; Tergaonkar, V.; Schmid, M.; Zubieta, C.; Conn, S.J. A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation. Nat. Plants, 2017, 3(5), 17053.
[http://dx.doi.org/10.1038/nplants.2017.53] [PMID: 28418376]

Salmena, L.; Poliseno, L.; Tay, Y.; Kats, L.; Pandolfi, P.P. A ceRNA hypothesis: The rosetta stone of a hidden RNA language? Cell, 2011, 146(3), 353-358.
[http://dx.doi.org/10.1016/j.cell.2011.07.014] [PMID: 21802130]

Wen, Y.; Chun, Y.; Lian, Z.; Yong, Z.; Lan, Y.; Huan, L.; Xi, C.; Juan, L.; Qing, Z.; Jia, C.; Ji, Z. circRNA-0006896-miR1264-DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis. Mol. Med. Rep., 2021, 23(5), 311.
[http://dx.doi.org/10.3892/mmr.2021.11950] [PMID: 33649864]

Holdt, L.M.; Stahringer, A.; Sass, K.; Pichler, G.; Kulak, N.A.; Wilfert, W.; Kohlmaier, A.; Herbst, A.; Northoff, B.H.; Nicolaou, A.; Gäbel, G.; Beutner, F.; Scholz, M.; Thiery, J.; Musunuru, K.; Krohn, K.; Mann, M.; Teupser, D. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nat. Commun., 2016, 7(1), 12429.
[http://dx.doi.org/10.1038/ncomms12429] [PMID: 27539542]

Legnini, I.; Di Timoteo, G.; Rossi, F.; Morlando, M.; Briganti, F.; Sthandier, O.; Fatica, A.; Santini, T.; Andronache, A.; Wade, M.; Laneve, P.; Rajewsky, N.; Bozzoni, I. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol. Cell, 2017, 66(1), 22-37.e9.
[http://dx.doi.org/10.1016/j.molcel.2017.02.017] [PMID: 28344082]

Kalani, M.Y.S.; Alsop, E.; Meechoovet, B.; Beecroft, T.; Agrawal, K.; Whitsett, T.G.; Huentelman, M.J.; Spetzler, R.F.; Nakaji, P.; Kim, S.; Van Keuren-Jensen, K. Extracellular microRNAs in blood differentiate between ischaemic and haemorrhagic stroke subtypes. J. Extracell. Vesicles, 2020, 9(1), 1713540.
[http://dx.doi.org/10.1080/20013078.2020.1713540] [PMID: 32128071]

Kim, T.; Oh, C.W.; Bang, J.S.; Kim, J.E.; Cho, W.S. Moyamoya disease: Treatment and outcomes. J. Stroke, 2016, 18(1), 21-30.
[http://dx.doi.org/10.5853/jos.2015.01739] [PMID: 26846757]

Wang, G.; Wen, Y.; Faleti, O.D.; Zhao, Q.; Liu, J.; Zhang, G.; Li, M.; Qi, S.; Feng, W.; Lyu, X. A panel of exosome-derived miRNAs of cerebrospinal fluid for the diagnosis of moyamoya disease. Front. Neurosci., 2020, 14, 548278.
[http://dx.doi.org/10.3389/fnins.2020.548278] [PMID: 33100957]

Li, X.; Gui, Z.; Han, Y.; Yang, X.; Wang, Z.; Zheng, L.; Zhang, L.; Wang, D.; Fan, X.; Su, L. Comprehensive analysis of dysregulated exosomal long non-coding RNA networks associated with arteriovenous malformations. Gene, 2020, 738, 144482.
[http://dx.doi.org/10.1016/j.gene.2020.144482] [PMID: 32087271]

Luo, X.; Wang, W.; Li, D.; Xu, C.; Liao, B.; Li, F.; Zhou, X.; Qin, W.; Liu, J. Plasma exosomal miR-450b-5p as a possible biomarker and therapeutic target for transient ischaemic attacks in rats. J. Mol. Neurosci., 2019, 69(4), 516-526.
[http://dx.doi.org/10.1007/s12031-019-01341-9] [PMID: 31368061]

Li, D.B.; Liu, J.L.; Wang, W.; Luo, X.M.; Zhou, X.; Li, J.P.; Cao, X.L.; Long, X.H.; Chen, J.G.; Qin, C. Plasma exosomal miRNA-122-5p and miR-300-3p as potential markers for transient ischaemic attack in rats. Front. Aging Neurosci., 2018, 10, 24.
[http://dx.doi.org/10.3389/fnagi.2018.00024] [PMID: 29467645]

Xu, X.; Zhuang, C.; Chen, L. Exosomal long non-coding RNA expression from serum of patients with acute minor stroke. Neuropsychiatr. Dis. Treat., 2020, 16, 153-160.
[http://dx.doi.org/10.2147/NDT.S230332] [PMID: 32021207]

Burrello, J.; Bianco, G.; Burrello, A.; Manno, C.; Maulucci, F.; Pileggi, M.; Nannoni, S.; Michel, P.; Bolis, S.; Melli, G.; Vassalli, G.; Albers, G.W.; Cianfoni, A.; Barile, L.; Cereda, C.W. Extracellular vesicle surface markers as a diagnostic tool in transient ischemic attacks. Stroke, 2021, 52(10), 3335-3347.
[http://dx.doi.org/10.1161/STROKEAHA.120.033170] [PMID: 34344167]

Wang, W.; Li, D.B.; Li, R.Y.; Zhou, X.; Yu, D.J.; Lan, X.Y.; Li, J.P.; Liu, J.L. Diagnosis of hyperacute and acute ischaemic stroke: The potential utility of exosomal microRNA-21-5p and microRNA-30a-5p. Cerebrovasc. Dis., 2018, 45(5-6), 204-212.
[http://dx.doi.org/10.1159/000488365] [PMID: 29627835]

Liu, Y.; Li, Y.; Zang, J.; Zhang, T.; Li, Y.; Tan, Z.; Ma, D.; Zhang, T.; Wang, S.; Zhang, Y.; Huang, L.; Wu, Y.; Su, X.; Weng, Z.; Deng, D.; Tsang, C.K.; Xu, A.; Lu, D. CircOGDH is a penumbra biomarker and therapeutic target in acute ischemic stroke. Circ. Res., 2022, 130(6), 907-924.
[http://dx.doi.org/10.1161/CIRCRESAHA.121.319412] [PMID: 35189704]

Zhang, S.; Wang, X.; Yin, R.; Xiao, Q.; Ding, Y.; Zhu, X.; Pan, X. Circulating exosomal lncRNAs as predictors of risk and unfavorable prognosis for large artery atherosclerotic stroke. Clin. Transl. Med., 2021, 11(12), e555.
[http://dx.doi.org/10.1002/ctm2.555] [PMID: 34923752]

Song, P.; Sun, H.; Chen, H.; Wang, Y.; Zhang, Q. Decreased serum exosomal miR-152-3p contributes to the progression of acute ischemic stroke. Clin. Lab., 2020, 66(08/2020)
[http://dx.doi.org/10.7754/Clin.Lab.2020.200106] [PMID: 32776748]

Zhang, S.; Wang, J.; Qu, M.J.; Wang, K.; Ma, A.J.; Pan, X.D.; Zhu, X.Y. Novel insights into the potential diagnostic value of circulating exosomal IncRNA-related networks in large artery atherosclerotic stroke. Front. Mol. Biosci., 2021, 8, 682769.
[http://dx.doi.org/10.3389/fmolb.2021.682769] [PMID: 34095232]

Niu, M.; Li, H.; Li, X.; Yan, X.; Ma, A.; Pan, X.; Zhu, X. Circulating exosomal miRNAs as novel biomarkers perform superior diagnostic efficiency compared with plasma miRNAs for large-artery atherosclerosis stroke. Front. Pharmacol., 2021, 12, 791644.
[http://dx.doi.org/10.3389/fphar.2021.791644] [PMID: 34899352]

van Kralingen, J.C.; McFall, A.; Ord, E.N.J.; Coyle, T.F.; Bissett, M.; McClure, J.D.; McCabe, C.; Macrae, I.M.; Dawson, J.; Work, L.M. Altered extracellular vesicle MicroRNA expression in ischemic stroke and small vessel disease. Transl. Stroke Res., 2019, 10(5), 495-508.
[http://dx.doi.org/10.1007/s12975-018-0682-3] [PMID: 30617992]

Zhou, J.; Chen, L.; Chen, B.; Huang, S.; Zeng, C.; Wu, H.; Chen, C.; Long, F. Increased serum exosomal miR-134 expression in the acute ischemic stroke patients. BMC Neurol., 2018, 18(1), 198.
[http://dx.doi.org/10.1186/s12883-018-1196-z] [PMID: 30514242]

Wang, S.; Jun, J.; Cong, L.; Du, L.; Wang, C. miR-328-3p, a predictor of stroke, aggravates the cerebral ischemia-reperfusion injury. Int. J. Gen. Med., 2021, 14, 2367-2376.
[http://dx.doi.org/10.2147/IJGM.S307392] [PMID: 34135620]

Chen, Y.; Song, Y.; Huang, J.; Qu, M.; Zhang, Y.; Geng, J.; Zhang, Z.; Liu, J.; Yang, G.Y. Increased circulating exosomal miRNA-223 is associated with acute ischemic stroke. Front. Neurol., 2017, 8, 57.
[http://dx.doi.org/10.3389/fneur.2017.00057] [PMID: 28289400]

Chen, F.; Du, Y.; Esposito, E.; Liu, Y.; Guo, S.; Wang, X.; Lo, E.H.; Xing, C.; Ji, X. Effects of focal cerebral ischemia on exosomal versus serum miR126. Transl. Stroke Res., 2015, 6(6), 478-484.
[http://dx.doi.org/10.1007/s12975-015-0429-3] [PMID: 26449616]

Wang, C.; Li, Z.; Liu, Y.; Yuan, L. Exosomes in atherosclerosis: Performers, bystanders, biomarkers, and therapeutic targets. Theranostics, 2021, 11(8), 3996-4010.
[http://dx.doi.org/10.7150/thno.56035] [PMID: 33664877]

Liu, Y.; Li, Q.; Hosen, M.R.; Zietzer, A.; Flender, A.; Levermann, P.; Schmitz, T.; Frühwald, D.; Goody, P.; Nickenig, G.; Werner, N.; Jansen, F. Atherosclerotic conditions promote the packaging of functional MicroRNA-92a-3p into endothelial microvesicles. Circ. Res., 2019, 124(4), 575-587.
[http://dx.doi.org/10.1161/CIRCRESAHA.118.314010] [PMID: 30582459]

Goetzl, E.J.; Schwartz, J.B.; Mustapic, M.; Lobach, I.V.; Daneman, R.; Abner, E.L.; Jicha, G.A. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB J., 2017, 31(8), 3689-3694.
[http://dx.doi.org/10.1096/fj.201700149] [PMID: 28476896]

Jiang, H.; Toscano, J.F.; Song, S.S.; Schlick, K.H.; Dumitrascu, O.M.; Pan, J.; Lyden, P.D.; Saver, J.L.; Gonzalez, N.R. Differential expression of circulating exosomal microRNAs in refractory intracranial atherosclerosis associated with antiangiogenesis. Sci. Rep., 2019, 9(1), 19429.
[http://dx.doi.org/10.1038/s41598-019-54542-y] [PMID: 31857618]

Dolz, S.; Górriz, D.; Tembl, J.I.; Sánchez, D.; Fortea, G.; Parkhutik, V.; Lago, A. Circulating MicroRNAs as novel biomarkers of stenosis progression in asymptomatic carotid stenosis. Stroke, 2017, 48(1), 10-16.
[http://dx.doi.org/10.1161/STROKEAHA.116.013650] [PMID: 27899750]

Li, D.B.; Liu, J.L.; Wang, W.; Li, R.Y.; Yu, D.J.; Lan, X.Y.; Li, J.P. Plasma exosomal miR-422a and miR-125b-2-3p serve as biomarkers for ischemic stroke. Curr. Neurovasc. Res., 2018, 14(4), 330-337.
[http://dx.doi.org/10.2174/1567202614666171005153434] [PMID: 28982331]

Kerr, N.; García-Contreras, M.; Abbassi, S.; Mejias, N.H.; Desousa, B.R.; Ricordi, C.; Dietrich, W.D.; Keane, R.W.; de Rivero Vaccari, J.P. Inflammasome proteins in serum and serum-derived extracellular vesicles as biomarkers of stroke. Front. Mol. Neurosci., 2018, 11, 309.
[http://dx.doi.org/10.3389/fnmol.2018.00309] [PMID: 30233311]

Goetzl, L.; Merabova, N.; Darbinian, N.; Martirosyan, D.; Poletto, E.; Fugarolas, K.; Menkiti, O. Diagnostic potential of neural exosome cargo as biomarkers for acute brain injury. Ann. Clin. Transl. Neurol., 2018, 5(1), 4-10.
[http://dx.doi.org/10.1002/acn3.499] [PMID: 29376087]

Sun, L.; Zhang, W.; Li, Z.; Li, M.; Guo, J.; Wang, H.; Wang, X. The expression of cerebrospinal fluid exosomal miR-630 plays an important role in the dysfunction of endothelial cells after subarachnoid hemorrhage. Sci. Rep., 2019, 9(1), 11510.
[http://dx.doi.org/10.1038/s41598-019-48049-9] [PMID: 31395931]

Starke, R.M.; Chalouhi, N.; Ding, D.; Raper, D.M.S.; Mckisic, M.S.; Owens, G.K.; Hasan, D.M.; Medel, R.; Dumont, A.S. Vascular smooth muscle cells in cerebral aneurysm pathogenesis. Transl. Stroke Res., 2014, 5(3), 338-346.
[http://dx.doi.org/10.1007/s12975-013-0290-1] [PMID: 24323713]

Wang, Y.; Jia, L.; Xie, Y.; Cai, Z.; Liu, Z.; Shen, J.; Lu, Y.; Wang, Y.; Su, S.; Ma, Y.; Xiang, M. Involvement of macrophage-derived exosomes in abdominal aortic aneurysms development. Atherosclerosis, 2019, 289, 64-72.
[http://dx.doi.org/10.1016/j.atherosclerosis.2019.08.016] [PMID: 31479773]

Feng, Z.; Zhang, X.; Li, L.; Wang, C.; Feng, M.; Zhao, K.; Zhao, R.; Liu, J.; Fang, Y. Tumor-associated macrophage-derived exosomal microRNA-155-5p stimulates intracranial aneurysm formation and macrophage infiltration. Clin. Sci. (Lond.), 2019, 133(22), 2265-2282.
[http://dx.doi.org/10.1042/CS20190680] [PMID: 31657855]

Boyer, M.J.; Kimura, Y.; Akiyama, T.; Baggett, A.Y.; Preston, K.J.; Scalia, R.; Eguchi, S.; Rizzo, V. Endothelial cell‐derived extracellular vesicles alter vascular smooth muscle cell phenotype through high‐mobility group box proteins. J. Extracell. Vesicles, 2020, 9(1), 1781427.
[http://dx.doi.org/10.1080/20013078.2020.1781427] [PMID: 32944170]

Li, B.; Zang, G.; Zhong, W.; Chen, R.; Zhang, Y.; Yang, P.; Yan, J. Activation of CD137 signaling promotes neointimal formation by attenuating TET2 and transferrring from endothelial cell-derived exosomes to vascular smooth muscle cells. Biomed. Pharmacother., 2020, 121, 109593.
[http://dx.doi.org/10.1016/j.biopha.2019.109593] [PMID: 31766102]

Wang, J.; Li, J.; Cheng, C.; Liu, S. Angiotensin-converting enzyme 2 augments the effects of endothelial progenitor cells-exosomes on vascular smooth muscle cell phenotype transition. Cell Tissue Res., 2020, 382(3), 509-518.
[http://dx.doi.org/10.1007/s00441-020-03259-w] [PMID: 32852610]

Kuwabara, A.; Liu, J.; Kamio, Y.; Liu, A.; Lawton, M.T.; Lee, J.W.; Hashimoto, T. Protective effect of mesenchymal stem cells against the development of intracranial aneurysm rupture in mice. Neurosurgery, 2017, 81(6), 1021-1028.
[http://dx.doi.org/10.1093/neuros/nyx172] [PMID: 28431181]

Yang, G.; Qin, H.; Liu, B.; Zhao, X.; Yin, H. Mesenchymal stem cells-derived exosomes modulate vascular endothelial injury via miR-144-5p/PTEN in intracranial aneurysm. Hum. Cell, 2021, 34(5), 1346-1359.
[http://dx.doi.org/10.1007/s13577-021-00571-7] [PMID: 34240392]

Spinosa, M.; Lu, G.; Su, G.; Bontha, S.V.; Gehrau, R.; Salmon, M.D.; Smith, J.R.; Weiss, M.L.; Mas, V.R.; Upchurch, G.R., Jr; Sharma, A.K. Human mesenchymal stromal cell-derived extracellular vesicles attenuate aortic aneurysm formation and macrophage activation via microRNA-147. Faseb J., 2018, 32, fj201701138RR.
[http://dx.doi.org/10.1096/fj.201701138RR]

Liu, J.; Kuwabara, A.; Kamio, Y.; Hu, S.; Park, J.; Hashimoto, T.; Lee, J.W. Human mesenchymal stem cell-derived microvesicles prevent the rupture of intracranial aneurysm in part by suppression of mast cell activation via a PGE2-dependent mechanism. Stem Cells, 2016, 34(12), 2943-2955.
[http://dx.doi.org/10.1002/stem.2448] [PMID: 27350036]

Sun, X.; Zheng, X.; Zhang, X.; Zhang, Y.; Luo, G. Exosomal microRNA-23b-3p from bone marrow mesenchymal stem cells maintains T helper/Treg balance by downregulating the PI3k/Akt/NF-κB signaling pathway in intracranial aneurysm. Brain Res. Bull., 2020, 165, 305-315.
[http://dx.doi.org/10.1016/j.brainresbull.2020.09.003] [PMID: 32956770]

Libby, P.; Buring, J.E.; Badimon, L.; Hansson, G.K.; Deanfield, J.; Bittencourt, M.S.; Tokgözoğlu, L.; Lewis, E.F. Atherosclerosis. Nat. Rev. Dis. Primers, 2019, 5(1), 56.
[http://dx.doi.org/10.1038/s41572-019-0106-z] [PMID: 31420554]

Patel, N.; Chin, D.D.; Chung, E.J. Exosomes in atherosclerosis, a double-edged sword: Their role in disease pathogenesis and their potential as novel therapeutics. AAPS J., 2021, 23(5), 95.
[http://dx.doi.org/10.1208/s12248-021-00621-w] [PMID: 34312734]

Bai, S.; Yin, Q.; Dong, T.; Dai, F.; Qin, Y.; Ye, L.; Du, J.; Zhang, Q.; Chen, H.; Shen, B. Endothelial progenitor cell-derived exosomes ameliorate endothelial dysfunction in a mouse model of diabetes. Biomed. Pharmacother., 2020, 131, 110756.
[http://dx.doi.org/10.1016/j.biopha.2020.110756] [PMID: 33152921]

Li, J.; Tan, M.; Xiang, Q.; Zhou, Z.; Yan, H. Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response. Thromb. Res., 2017, 154, 96-105.
[http://dx.doi.org/10.1016/j.thromres.2017.04.016] [PMID: 28460288]

Zheng, B.; Yin, W.; Suzuki, T.; Zhang, X.; Zhang, Y.; Song, L.; Jin, L.; Zhan, H.; Zhang, H.; Li, J.; Wen, J. Exosome-Mediated miR-155 transfer from smooth muscle cells to endothelial cells induces endothelial injury and promotes atherosclerosis. Mol. Ther., 2017, 25(6), 1279-1294.
[http://dx.doi.org/10.1016/j.ymthe.2017.03.031] [PMID: 28408180]

Ke, X.; Liao, Z.; Luo, X.; Chen, J.; Deng, M.; Huang, Y.; Wang, Z.; Wei, M. Endothelial colony-forming cell-derived exosomal miR-21-5p regulates autophagic flux to promote vascular endothelial repair by inhibiting SIPL1A2 in atherosclerosis. Cell Commun. Signal., 2022, 20(1), 30.
[http://dx.doi.org/10.1186/s12964-022-00828-0] [PMID: 35279183]

Zhang, Z.G.; Chopp, M. Exosomes in stroke pathogenesis and therapy. J. Clin. Invest., 2016, 126(4), 1190-1197.
[http://dx.doi.org/10.1172/JCI81133] [PMID: 27035810]

Leroyer, A.S.; Rautou, P.E.; Silvestre, J.S.; Castier, Y.; Lesèche, G.; Devue, C.; Duriez, M.; Brandes, R.P.; Lutgens, E.; Tedgui, A.; Boulanger, C.M. CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization. J. Am. Coll. Cardiol., 2008, 52(16), 1302-1311.
[http://dx.doi.org/10.1016/j.jacc.2008.07.032] [PMID: 18929241]

Virmani, R.; Kolodgie, F.D.; Burke, A.P.; Finn, A.V.; Gold, H.K.; Tulenko, T.N.; Wrenn, S.P.; Narula, J. Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler. Thromb. Vasc. Biol., 2005, 25(10), 2054-2061.
[http://dx.doi.org/10.1161/01.ATV.0000178991.71605.18] [PMID: 16037567]

Li, S.; Yuan, L.; Su, L.; Lian, Z.; Liu, C.; Zhang, F.; Cui, Y.; Wu, M.; Chen, H. Decreased miR-92a-3p expression potentially mediates the pro-angiogenic effects of oxidative stress-activated endothelial cell-derived exosomes by targeting tissue factor. Int. J. Mol. Med., 2020, 46(5), 1886-1898.
[http://dx.doi.org/10.3892/ijmm.2020.4713] [PMID: 32901851]

Sun, Y.; Liu, X.; Zhang, D.; Liu, F.; Cheng, Y.; Ma, Y.; Zhou, Y.; Zhao, Y. Platelet-derived exosomes affect the proliferation and migration of human umbilical vein endothelial cells via miR-126. Curr. Vasc. Pharmacol., 2019, 17(4), 379-387.
[http://dx.doi.org/10.2174/1570161116666180313142139] [PMID: 29532758]

Basatemur, G.L.; Jørgensen, H.F.; Clarke, M.C.H.; Bennett, M.R.; Mallat, Z. Vascular smooth muscle cells in atherosclerosis. Nat. Rev. Cardiol., 2019, 16(12), 727-744.
[http://dx.doi.org/10.1038/s41569-019-0227-9] [PMID: 31243391]

Niu, C.; Wang, X.; Zhao, M.; Cai, T.; Liu, P.; Li, J.; Willard, B.; Zu, L.; Zhou, E.; Li, Y.; Pan, B.; Yang, F.; Zheng, L. Macrophage foam cell-derived extracellular vesicles promote vascular smooth muscle cell migration and adhesion. J. Am. Heart Assoc., 2016, 5(10), e004099.
[http://dx.doi.org/10.1161/JAHA.116.004099] [PMID: 27792649]

Lin, C.M.; Wang, B.W.; Pan, C.M.; Fang, W.J.; Chua, S.K.; Cheng, W.P.; Shyu, K.G. Chrysin boosts KLF2 expression through suppression of endothelial cell-derived exosomal microRNA-92a in the model of atheroprotection. Eur. J. Nutr., 2021, 60(8), 4345-4355.
[http://dx.doi.org/10.1007/s00394-021-02593-1] [PMID: 34041583]

Hergenreider, E.; Heydt, S.; Tréguer, K.; Boettger, T.; Horrevoets, A.J.G.; Zeiher, A.M.; Scheffer, M.P.; Frangakis, A.S.; Yin, X.; Mayr, M.; Braun, T.; Urbich, C.; Boon, R.A.; Dimmeler, S. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat. Cell Biol., 2012, 14(3), 249-256.
[http://dx.doi.org/10.1038/ncb2441] [PMID: 22327366]

Fang, Y.; Shi, C.; Manduchi, E.; Civelek, M.; Davies, P.F. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc. Natl. Acad. Sci. USA, 2010, 107(30), 13450-13455.
[http://dx.doi.org/10.1073/pnas.1002120107] [PMID: 20624982]

Njock, M.S.; Cheng, H.S.; Dang, L.T.; Nazari-Jahantigh, M.; Lau, A.C.; Boudreau, E.; Roufaiel, M.; Cybulsky, M.I.; Schober, A.; Fish, J.E. Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs. Blood, 2015, 125(20), 3202-3212.
[http://dx.doi.org/10.1182/blood-2014-11-611046] [PMID: 25838349]

Goetzl, E.J.; Goetzl, L.; Karliner, J.S.; Tang, N.; Pulliam, L. Human plasma platelet‐derived exosomes: Effects of aspirin. FASEB J., 2016, 30(5), 2058-2063.
[http://dx.doi.org/10.1096/fj.201500150R] [PMID: 26873936]

Nguyen, M.A.; Karunakaran, D.; Geoffrion, M.; Cheng, H.S.; Tandoc, K.; Perisic Matic, L.; Hedin, U.; Maegdefessel, L.; Fish, J.E.; Rayner, K.J. Extracellular vesicles secreted by atherogenic macrophages transfer MicroRNA to inhibit cell migration. Arterioscler. Thromb. Vasc. Biol., 2018, 38(1), 49-63.
[http://dx.doi.org/10.1161/ATVBAHA.117.309795] [PMID: 28882869]

Ouimet, M.; Barrett, T.J.; Fisher, E.A. HDL and reverse cholesterol transport. Circ. Res., 2019, 124(10), 1505-1518.
[http://dx.doi.org/10.1161/CIRCRESAHA.119.312617] [PMID: 31071007]

Liu, Y.; Sun, Y.; Lin, X.; Zhang, D.; Hu, C.; Liu, J.; Zhu, Y.; Gao, A.; Han, H.; Chai, M.; Zhang, J.; Zhao, Y.; Zhou, Y. Perivascular adipose-derived exosomes reduce macrophage foam cell formation through miR-382-5p and the BMP4-PPARγ-ABCA1/ABCG1 pathways. Vascul. Pharmacol., 2022, 143, 106968.
[http://dx.doi.org/10.1016/j.vph.2022.106968] [PMID: 35123060]

Xu, B.; Zhang, Y.; Du, X.F.; Li, J.; Zi, H.X.; Bu, J.W.; Yan, Y.; Han, H.; Du, J.L. Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity. Cell Res., 2017, 27(7), 882-897.
[http://dx.doi.org/10.1038/cr.2017.62] [PMID: 28429770]

Wang, X.; Han, C.; Jia, Y.; Wang, J.; Ge, W.; Duan, L. Proteomic profiling of exosomes from hemorrhagic moyamoya disease and dysfunction of mitochondria in endothelial cells. Stroke, 2021, 52(10), 3351-3361.
[http://dx.doi.org/10.1161/STROKEAHA.120.032297] [PMID: 34334053]

Hu, D.; Wang, Y.; You, Z.; Lu, Y.; Liang, C. lnc-MRGPRF-6:1 Promotes m1 polarization of macrophage and inflammatory response through the TLR4-MyD88-MAPK pathway. Mediators Inflamm., 2022, 2022, 1-18.
[http://dx.doi.org/10.1155/2022/6979117] [PMID: 35125964]

Bouchareychas, L.; Duong, P.; Covarrubias, S.; Alsop, E.; Phu, T.A.; Chung, A.; Gomes, M.; Wong, D.; Meechoovet, B.; Capili, A.; Yamamoto, R.; Nakauchi, H.; McManus, M.T.; Carpenter, S.; Van Keuren-Jensen, K.; Raffai, R.L. Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo. Cell Rep., 2020, 32(2), 107881.
[http://dx.doi.org/10.1016/j.celrep.2020.107881] [PMID: 32668250]

Ma, X.; Wang, J.; Li, J.; Ma, C.; Chen, S.; Lei, W.; Yang, Y.; Liu, S.; Bihl, J.; Chen, C. Loading MiR-210 in endothelial progenitor cells derived exosomes boosts their beneficial effects on hypoxia/] reoxygeneation-injured human endothelial cells via protecting mitochondrial function. Cell. Physiol. Biochem., 2018, 46(2), 664-675.
[http://dx.doi.org/10.1159/000488635] [PMID: 29621777]

Bäck, M.; Yurdagul, A., Jr; Tabas, I.; Öörni, K.; Kovanen, P.T. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nat. Rev. Cardiol., 2019, 16(7), 389-406.
[http://dx.doi.org/10.1038/s41569-019-0169-2] [PMID: 30846875]

Italiani, P.; Boraschi, D. From Monocytes to M1/M2 macrophages: Phenotypical vs. functional differentiation. Front. Immunol., 2014, 5, 514.
[http://dx.doi.org/10.3389/fimmu.2014.00514] [PMID: 25368618]

Gasior, P.; Cheng, Y.; Valencia, A.F.; McGregor, J.; Conditt, G.B.; Kaluza, G.L.; Granada, J.F. Impact of fluoropolymer-based paclitaxel delivery on neointimal proliferation and vascular healing. Circ. Cardiovasc. Interv., 2017, 10(5), e004450.
[http://dx.doi.org/10.1161/CIRCINTERVENTIONS.116.004450] [PMID: 28487355]

Yan, W.; Li, T.; Yin, T.; Hou, Z.; Qu, K.; Wang, N.; Durkan, C.; Dong, L.; Qiu, J.; Gregersen, H.; Wang, G. M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation. Theranostics, 2020, 10(23), 10712-10728.
[http://dx.doi.org/10.7150/thno.46143] [PMID: 32929376]

Wang, Z.; Zhu, H.; Shi, H.; Zhao, H.; Gao, R.; Weng, X.; Liu, R.; Li, X.; Zou, Y.; Hu, K.; Sun, A.; Ge, J. Exosomes derived from M1 macrophages aggravate neointimal hyperplasia following carotid artery injuries in mice through miR-222/CDKN1B/CDKN1C pathway. Cell Death Dis., 2019, 10(6), 422.
[http://dx.doi.org/10.1038/s41419-019-1667-1] [PMID: 31142732]

Endres, M.; Moro, M.A.; Nolte, C.H.; Dames, C.; Buckwalter, M.S.; Meisel, A. Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke. Circ. Res., 2022, 130(8), 1167-1186.
[http://dx.doi.org/10.1161/CIRCRESAHA.121.319994] [PMID: 35420915]

Rosenberg, G.A. Neurological diseases in relation to the blood-brain barrier. J. Cereb. Blood Flow Metab., 2012, 32(7), 1139-1151.
[http://dx.doi.org/10.1038/jcbfm.2011.197] [PMID: 22252235]

Candelario-Jalil, E.; Dijkhuizen, R.M.; Magnus, T. Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities. Stroke, 2022, 53(5), 1473-1486.
[http://dx.doi.org/10.1161/STROKEAHA.122.036946] [PMID: 35387495]

Nudo, R.J. Postinfarct cortical plasticity and behavioral recovery. Stroke, 2007, 38(2)(Suppl.), 840-845.
[http://dx.doi.org/10.1161/01.STR.0000247943.12887.d2] [PMID: 17261749]

Kanazawa, M.; Takahashi, T.; Ishikawa, M.; Onodera, O.; Shimohata, T.; del Zoppo, G.J. Angiogenesis in the ischemic core: A potential treatment target? J. Cereb. Blood Flow Metab., 2019, 39(5), 753-769.
[http://dx.doi.org/10.1177/0271678X19834158] [PMID: 30841779]

Marques, B.L.; Carvalho, G.A.; Freitas, E.M.M.; Chiareli, R.A.; Barbosa, T.G.; Di Araújo, A.G.P.; Nogueira, Y.L.; Ribeiro, R.I.; Parreira, R.C.; Vieira, M.S.; Resende, R.R.; Gomez, R.S.; Oliveira-Lima, O.C.; Pinto, M.C.X. The role of neurogenesis in neurorepair after ischemic stroke. Semin. Cell Dev. Biol., 2019, 95, 98-110.
[http://dx.doi.org/10.1016/j.semcdb.2018.12.003] [PMID: 30550812]

Jiang, L.; Shen, F.; Degos, V.; Schonemann, M.; Pleasure, S.J.; Mellon, S.H.; Young, W.L.; Su, H. Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Transl. Stroke Res., 2011, 2(3), 366-375.
[http://dx.doi.org/10.1007/s12975-011-0078-0] [PMID: 22022343]

Martinez, M.C.; Tual-Chalot, S.; Leonetti, D.; Andriantsitohaina, R. Microparticles: targets and tools in cardiovascular disease. Trends Pharmacol. Sci., 2011, 32(11), 659-665.
[http://dx.doi.org/10.1016/j.tips.2011.06.005] [PMID: 21794929]

EL Andaloussi, S.; Mäger, I.; Breakefield, X.O.; Wood, M.J.A. Extracellular vesicles: Biology and emerging therapeutic opportunities. Nat. Rev. Drug Discov., 2013, 12(5), 347-357.
[http://dx.doi.org/10.1038/nrd3978] [PMID: 23584393]

Tian, T.; Zhang, H.X.; He, C.P.; Fan, S.; Zhu, Y.L.; Qi, C.; Huang, N.P.; Xiao, Z.D.; Lu, Z.H.; Tannous, B.A.; Gao, J. Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy. Biomaterials, 2018, 150, 137-149.
[http://dx.doi.org/10.1016/j.biomaterials.2017.10.012] [PMID: 29040874]

Chen, C.C.; Liu, L.; Ma, F.; Wong, C.W.; Guo, X.E.; Chacko, J.V.; Farhoodi, H.P.; Zhang, S.X.; Zimak, J.; Ségaliny, A.; Riazifar, M.; Pham, V.; Digman, M.A.; Pone, E.J.; Zhao, W. Elucidation of exosome migration across the blood-brain barrier model in vitro. Cell. Mol. Bioeng., 2016, 9(4), 509-529.
[http://dx.doi.org/10.1007/s12195-016-0458-3] [PMID: 28392840]

Muhammad, S.A.; Abbas, A.Y.; Imam, M.U.; Saidu, Y.; Bilbis, L.S. Efficacy of stem cell secretome in the treatment of traumatic brain injury: A systematic review and meta-analysis of preclinical studies. Mol. Neurobiol., 2022, 59(5), 2894-2909.
[http://dx.doi.org/10.1007/s12035-022-02759-w] [PMID: 35230664]

Huang, L.; Hua, L.; Zhang, X. The exosomal microrna profile is responsible for the mesenchymal stromal cell transplantation-induced improvement of functional recovery after stroke in rats. Neuroimmunomodulation, 2022, 29(2), 151-160.
[http://dx.doi.org/10.1159/000518637] [PMID: 34569545]

Xiao, Y.; Geng, F.; Wang, G.; Li, X.; Zhu, J.; Zhu, W. Bone marrow-derived mesenchymal stem cells-derived exosomes prevent oligodendrocyte apoptosis through exosomal miR-134 by targeting caspase-8. J. Cell. Biochem., 2018.
[http://dx.doi.org/10.1002/jcb.27519] [PMID: 30191592]

Xin, H.; Li, Y.; Cui, Y.; Yang, J.J.; Zhang, Z.G.; Chopp, M. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J. Cereb. Blood Flow Metab., 2013, 33(11), 1711-1715.
[http://dx.doi.org/10.1038/jcbfm.2013.152] [PMID: 23963371]

Xin, H.; Li, Y.; Buller, B.; Katakowski, M.; Zhang, Y.; Wang, X.; Shang, X.; Zhang, Z.G.; Chopp, M. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells, 2012, 30(7), 1556-1564.
[http://dx.doi.org/10.1002/stem.1129] [PMID: 22605481]

Liu, B.; Zheng, W.; Dai, L.; Fu, S.; Shi, E. Bone marrow mesenchymal stem cell derived exosomal miR-455-5p protects against spinal cord ischemia reperfusion injury. Tissue Cell, 2022, 74, 101678.
[http://dx.doi.org/10.1016/j.tice.2021.101678] [PMID: 34823099]

Xin, H.; Li, Y.; Liu, Z.; Wang, X.; Shang, X.; Cui, Y.; Zhang, Z.G.; Chopp, M. MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells, 2013, 31(12), 2737-2746.
[http://dx.doi.org/10.1002/stem.1409] [PMID: 23630198]

Dumbrava, D.A.; Surugiu, R.; Börger, V.; Ruscu, M.; Tertel, T.; Giebel, B.; Hermann, D.M.; Popa-Wagner, A. Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats. Geroscience, 2022, 44(1), 293-310.
[http://dx.doi.org/10.1007/s11357-021-00483-2] [PMID: 34757568]

Wei, R.; Zhang, L.; Hu, W.; Shang, X.; He, Y.; Zhang, W. Zeb2/Axin2-enriched BMSC-derived exosomes promote post-stroke functional recovery by enhancing neurogenesis and neural plasticity. J. Mol. Neurosci., 2022, 72(1), 69-81.
[http://dx.doi.org/10.1007/s12031-021-01887-7] [PMID: 34401997]

Nalamolu, K.R.; Venkatesh, I.; Mohandass, A.; Klopfenstein, J.D.; Pinson, D.M.; Wang, D.Z.; Kunamneni, A.; Veeravalli, K.K. Exosomes secreted by the cocultures of normal and oxygen-glucose-deprived stem cells improve post-stroke outcome. Neuromol. Med., 2019, 21(4), 529-539.
[http://dx.doi.org/10.1007/s12017-019-08540-y] [PMID: 31077035]

Zhang, Z.; Zou, X.; Zhang, R.; Xie, Y.; Feng, Z.; Li, F.; Han, J.; Sun, H.; Ouyang, Q.; Hua, S.; Lv, B.; Hua, T.; Liu, Z.; Cai, Y.; Zou, Y.; Tang, Y.; Jiang, X. Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke. Aging (Albany NY), 2021, 13(2), 3060-3079.
[http://dx.doi.org/10.18632/aging.202466] [PMID: 33479185]

Castelli, V.; Antonucci, I.; d’Angelo, M.; Tessitore, A.; Zelli, V.; Benedetti, E.; Ferri, C.; Desideri, G.; Borlongan, C.; Stuppia, L.; Cimini, A. Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model. Stem Cells Transl. Med., 2021, 10(2), 251-266.
[http://dx.doi.org/10.1002/sctm.20-0268] [PMID: 33027557]

Sun, X.; Jung, J.H.; Arvola, O.; Santoso, M.R.; Giffard, R.G.; Yang, P.C.; Stary, C.M. Stem cell-derived exosomes protect astrocyte cultures from in vitro Ischemia and Decrease Injury as Post-stroke Intravenous Therapy. Front. Cell. Neurosci., 2019, 13, 394.
[http://dx.doi.org/10.3389/fncel.2019.00394] [PMID: 31551712]

Yang, H.; Tu, Z.; Yang, D.; Hu, M.; Zhou, L.; Li, Q.; Yu, B.; Hou, S. Exosomes from hypoxic pre-treated ADSCs attenuate acute ischemic stroke-induced brain injury via delivery of circ-Rps5 and promote M2 microglia/macrophage polarization. Neurosci. Lett., 2022, 769, 136389.
[http://dx.doi.org/10.1016/j.neulet.2021.136389] [PMID: 34896256]

Jiang, M.; Wang, H.; Jin, M.; Yang, X.; Ji, H.; Jiang, Y.; Zhang, H.; Wu, F.; Wu, G.; Lai, X.; Cai, L.; Hu, R.; Xu, L.; Li, L. Exosomes from MiR-30d-5p-ADSCs reverse acute ischemic stroke-induced, autophagy-mediated brain injury by promoting M2 microglial/macrophage polarization. Cell. Physiol. Biochem., 2018, 47(2), 864-878.
[http://dx.doi.org/10.1159/000490078] [PMID: 29807362]

Chen, K.H.; Chen, C.H.; Wallace, C.G.; Yuen, C.M.; Kao, G.S.; Chen, Y.L.; Shao, P.L.; Chen, Y.L.; Chai, H.T.; Lin, K.C.; Liu, C.F.; Chang, H.W.; Lee, M.S.; Yip, H.K. Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke. Oncotarget, 2016, 7(46), 74537-74556.
[http://dx.doi.org/10.18632/oncotarget.12902] [PMID: 27793019]

Ling, X.; Zhang, G.; Xia, Y.; Zhu, Q.; Zhang, J.; Li, Q.; Niu, X.; Hu, G.; Yang, Y.; Wang, Y.; Deng, Z. Exosomes from human urine‐derived stem cells enhanced neurogenesis via miR‐26a/HDAC6 axis after ischaemic stroke. J. Cell. Mol. Med., 2020, 24(1), 640-654.
[http://dx.doi.org/10.1111/jcmm.14774] [PMID: 31667951]

Zhong, Y.; Luo, L. Exosomes from human umbilical vein endothelial cells ameliorate ischemic injuries by suppressing the RNA component of mitochondrial RNA-processing endoribonuclease via the induction of miR-206/miR-1-3p levels. Neuroscience, 2021, 476, 34-44.
[http://dx.doi.org/10.1016/j.neuroscience.2021.08.026] [PMID: 34481913]

Yu, Y.; Zhou, H.; Xiong, Y.; Liu, J. Exosomal miR-199a-5p derived from endothelial cells attenuates apoptosis and inflammation in neural cells by inhibiting endoplasmic reticulum stress. Brain Res., 2020, 1726, 146515.
[http://dx.doi.org/10.1016/j.brainres.2019.146515] [PMID: 31634452]

Zang, J.; Wu, Y.; Su, X.; Zhang, T.; Tang, X.; Ma, D.; Li, Y.; Liu, Y.; Weng, Z.; Liu, X.; Tsang, C.K.; Xu, A.; Lu, D. Inhibition of PDE1-B by vinpocetine regulates microglial exosomes and polarization through enhancing autophagic flux for neuroprotection against ischemic stroke. Front. Cell Dev. Biol., 2021, 8, 616590.
[http://dx.doi.org/10.3389/fcell.2020.616590] [PMID: 33614626]

Song, Y.; Li, Z.; He, T.; Qu, M.; Jiang, L.; Li, W.; Shi, X.; Pan, J.; Zhang, L.; Wang, Y.; Zhang, Z.; Tang, Y.; Yang, G.Y. M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124. Theranostics, 2019, 9(10), 2910-2923.
[http://dx.doi.org/10.7150/thno.30879] [PMID: 31244932]

Chen, W.; Wang, H.; Zhu, Z.; Feng, J.; Chen, L. Exosome-shuttled circSHOC2 from IPASs regulates neuronal autophagy and ameliorates ischemic brain injury via the miR-7670-3p/SIRT1 axis. Mol. Ther. Nucleic Acids, 2020, 22, 657-672.
[http://dx.doi.org/10.1016/j.omtn.2020.09.027] [PMID: 33230464]

Pei, X.; Li, Y.; Zhu, L.; Zhou, Z. Astrocyte-derived exosomes transfer miR-190b to inhibit oxygen and glucose deprivation-induced autophagy and neuronal apoptosis. Cell Cycle, 2020, 19(8), 906-917.
[http://dx.doi.org/10.1080/15384101.2020.1731649] [PMID: 32150490]

Kim, M.; Lee, Y.; Lee, M. Hypoxia-specific anti-RAGE exosomes for nose-to-brain delivery of anti-miR-181a oligonucleotide in an ischemic stroke model. Nanoscale, 2021, 13(33), 14166-14178.
[http://dx.doi.org/10.1039/D0NR07516G] [PMID: 34477698]

Kim, H.Y.; Kim, T.J.; Kang, L.; Kim, Y.J.; Kang, M.K.; Kim, J.; Ryu, J.H.; Hyeon, T.; Yoon, B.W.; Ko, S.B.; Kim, B.S. Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke. Biomaterials, 2020, 243, 119942.
[http://dx.doi.org/10.1016/j.biomaterials.2020.119942] [PMID: 32179302]

Guo, L.; Huang, Z.; Huang, L.; Liang, J.; Wang, P.; Zhao, L.; Shi, Y. Surface-modified engineered exosomes attenuated cerebral ischemia/reperfusion injury by targeting the delivery of quercetin towards impaired neurons. J. Nanobiotechnol., 2021, 19(1), 141.
[http://dx.doi.org/10.1186/s12951-021-00879-4] [PMID: 34001136]

Zhang, H.; Wu, J.; Wu, J.; Fan, Q.; Zhou, J.; Wu, J.; Liu, S.; Zang, J.; Ye, J.; Xiao, M.; Tian, T.; Gao, J. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. J. Nanobiotechnol., 2019, 17(1), 29.
[http://dx.doi.org/10.1186/s12951-019-0461-7] [PMID: 30782171]

Kim, M.; Kim, G.; Hwang, D.W.; Lee, M. Delivery of high mobility group box-1 siRNA using brain-targeting exosomes for ischemic stroke therapy. J. Biomed. Nanotechnol., 2019, 15(12), 2401-2412.
[http://dx.doi.org/10.1166/jbn.2019.2866] [PMID: 31748020]

Raya, A.K.; Diringer, M.N. Treatment of subarachnoid hemorrhage. Crit. Care Clin., 2014, 30(4), 719-733.
[http://dx.doi.org/10.1016/j.ccc.2014.06.004] [PMID: 25257737]

Vivancos, J.; Gilo, F.; Frutos, R.; Maestre, J.; García-Pastor, A.; Quintana, F.; Roda, J.M.; Ximénez-Carrillo, A.; Díez Tejedor, E.; Fuentes, B.; Alonso de Leciñana, M.; Alvarez-Sabin, J.; Arenillas, J.; Calleja, S.; Casado, I.; Castellanos, M.; Castillo, J.; Dávalos, A.; Díaz-Otero, F.; Egido, J.A.; Fernández, J.C.; Freijo, M.; Gállego, J.; Gil-Núñez, A.; Irimia, P.; Lago, A.; Masjuan, J.; Martí-Fábregas, J.; Martínez-Sánchez, P.; Martínez-Vila, E.; Molina, C.; Morales, A.; Nombela, F.; Purroy, F.; Ribó, M.; Rodríguez-Yañez, M.; Roquer, J.; Rubio, F.; Segura, T.; Serena, J.; Simal, P.; Tejada, J. Clinical management guidelines for subarachnoid haemorrhage. Diagnosis and treatment. Neurologia, 2014, 29(6), 353-370.
[http://dx.doi.org/10.1016/j.nrl.2012.07.009] [PMID: 23044408]

Helbok, R.; Schiefecker, A.J.; Beer, R.; Dietmann, A.; Antunes, A.P.; Sohm, F.; Fischer, M.; Hackl, W.O.; Rhomberg, P.; Lackner, P.; Pfausler, B.; Thomé, C.; Humpel, C.; Schmutzhard, E. Early brain injury after aneurysmal subarachnoid hemorrhage: a multimodal neuromonitoring study. Crit. Care, 2015, 19(1), 75.
[http://dx.doi.org/10.1186/s13054-015-0809-9] [PMID: 25887441]

Xiong, L.; Sun, L.; Zhang, Y.; Peng, J.; Yan, J.; Liu, X. Exosomes from bone marrow mesenchymal stem cells can alleviate early brain injury after subarachnoid hemorrhage through miRNA129-5p-HMGB1 pathway. Stem Cells Dev., 2020, 29(4), 212-221.
[http://dx.doi.org/10.1089/scd.2019.0206] [PMID: 31801411]

Liu, Z.; Wang, B.; Guo, Q. MiR-26b-5p-modified hUB-MSCs derived exosomes attenuate early brain injury during subarachnoid hemorrhage via MAT2A-mediated the p38 MAPK/STAT3 signaling pathway. Brain Res. Bull., 2021, 175, 107-115.
[http://dx.doi.org/10.1016/j.brainresbull.2021.07.014] [PMID: 34284075]

Lai, N.; Wu, D.; Liang, T.; Pan, P.; Yuan, G.; Li, X.; Li, H.; Shen, H.; Wang, Z.; Chen, G. Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice. J. Neuroinflammation, 2020, 17(1), 74.
[http://dx.doi.org/10.1186/s12974-020-01745-0] [PMID: 32098619]