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Current Nanomedicine

Author(s): Nitin Mishra, Niranjan Kaushik*, Pramod Kumar Sharma and Md. Aftab Alam

DOI: 10.2174/2468187313666230213121011

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Nano Emulsion Drug Delivery System: A Review

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Abstract

In nanoemulsions, both oil and water droplets are stabilised by an amphiphilic surfactant. Ultrafine dispersions with varying drug loading, viscoelastic properties, and aesthetic characteristics may be useful for the administration of medication. A 20-500-nanometer droplet size range for nanoemulsions has been established. The biological behavior of a nanoemulsions formulation is heavily influenced by its droplet diameter and surface properties. Small droplet size results in clear emulsions; therefore, the appearance of the product is unaffected even by the addition of an oil phase. Nanoemulsions are oil-in-water dispersions that are transparent or translucent and are stabilized by an interfacial layer of surfactants and cosurfactant particles with droplet size smaller than 100 nm. New nanoscience-based technologies are becoming increasingly popular as a means of improving food safety, quality, and nutrition. In this field, nanoemulsions have been a key focus since they can be readily manufactured using current food components and technology. Food nanoemulsions, which are tiny oil droplets distributed in water, are being used as delivery methods for a variety of hydrophobic compounds, including nutrients, nutraceuticals, antioxidants, and antimicrobial agents. The present review is focused on the formulation, characterization, and applications of nanoemulsions.

Keywords: Nanoemulsions, high-pressure homogenization, ostwald ripening, thermodynamic stability, physical stability, shelf life, ostwald ripening.

Graphical Abstract

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