LncRNA-mediated Modulation of Endothelial Cells: Novel Progress
in the Pathogenesis of Coronary Atherosclerotic Disease

Shao      Ouyang; Zhi-Xiang      Zhou; Hui-Ting      Liu; Zhong      Ren; Huan      Liu; Nian-Hua      Deng; Kai-Jiang      Tian; Kun      Zhou; Hai-lin      Xie; Zhi-Sheng      Jiang
Abstract

Coronary atherosclerotic disease (CAD) is a common cardiovascular disease and an important cause of death. Moreover, endothelial cells (ECs) injury is an early pathophysiological feature of CAD, and long noncoding RNAs (lncRNAs) can modulate gene expression. Recent studies have shown that lncRNAs are involved in the pathogenesis of CAD, especially by regulating ECs. In this review, we summarize the novel progress of lncRNA-modulated ECs in the pathogenesis of CAD, including ECs proliferation, migration, adhesion, angiogenesis, inflammation, apoptosis, autophagy, and pyroptosis. Thus, as lncRNAs regulate ECs in CAD, lncRNAs will provide ideal and novel targets for the diagnosis and drug therapy of CAD.
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Cite As
Current Medicinal Chemistry

LncRNA-mediated Modulation of Endothelial Cells: Novel Progress in the Pathogenesis of Coronary Atherosclerotic Disease

Abstract
