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Letters in Organic Chemistry

Author(s): Monika Sihag, Rinku Soni, Neha Rani, Mayank Kinger and Deepak Kumar Aneja*

DOI: 10.2174/1570178620666230209145324

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Regeneration of Aryl Ketones by Oxidative Cleavage of Pyridyl Hydrazones Mediated by Koser’s Reagent

Page: [696 - 700] Pages: 5

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Abstract

[Hydroxy(tosyloxy)iodo]benzene mediated the oxidative cleavage of pyridyl hydrazones to regenerate aryl ketones efficiently. Reaction occurred by simply stirring the hydrazone with hypervalent iodine reagent in dichloromethane at room temperature, where aryl ketones are produced up to 90% yield.

Keywords: Aryl ketones, hypervalent iodine reagent, oxidative cleavage, protecting group, pyridyl hydrazones, HTIB.

Graphical Abstract

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