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Current Drug Delivery

Author(s): Rohitas Deshmukh, Aman Kumar Jain, Rajesh Singh, Swarnali Das Paul and Ranjit K. Harwansh*

DOI: 10.2174/1567201820666230203115752

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Andrographis paniculata and Andrographolide - A Snapshot on Recent Advances in Nano Drug Delivery Systems against Cancer

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Abstract

Cancer is one of the deadliest illnesses of the 21st century. Chemotherapy and radiation therapies both have considerable side effects. Antitumor antibiotics are one of them. Coughs, common colds, fevers, laryngitis, and infectious disorders have all been treated with Andrographis paniculata for centuries. Extracts of Andrographis effectively treat various ailments, as well as cancer. The most active molecule in Andrographis paniculata is andrographolide a, diterpene, and lactone. Andrographis paniculata and its derivatives have long been used to treat various ailments. Anti-inflammatory and cancerfighting characteristics have been observed in Andrographolide. Andrographolide, a diterpene lactone separated from Andrographis paniculata, has also been shown to have important criticalessential biological protective properties. It has also been suggested that it could be used to treat major human diseases like-rheumatoid like rheumatoid, colitis, and Parkinsons disease. This summary aims to highlight Andrographolide as a promising cancer treatment option. Several databases were searched for andrographolides cytotoxic/anti-cancer effects in pre-clinical and clinical research to serve this purpose. Several studies have shown that Andrographolide is helpful in cancer medication, as detailed in this review.

Keywords: Andrographis paniculata, andrographolide, cancer, nanoparticles, nanocarriers, herbal bioactives.

Graphical Abstract

[1]
Zhang, Y.; Li, M.; Gao, X.; Chen, Y.; Liu, T. Nanotechnology in cancer diagnosis: Progress, challenges and opportunities. J. Hematol. Oncol., 2019, 12(1), 137.
[http://dx.doi.org/10.1186/s13045-019-0833-3] [PMID: 31847897]
[2]
Sutradhar, K.B.; Amin, M.L. Nanotechnology in cancer drug delivery and selective targeting. ISRN Nanotechnol., 2014, 2014, 1-12.
[http://dx.doi.org/10.1155/2014/939378]
[3]
Singh, R.; Deshmukh, R. DNA nanobots - emerging customized nanomedicine in oncology. Curr. Drug Deliv., 2023, 20(2), 111-126.
[4]
Adiguna, S.P.; Panggabean, J.A.; Atikana, A.; Untari, F.; Izzati, F.; Bayu, A.; Rosyidah, A.; Rahmawati, S.I.; Putra, M.Y. Antiviral activities of andrographolide and its derivatives: Mechanism of action and delivery system. Pharmaceuticals (Basel), 2021, 14(11), 1102.
[http://dx.doi.org/10.3390/ph14111102] [PMID: 34832884]
[5]
Gmeiner, W.H.; Ghosh, S. Nanotechnology for cancer treatment. Nanotechnol. Rev., 2015, 3(2), 111-122.
[PMID: 26082884]
[6]
Liao, Z.; Tan, Z.W.; Zhu, P.; Tan, N.S. Cancer-associated fibroblasts in tumor microenvironment – Accomplices in tumor malignancy. Cell. Immunol., 2019, 343, 103729.
[http://dx.doi.org/10.1016/j.cellimm.2017.12.003] [PMID: 29397066]
[7]
Bharali, D.J.; Mousa, S.A. Emerging nanomedicines for early cancer detection and improved treatment: Current perspective and future promise. Pharmacol. Ther., 2010, 128(2), 324-335.
[http://dx.doi.org/10.1016/j.pharmthera.2010.07.007] [PMID: 20705093]
[8]
Vaidya, A.; Pathak, D.; Shah, K. 1,3,4-oxadiazole and its derivatives: A review on recent progress in anticancer activities. Chem. Biol. Drug Des., 2021, 97(3), 572-591.
[http://dx.doi.org/10.1111/cbdd.13795] [PMID: 32946168]
[9]
David, A.R.; Zimmerman, M.R. Cancer: An old disease, a new disease or something in between? Nat. Rev. Cancer, 2010, 10(10), 728-733.
[http://dx.doi.org/10.1038/nrc2914] [PMID: 20814420]
[10]
Mullard, A. Addressing cancer’s grand challenges. Nat. Rev. Drug Discov., 2020, 19(12), 825-826.
[http://dx.doi.org/10.1038/d41573-020-00202-0] [PMID: 33173229]
[11]
Komath, S.; Garg, A.; Wahajuddin, M. Development and evaluation of Chrysin-Phospholipid complex loaded solid lipid nanoparticles - storage stability and in vitro anti-cancer activity. J. Microencapsul., 2018, 35(6), 600-617.
[http://dx.doi.org/10.1080/02652048.2018.1559369] [PMID: 30557060]
[12]
Zaimy, M.A.; Saffarzadeh, N.; Mohammadi, A.; Pourghadamyari, H.; Izadi, P.; Sarli, A.; Moghaddam, L.K.; Paschepari, S.R.; Azizi, H.; Torkamandi, S.; Tavakkoly-Bazzaz, J. New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles. Cancer Gene Ther., 2017, 24(6), 233-243.
[http://dx.doi.org/10.1038/cgt.2017.16] [PMID: 28574057]
[13]
Harwansh, R.K.; Bahadur, S.; Deshmukh, R.; Rahman, M.A. Exciting potential of nanoparticlized lipidic system for effective treatment of breast cancer and clinical updates: A translational prospective. Curr. Pharm. Des., 2020, 26(11), 1191-1205.
[http://dx.doi.org/10.2174/1381612826666200131101156] [PMID: 32003686]
[14]
Harwansh, R.K.; Deshmukh, R. Breast cancer: An insight into its inflammatory, molecular, pathological and targeted facets with update on investigational drugs. Crit. Rev. Oncol. Hematol., 2020, 154, 103070.
[http://dx.doi.org/10.1016/j.critrevonc.2020.103070] [PMID: 32871325]
[15]
Venkatesan, M.; Jolad, B. Nanorobots in Cancer Treatment. International Conference on Emerging Trends in Robotics and Communication Technologies -INTERACT-2010; Chennai, India, December 03- 05, 2010; IEEE 2010, pp. 258-264.
[16]
Mirghani, H.; Sturgis, E.M.; Aupérin, A.; Monsonego, J.; Blanchard, P. Is there an increased risk of cancer among spouses of patients with an HPV-related cancer: A systematic review. Oral Oncol., 2017, 67, 138-145.
[http://dx.doi.org/10.1016/j.oraloncology.2017.02.024] [PMID: 28351568]
[17]
Linos, E.; Katz, K.A.; Colditz, G.A. Skin cancer—the importance of prevention. JAMA Intern. Med., 2016, 176(10), 1435-1436.
[http://dx.doi.org/10.1001/jamainternmed.2016.5008] [PMID: 27459394]
[18]
Bibbins-Domingo, K.; Grossman, D.C.; Curry, S.J.; Davidson, K.W.; Ebell, M.; Epling, J.W., Jr; García, F.A.R.; Gillman, M.W.; Kemper, A.R.; Krist, A.H.; Kurth, A.E.; Landefeld, C.S.; Mangione, C.M.; Phillips, W.R.; Phipps, M.G.; Pignone, M.P.; Siu, A.L. Screening for skin cancer. JAMA, 2016, 316(4), 429-435.
[http://dx.doi.org/10.1001/jama.2016.8465] [PMID: 27458948]
[19]
Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 2021, 71(3), 209-249.
[http://dx.doi.org/10.3322/caac.21660] [PMID: 33538338]
[20]
Singh, S.; Semwal, B.C.; Murti, Y. Role of herbal supplements in the treatment of obesity and diabetes. In Treating Endocrine and Metabolic Disorders with Herbal Medicines. IGI Global, 2021, 74-103.
[21]
Akbar, S. Andrographis paniculata: A review of pharmacological activities and clinical effects. Altern. Med. Rev., 2011, 16(1), 66-77.
[22]
Hu, X.Y.; Wu, R.H.; Logue, M.; Blondel, C.; Lai, L.Y.W.; Stuart, B.; Flower, A.; Fei, Y.T.; Moore, M.; Shepherd, J.; Liu, J.P.; Lewith, G. Andrographis paniculata (Chuān Xīn Lián) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis. PLoS One, 2017, 12(8), e0181780.
[http://dx.doi.org/10.1371/journal.pone.0181780] [PMID: 28783743]
[23]
Banerjee, S.; Kar, A.; Mukherjee, P.K.; Haldar, P.K.; Sharma, N.; Katiyar, C.K. Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis paniculata) against respiratory viral infections – LC–MS/MS and network pharmacology analysis. Phytochem. Anal., 2021, 32(4), 629-639.
[http://dx.doi.org/10.1002/pca.3011] [PMID: 33167083]
[24]
Hossain, M.S.; Urbi, Z.; Sule, A.; Rahman, K.M.H. Andrographis paniculata (Burm. f.) Wall. ex Nees: A review of ethnobotany, phytochemistry, and pharmacology. ScientificWorldJournal, 2014, 2014, 1-28.
[http://dx.doi.org/10.1155/2014/274905] [PMID: 25950015]
[25]
Worakunphanich, W.; Thavorncharoensap, M.; Youngkong, S.; Thadanipon, K.; Thakkinstian, A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol. Drug Saf., 2021, 30(6), 727-739.
[http://dx.doi.org/10.1002/pds.5190] [PMID: 33372366]
[26]
Stopponi, S.; Fotio, Y.; Cifani, C.; Li, H.; Haass-Koffler, C.L.; Cannella, N.; Demopulos, G.; Gaitanaris, G.; Ciccocioppo, R. Andrographis paniculata and its main bioactive ingredient andrographolide decrease alcohol drinking and seeking in rats through activation of nuclear pparγ pathway. Alcohol Alcohol., 2021, 56(2), 240-249.
[http://dx.doi.org/10.1093/alcalc/agaa136] [PMID: 33401299]
[27]
Dua, V.K.; Ojha, V.P.; Roy, R.; Joshi, B.C.; Valecha, N.; Devi, C.U.; Bhatnagar, M.C.; Sharma, V.P.; Subbarao, S.K. Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata. J. Ethnopharmacol., 2004, 95(2-3), 247-251.
[http://dx.doi.org/10.1016/j.jep.2004.07.008] [PMID: 15507344]
[28]
Mukherjee, P.K.; Harwansh, R.K.; Bhattacharyya, S. Evidence-Based Validation of Herbal Medicine; Mukherjee, P.K., Ed.; Elsevier: Boston, 2015, pp. 217-245.
[http://dx.doi.org/10.1016/B978-0-12-800874-4.00010-6]
[29]
Sirion, U.; Kasemsook, S.; Suksen, K.; Piyachaturawat, P.; Suksamrarn, A.; Saeeng, R. New substituted C-19-andrographolide analogues with potent cytotoxic activities. Bioorg. Med. Chem. Lett., 2012, 22(1), 49-52.
[http://dx.doi.org/10.1016/j.bmcl.2011.11.085] [PMID: 22154665]
[30]
Tan, M.L.; Tan, H.K.; Oon, C.E.; Kuroyanagi, M.; Muhammad, T.S. Identification of genes involved in the regulation of 14-deoxy-11,12-didehydroandrographolide-induced toxicity in T-47D mammary cells. Food Chem. Toxicol., 2012, 50(2), 431-444.
[31]
Murthy, H.N.; Dalawai, D. Biotechnological production of diterpenoid lactones from cell and organ cultures of Andrographis paniculata. Appl. Microbiol. Biotechnol., 2021, 105(20), 7683-7694.
[http://dx.doi.org/10.1007/s00253-021-11599-y] [PMID: 34568965]
[32]
Sareer, O.; Ahmad, S.; Umar, S. Andrographis paniculata: A critical appraisal of extraction, isolation and quantification of andrographolide and other active constituents. Nat. Prod. Res., 2014, 28(23), 2081-2101.
[http://dx.doi.org/10.1080/14786419.2014.924004] [PMID: 24912126]
[33]
Hao, M.; Lv, M.; Xu, H. Andrographolide: Synthetic methods and biological activities. Mini Rev. Med. Chem., 2020, 20(16), 1633-1652.
[http://dx.doi.org/10.2174/1389557520666200429100326] [PMID: 32348215]
[34]
Mussard, E.; Cesaro, A.; Lespessailles, E.; Legrain, B.; Berteina-Raboin, S.; Toumi, H. Andrographolide, a natural antioxidant: An update. Antioxidants (Basel, Switzerland), 2019, 8(12), 571.
[35]
Lim, J.C.W.; Chan, T.K.; Ng, D.S.W.; Sagineedu, S.R.; Stanslas, J.; Wong, W.S.F. Andrographolide and its analogues: Versatile bioactive molecules for combating inflammation and cancer. Clin. Exp. Pharmacol. Physiol., 2012, 39(3), 300-310.
[http://dx.doi.org/10.1111/j.1440-1681.2011.05633.x] [PMID: 22017767]
[36]
Enmozhi, S.K.; Raja, K.; Sebastine, I.; Joseph, J. Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: An in silico approach. J. Biomol. Struct. Dyn., 2021, 39(9), 3092-3098.
[PMID: 32329419]
[37]
Gupta, S.; Mishra, K.P.; Gupta, R.; Singh, S.B. Andrographolide – A prospective remedy for chikungunya fever and viral arthritis. Int. Immunopharmacol., 2021, 99, 108045.
[http://dx.doi.org/10.1016/j.intimp.2021.108045] [PMID: 34435582]
[38]
Geng, J.; Liu, W.; Gao, J.; Jiang, C.; Fan, T.; Sun, Y.; Qin, Z.H.; Xu, Q.; Guo, W.; Gao, J. Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1. Br. J. Pharmacol., 2019, 176(23), 4574-4591.
[http://dx.doi.org/10.1111/bph.14823] [PMID: 31389613]
[39]
Wang, D.W.; Xiang, Y.J.; Wei, Z.L.; Yao, H.; Shen, T. Andrographolide and its derivatives are effective compounds for gastrointestinal protection: A review. Eur. Rev. Med. Pharmacol. Sci., 2021, 25(5), 2367-2382.
[PMID: 33755974]
[40]
Dai, Y.; Chen, S.R.; Chai, L.; Zhao, J.; Wang, Y.; Wang, Y. Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide. Crit. Rev. Food Sci. Nutr., 2019, 59(sup1), S17-s29.
[http://dx.doi.org/10.1080/10408398.2018.1501657]
[41]
Burgos, R.A.; Alarcón, P.; Quiroga, J.; Manosalva, C.; Hancke, J. Andrographolide, an anti-inflammatory multitarget drug: All roads lead to cellular metabolism. Molecules, 2020, 26(1), 5.
[http://dx.doi.org/10.3390/molecules26010005] [PMID: 33374961]
[42]
Latif, R.; Wang, C.Y. Andrographolide as a potent and promising antiviral agent. Chin. J. Nat. Med., 2020, 18(10), 760-769.
[http://dx.doi.org/10.1016/S1875-5364(20)60016-4] [PMID: 33039055]
[43]
Gao, J.; Peng, S.; Shan, X.; Deng, G.; Shen, L.; Sun, J.; Jiang, C.; Yang, X.; Chang, Z.; Sun, X.; Feng, F.; Kong, L.; Gu, Y.; Guo, W.; Xu, Q.; Sun, Y. Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. Cell Death Dis., 2019, 10(12), 957.
[http://dx.doi.org/10.1038/s41419-019-2195-8] [PMID: 31862870]
[44]
Liu, W.; Liang, L.; Zhang, Q.; Li, Y.; Yan, S.; Tang, T.; Ren, Y.; Mo, J.; Liu, F.; Chen, X.; Lan, T. Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action. Phytomedicine, 2021, 91, 153650.
[http://dx.doi.org/10.1016/j.phymed.2021.153650] [PMID: 34332282]
[45]
Zhang, X.F.; Tan, B.K. Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats. Acta Pharmacol. Sin., 2000, 21(12), 1157-1164.
[PMID: 11603293]
[46]
Jayakumar, T.; Hsieh, C-Y.; Lee, J-J.; Sheu, J-R. Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide. Evid. Based Complement. Alternat. Med., 2013, 2013, 846740.
[47]
Batkhuu, J.; Hattori, K.; Takano, F.; Fushiya, S.; Oshiman, K.; Fujimiya, Y. Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculata. Biol. Pharm. Bull., 2002, 25(9), 1169-1174.
[http://dx.doi.org/10.1248/bpb.25.1169] [PMID: 12230111]
[48]
Zou, W.; Xiao, Z.; Wen, X.; Luo, J.; Chen, S.; Cheng, Z.; Xiang, D.; Hu, J.; He, J. The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway. BMC Complement. Altern. Med., 2016, 16(1), 483-483.
[http://dx.doi.org/10.1186/s12906-016-1466-5] [PMID: 27887650]
[49]
Matsuda, T.; Kuroyanagi, M.; Sugiyama, S.; Umehara, K.; Ueno, A.; Nishi, K. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem. Pharm. Bull. (Tokyo), 1994, 42(6), 1216-1225.
[http://dx.doi.org/10.1248/cpb.42.1216] [PMID: 8069972]
[50]
Hung, S.K.; Hung, L.C.; Kuo, C.D.; Lee, K.Y.; Lee, M.S.; Lin, H.Y.; Chen, Y.J.; Fu, S.L. Andrographolide sensitizes Ras-transformed cells to radiation in vitro and in vivo. Int. J. Radiat. Oncol. Biol. Phys., 2010, 77(4), 1232-1239.
[http://dx.doi.org/10.1016/j.ijrobp.2010.01.007] [PMID: 20610044]
[51]
Jiang, C.G.; Li, J.B.; Liu, F.R.; Wu, T.; Yu, M.; Xu, H.M. Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression. Anticancer Res., 2007, 27(4B), 2439-2447.
[PMID: 17695536]
[52]
Singha, P.K.; Roy, S.; Dey, S. Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. against ethanol-induced toxicity in mice. J. Ethnopharmacol., 2007, 111(1), 13-21.
[http://dx.doi.org/10.1016/j.jep.2006.10.026] [PMID: 17127022]
[53]
Shi, G.; Zhang, Z.; Zhang, R.; Zhang, X.; Lu, Y.; Yang, J.; Zhang, D.; Zhang, Z.; Li, X.; Ning, G. Protective effect of andrographolide against concanavalin A-induced liver injury. Naunyn Schmiedebergs Arch. Pharmacol., 2012, 385(1), 69-79.
[http://dx.doi.org/10.1007/s00210-011-0685-z] [PMID: 21947229]
[54]
Kunwar, R.M.; Shrestha, K.P.; Bussmann, R.W. Traditional herbal medicine in Far-west Nepal: A pharmacological appraisal. J. Ethnobiol. Ethnomed., 2010, 6(1), 35.
[http://dx.doi.org/10.1186/1746-4269-6-35] [PMID: 21144003]
[55]
Najib Nik A Rahman, N.; Furuta, T. kojima, S.; Takane, K.; Ali Mohd, M. Antimalarial activity of extracts of Malaysian medicinal plants. J. Ethnopharmacol., 1999, 64(3), 249-254.
[http://dx.doi.org/10.1016/S0378-8741(98)00135-4] [PMID: 10363840]
[56]
Wiart, C.; Kumar, K.; Yusof, M.Y.; Hamimah, H.; Fauzi, Z.M.; Sulaiman, M. Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1. Phytother. Res., 2005, 19(12), 1069-1070.
[http://dx.doi.org/10.1002/ptr.1765] [PMID: 16372376]
[57]
Yob, N.J.; Jofrry, S.M.; Affandi, M.M.R.M.M.; Teh, L.K.; Salleh, M.Z.; Zakaria, Z.A. Zingiber zerumbet (L.) Smith: A review of its ethnomedicinal, chemical, and pharmacological uses. Evid. Based Complement. Alternat. Med., 2011, 2011, 1-12.
[http://dx.doi.org/10.1155/2011/543216] [PMID: 21584247]
[58]
Dandu, A.M.; Inamdar, N.M. Evaluation of beneficial effects of antioxidant properties of aqueous leaf extract of Andrographis paniculata in STZ-induced diabetes. Pak. J. Pharm. Sci., 2009, 22(1), 49-52.
[PMID: 19168420]
[59]
Peng, Y.; Wang, Y.; Tang, N.; Sun, D.; Lan, Y.; Yu, Z.; Zhao, X.; Feng, L.; Zhang, B.; Jin, L.; Yu, F.; Ma, X.; Lv, C. Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway. J. Exp. Clin. Cancer Res., 2018, 37(1), 248.
[http://dx.doi.org/10.1186/s13046-018-0926-9] [PMID: 30314513]
[60]
Beesetti, S.L.; Jayadev, M.; Subhashini, G.V.; Mansour, L.; Alwasel, S.; Harrath, A.H. Andrographolide as a therapeutic agent against breast and ovarian cancers. Open Life Sci., 2019, 14(1), 462-469.
[http://dx.doi.org/10.1515/biol-2019-0052] [PMID: 33817182]
[61]
Singh, P.; Srivastava, M.M.; Khemani, L.D. Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats. Ups. J. Med. Sci., 2009, 114(3), 136-139.
[http://dx.doi.org/10.1080/03009730903174321] [PMID: 19736602]
[62]
Parveen, R.; Ahmad, F.J.; Iqbal, Z.; Samim, M.; Ahmad, S. Solid lipid nanoparticles of anticancer drug andrographolide: Formulation, in vitro and in vivo studies. Drug Dev. Ind. Pharm., 2014, 40(9), 1206-1212.
[http://dx.doi.org/10.3109/03639045.2013.810636] [PMID: 23826860]
[63]
Mussard, E.; Jousselin, S.; Cesaro, A.; Legrain, B.; Lespessailles, E.; Esteve, E.; Berteina-Raboin, S.; Toumi, H. Andrographis paniculata and its bioactive diterpenoids against inflammation and oxidative stress in keratinocytes. Antioxidants (Basel, Switzerland), 2020, 9(6)
[http://dx.doi.org/10.3390/antiox9060530]
[64]
Li, H.; Qu, X.; Qian, W.; Song, Y.; Wang, C.; Liu, W. Andrographolide-loaded solid lipid nanoparticles enhance anti-cancer activity against head and neck cancer and precancerous cells. Oral Dis., 2022, 28(1), 142-149.
[http://dx.doi.org/10.1111/odi.13751] [PMID: 33295090]
[65]
Khan, I.; Mahfooz, S.; Faisal, M.; Alatar, A.A.; Ansari, I.A. Andrographolide induces apoptosis and cell cycle arrest through inhibition of aberrant hedgehog signaling pathway in colon cancer cells. Nutr. Cancer, 2021, 73(11-12), 2428-2446.
[http://dx.doi.org/10.1080/01635581.2020.1828942] [PMID: 33030050]
[66]
Pasha, A.; Kumbhakar, D.V.; Doneti, R.; Kumar, K.; Dharmapuri, G.; Poleboyina, P.K. S K, H.; Basavaraju, P.; Pasumarthi, D.; S D, A.; Soujanya, P.; Arnold Emeson, I.; Bodiga, V.; Pawar, S.C. Inhibition of Inducible Nitric Oxide Synthase (iNOS) by andrographolide and in vitro evaluation of its antiproliferative and proapoptotic effects on cervical cancer. Oxid. Med. Cell. Longev., 2021, 2021, 6692628.
[http://dx.doi.org/10.1155/2021/6692628] [PMID: 33815659]
[67]
Quah, S.Y.; Wong, C.C.; Wong, H.C.; Ho, K.L.; Abdul Manan, N.; Deb, P.K.; Sagineedu, S.R.; Stanslas, J. Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines. Toxicol. Appl. Pharmacol., 2021, 425, 115605.
[http://dx.doi.org/10.1016/j.taap.2021.115605] [PMID: 34087331]
[68]
Khan, I.; Mahfooz, S.; Ansari, I.A. Antiproliferative and apoptotic properties of andrographolide against human colon cancer DLD1 cell line. Endocr. Metab. Immune Disord. Drug Targets, 2020, 20(6), 930-942.
[http://dx.doi.org/10.2174/1871530319666191125111920] [PMID: 31774047]
[69]
Wang, S.; Li, H.; Chen, S.; Wang, Z.; Yao, Y.; Chen, T.; Ye, Z.; Lin, P. Andrographolide induces apoptosis in human osteosarcoma cells via the ROS/JNK pathway. Int. J. Oncol., 2020, 56(6), 1417-1428.
[http://dx.doi.org/10.3892/ijo.2020.5032] [PMID: 32236589]
[70]
Chao, H.P.; Kuo, C.D.; Chiu, J.H.; Fu, S.L. Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity. Planta Med., 2010, 76(16), 1827-1833.
[http://dx.doi.org/10.1055/s-0030-1250039] [PMID: 20539971]
[71]
Bi, R.; Deng, Y.; Tang, C.; Xuan, L.; Xu, B.; Du, Y.; Wang, C.; Wei, W. Andrographolide sensitizes human renal carcinoma cells to TRAIL induced apoptosis through upregulation of death receptor 4. Oncol. Rep., 2020, 44(5), 1939-1948.
[http://dx.doi.org/10.3892/or.2020.7737] [PMID: 33000263]
[72]
Roy, P.; Das, S.; Mondal, A.; Chatterji, U.; Mukherjee, A. Nanoparticle engineering enhances anticancer efficacy of andrographolide in MCF-7 cells and mice bearing EAC. Curr. Pharm. Biotechnol., 2012, 13(15), 2669-2681.
[http://dx.doi.org/10.2174/138920112804724855] [PMID: 23072387]
[73]
Ahiwale, R.J.; Chellampillai, B.; Pawar, A.P. Investigation of 1,2-Dimyristoyl-sn-Glycero-3-Phosphoglycerol-Sodium (DMPG-Na) lipid with various metal cations in nanocochleate preformulation: application for andrographolide oral delivery in cancer therapy. AAPS PharmSciTech, 2020, 21(7), 279.
[http://dx.doi.org/10.1208/s12249-020-01801-1] [PMID: 33037507]
[74]
Sanati, P.; Chua, L.S.; Nasiri, R.; Hashemi, S.S. Nanoencapsulation of andrographolide rich extract for the inhibition of cervical and neuroblastoma cancer cells. J. Biomed. Nanotechnol., 2020, 16(9), 1370-1380.
[http://dx.doi.org/10.1166/jbn.2020.2973] [PMID: 33419491]
[75]
Oseni, B.A.; Azubuike, C.P.; Okubanjo, O.O.; Igwilo, C.I.; Panyam, J. Encapsulation of andrographolide in poly(lactide-co-glycolide) nanoparticles: Formulation optimization and in vitro efficacy studies. Front. Bioeng. Biotechnol., 2021, 9, 639409.
[http://dx.doi.org/10.3389/fbioe.2021.639409] [PMID: 33681172]
[76]
Kansom, T.; Sajomsang, W.; Saeeng, R.; Charoensuksai, P.; Opanasopit, P.; Tonglairoum, P. Apoptosis induction and antimigratory activity of andrographolide analog (3a.1)-incorporated self-assembled nanoparticles in cancer cells. AAPS PharmSciTech, 2018, 19(7), 3123-3133.
[http://dx.doi.org/10.1208/s12249-018-1139-4] [PMID: 30117042]
[77]
Reabroi, S.; Chairoungdua, A.; Saeeng, R.; Kasemsuk, T.; Saengsawang, W.; Zhu, W.; Piyachaturawat, P. A silyl andrographolide analogue suppresses Wnt/β-catenin signaling pathway in colon cancer. Biomed. Pharmacother., 2018, 101, 414-421.
[78]
Kang, X.; Zheng, Z.; Liu, Z.; Wang, H.; Zhao, Y.; Zhang, W.; Shi, M.; He, Y.; Cao, Y.; Xu, Q.; Peng, C.; Huang, Y. Liposomal codelivery of doxorubicin and andrographolide inhibits breast cancer growth and metastasis. Mol. Pharm., 2018, 15(4), 1618-1626.
[http://dx.doi.org/10.1021/acs.molpharmaceut.7b01164] [PMID: 29498868]
[79]
Zhang, J.; Li, Y.; Gao, W.; Repka, M.A.; Wang, Y.; Chen, M. Andrographolide-loaded PLGA-PEG-PLGA micelles to improve its bioavailability and anticancer efficacy. Expert Opin. Drug Deliv., 2014, 11(9), 1367-1380.
[http://dx.doi.org/10.1517/17425247.2014.924503] [PMID: 24935153]
[80]
Puntawee, S.; Theerasilp, M.; Reabroi, S.; Saeeng, R.; Piyachaturawat, P.; Chairoungdua, A.; Nasongkla, N. Solubility enhancement and in vitro evaluation of PEG-b-PLA micelles as nanocarrier of semi-synthetic andrographolide analogue for cholangiocarcinoma chemotherapy. Pharm. Dev. Technol., 2016, 21(4), 437-444.
[PMID: 25738423]
[81]
Tan, W.S.D.; Liao, W.; Zhou, S.; Wong, W.S.F. Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action. Biochem. Pharmacol., 2017, 139, 71-81.
[http://dx.doi.org/10.1016/j.bcp.2017.03.024] [PMID: 28377280]
[82]
Zhang, H.; Li, S.; Si, Y.; Xu, H. Andrographolide and its derivatives: Current achievements and future perspectives. Eur. J. Med. Chem., 2021, 224, 113710.
[http://dx.doi.org/10.1016/j.ejmech.2021.113710] [PMID: 34315039]