Abstract

A base-promoted cascade reaction of α-ketoester with benzylidene-malononitrile was developed under mild reaction conditions, which enabled the synthesis of polyfunctionalized 2-amino- 3-cyano-4H-pyrans containing ester motifs at 6-position with good to excellent yields. These transformations not only construct various polyfunctionalized 4H-pyrans, which add a new member to the family of 4H-pyrans, but also provide an efficient approach for the synthesis of fully substituted 4Hpyran derivatives.

Keywords: Cascade reaction, polyfunctionalized 4H-pyrans, α-Ketoester, benzylidene-malononitrile, 2-Amino-3-cyano-4Hpyrans, multi-component one-pot cascade reaction.