Hypoxia and Hypoxia Mimetic Agents As Potential Priming Approaches to
Empower Mesenchymal Stem Cells

Goknur   Topaloglu   Yasan; Aysen      Gunel-Ozcan
Abstract

Mesenchymal stem cells (MSC) exhibit self-renewal capacity and multilineage differentiation potential, making them attractive for research and clinical application. The properties of MSC can vary depending on specific micro-environmental factors. MSC resides in specific niches with low oxygen concentrations, where oxygen functions as a metabolic substrate and a signaling molecule. Conventional physical incubators or chemically hypoxia mimetic agents are applied in cultures to mimic the original low oxygen tension settings where MSC originated.
This review aims to focus on the current knowledge of the effects of various physical hypoxic conditions and widely used hypoxia-mimetic agents-PHD inhibitors on mesenchymal stem cells at a cellular and molecular level, including proliferation, stemness, differentiation, viability, apoptosis, senescence, migration, immunomodulation behaviors, as well as epigenetic changes.
Keywords: Hypoxia, mesenchymal stem cells, hypoxia-mimetic agent, prolyl hydroxylase inhibitors, secretome, hypoxiainducible factor.
Graphical Abstract

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Cite As
Current Stem Cell Research & Therapy

Hypoxia and Hypoxia Mimetic Agents As Potential Priming Approaches to Empower Mesenchymal Stem Cells

Abstract

Graphical Abstract
