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Current Biotechnology

Author(s): Venkateshwaran Krishnaswami*, Balakrishnan Natarajan, Saravanakumar Arthanari, Jeseeta Suresh and Nirmal Aranvindaraj

DOI: 10.2174/2211550112666230104123153

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Insights on Bioactive Peptide-loaded Nanoformulations

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Abstract

In order to tackle multifactorial illnesses, the importance of bioactive peptides in nano drug delivery systems is emphasised. Multifactorial diseases are primarily brought on by protein misfolding. Therefore, pharmaceutical formulations are recommended to deliver a successful treatment. Difficulties hinder its application in delivering raw peptides with poor bioavailability, absorption, and circulation time, making it a difficult assignment for researchers. Recently, bioactive peptides have become increasingly important in therapy. In addition, several bioactive proteins have poor absorption characteristics in the GIT. These issues can be resolved by creating nano-based peptide-based delivery systems that encapsulate, retain, protect, and transport bioactive peptides. The focus of the proposed review paper is to provide an overview of peptides, commercialization concerns, and their related attempts to develop into novel peptide-based nanoformulations.

Keywords: Peptides, bioactive, drug delivery, nanoformulations, multifactorial illnesses, protein misfolding, bioavailability.

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