Introduction: Limited experience exists regarding the clinical features of focal lipogranuloma inflammation of the lung, and there are no supporting guidelines for the diagnostic approach.
Case Description: We present the case of a 20-year-old man who was found to have a pulmonary nodule with a smooth margin during a health examination. He underwent wedge resection of the left lower lung to achieve a tissue diagnosis; this showed focal lipogranuloma inflammation of the lung.
Conclusion: In this report, we combined imaging and pathological findings to reach the diagnosis, with a view to assisting clinicians in navigating this challenging clinical situation.