Acemannan from Aloe vera Extract: A Catalyst-Free, Approach for the
Access of Imidazole-Fused Nitrogen-Bridgehead Heterocycles

Jyoti      Baranwal; Swastika      Singh; Smriti      Kushwaha; Archana      Jyoti
Abstract

A series of 2-phenyl substituted imidazo-pyridines, pyrazines and pyrimidines were synthesized through an efficient one-pot, environmentally benign, and regioselective strategy which involves the reaction between 2-bromocarbonyl compounds and 2-aminopyridines, 2-aminopyrazines, 2- aminopyrimidines, respectively using A Aloe vera loe vera/water (3:2) as a green promoting media. To the best of our knowledge, this is the first Aloe vera promoted protocol for the synthesis of this important scaffold having potential applications in medicinal and materials chemistry. The use of Aloe vera as a bio-renewable and biodegradable reaction medium-cum-promoter, operational simplicity, use of readily available substrates, mild reaction conditions, broad substrate scope, short reaction time, easy workup, and high yields, makes the disclosed protocol a superior alternative to existing methods. Substituted imidazo-pyridines, pyrazines and pyrimidines were obtained with 95%, 76% and 84% yields, respectively.
Keywords: Imidazole-fused nitrogen-bridgehead heterocycles, catalyst-free, Aloe vera, green synthesis, pyrimidines, heteroatoms.
Graphical Abstract

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Cite As
Letters in Organic Chemistry

Acemannan from Aloe vera Extract: A Catalyst-Free, Approach for the Access of Imidazole-Fused Nitrogen-Bridgehead Heterocycles

Abstract

Graphical Abstract
