Abstract

In recent years, there has been an increased interest in ⁴⁴Ti/⁴⁴Sc generators as an onsite source of ⁴⁴Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of ⁴⁴Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current ⁴⁴Ti/⁴⁴Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the ⁴⁴Sc for potential PET radiopharmaceuticals.

Keywords: Scandium, titanium, generators, PET, radioisotope production, diagnostics, radiolabeling.