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Current Stem Cell Research & Therapy

Author(s): Helia Sadat Haeri Boroojeni, Sadra Mohaghegh and Arash Khojasteh*

DOI: 10.2174/1574888X18666221111154057

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Application of CAD-CAM Technologies for Maxillofacial Bone Regeneration: A Narrative Review of the Clinical Studies

Page: [461 - 472] Pages: 12

  • * (Excluding Mailing and Handling)

Abstract

The application of regenerative methods in treating maxillofacial defects can be categorized as functional bone regeneration in which scaffolds without protection are used and in-situ bone regeneration in which a protected healing space is created to induce bone formation. It has been shown that functional bone regeneration can reduce surgical time and obviate the necessity of autogenous bone grafting. However, studies mainly focused on applying this method to reconstruct minor bone effects, and more investigation concerning the large defects is required. In terms of in situ maxillofacial bone regeneration with the help of CAD-CAM technologies, the present data have suggested feasible mesh rigidity, perseverance of the underlying space, and apt augmentative results with CAD-CAM-based individualized Ti meshes. However, complications, including dehiscence and mesh exposure, coupled with consequent graft loss, infection and impeded regenerative rates have also been reported.

Graphical Abstract

[1]
Kumar VV, Rometsch E, Thor A, Wolvius E, Hurtado CA. Segmental mandibular reconstruction using tissue engineering strategies: A systematic review of individual patient data. Craniomaxillofac Trauma Reconstr 2020; 13(4): 267-84.
[http://dx.doi.org/10.1177/1943387520917511] [PMID: 33456698]
[2]
Chanchareonsook N, Junker R, Jongpaiboonkit L, Jansen JA. Tissue-engineered mandibular bone reconstruction for continuity defects: A systematic approach to the literature. Tissue Eng Part B Rev 2014; 20(2): 147-62.
[http://dx.doi.org/10.1089/ten.teb.2013.0131] [PMID: 23865639]
[3]
Nkenke E, Neukam FW. Autogenous bone harvesting and grafting in advanced jaw resorption: morbidity, resorption and implant survival. Eur J Oral Implantology 2014; 7 (Suppl. 2): S203-17.
[PMID: 24977256]
[4]
Elgali I, Omar O, Dahlin C, Thomsen P. Guided bone regeneration: Materials and biological mechanisms revisited. Eur J Oral Sci 2017; 125(5): 315-37.
[http://dx.doi.org/10.1111/eos.12364] [PMID: 28833567]
[5]
Yamada M, Egusa H. Current bone substitutes for implant dentistry. J Prosthodont Res 2018; 62(2): 152-61.
[http://dx.doi.org/10.1016/j.jpor.2017.08.010] [PMID: 28927994]
[6]
Melville JC, Mañón VA, Blackburn C, Young S. Current methods of maxillofacial tissue engineering. Oral Maxillofac Surg Clin North Am 2019; 31(4): 579-91.
[http://dx.doi.org/10.1016/j.coms.2019.07.003] [PMID: 31445759]
[7]
Aghaloo T, Misch C, Lin GH, Iacono V, Wang HL. Bone Augmentation of the edentulous maxilla for implant placement: A systematic review. Int J Oral Maxillofac Implants 2017; 31 (Suppl.): s19-30.
[http://dx.doi.org/10.11607/jomi.16suppl.g1] [PMID: 27228250]
[8]
Aghaloo TL, Hadaya D. Basic principles of bioengineering and regeneration. Oral Maxillofac Surg Clin North Am 2017; 29(1): 1-7.
[http://dx.doi.org/10.1016/j.coms.2016.08.008] [PMID: 27890223]
[9]
Diño MJS, Ong IL. Research, technology, education & scholarship in the fourth industrial revolution [4IR]: Influences in nursing and the health sciences. J Med Invest 2019; 66(1 .2): 3-7.
[10]
Han S. The fourth industrial revolution and oral and maxillofacial surgery. J Korean Assoc Oral Maxillofac Surg 2018; 44(5): 205-6.
[http://dx.doi.org/10.5125/jkaoms.2018.44.5.205] [PMID: 30402410]
[11]
Tanveer W, Ridwan PA, Molinero MP, Koolstra JH, Forouzanfar T. Systematic review of clinical applications of CAD/CAM technology for craniofacial implants placement and manufacturing of nasal prostheses. Int J Environ Res Public Health 2021; 18(7): 3756.
[http://dx.doi.org/10.3390/ijerph18073756] [PMID: 33916853]
[12]
Ismail MB, Darwich K. Reconstruction of large mandibular bone defects extended to the condyle using patient-specific implants based on CAD-CAM technology and 3D printing. Adv Oral Maxillofac Surg 2022; 5: 100229.
[http://dx.doi.org/10.1016/j.adoms.2021.100229]
[13]
Tappa K, Jammalamadaka U. Novel biomaterials used in medical 3D printing techniques. J Funct Biomater 2018; 9(1): 17.
[http://dx.doi.org/10.3390/jfb9010017] [PMID: 29414913]
[14]
Roseti L, Parisi V, Petretta M, et al. Scaffolds for bone tissue engineering: State of the art and new perspectives. Mater Sci Eng C 2017; 78: 1246-62.
[http://dx.doi.org/10.1016/j.msec.2017.05.017] [PMID: 28575964]
[15]
Tahmaseb A, Wismeijer D, Coucke W, Derksen W. Computer technology applications in surgical implant dentistry: A systematic review. Int J Oral Maxillofac Implants 2014; 29 (Suppl.): 25-42.
[http://dx.doi.org/10.11607/jomi.2014suppl.g1.2] [PMID: 24660188]
[16]
Cui J, Chen L, Guan X, Ye L, Wang H, Liu L. Surgical planning, three-dimensional model surgery and preshaped implants in treatment of bilateral craniomaxillofacial post-traumatic deformities. J Oral Maxillofac Surg 2014; 72(6): 1138.e1-1138.e14.
[http://dx.doi.org/10.1016/j.joms.2014.02.023]
[17]
Vera C, Barrero C, Shockley W, Rothenberger S, Minsley G, Drago C. Prosthetic reconstruction of a patient with an acquired nasal defect using extraoral implants and a CAD/CAM copy-milled bar. J Prosthodont 2014; 23(7): 582-7.
[18]
Milovanovic JR, Stojkovic MS, Husain KN, Korunovic ND, Arandjelovic J. Holistic Approach in designing the personalized bone scaffold: The case of reconstruction of large missing piece of mandible caused by congenital anatomic anomaly. J Healthc Eng 2020; 2020: 6689961.
[http://dx.doi.org/10.1155/2020/6689961] [PMID: 33299535]
[19]
Maroulakos M, Kamperos G, Tayebi L, Halazonetis D, Ren Y. Applications of 3D printing on craniofacial bone repair: A systematic review. J Dent 2019; 80: 1-14.
[http://dx.doi.org/10.1016/j.jdent.2018.11.004] [PMID: 30439546]
[20]
Garot C, Bettega G, Picart C. Additive manufacturing of material scaffolds for bone regeneration: toward application in the clinics. Adv Funct Mater 2021; 31(5): 2006967.
[http://dx.doi.org/10.1002/adfm.202006967] [PMID: 33531885]
[21]
Goh BT, Teh LY, Tan DBP, Zhang Z, Teoh SH. Novel 3D polycaprolactone scaffold for ridge preservation – A pilot randomised controlled clinical trial. Clin Oral Implants Res 2015; 26(3): 271-7.
[http://dx.doi.org/10.1111/clr.12486] [PMID: 25263527]
[22]
Rasperini G, Pilipchuk SP, Flanagan CL, et al. 3D-printed bioresorbable scaffold for periodontal repair. J Dent Res 2015; 94(9) (Suppl.): 153S-7S.
[http://dx.doi.org/10.1177/0022034515588303] [PMID: 26124215]
[23]
Mangano FG, Zecca PA, Van Noort R, et al. Custom-made computer-aided-design/computer-aided-manufacturing biphasic calcium-phosphate scaffold for augmentation of an atrophic mandibular anterior ridge. Case Rep Dent 2015; 2015: 1-11.
[http://dx.doi.org/10.1155/2015/941265] [PMID: 26064701]
[24]
Luongo F, Mangano FG, Macchi A, Luongo G, Mangano C. Custom-made synthetic scaffolds for bone reconstruction: A retrospective, multicenter clinical study on 15 patients. BioMed Res Int 2016; 2016: 5862586.
[http://dx.doi.org/10.1155/2016/5862586] [PMID: 28070512]
[25]
Mangano C, Giuliani A, De Tullio I, Raspanti M, Piattelli A, Iezzi G. Case report: Histological and histomorphometrical results of a 3-D printed biphasic calcium phosphate ceramic 7 years after insertion in a human maxillary alveolar ridge. Front Bioeng Biotechnol 2021; 9: 614325.
[http://dx.doi.org/10.3389/fbioe.2021.614325] [PMID: 33937211]
[26]
Figliuzzi M, Mangano FG, Fortunato L, et al. Vertical ridge augmentation of the atrophic posterior mandible with custom-made, computer-aided design/computer-aided manufacturing porous hydroxyapatite scaffolds. J Craniofac Surg 2013; 24(3): 856-9.
[http://dx.doi.org/10.1097/SCS.0b013e31827ca3a7] [PMID: 23714896]
[27]
Garagiola U, Grigolato R, Soldo R, et al. Computer-aided design/computer-aided manufacturing of hydroxyapatite scaffolds for bone reconstruction in jawbone atrophy: A systematic review and case report. Maxillofac Plast Reconstr Surg 2016; 38(1): 2.
[http://dx.doi.org/10.1186/s40902-015-0048-7] [PMID: 26767187]
[28]
Mangano F, Macchi A, Shibli JA, et al. Maxillary ridge augmentation with custom-made CAD/CAM scaffolds. A 1-year prospective study on 10 patients. J Oral Implantol 2014; 40(5): 561-9.
[http://dx.doi.org/10.1563/AAID-JOI-D-12-00122] [PMID: 23343341]
[29]
Jacotti M, Barausse C, Felice P. Posterior atrophic mandible rehabilitation with onlay allograft created with CAD-CAM procedure: A case report. Implant Dent 2014; 23(1): 22-8.
[http://dx.doi.org/10.1097/ID.0000000000000023] [PMID: 24378654]
[30]
Blume O, Hoffmann L, Donkiewicz P, et al. Treatment of severely resorbed maxilla due to peri-implantitis by guided bone regeneration using a customized allogenic bone block: A case report. Materials 2017; 10(10): 1213.
[http://dx.doi.org/10.3390/ma10101213] [PMID: 29065477]
[31]
Grassi FR, Grassi R, Vivarelli L, et al. Design techniques to optimize the scaffold performance: Freeze-dried bone custom-made allografts for maxillary alveolar horizontal ridge augmentation. Materials 2020; 13(6): 1393.
[http://dx.doi.org/10.3390/ma13061393] [PMID: 32204393]
[32]
Venet L, Perriat M, Mangano FG, Fortin T. Horizontal ridge reconstruction of the anterior maxilla using customized allogeneic bone blocks with a minimally invasive technique - A case series. BMC Oral Health 2017; 17(1): 146.
[http://dx.doi.org/10.1186/s12903-017-0423-0] [PMID: 29216869]
[33]
Blume O, Back M, Martin K, Windisch P. A customized allogenic bone block for alveolar reconstruction quantitated by a 3D matching technique: A case report. Clin Case Rep 2021; 9(9): e04771.
[34]
Kloss FR, Offermanns V, Donkiewicz P, Kloss BA. Customized allogeneic bone grafts for maxillary horizontal augmentation: A 5‐year follow‐up radiographic and histologic evaluation. Clin Case Rep 2020; 8(5): 886-93.
[http://dx.doi.org/10.1002/ccr3.2777] [PMID: 32477540]
[35]
Mirković S, Budak I, Puskar T, et al. Application of modern computer-aided technologies in the production of individual bone graft: A case report Vojnosanitetski pregled 2015; 72(12): 1126-31.
[http://dx.doi.org/10.2298/VSP140915117M]
[36]
Schlee M, Rothamel D. Ridge augmentation using customized allogenic bone blocks: Proof of concept and histological findings. Implant Dent 2013; 22(3): 212-8.
[http://dx.doi.org/10.1097/ID.0b013e3182885fa1] [PMID: 23615661]
[37]
Mangano F, Zecca P, Pozzi TS, et al. Maxillary sinus augmentation using Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) technology. Int J Med Robot 2013; 9(3): 331-8.
[http://dx.doi.org/10.1002/rcs.1460] [PMID: 22961733]
[38]
Probst FA, Hutmacher DW, Müller DF, Machens HG, Schantz JT. Calvarial reconstruction by customized bioactive implant. Handchir Mikrochir Plast Chir 2010; 42(6): 369-73.
[39]
Han HH, Shim JH, Lee H, et al. Reconstruction of complex maxillary defects using patient-specific 3D-printed biodegradable scaffolds. Plast Reconstr Surg Glob Open 2018; 6(11): e1975-e.
[40]
Kanno Y, Nakatsuka T, Saijo H, et al. Computed tomographic evaluation of novel custom-made artificial bones, “CT-bone”, applied for maxillofacial reconstruction. Regen Ther 2016; 5: 114978062.
[http://dx.doi.org/10.1016/j.reth.2016.05.002] [PMID: 31245494]
[41]
Ghobeira R, Philips C, Declercq H, et al. Effects of different sterilization methods on the physico-chemical and bioresponsive properties of plasma-treated polycaprolactone films. Biomed Mater 2017; 12(1): 015017.
[http://dx.doi.org/10.1088/1748-605X/aa51d5] [PMID: 28117304]
[42]
Zhao Y, Zhu B, Wang Y, Liu C, Shen C. Effect of different sterilization methods on the properties of commercial biodegradable polyesters for single-use, disposable medical devices. Mater Sci Eng C 2019; 105: 110041.
[http://dx.doi.org/10.1016/j.msec.2019.110041] [PMID: 31546462]
[43]
O’Connell CD, Onofrillo C, Duchi S, et al. Evaluation of sterilisation methods for bio-ink components: gelatin, gelatin methacryloyl, hyaluronic acid and hyaluronic acid methacryloyl. Biofabrication 2019; 11(3): 035003.
[http://dx.doi.org/10.1088/1758-5090/ab0b7c] [PMID: 30818298]
[44]
Monaco G, Cholas R, Salvatore L, Madaghiele M, Sannino A. Sterilization of collagen scaffolds designed for peripheral nerve regeneration: Effect on microstructure, degradation and cellular colonization. Mater Sci Eng C 2017; 71: 335-44.
[http://dx.doi.org/10.1016/j.msec.2016.10.030] [PMID: 27987715]
[45]
Tipnis NP, Burgess DJ. Sterilization of implantable polymer-based medical devices: A review. Int J Pharm 2018; 544(2): 455-60.
[http://dx.doi.org/10.1016/j.ijpharm.2017.12.003] [PMID: 29274370]
[46]
Costa PF, Vaquette C, Baldwin J, et al. Biofabrication of customized bone grafts by combination of additive manufacturing and bioreactor knowhow. Biofabrication 2014; 6(3): 035006.
[http://dx.doi.org/10.1088/1758-5082/6/3/035006] [PMID: 24809431]
[47]
Hikita A, Chung U, Hoshi K, Takato T. Bone regenerative medicine in oral and maxillofacial region using a three-dimensional printer. Tissue Eng Part A 2017; 23(11-12): 515-21.
[http://dx.doi.org/10.1089/ten.tea.2016.0543] [PMID: 28351222]
[48]
Cheah CW, Al-Namnam NM, Lau MN, et al. Synthetic material for bone, periodontal, and dental tissue regeneration: Where are we now, and where are we heading next? Materials 2021; 14(20): 6123.
[http://dx.doi.org/10.3390/ma14206123] [PMID: 34683712]
[49]
Omar O, Elgali I, Dahlin C, Thomsen P. Barrier membranes: More than the barrier effect? J Clin Periodontol 2019; 46(S21) (Suppl. 21): 103-23.
[http://dx.doi.org/10.1111/jcpe.13068] [PMID: 30667525]
[50]
Briguglio F, Falcomatà D, Marconcini S, Fiorillo L, Briguglio R, Farronato D. The use of titanium mesh in guided bone regeneration: A systematic review. Int J Dent 2019; 2019: 9065423.
[http://dx.doi.org/10.1155/2019/9065423] [PMID: 30881455]
[51]
Cucchi A, Giavatto MA, Giannatiempo J, Lizio G, Corinaldesi G. Custom-made titanium mesh for maxillary bone augmentation with immediate implants and delayed loading. J Oral Implantol 2019; 45(1): 59-64.
[http://dx.doi.org/10.1563/aaid-joi-D-18-00141] [PMID: 30091941]
[52]
Abrahamsson P, Wälivaara DÅ, Isaksson S, Andersson G. Periosteal expansion before local bone reconstruction using a new technique for measuring soft tissue profile stability: A clinical study. J Oral Maxillofac Surg 2012; 70(10): e521-30.
[http://dx.doi.org/10.1016/j.joms.2012.06.003] [PMID: 22871307]
[53]
Miyamoto I, Funaki K, Yamauchi K, Kodama T, Takahashi T. Alveolar ridge reconstruction with titanium mesh and autogenous particulate bone graft: computed tomography-based evaluations of augmented bone quality and quantity. Clin Implant Dent Relat Res 2012; 14(2): 304-11.
[http://dx.doi.org/10.1111/j.1708-8208.2009.00257.x] [PMID: 21453391]
[54]
Nickenig HJ, Riekert M, Zirk M, Lentzen MP, Zöller JE, Kreppel M. 3D-based buccal augmentation for ideal prosthetic implant alignment—an optimized method and report on 7 cases with pronounced buccal concavities. Clin Oral Investig 2022; 26(5): 3999-4010.
[http://dx.doi.org/10.1007/s00784-022-04369-1] [PMID: 35066689]
[55]
Seiler M, Kämmerer PW, Peetz M, Hartmann A. Customized lattice structure in reconstruction of three-dimensional alveolar defects. Int J Comput Dent 2018; 21(3): 261-7.
[PMID: 30264055]
[56]
Sagheb K, Schiegnitz E, Moergel M, Walter C, Al-Nawas B, Wagner W. Clinical outcome of alveolar ridge augmentation with individualized CAD-CAM-produced titanium mesh. Int J Implant Dent 2017; 3(1): 36.
[http://dx.doi.org/10.1186/s40729-017-0097-z] [PMID: 28748521]
[57]
Sumida T, Otawa N, Kamata YU, et al. Custom-made titanium devices as membranes for bone augmentation in implant treatment: Clinical application and the comparison with conventional titanium mesh. J Craniomaxillofac Surg 2015; 43(10): 2183-8.
[58]
Mounir M, Shalash M, Mounir S, Nassar Y, El Khatib O. Assessment of three dimensional bone augmentation of severely atrophied maxillary alveolar ridges using prebent titanium mesh vs customized Poly‐Ether‐Ether‐Ketone (PEEK) mesh: A randomized clinical trial. Clin Implant Dent Relat Res 2019; 21(5): 960-7.
[http://dx.doi.org/10.1111/cid.12748] [PMID: 30895678]
[59]
Connors C, Liacouras P, Grant G. Custom Titanium Ridge Augmentation Matrix (CTRAM): A case report. Int J Periodont Restor Dent 2016; 36(5): 707-14.
[http://dx.doi.org/10.11607/prd.2620] [PMID: 27560675]
[60]
Tallarico M, Park CJ, Lumbau AI, et al. Customized 3D-printed titanium mesh developed to regenerate a complex bone defect in the aesthetic zone: A case report approached with a fully digital workflow. Materials 2020; 13(17): 3874.
[http://dx.doi.org/10.3390/ma13173874] [PMID: 32887390]
[61]
Ciocca L, Lizio G, Baldissara P, Sambuco A, Scotti R, Corinaldesi G. Prosthetically CAD-CAM–guided bone augmentation of atrophic jaws using customized titanium mesh: Preliminary results of an open prospective study. J Oral Implantol 2018; 44(2): 131-7.
[http://dx.doi.org/10.1563/aaid-joi-D-17-00125] [PMID: 29303418]
[62]
Dellavia C, Canciani E, Pellegrini G, Tommasato G, Graziano D, Chiapasco M. Histological assessment of mandibular bone tissue after guided bone regeneration with customized computer‐aided design/computer‐assisted manufacture titanium mesh in humans: A cohort study. Clin Implant Dent Relat Res 2021; 23(4): 600-11.
[http://dx.doi.org/10.1111/cid.13025] [PMID: 34139056]
[63]
Chiapasco M, Casentini P, Tommasato G, Dellavia C, Del Fabbro M. Customized CAD/CAM titanium meshes for the guided bone regeneration of severe alveolar ridge defects: Preliminary results of a retrospective clinical study in humans. Clin Oral Implants Res 2021; 32(4): 498-510.
[http://dx.doi.org/10.1111/clr.13720] [PMID: 33548069]
[64]
Li L, Wang C, Li X, Fu G, Chen D, Huang Y. Research on the dimensional accuracy of customized bone augmentation combined with 3D ‐printing individualized titanium mesh: A retrospective case series study. Clin Implant Dent Relat Res 2021; 23(1): 5-18.
[http://dx.doi.org/10.1111/cid.12966] [PMID: 33336492]
[65]
Al-Ardah AJ, Alqahtani N, AlHelal A, et al. Using virtual ridge augmentation and 3-dimensional printing to fabricate a titanium mesh positioning device: A novel technique letter. J Oral Implantol 2018; 44(4): 293-9.
[http://dx.doi.org/10.1563/aaid-joi-D-17-00160] [PMID: 29498903]
[66]
Hartmann A, Seiler M. Minimizing risk of customized titanium mesh exposures – A retrospective analysis. BMC Oral Health 2020; 20(1): 36.
[http://dx.doi.org/10.1186/s12903-020-1023-y] [PMID: 32013940]
[67]
Ciocca L, Fantini M, De Crescenzio F, Corinaldesi G, Scotti R. Direct Metal Laser Sintering (DMLS) of a customized titanium mesh for prosthetically guided bone regeneration of atrophic maxillary arches. Med Biol Eng Comput 2011; 49(11): 1347-52.
[http://dx.doi.org/10.1007/s11517-011-0813-4] [PMID: 21779902]
[68]
Navarro CC, Tousidonis Rial M, Antúnez CR, et al. Virtual surgical planning, stereolitographic models and CAD/CAM titanium mesh for three-dimensional reconstruction of fibula flap with iliac crest graft and dental implants. J Clin Med 2021; 10(9): 1922.
[http://dx.doi.org/10.3390/jcm10091922] [PMID: 33946731]
[69]
Antúnez CR, Salmerón JI, Díez MA, et al. Mandibular reconstruction with fibula flap and dental implants through virtual surgical planning and three different techniques: Double-barrel flap, implant dynamic navigation and CAD/CAM mesh with iliac crest graft. Front Oncol 2021; 11: 719712.
[http://dx.doi.org/10.3389/fonc.2021.719712] [PMID: 34676161]
[70]
Lee W, Choi W, Lee H, Choi N, Hwang D, Kim U. Mandibular reconstruction with a ready-made type and a custom-made type titanium mesh after mandibular resection in patients with oral cancer. Maxillofac Plast Reconstr Surg 2018; 40(1): 35.
[http://dx.doi.org/10.1186/s40902-018-0175-z] [PMID: 30538971]
[71]
Farid SM, Hamid NMA, Askar NA, Elmardenly AM. Immediate mandibular reconstruction via patient-specific titanium mesh tray using electron beam melting/CAD/rapid prototyping techniques: One-year follow-up. Int J Med Robot 2018; 14(3): e1895.
[http://dx.doi.org/10.1002/rcs.1895] [PMID: 29464889]
[72]
Ma J, Ma L, Wang Z, Zhu X, Wang W. The use of 3D-printed titanium mesh tray in treating complex comminuted mandibular fractures: A case report. Medicine 2017; 96(27): e7250-e.
[73]
Shan XF, Chen HM, Liang J, Huang JW, Cai ZG. Surgical reconstruction of maxillary and mandibular defects using a printed titanium mesh. J Oral Maxillofac Surg 2015; 73(7): 1437.e1-9.
[http://dx.doi.org/10.1016/j.joms.2015.02.025]
[74]
Tarsitano A, Battaglia S, Ciocca L, Scotti R, Cipriani R, Marchetti C. Surgical reconstruction of maxillary defects using a computer-assisted design/computer-assisted manufacturing-produced titanium mesh supporting a free flap. J Cranio-Maxillo-Fac Surg 2016; 44(9): 1320-6.
[75]
Fu K, Liu Y, Gao N, Cai J, He W, Qiu W. Reconstruction of maxillary and orbital floor defect with free fibula flap and whole individualized titanium mesh assisted by computer techniques. J Oral Maxillofac Surg 2017; 75(8): 1791.e1-.e9.
[http://dx.doi.org/10.1016/j.joms.2017.03.054]
[76]
Ciocca L, Ragazzini S, Fantini M, Corinaldesi G, Scotti R. Work flow for the prosthetic rehabilitation of atrophic patients with a minimal-intervention CAD/CAM approach. J Prosthet Dent 2015; 114(1): 22-6.
[http://dx.doi.org/10.1016/j.prosdent.2014.11.014] [PMID: 25862269]
[77]
Cucchi A, Vignudelli E, Franceschi D, et al. Vertical and horizontal ridge augmentation using customized CAD/CAM titanium mesh with versus without resorbable membranes. A randomized clinical trial. Clin Oral Implants Res 2021; 32(12): 1411-24.
[http://dx.doi.org/10.1111/clr.13841] [PMID: 34551168]
[78]
Garcia J, Dodge A, Luepke P, Wang HL, Kapila Y, Lin GH. Effect of membrane exposure on guided bone regeneration: A systematic review and meta-analysis. Clin Oral Implants Res 2018; 29(3): 328-38.
[http://dx.doi.org/10.1111/clr.13121] [PMID: 29368353]
[79]
Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K. Current barrier membranes: Titanium mesh and other membranes for guided bone regeneration in dental applications. J Prosthodont Res 2013; 57(1): 3-14.
[http://dx.doi.org/10.1016/j.jpor.2012.12.001] [PMID: 23347794]