A Review of Punarnava’s Pharmacological Profile Focusing on its Beneficial and Adverse Effects

Article ID: e041122210655 Pages: 10

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Abstract

Background: Punarnava is recognized as an essential remedy because it treats a wide range of health problems. It is commonly known as a rejuvenator. Its chemical constituents are all responsible for pharmacological activity in the body in some ways. There is a lot of evidence that the leaves, stems, and roots can be used as medicine.

Objective: The morphological, chemical, and pharmacological characteristics of Boerhaavia diffusa are discussed in this article. The purpose of this review is to discuss the pharmacological profile of Punarnava and its chemical elements, as well as the benefits and drawbacks of its steroidal component β-Ecdysone.

Methods: This article compiled information by reviewing a variety of published articles and research papers from several sources, including Research Gate, WJPRT, IJPSM, Elsevier, Taylor & Francis, Springer Nature, and The Journal of Ayurveda and Integrated Medicine.

Results: It is a widely used remedy for numerous ailments among diverse cultural groups, Ayurvedic, and traditional practitioners. To some extent, it is used in a variety of formulations to treat sciatica, cancer, immunomodulation, obesity, diabetes, jaundice, inflammation, asthma, rheumatism, nephrological difficulties, ascites, anemia, and gynaecological disorders.

Conclusion: Herbal medications are becoming increasingly popular nowadays. Punarnava is one of the most beneficial herbs available. More analysis is needed to investigate the impacts of each chemical ingredient in Punarnava. β -Ecdysone is a key component of Punarnava, which is both beneficial and detrimental to humans in different ways. Hence, further research is also needed to emphasize the impacts of each Punarnava chemical ingredient.

Graphical Abstract

[1]
Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J Ethnopharmacol 2005; 99(2): 165-78.
[http://dx.doi.org/10.1016/j.jep.2005.02.035] [PMID: 15894123]
[2]
Nayak P, Thirunavoukkarasu M. A review of the plant Boerhaavia diffusa: Its chemistry, pharmacology and therapeutical potential. J Phytopharmacol 2016; 5(2): 83-92.
[http://dx.doi.org/10.31254/phyto.2016.5208]
[3]
Banjare L, Prasad AK, Naik ML. Boerhaavia diffusa from traditional use to scientific assessment-a review. Int J Pharm Biol Arch 2012; 3(6): 1346-54.
[4]
Bhowmik D, Kumar KS, Srivastava S, Paswan S, Sankar A, Dutta D. Traditional Indian herbs Punarnava and its medicinal importance. J Pharmacogn Phytochem 2012; 1(1): 52-8.
[5]
Kaur J, Singh S, Mittal A, Chaudhary AK, Baghel DS. A synoptic overview on Boerhavia diffusa for its medicinal importance. Plant Arch 2020; 20(2): 1217-23.
[6]
Gupta V, Virmani T, Singh V. Review on phytochemicals and pharmacological activities of Boerhaavia diffusa Linn. J Pharm Res Int 2021; 13(2): 2662-74.
[7]
Kaur S, Roy A. A review on the nutritional aspects of wild edible plants. Curr Tradit Med 2021; 7(4): 552-63.
[http://dx.doi.org/10.2174/2215083806999201123201150]
[8]
Mahesh AR, Kumar H, Ranganath MK, Devkar RA. Detail study on Boerhaavia diffusa plant for its medicinal importance-A Review. Res J Pharm Sci 2012; 1(1): 28-36.
[9]
Sharma K, Sahai M. Chemical constituents of Boerhavia diffusa leaves. J Med Plants Res 2017; 5(4): 166-9.
[10]
Humayun R, Syed AR, Shahzad H, Sidra M, Farnaz M. An overview of ethnopharmacological properties of Boerhaavia diffusa. Afr J Pharm Pharmacol 2014; 8(2): 49-58.
[http://dx.doi.org/10.5897/AJPP2013.3718]
[11]
Kamlekar DS, Tahashildar J, Gupta S. Role of Boerhaavia diffusa L: A in relief of neuropathic pain of paclitaxel induced neuropathy. J Med Sci clinic Res 2019; 7(8): 566-73.
[http://dx.doi.org/10.18535/jmscr/v7i8.96]
[12]
Kaur M, Goel RK. Anti-convulsant activity of Boerhaavia diffusa: Plausible role of calcium channel antagonism. Evid Based Complementary Altern Med 2011; 2011: 1-7.
[13]
Bhuminathan S, Rekha S, Nandhini M, Shankar R. Therapeutic and pharmacological efficacy of plant Boerhaavia diffusa–a review. Int J App Pharm 2022; 58-62.
[14]
Nguyen HH, Tran NMA, Nguyen THT, et al. Rotenoids and coumaronochromonoids from Boerhavia erecta and their biological activities: In vitro and in silico studies. J Saudi Chem Soc 2022; 26(4): 101489.
[http://dx.doi.org/10.1016/j.jscs.2022.101489]
[15]
Manu KA, Kuttan G. Effect of Punarnavine, an alkaloid from Boerhaavia diffusa, on cell-mediated immune responses and TIMP-1 in B16F-10 metastatic melanoma-bearing mice. Immunopharmacol Immunotoxicol 2007; 29(3-4): 569-86.
[http://dx.doi.org/10.1080/08923970701692676] [PMID: 18075866]
[16]
Nandi R, Ghosh R. Phytochemical and biological importance of Boerhavia diffusa: A plant of ethnopharmacological knowledge. Int J Pharm Sci Res 2016; 7(3): 134-43.
[17]
Manu KA, Kuttan G. Anti-metastatic potential of Punarnavine, an alkaloid from Boerhaavia diffusa Linn. Immunobiology 2009; 214(4): 245-55.
[http://dx.doi.org/10.1016/j.imbio.2008.10.002] [PMID: 19171408]
[18]
Pandey R, Maurya R, Singh G, Sathiamoorthy B, Naik S. Immunosuppressive properties of flavonoids isolated from Boerhaavia diffusa Linn. Int Immunopharmacol 2005; 5(3): 541-53.
[http://dx.doi.org/10.1016/j.intimp.2004.11.001] [PMID: 15683850]
[19]
Kumar R, Gautam S, Singh KD, et al. Pharmacological properties of Boerhavia diffusa: A review. Int J Chem Stud 2018; SP4: 72-80.
[20]
Bhalodiya M, Chavda J, Patel N, Manek R, Patel A, Faldu S. Determination of polyphenolic content and antioxidant activity from various extracts of Boerhaavia diffusa linn root: an in vitro approach for selection of appropriate extracting solvent. Pharmacogn J 2020; 12(6s): 1578-85.
[http://dx.doi.org/10.5530/pj.2020.12.216]
[21]
Hirunpanich V, Utaipat A, Morales NP, et al. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol 2006; 103(2): 252-60.
[http://dx.doi.org/10.1016/j.jep.2005.08.033] [PMID: 16213683]
[22]
Verma R. A review on hepatoprotective activity of medicinal plants. J Med Plants Stud 2018; 6(1): 188-90.
[23]
Pareta SK, Patra KC, Mazumder PM, Sasmal D. Boerhaavia diffusa Linn aqueous extract as curative agent in ethylene glycol induced urolithiasis. Pharmacologyonline 2010; 3: 112-20.
[24]
Yasir F, Waqar MA. Effect of indigenous plant extracts on calcium oxalate crystallization having a role in urolithiasis. Urol Res 2011; 39(5): 345-50.
[http://dx.doi.org/10.1007/s00240-011-0374-x] [PMID: 21643743]
[25]
Khalid M, Siddiqui HH. Evaluation of weight reduction and anti–cholesterol activity of Punarnava root extract against high fat diets induced obesity in experimental rodent. Asian Pac J Trop Biomed 2012; 2(3): S1323-8.
[http://dx.doi.org/10.1016/S2221-1691(12)60409-2]
[26]
Mishra S, Aeri V, Gaur PK, Jachak SM. Phytochemical, therapeutic, and ethnopharmacological overview for a traditionally important herb: Boerhavia diffusa Linn. BioMed Res Int 2014; 2014: 1-19.
[http://dx.doi.org/10.1155/2014/808302] [PMID: 24949473]
[27]
a) Mehrotra S, Mishra KP, Maurya R, Srimal RC, Singh VK. Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. Int Immunopharmacol 2005; 5(3): 541-3.;
b) Murti K, Panchal MA, Lambole V. Pharmacological properties of Boerhaavia diffusa-a review. Int J Pharm Sci Rev Res 2010; 5(2): 107-10.
[28]
Alam P, Shahzad N, Gupta AK, et al. Anti-diabetic effect of Boerhavia diffusa L. root extract via free radical scavenging and antioxidant mechanism. Toxicol Environ Health Sci 2018; 10(3): 220-7.
[http://dx.doi.org/10.1007/s13530-018-0367-z]
[29]
Sahu A, Damiki L, Nilanjan G, Dubey S. Phytopharmacological review of Boerhaavia diffusa Linn. (Punarnava). Pharmacogn Rev 2008; 2(4): 14.
[30]
Shirwaikar A, Punitha IS, Shirwaikar A. Antioxidant studies on the methanol stem extract of Coscinium fenestratum. Nat Prod Res 2007; 13(1): 40-5.
[31]
Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asia Pacif J Trop Biomed 2012; 3(4): 320-30.
[http://dx.doi.org/10.1016/S2221-1691(12)60032-X]
[32]
Gupta V, Virmani T, Singh V. A comparative diagnostic account of the roots of Boerhavia diffusa linn. from four different geographical regions in india. Int J Agricult Animal Product (IJAAP) 2022; 2(03): 14-9.
[33]
Singh A, Sharma H, Singh R, Srikanth N. High-performance thin-layer chromatography estimation of boeravinone-B in Boerhavia diffusa L. and its polyherbal dosage form (capsule). Pharmacognosy Res 2019; 11(3): 267.
[http://dx.doi.org/10.4103/pr.pr_161_18]
[34]
Sharma N, Singh B, Bhatia A, Gupta RC, Wani MS. Morphological and cytogenetic analysis of different cytotypes of Boerhaavia diffusa L. and their evaluation for biological activity. Adv Trad Med 2021; 21(4): 791-803.
[http://dx.doi.org/10.1007/s13596-020-00518-7]
[35]
Mishra MC, Shukla SP, Rajak V, Tripathi M. Pharmacognostic evaluation of stem of Punarnawa (Boerhavia diffusa Linn.). Int J Rec Biotech 2020; 8(4): 1-7.
[36]
Premkumar P, Priya J, Suriyavathana M. Evaluation of antioxidant potential of Andrographis echioides and Boerhavia diffusa. Int J Curr Res 2010; 3: 59-62.
[37]
Rachh PR, Rachh MR, Modi DC, et al. In vitro evaluation of antioxidant activity of Punarnava (Boerhaavia diffusa Linn.). Int J Pharm Res 2009; 1: 36-40.
[38]
Shankar S, Sathiavelu M. In vitro Antioxidant activity, FTIR analysis and Total Phenolic content of Endophytic Fungus Penicillium sp. isolated from Boerhaavia diffusa L. Res J Pharm Technol 2022; 15(7): 2951-6.
[http://dx.doi.org/10.52711/0974-360X.2022.00492]
[39]
Venkatalakshmi P, Eazhisai VD, Netaji S. Hepatoprotective Activity of Boerhavia diffusa against paracetamol induced toxicity in rats. J Chem Pharm Res 2011; 3: 229-32.
[40]
Devaki T, Shivashangari KS, Ravikumar V, Govindaraju P. Effect of Boerhaavia diffusa on tissue antioxidant defense system during ethanol-induced hepatotoxicity in rats. J Nat Med 2005; 5(2): 102-7.
[41]
Pradhan D, Panda S, Das D, Kar DM, Ghosh G, Das C. Isolation of major phytoconstituents and standardization of different extracts of Boerhavia diffusa by RP-HPLC. Res J Pharm Technol 2020; 13(1): 297-302.
[http://dx.doi.org/10.5958/0974-360X.2020.00060.8]
[42]
Santhosha DU, Manasa R, Mahesh MS. Hepatoprotective activity of Boerhaavia diffusa L. IP J Nutr Metab Health Sci 2021; 3(4): 109-3.
[43]
Gharate M, Kasture V. Evaluation of anti-inflammatory, analgesic, antipyretic and antiulcer activity of Punarnavasava: an Ayurvedic formulation of Boerhavia diffusa. Orient Pharm Exp Med 2013; 13(2): 121-6.
[44]
Tyagi K, Sharma S. Effect of industry effluent on histopharmacognosy of Boerhaavia diffusa Linn. used as blood purifier. 2021.
[45]
Agrawal B, Das S, Pandey A. Boerhaavia diffusa Linn.: A review on its phytochemical and pharmacological profile. As J Appl Sci 2011; 4(7): 663-84.
[http://dx.doi.org/10.3923/ajaps.2011.663.684]
[46]
Mathiyazhagan M, Raj JJ, Gabriel JJ. Characterization and antimicrobial properties of biofabricated silver nanoparticles using different extracts of Boerhavia diffusa L. Adv Sci Eng Med 2020; 12(4): 530-4.
[http://dx.doi.org/10.1166/asem.2020.2555]
[47]
Kala S, Kumar V, Gauthaman K. Relevance of the use of alternative medicine for bronchial asthma: A review. J Young Pharm 2009; 1(2): 184.
[http://dx.doi.org/10.4103/0975-1483.55754]
[48]
Ghosh S. Boerhavia diffusa: One plant with many functions. Int J Green Pharm 2018; 12(3): S442-8.
[49]
Negalur VB. Clinical study on the Rasayana effect of Ashwaganda and Punarnava. J Ayurveda Integr Med 2016; 1(03): 19-23.
[50]
Thangavelu L, Rajeshkumar S, Arivarasu L, Jalan RS. Anti-Inflammatory activity of Boerhavia diffusa zinc oxide nanoparticle. J Pharm Res Int 2021; 33(61): 343-53.
[51]
Sharma R, Amin H, Prajapati PK. RAsayana therapy: Ayurvedic contribution to improve quality of life. WJPRT 2015; 4(1): 23-33.
[52]
Lu M, Wang P, Zhou S, et al. Ecdysone elicits chronic renal impairment via mineralocorticoid-like pathogenic activities. Cell Physiol Biochem 2018; 49(4): 1633-45.
[http://dx.doi.org/10.1159/000493499] [PMID: 30227391]
[53]
Ahmad N, Hui-Yin Y, Makmor-Bakry M. Mechanisms of natural products as potential antiepileptic drugs. Pak J Pharm Sci 2022; 35(4): 1043-53.
[PMID: 36008901]
[54]
Lafont R, Dinan L. Practical uses for ecdysteroids in mammals including humans: An update. J Insect Sci 2003; 3(1): 7.
[http://dx.doi.org/10.1093/jis/3.1.7] [PMID: 15844229]
[55]
Dinan L, Lafont R. Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals. J Endocrinol 2006; 191(1): 1-8.
[http://dx.doi.org/10.1677/joe.1.06900] [PMID: 17065383]
[56]
Cahlíková L, Macáková K, Chlebek J, Hošt'álková A, Kulhánková A, Opletal L. Ecdysterone and its activity on some degenerative diseases. Nat Prod Commun 2011; 6(5): 1934578X1100600527.
[http://dx.doi.org/10.1177/1934578X1100600527]
[57]
Rajpoot K, Mishra RN. Boerhaavia diffusa roots (Punarnava mool)–review as rasayan (rejuvenator/antiaging). Int J Res Pharm Biomed Sci 2011; 2: 1451-60.
[58]
Chvilicek MM, Titos I, Rothenfluh A. The neurotransmitters involved in Drosophila alcohol-induced behaviors. Front Behav Neurosci 2020; 14: 607700.
[http://dx.doi.org/10.3389/fnbeh.2020.607700] [PMID: 33384590]
[59]
Naresh KR, Sundaram R, Shanthi P, Sachdanandam P. Protective role of 20-OH ecdysone on lipid profile and tissue fatty acid changes in streptozotocin induced diabetic rats. Eur J Pharmacol 2013; 698(1-3): 489-98.
[http://dx.doi.org/10.1016/j.ejphar.2012.10.016] [PMID: 23110815]
[60]
Dai WW, Wang LB, Jin GQ, et al. Beta-ecdysone protects mouse osteoblasts from glucocorticoid-induced apoptosis in vitro. Planta Med 2017; 83(11): 888-94.
[http://dx.doi.org/10.1055/s-0043-107808] [PMID: 28388784]
[61]
Yusupova UY, Ramazonov NS, Syrov VN, Sagdullaev SS. Biological activities of phytoecdisteroids. In phytoecdysteroids. Singapore: Springer 2022; pp. 161-77.
[http://dx.doi.org/10.1007/978-981-16-6711-4_6]
[62]
Kayani WK, Hasan H, Mirza B. Advances in genetic engineering of ajuga species. Biotechnological approaches for medicinal and aromatic plants. Singapore: Springer 2018; pp. 599-629.
[63]
Parr M, Botrè F, Naß A, Hengevoss J, Diel P, Wolber G. Ecdysteroids: A novel class of anabolic agents? Biol Sport 2014; 32(2): 169-73.
[http://dx.doi.org/10.5604/20831862.1144420] [PMID: 26060342]
[64]
Maravelias C, Dona A, Stefanidou M, Spiliopoulou C. Adverse effects of anabolic steroids in athletes. Toxicol Lett 2005; 158(3): 167-75.
[http://dx.doi.org/10.1016/j.toxlet.2005.06.005] [PMID: 16005168]
[65]
Herlitz LC, Markowitz GS, Farris AB, et al. Development of focal segmental glomerulosclerosis after anabolic steroid abuse. J Am Soc Nephrol 2010; 21(1): 163-72.
[http://dx.doi.org/10.1681/ASN.2009040450] [PMID: 19917783]
[66]
Martin WF, Armstrong LE, Rodriguez NR. Dietary protein intake and renal function. Nutr Metab (Lond) 2005; 2(1): 25.
[http://dx.doi.org/10.1186/1743-7075-2-25] [PMID: 16174292]
[67]
Minakuchi C, Nakagawa Y, Kamimura M, Miyagawa H. Binding affinity of nonsteroidal ecdysone agonists against the ecdysone receptor complex determines the strength of their molting hormonal activity. Eur J Biochem 2003; 270(20): 4095-104.
[http://dx.doi.org/10.1046/j.1432-1033.2003.03801.x] [PMID: 14519121]
[68]
Kopple JD, Kalantar-Zadeh K, Mehrotra R. Risks of chronic metabolic acidosis in patients with chronic kidney disease. Kidney Int 2005; 67(95): S21-7.
[http://dx.doi.org/10.1111/j.1523-1755.2005.09503.x] [PMID: 15882309]
[69]
Han J, Guan J, Zhu X. β-Ecdysone attenuates cartilage damage in a mouse model of collagenase-induced osteoarthritis via mediating FOXO1/ADAMTS-4/5 signaling axis. Histol Histopathol 2021; 36(7): 785-94.
[PMID: 33876419]