Herbal Drugs to Targets in the Treatment of Cancer - A Futuristic
Approach

Anshu      Tiwari; Md.   Aftab   Alam; Awaneet      Kaur; Shaweta      Sharma; Shikha      Yadav
Abstract

In the last few decades, cancer has affected people globally and is the most minacious disease that affects human body cells. It is a prominent cause of death. Cancer can affect anyone anywhere in the body. Most ordinary cancers are lung, colorectal, prostate, breast, etc. There are various options for the treatment of cancer, such as chemotherapy, radiation, surgery, or hormonal therapy, but the adverse effects may be harmful and can vary considerably depending on the health outcomes of the person. Many studies have recently focused on herbal species for anticancer purposes. Several herbal components and their analogues are mostly recognised as crucial anticancer factors. However, different plants have anticancer properties. Various medicinal herbs were revealed to improve the quality of life of cancer patients. This study shows that herbal goods with related analogues are cancer-resistant compounds with in vivo or in vitro anticancer effects. His study aims to demonstrate the herbal products with related analogues as cancer-resistant compounds as novel species with in vivo or in vitro anticancer effects. This review has focused on several natural anticancer substances, besides several other organic products. Most herbs seemed to progress through the process of anti-cancer. An herbal compound analysis is often valuable for discovering new pharmacologically important materials with special pathways. It can be noted that to provide nature’s variability, chemically, components that can be associated with most targeted therapies are often developed.
Keywords: Cancer cells, Medicinal plants, Tumours, natural products, Herbal therapies.
Graphical Abstract

[1]
Dy GK, Adjei AA. Understanding, recognizing, and managing toxicities of targeted anticancer therapies. CA Cancer J Clin  2013; 63(4): 249-79.
 [http://dx.doi.org/10.3322/caac.21184] [PMID:  23716430]

[2]
Tan W, Lu J, Huang M, et al. Anti-cancer natural products isolated from chinese medicinal herbs. Chin Med  2011; 6(1): 27.
 [http://dx.doi.org/10.1186/1749-8546-6-27] [PMID:  21777476]

[3]
David B, Wolfender JL, Dias DA. The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev  2015; 14(2): 299-315.
 [http://dx.doi.org/10.1007/s11101-014-9367-z]

[4]
Mangal M, Sagar P, Singh H, Raghava GPS, Agarwal SM. NPACT: Naturally occurring plant-based anti-cancer compound-activity-target database. Nucleic Acids Res  2013; 41(D1): D1124-9.
 [http://dx.doi.org/10.1093/nar/gks1047] [PMID:  23203877]

[5]
Abdel-Aziz SM, Aeron A, Kahil TA. Health Benefits and Possible Risks of Herbal Medicine. In: Microbes in food and health.  Cham: Springer International Publishing 2016; pp. 97-116.
 [http://dx.doi.org/10.1007/978-3-319-25277-3_6]

[6]
Hardy K, Buckley S, Collins MJ, et al. Neanderthal medics? Evidence for food, cooking, and medicinal plants entrapped in dental calculus. Naturwissenschaften  2012; 99(8): 617-26.
 [http://dx.doi.org/10.1007/s00114-012-0942-0] [PMID:  22806252]

[7]
El-Soud NHA. Herbal medicine in ancient Egypt. J Med Plants Res  2010; 4(2): 82-6.

[8]
Yang S. The divine farmer’s materia medica: A translation of the Shen Nong Ben Cao Jing. Blue Poppy Enterprises, Inc 1998.

[9]
Patridge E, Gareiss P, Kinch MS, Hoyer D. An analysis of FDA-approved drugs: natural products and their derivatives. Drug Discov Today  2016; 21(2): 204-7.
 [http://dx.doi.org/10.1016/j.drudis.2015.01.009] [PMID:  25617672]

[10]
Svoboda GH, Neuss N, Gorman M. Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.) V. **Organic Chemical Development and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Ind. J Am Pharm Assoc (Sci Ed)  1959; 48(11): 659-66.
 [http://dx.doi.org/10.1002/jps.3030481115] [PMID:  13854990]

[11]
Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc  1971; 93(9): 2325-7.
 [http://dx.doi.org/10.1021/ja00738a045] [PMID:  5553076]

[12]
Moraes DFC, de Mesquita LSS, do Amaral FMM, de Sousa Ribeiro MN, Malik S. Anticancer Drugs from Plants. In: Biotechnology and production of anti-cancer compounds.  Springer International Publishing 2017; pp. 121-42.
 [http://dx.doi.org/10.1007/978-3-319-53880-8_5]

[13]
Sharma R, Kr Sharma H. A review on plants having anti-cancer activity formulation of herbal mosquito repellent view project in vitro evaluation for the antimalarial activity of designed novel quinuclidine derivative view project 2018.

[14]
Ames BN, Gold LS. Endogenous mutagens and the causes of aging and cancer. Mutat Res  1991; 250(1-2): 3-16.
 [http://dx.doi.org/10.1016/0027-5107(91)90157-J] [PMID:  1944345]

[15]
Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants.  Paris: Lavoisier Publishing 1995; 265. Available from:

[16]
Giddings LA, Newman DJ. Microbial natural products: molecular blueprints for antitumor drugs. J Ind Microbiol Biotechnol  2013; 40(11): 1181-210.
 [http://dx.doi.org/10.1007/s10295-013-1331-1] [PMID:  23999966]

[17]
Gorski LA. Chemotherapy and Biotherapy Guidelines and Recommendations for Practice: Polovich, M., White, M., & Kelleher, LO (Eds.). Pittsburgh: Oncology Nursing Society, 2005. 246pp; $55.00, ONS members; nonmembers; telephone: 412-859-6100. Home Healthcare Now  2006 Mar 1; 24(3): 187.

[18]
Dias DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites  2012; 2(2): 303-36.
 [http://dx.doi.org/10.3390/metabo2020303] [PMID:  24957513]

[19]
Keating GM. Cabazitaxel: a guide to its use in hormone-refractory metastatic prostate cancer. Drugs Aging  2013; 30(5): 359-65.
 [http://dx.doi.org/10.1007/s40266-013-0078-8] [PMID:  23532557]

[20]
Lyseng-Williamson KA, Yang LPH. Romidepsin: a guide to its clinical use in cutaneous T-cell lymphoma. Am J Clin Dermatol  2012; 13(1): 67-71.
 [http://dx.doi.org/10.2165/11208520-000000000-00000] [PMID:  22066664]

[21]
Ansari SH, Sameem M, Islam F. Influence of nanotechnology on herbal drugs: A Review. J Adv Pharm Technol Res  2012; 3(3): 142-6.
 [http://dx.doi.org/10.4103/2231-4040.101006] [PMID:  23057000]

[22]
Zheng L, Chemical JS-S. Curcumin multi-wall carbon nanotubes modified glassy carbon electrode and its electrocatalytic activity towards oxidation of hydrazine. Sensors and Actuators B: Chemical  2009; 135(2): 650-5.
 [http://dx.doi.org/10.1016/j.snb.2008.09.035]

[23]
Akhtar N, Bansal JG. Risk factors of lung cancer in nonsmoker. Curr Probl Cancer  2017; 41(5): 328-39.
 [http://dx.doi.org/10.1016/j.currproblcancer.2017.07.002] [PMID:  28823540]

[24]
van Meerbeeck JP, Fennell DA, De Ruysscher DKM. Small-cell lung cancer. Lancet  2011; 378(9804): 1741-55.
 [http://dx.doi.org/10.1016/S0140-6736(11)60165-7] [PMID:  21565397]

[25]
Gridelli C, Rossi A, Carbone DP, et al. Non-small-cell lung cancer. Nat Rev Dis Primers  2015; 1(1): 15009.
 [http://dx.doi.org/10.1038/nrdp.2015.9] [PMID:  27188576]

[26]
Swamy MK. Plant-derived Bioactives: Chemistry and mode of action. Singapore: Springer 2020.
 [http://dx.doi.org/10.1007/978-981-15-2361-8]

[27]
Liu Z. Essentials of Chinese Medicine. London: Springer-Verlag 2009.
 [http://dx.doi.org/10.1007/978-1-84882-590-1]

[28]
Edward MJ. American herbal products association’s botanical safety handbook edited by M. McGuffin, C. Hobbs, R. Upton, and A. Goldberg, CRC Press, Boca Raton, FL, 231 Pages, 1997. $$39.95. J Toxicol  2000; 19(2-3): 167-8.
 [http://dx.doi.org/10.3109/15569520009051512]

[29]
Mac Namara S. traditional chinese medicine : Complete Guide. Hamish Hamilton 1995.

[30]
Fischer W, Wu Y. Practical therapeutics of traditional chinese medicine. Paradigm Publications 1997.

[31]
Huang KC. The pharmacology of chinese herbs.  (2nd Ed..), 

[32]
De Silva DD, Rapior S, Fons F, Bahkali AH, Hyde KD. Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action. Fungal Divers  2012; 55(1): 1-35.
 [http://dx.doi.org/10.1007/s13225-012-0151-3]

[33]
Leem J. Is traditional Chinese herbal medicine effective in prolonging survival times in extensive-stage small-cell lung cancer patients? Integr Med Res  2015; 4(4): 256-9.
 [http://dx.doi.org/10.1016/j.imr.2015.09.004] [PMID:  28664133]

[34]
Sun YS, Zhao Z, Yang ZN, et al. Risk factors and preventions of breast cancer. Int J Biol Sci  2017; 13(11): 1387-97.
 [http://dx.doi.org/10.7150/ijbs.21635] [PMID:  29209143]

[35]
Deng CX. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res  2006; 34(5): 1416-26.
 [http://dx.doi.org/10.1093/nar/gkl010] [PMID:  16522651]

[36]
Handbook of ayurvedic medicinal plants.  (1st ed.), CRC Press 2000.

[37]
Shareef M, Ashraf MA, Sarfraz M. Natural cures for breast cancer treatment. Saudi Pharm J  2016; 24(3): 233-40.
 [http://dx.doi.org/10.1016/j.jsps.2016.04.018] [PMID:  27275107]

[38]
Anticancer activities of Oldenlandia diffusa. J Herb Pharmacother  2004; 4(1): 21-33.

[39]
Barnes J, Anderson LA, Gibbons S, Phillipson JD. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol  2010; 57(8): 929-54.
 [http://dx.doi.org/10.1211/0022357056127] [PMID:  16102249]

[40]
Wu CH, Wang CC, Kennedy J. Changes in herb and dietary supplement use in the U.S. adult population: a comparison of the 2002 and 2007 National Health Interview Surveys. Clin Ther  2011; 33(11): 1749-58.
 [http://dx.doi.org/10.1016/j.clinthera.2011.09.024] [PMID:  22030445]

[41]
Mármol I, Sánchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi M. Colorectal carcinoma: A general overview and future perspectives in colorectal cancer. Int J Mol Sci  2017; 18(1): 197.
 [http://dx.doi.org/10.3390/ijms18010197] [PMID:  28106826]

[42]
Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med  2003; 348(10): 919-32.
 [http://dx.doi.org/10.1056/NEJMra012242] [PMID:  12621137]

[43]
Stoilova I, Krastanov A, Stoyanova A, Denev P, Gargova S. Antioxidant activity of a ginger extract (Zingiber officinale). Food Chem  2007; 102(3): 764-70.
 [http://dx.doi.org/10.1016/j.foodchem.2006.06.023]

[44]
Abdullah S, Amalina S, Abidin Z, et al. Ginger extract (Zingiber officinale) triggers apoptosis and G 0 /G 1 cells arrest in HCT 116 and HT 29 colon cancer cell lines. Afr J Biochem Res  2010; 4(4): 134-42.

[45]
Kleshinski JF, Crews C, Fry E, et al. A survey of herbal product use in a dialysis population in Northwest Ohio. J Ren Nutr  2003; 13(2): 93-7.
 [http://dx.doi.org/10.1053/jren.2003.50028]

[46]
Velonas V, Woo H, Remedios C, Assinder S. Current status of biomarkers for prostate cancer. Int J Mol Sci  2013; 14(6): 11034-60.
 [http://dx.doi.org/10.3390/ijms140611034] [PMID:  23708103]

[47]
Pinsky PF, Kramer BS, Crawford ED, et al. Prostate volume and prostate-specific antigen levels in men enrolled in a large screening trial. Urology  2006; 68(2): 352-6.
 [http://dx.doi.org/10.1016/j.urology.2006.02.026] [PMID:  16904451]

[48]
Ouyang XS, Wang X, Lee DTW, Tsao SW, Wong YC. Over expression of ID-1 in prostate cancer. J Urol  2002; 167(6): 2598-602.
 [http://dx.doi.org/10.1016/S0022-5347(05)65044-6] [PMID:  11992094]

[49]
Hermanson DJ, Marnett LJ. Cannabinoids, endocannabinoids, and cancer. Cancer Metastasis Rev  2011; 30(3-4): 599-612.
 [http://dx.doi.org/10.1007/s10555-011-9318-8] [PMID:  22038019]

[50]
Ruixing Y, Weixiong L, Hanjun Y, et al. Diet, lifestyle, and blood pressure of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations. Am J Hypertens  2008; 21(4): 382-7.
 [http://dx.doi.org/10.1038/ajh.2008.1] [PMID:  18369357]

[51]
Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res  2006; 66(6): 3222-9.

[52]
Scher HI, Kelly WMK, Zhang Z-F, et al. Post-therapy serum prostate-specific antigen level and survival in patients with androgen-independent prostate cancer. J Natl Cancer Inst  1999; 91(3): 244-51.
 [http://dx.doi.org/10.1093/jnci/91.3.244]

[53]
Sánchez AM, Malagarie-Cazenave S, Olea N, Vara D, Chiloeches A, Díaz-Laviada I. Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis  2007; 12(11): 2013-24.
 [http://dx.doi.org/10.1007/s10495-007-0119-z] [PMID:  17828457]

[54]
Gokhale SB, Purohit AP, Kokate CK. Pharmacognosy. Nirali Prakashan 2007.

[55]
Buyel JF. Plants as sources of natural and recombinant anti-cancer agents. Biotechnol Adv  2018; 36(2): 506-20.
 [http://dx.doi.org/10.1016/j.biotechadv.2018.02.002] [PMID:  29408560]

[56]
Kleeff J, Korc M, Apte M, et al. Pancreatic cancer. Nat Rev Dis Primers  2016; 2(1): 16022.
 [http://dx.doi.org/10.1038/nrdp.2016.22] [PMID:  27158978]

[57]
Li L, Leung PS. Use of herbal medicines and natural products: An alternative approach to overcoming the apoptotic resistance of pancreatic cancer. Int J Biochem Cell Biol  2014; 53: 224-36.
 [http://dx.doi.org/10.1016/j.biocel.2014.05.021] [PMID:  24875648]

[58]
Friedman L, Lin L, Ball S, et al. Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. Anticancer Drugs  2009; 20(6): 444-9.
 [http://dx.doi.org/10.1097/CAD.0b013e32832afc04]

[59]
Cordell GA, Araujo OE. Capsaicin: Identification, nomenclature, and pharmacotherapy. Ann Pharmacother  1993; 27(3): 330-6.
 [http://dx.doi.org/10.1177/106002809302700316] [PMID:  8453173]

[60]
Zhang R, Humphreys I, Sahu RP, Shi Y, Srivastava SK. In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis  2008; 13(12): 1465-78.
 [http://dx.doi.org/10.1007/s10495-008-0278-6] [PMID:  19002586]

[61]
Pramanik KC, Srivastava SK. Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid Redox Signal  2012; 17(10): 1417-32.
 [http://dx.doi.org/10.1089/ars.2011.4369] [PMID:  22530568]

[62]
Shamon LA, Pezzuto JM, Graves JM, et al. Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii. Cancer Lett  1997; 112(1): 113-7.
 [http://dx.doi.org/10.1016/S0304-3835(96)04554-5] [PMID:  9029176]

[63]
Phillips PA, Dudeja V, McCarroll JA, et al. Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70. Cancer Res  2007; 67(19): 9407-16.
 [http://dx.doi.org/10.1158/0008-5472.CAN-07-1077] [PMID:  17909050]

[64]
Steward WP, Brown K. Cancer chemoprevention: a rapidly evolving field. Br J Cancer  2013; 109(1): 1-7.
 [http://dx.doi.org/10.1038/bjc.2013.280] [PMID:  23736035]

[65]
De Flora S, Ferguson LR. Overview of mechanisms of cancer chemopreventive agents. Mutat Res  2005; 591(1-2): 8-15.
 [http://dx.doi.org/10.1016/j.mrfmmm.2005.02.029] [PMID:  16107270]

[66]
Walaszek Z, Hanausek M, Slaga TJ. Mechanisms of chemoprevention. Chest  2004; 125(5) (Suppl.): 128S-33S.
 [http://dx.doi.org/10.1378/chest.125.5_suppl.128S-a] [PMID:  15136462]

[67]
Pietta PG. Flavonoids as antioxidants. J Nat Prod  2000; 63(7): 1035-42.
 [http://dx.doi.org/10.1021/np9904509] [PMID:  10924197]

[68]
Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen  2014; 22(5): 569-78.
 [http://dx.doi.org/10.1111/wrr.12205] [PMID:  24942811]

[69]
Ahmed SA, Nazim S, Siraj S, Siddik PM, Wahid CA. Euphorbia neriifolia Linn: A J Pharm  2011; 2(5): 41-8.

[70]
Sakarkar DM, Deshmukh VN. Ethnopharmacological review of traditional medicinal plants for anticancer activity. Int J Pharm Tech Res  2011; 3(1): 298-308.

[71]
Sporn MB, Dunlop NM, Newton DL, Smith JM. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc  1976; 35(6): 1332-8.
 [PMID:  770206]

[72]
Ren W, Qiao Z, Wang H, Zhu L, Zhang L. Flavonoids: Promising anticancer agents. Med Res Rev  2003; 23(4): 519-34.
 [http://dx.doi.org/10.1002/med.10033] [PMID:  12710022]

[73]
Hollman PCH, Katan MB. Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol  1999; 37(9-10): 937-42.
 [http://dx.doi.org/10.1016/S0278-6915(99)00079-4] [PMID:  10541448]

[74]
Lee KW, Ching SM, Hoo FK, Ramachandran V, Swamy MK. Traditional medicinal plants and their therapeutic potential against major cancer types. In: Anticancer Plants: Natural Products and Biotechnological Implements. Singapore: Springer 2018.
 [http://dx.doi.org/10.1007/978-981-10-8064-7_16]

[75]
Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res  2003; 231: 363-98.

[76]
Yang X, Li Z, Wang N, et al. Curcumin-encapsulated polymeric micelles suppress the development of colon cancer in vitro and in vivo. Sci Rep  2015; 5(1): 10322.
 [http://dx.doi.org/10.1038/srep10322] [PMID:  25980982]

[77]
Lassed S, Deus CM, Djebbari R, et al. Protective effect of green tea (Camellia sinensis (L.) Kuntze) against prostate cancer: From in vitro data to Algerian patients. Evid Based Complement Alternat Med  2017; 2017: 1-12.
 [http://dx.doi.org/10.1155/2017/1691568] [PMID:  28133488]

[78]
Chemat F, Abert-Vian M, Fabiano-Tixier AS, et al. Green extraction of natural products. Origins, current status, and future challenges. Trends Analyt Chem  2019; 118: 248-63.
 [http://dx.doi.org/10.1016/j.trac.2019.05.037]

[79]
Kaufmann B, Christen P. Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction. Phytochem Anal  2002; 13(2): 105-13.
 [http://dx.doi.org/10.1002/pca.631] [PMID:  12018022]

[80]
Azmir J, Zaidul ISM, Rahman MM, et al. Techniques for extraction of bioactive compounds from plant materials: A review. J Food Eng  2013; 117(4): 426-36.
 [http://dx.doi.org/10.1016/j.jfoodeng.2013.01.014]

[81]
Soshnikova V. Kim YJ, Singh P, Huo Y, Markus J, Ahn S, Castro-Aceituno V, Kang J, Chokkalingam M, Mathiyalagan R, Yang DC. Cardamom fruits as a green resource for facile synthesis of gold and silver nanoparticles and their biological applications. Artificial Cells Nanomed Biotechnol  2018; 46(1): 108-17.

[82]
Ethnobotany and its role in drug development. Phytotherapy Research  2000; 14(7): 479-88.

[83]
Ayurveda and natural products discovery. Current Science  2004; 86(6)

[84]
Preliminary phytochemical screening of six medicinal plants used in traditional medicine. Int J Pharm Sci  2014; 6(5): 539-42.

[85]
Clark AM. Natural products as a resource for new drugs. Pharm Res  1996; 13(8): 1133-41.
 [http://dx.doi.org/10.1023/A:1016091631721] [PMID:  8865302]

[86]
Thomford N, Senthebane D, Rowe A, et al. Natural products for drug discovery in the 21st century: Innovations for novel drug discovery. Int J Mol Sci  2018; 19(6): 1578.
 [http://dx.doi.org/10.3390/ijms19061578] [PMID:  29799486]

[87]
Nanotechnological approaches to herbal drugs used in cancer therapy. Int J Pharm Sci Res  2015; 6(10): 4137-4.

[88]
Liu Y, Feng N. Nanocarriers for the delivery of active ingredients and fractions extracted from natural products used in traditional Chinese medicine (TCM). Adv Colloid Interface Sci  2015; 221: 60-76.
 [http://dx.doi.org/10.1016/j.cis.2015.04.006] [PMID:  25999266]

[89]
Singh SP, Alvi SB, Pemmaraju DB, et al. NIR triggered liposome gold nanoparticles entrapping curcumin as in situ adjuvant for photothermal treatment of skin cancer. Int J Biol Macromol  2018; 110: 375-82.
 [http://dx.doi.org/10.1016/j.ijbiomac.2017.11.163] [PMID:  29195800]

[90]
Khorsand B, Lapointe G, Brett C, Oh JK. Intracellular drug delivery nanocarriers of glutathione-responsive degradable block copolymers having pendant disulfide linkages. Biomacromolecules  2013; 14(6): 2103-11.
 [http://dx.doi.org/10.1021/bm4004805] [PMID:  23647437]

[91]
Ovais M, Khalil AT, Raza A, et al. Green synthesis of silver nanoparticles via plant extracts: beginning a new era in cancer theranostics. Nanomedicine (Lond)  2016; 11(23): 3157-77.
 [http://dx.doi.org/10.2217/nnm-2016-0279] [PMID:  27809668]

[92]
Pandian AMK, Karthikeyan C, Rajasimman M, Dinesh MG. Synthesis of silver nanoparticle and its application. Ecotoxicol Environ Saf  2015; 121: 211-7.
 [http://dx.doi.org/10.1016/j.ecoenv.2015.03.039] [PMID:  25866204]

[93]
Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci  2005; 78(5): 431-41.
 [http://dx.doi.org/10.1016/j.lfs.2005.09.012] [PMID:  16198377]

[94]
Altman I. On oxidation kinetics of burning metal nanoparticles. Chem Phys Lett  2019; 735: 136780.
 [http://dx.doi.org/10.1016/j.cplett.2019.136780]

[95]
Juste B, Miró R, Morató S, Verdú G, Peris S. Prostate cancer Monte Carlo dose model with 177 Lutetium and 125 Iodine treatments. Radiat Phys Chem  2020; 174: 108908.
 [http://dx.doi.org/10.1016/j.radphyschem.2020.108908]

[96]
Butler MS. Erratum: The role of natural product chemistry in drug discovery (Journal of Natural Products (2004) 67 (2142-2149)). J Nat Prod  2006; 69(1): 172.
 [http://dx.doi.org/10.1021/np058132z]

[97]
Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z. Medicinal plants in therapy. Bull World Health Organ  1985; 63(6): 965-81.

[98]
Resource and utilization of medicinal plant of the genus Adenophora in Qinling Mountains.  Available from: https://www.cabdirect.org/cabdirect/abstract/20113207876

[99]
Madhushree MR, Seep BR, Jayant SR. S MK. Anticancer drugs as enhancers of fluconazole sensitivity in Candida albicans. Afr J Microbiol Res  2013; 7(14): 1253-61.
 [http://dx.doi.org/10.5897/AJMR12.1837]

[100]
Routh MM, Raut JS, Karuppayil SM. Dual properties of anticancer agents: an exploratory study on the in vitro anti-Candida properties of thirty drugs. Chemotherapy  2011; 57(5): 372-80.
 [http://dx.doi.org/10.1159/000330454] [PMID:  21997126]

[101]
Ginger and inula flower composition for reducing vomiting caused by cancer chemotherapy and increasing curative effect for chemotherapy and preparing method thereof. CN 201210014630, 2012.

[102]
Chan YS, Cheng LN, Wu JH, et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacol  2011; 19: 245-54.
 [http://dx.doi.org/10.1007/s10787-010-0062-4]

[103]
Conte PF, Gennari A, Landucci E, Orlandini C. Role of epirubicin in advanced breast cancer. Clin Breast Cancer  2000; 1 (Suppl. 1): S46-51.
 [http://dx.doi.org/10.3816/CBC.2000.s.009] [PMID:  11970749]

[104]
Mitomycin C for the treatment of bladder cancer. Minerva Urol Nefrol  2010; 62(2): 133-44.

[105]
Ho M, Mackey J. Presentation and management of docetaxel-related adverse effects in patients with breast cancer. Cancer Manag Res  2014; 6: 253-9.
 [http://dx.doi.org/10.2147/CMAR.S40601] [PMID:  24904223]

[106]
Yin SY, Wei WC, Jian FY, Yang NS. Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Alternat Med  2013; 2013: 1-15.
 [http://dx.doi.org/10.1155/2013/302426] [PMID:  23956768]

[107]
Staats: Cytokine requirements for induction of systemic.  Available from: https://scholar.google.com/scholar_lookup?title=Cytokine%20requirements%20for%20induction%20of%20systemic%20and%20mucosal%20CTL%20after%20nasal%20immunization&author=H.%20F.%20Staats&author=C.%20P.%20Bradney&author=W.%20M.%20Gwinn%20et%20al.&publication_year=2001

[108]
Su P, Li C, Hsu C, Benson S. Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo. Evid Based Complement Alternat Med  2011; 2011: 731308.

[109]
Lai C, Hung J, Lin H, Alice L, Chen S, Vaccine YT. Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro. Vaccine  2010; 28(31): 4945-54.
 [http://dx.doi.org/10.1016/j.vaccine.2010.05.037]

[110]
Liu JY, Yang FL, Lu CP, et al. Polysaccharides from Dioscorea batatas induce tumor necrosis factor-α secretion via toll-like receptor 4-mediated protein kinase signaling pathways. J Agric Food Chem  2008; 56(21): 9892-8.
 [http://dx.doi.org/10.1021/jf8018722] [PMID:  18841980]

[111]
Chen HM, Wang PH, Aravindaram K, et al. Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES. J Biomed Sci  2012; 19(1): 42.
 [http://dx.doi.org/10.1186/1423-0127-19-42] [PMID:  22494696]

[112]
Yin SY, Wang WH, Wang PH, et al. Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses. BMC Genomics  2010; 11(1): 612.
 [http://dx.doi.org/10.1186/1471-2164-11-612] [PMID:  21040561]

[113]
Krysko D, Garg A, Kaczmarek A. Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer  2012; 12(12): 860-75.

[114]
Huang M, Lu JJ, Ding J. Natural products in cancer therapy: Past, present and future. Nat Prod Bioprospect  2021; 11(1): 5-13.
 [http://dx.doi.org/10.1007/s13659-020-00293-7] [PMID:  33389713]

[115]
Futreal PA, Coin L, Marshall M, et al. A census of human cancer genes. Nat Rev Cancer  2004; 4(3): 177-83.
 [http://dx.doi.org/10.1038/nrc1299] [PMID:  14993899]

[116]
Davoli T, Xu AW, Mengwasser KE, et al. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell  2013; 155(4): 948-62.
 [http://dx.doi.org/10.1016/j.cell.2013.10.011] [PMID:  24183448]

[117]
Kandoth C, McLellan MD, Vandin F, et al. Mutational landscape and significance across 12 major cancer types. Nature  2013; 502(7471): 333-9.
 [http://dx.doi.org/10.1038/nature12634] [PMID:  24132290]

[118]
Hodos RA, Kidd BA, Shameer K, Readhead BP, Dudley JT. In silico methods for drug repurposing and pharmacology. Wiley Interdiscip Rev Syst Biol Med  2016; 8(3): 186-210.
 [http://dx.doi.org/10.1002/wsbm.1337] [PMID:  27080087]

[119]
Rask-Andersen M, Almén MS, Schiöth HB. Trends in the exploitation of novel drug targets. Nat Rev Drug Discov  2011; 10(8): 579-90.
 [http://dx.doi.org/10.1038/nrd3478] [PMID:  21804595]

[120]
Kummar S, Chen HX, Wright J, et al. Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements. Nat Rev Drug Discov  2010; 9(11): 843-56.
 [http://dx.doi.org/10.1038/nrd3216] [PMID:  21031001]

[121]
Kwak EL, Clark JW, Chabner B. Targeted agents: the rules of combination. Clin Cancer Res  2007; 13(18): 5232-7.
 [http://dx.doi.org/10.1158/1078-0432.CCR-07-1385] [PMID:  17875749]

[122]
Rajendran L, Knölker HJ, Simons K. Subcellular targeting strategies for drug design and delivery. Nat Rev Drug Discov  2010; 9(1): 29-42.
 [http://dx.doi.org/10.1038/nrd2897] [PMID:  20043027]

[123]
Garraway LA. Genomics-driven oncology: framework for an emerging paradigm. J Clin Oncol  2013; 31(15): 1806-14.
 [http://dx.doi.org/10.1200/JCO.2012.46.8934] [PMID:  23589557]

[124]
Thorn CF, Oshiro C, Marsh S, et al. Doxorubicin pathways. Pharmacogenet Genomics  2011; 21(7): 440-6.
 [http://dx.doi.org/10.1097/FPC.0b013e32833ffb56] [PMID:  21048526]

[125]
Fouche G, Cragg GM, Pillay P, Kolesnikova N, Maharaj VJ, Senabe J. In vitro anticancer screening of South African plants. J Ethnopharmacol  2008; 119(3): 455-61.
 [http://dx.doi.org/10.1016/j.jep.2008.07.005]

[126]
Kamatou GPP, Van Zyl RL, Davids H, Van Heerden FR, Lourens ACU, Viljoen AM. Antimalarial and anticancer activities of selected South African Salvia species and isolated compounds from S. radula. S Afr J Bot  2008; 74(2): 238-43.
 [http://dx.doi.org/10.1016/j.sajb.2007.08.001]

[127]
Schnekenburger M, Dicato M, Diederich M. Plant-derived epigenetic modulators for cancer treatment and prevention. Biotechnol Adv  2014; 32(6): 1123-32.
 [http://dx.doi.org/10.1016/j.biotechadv.2014.03.009] [PMID:  24699435]

[128]
Kumar S, Pathania AS, Saxena AK, Vishwakarma RA, Ali A, Bhushan S. The anticancer potential of flavonoids isolated from the stem bark of Erythrina suberosa through induction of apoptosis and inhibition of STAT signaling pathway in human leukemia HL-60 cells. Chem Biol Interact  2013; 205(2): 128-37.
 [http://dx.doi.org/10.1016/j.cbi.2013.06.020] [PMID:  23850732]

[129]
Rajeswara Rao BR, Singh K, Sastry KP, et al. Cultivation Technology for Economicaly Important Medicinal Plants. In: Reddy KJ, Bahadur B, Bhadraiah B, Rao MLN, Eds.  Advances in medicinal plantS.  University Press 2007; pp. 112-22.

[130]
Azmi AS, Bhat SH, Hanif S, Hadi SM. Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for anticancer properties. FEBS Lett  2006; 580(2): 533-8.
 [http://dx.doi.org/10.1016/j.febslet.2005.12.059] [PMID:  16412432]

[131]
Apostolou A, Stagos D, Galitsiou E, et al. Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts. Food Chem Toxicol  2013; 61: 60-8.
 [http://dx.doi.org/10.1016/j.fct.2013.01.029] [PMID:  23380202]

[132]
Siriwatanametanon N, Fiebich BL, Efferth T, Prieto JM, Heinrich M. Traditionally used Thai medicinal plants: In vitro anti-inflammatory, anticancer and antioxidant activities. J Ethnopharmacol  2010; 130(2): 196-207.
 [http://dx.doi.org/10.1016/j.jep.2010.04.036] [PMID:  20435130]

[133]
Gupta SC, Tyagi AK, Deshmukh-Taskar P, Hinojosa M, Prasad S, Aggarwal BB. Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. Arch Biochem Biophys  2014; 559: 91-9.
 [http://dx.doi.org/10.1016/j.abb.2014.06.006] [PMID:  24946050]

[134]
Cao J, Xia X, Chen X, Xiao J, Wang Q. Characterization of flavonoids from Dryopteris erythrosora and evaluation of their antioxidant, anticancer and acetylcholinesterase inhibition activities. Food Chem Toxicol  2013; 51: 242-50.
 [http://dx.doi.org/10.1016/j.fct.2012.09.039] [PMID:  23063594]

[135]
Huntley AL. The health benefits of berry flavonoids for menopausal women: Cardiovascular disease, cancer and cognition. Maturitas  2009; 63(4): 297-301.
 [http://dx.doi.org/10.1016/j.maturitas.2009.05.005] [PMID:  19520526]

[136]
Wen L, Wu D, Jiang Y, et al. Identification of flavonoids in litchi (Litchi chinensis Sonn.) leaf and evaluation of anticancer activities. J Funct Foods  2014; 6: 555-63.
 [http://dx.doi.org/10.1016/j.jff.2013.11.022]

[137]
Xia X, Cao J, Zheng Y, Wang Q, Xiao J. Flavonoid concentrations and bioactivity of flavonoid extracts from 19 species of ferns from China. Ind Crops Prod  2014; 58: 91-8.
 [http://dx.doi.org/10.1016/j.indcrop.2014.04.005]

[138]
Sahpazidou D, Geromichalos GD, Stagos D, et al. Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells. Toxicol Lett  2014; 230(2): 218-24.
 [http://dx.doi.org/10.1016/j.toxlet.2014.01.042] [PMID:  24508987]

[139]
Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhäuser C. Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem  2001; 276(34): 32008-15.
 [http://dx.doi.org/10.1074/jbc.M104794200] [PMID:  11410599]

[140]
Son IH, Chung IM, Lee SI, Yang HD, Moon HI. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett  2007; 17(17): 4753-5.
 [http://dx.doi.org/10.1016/j.bmcl.2007.06.060] [PMID:  17662606]

[141]
Zugazagoitia J, Guedes C, Ponce S, Ferrer I, Molina-Pinelo S, Paz-Ares L. Current challenges in cancer treatment. Clin Ther  2016; 38(7): 1551-66.
 [http://dx.doi.org/10.1016/j.clinthera.2016.03.026]

[142]
Hortobágyi GN. Anthracyclines in the treatment of cancer. An overview. Drugs  1997; 54(4) (Suppl. 4): 1-7.
 [http://dx.doi.org/10.2165/00003495-199700544-00003] [PMID:  9361955]

[143]
Warren JL, Yabroff KR, Meekins A, Topor M, Lamont EB, Brown ML. Evaluation of trends in the cost of initial cancer treatment. J Natl Cancer Inst  2008; 100(12): 888-97.
 [http://dx.doi.org/10.1093/jnci/djn175] [PMID:  18544740]

[144]
Denmeade SR, Isaacs JT. A history of prostate cancer treatment. Nat Rev Cancer  2002; 2(5): 389-96.
 [http://dx.doi.org/10.1038/nrc801]

[145]
Miller KD, Siegel RL, Lin CC, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin  2016; 66(4): 271-89.
 [http://dx.doi.org/10.3322/caac.21349] [PMID:  27253694]

[146]
Miller KD, Nogueira L, Mariotto AB, et al. Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin  2019; 69(5): 363-85.
 [http://dx.doi.org/10.3322/caac.21565]

[147]
Siegel R, DeSantiC C, Virgo K, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin  2012; 62(4): 220-41.
 [http://dx.doi.org/10.3322/caac.21149]

[148]
Arruebo M, Vilaboa N, Sáez-Gutierrez B, et al. Assessment of the evolution of cancer treatment therapies. Cancers (Basel)  2011; 3(3): 3279-330.
 [http://dx.doi.org/10.3390/cancers3033279] [PMID:  24212956]

[149]
DeSantis CE, Lin CC, Mariotto AB, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin  2014; 64(4): 252-71.
 [http://dx.doi.org/10.3322/caac.21235] [PMID:  24890451]

[150]
Hakim IA, Harris RB, Brown S, et al. Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study. J Nutr  2003; 133(10): 3303S-9S.
 [http://dx.doi.org/10.1093/jn/133.10.3303S] [PMID:  14519830]

[151]
Raza H, John A. Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments. Toxicol Appl Pharmacol  2005; 207(3): 212-20.
 [http://dx.doi.org/10.1016/j.taap.2005.01.004] [PMID:  16129114]

[152]
Valanis BG, Vollmer WM, Labuhn KT, Glass AG. Acute symptoms associated with antineoplastic drug handling among nurses. Cancer Nurs  1993; 16(4): 288-95. a
 [http://dx.doi.org/10.1097/00002820-199308000-00005] [PMID:  8402605]

[153]
Sharma A, Thomas J, Bairy KL, Kumari KM, Manohar HD. Pattern of adverse drug reactions due to cancer chemotherapy in a tertiary care hospital in South India. Perspect Clin Res  2015; 6(2): 109-15.
 [http://dx.doi.org/10.4103/2229-3485.154014] [PMID:  25878957]

[154]
Goyal YN, College PDUM, Govt MPS. Pattern of adverse drug reactions due to cancer chemotherapy in tertiary care teaching hospital in gujarat. Int J Sci Res  2014; 3(1): 333-5.

[155]
Chopra D, Rehan H, Sharma V, Mishra R. Chemotherapy-induced adverse drug reactions in oncology patients: A prospective observational survey. Indian J Med Paediatr Oncol  2016; 37(1): 42-6.
 [http://dx.doi.org/10.4103/0971-5851.177015] [PMID:  27051157]
Cite As
Current Cancer Therapy Reviews

Herbal Drugs to Targets in the Treatment of Cancer - A Futuristic Approach

Abstract

Graphical Abstract
