Polymeric Nanoparticles: Prospective on the Synthesis, Characterization
and Applications in Nose-to-Brain Drug Delivery

Prakash   N.   Kendre; Dhiraj   R.   Kayande; Shirish   P.   Jain; Tejaswini   G.   Malge; Namrata   N.   Zadpe; Bhupendra   G.   Prajapati
Abstract

For the treatment of brain illnesses, there is growing interest in nose-to-brain drug administration. Other, more traditional methods of crossing the blood–brain barrier (BBB) are ineffective. As a result, the therapeutic concentration in the brain cannot be achieved, and the reaction is inadequate. Intranasal medication delivery is one intriguing technique for avoiding first-pass metabolism and bypassing the blood-brain barrier. It lowers medicine doses while reducing systemic side effects. Compared to conventional drug delivery platforms, a nanoparticulate drug delivery method allows for greater penetration via the nasal route. It is better to make the nanoparticles for nose-to-brain administration when a good carrier (polymers) is used. This review focuses on the many processes for creating polymeric nanoparticles, strategies and tactics for improving nose-tobrain drug delivery efficiency, and nanoparticle characterization. The use of the nose-to-brain drug delivery platform is being explored using a variety of nanoparticles created by researchers for the treatment of brain illnesses.
Keywords: Polymeric nanoparticles, synthesis, blood-brain-barrier, brain diseases, techniques, drug delivery.
Graphical Abstract

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Cite As
Current Nanoscience

Polymeric Nanoparticles: Prospective on the Synthesis, Characterization and Applications in Nose-to-Brain Drug Delivery

Abstract

Graphical Abstract
