Abstract

Recent advances in electrospinning have transformed the process of fabricating ultrafine nano-fiber scaffolds with side benefits to drug delivery systems and delivery systems in general. The extremely thin quality of electrospun nanofiber scaffolds, along with an effective area of high specificity and a stereological porous structure, capacitates them for the delivery of biomolecules, genes, and drugs. Accordingly, the present study gives a close preface on certain approaches to incorporating drugs and biomolecules into an electrospun nanofiber scaffold, including blending, surface engineering and modification, coaxial electrospinning and emulsion-based systems. The study further elaborates on certain biomedical applications of nanofibers as drug delivery systems, with case examples of Transdermal systems/ antibacterial agents/ wound dressing, cancer treatment, scaffolds for Growth Factor delivery and carriers for stem cell delivery systems.

Keywords: Drug delivery system, electrospun nanofibers, electrospinning, growth factor (GF), stem cell (SC), wound healing.