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Letters in Organic Chemistry

Author(s): Fengtian Wu*, Fangming Yan, Rong Zeng, Yijia Sun, Xiuping Liu, Caihong Zhang, Yenan Chen, Ling Wu* and Chunna Cui*

DOI: 10.2174/1570178619666220928152249

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The Synthesis of Amides from Benzoic Acids and Dicarbodiimides Under Catalyst-Free Conditions

Page: [221 - 229] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Amides are a critical class of widely distributed heterocycles in nature. The preparation of amides from benzoic acids and dicarbodiimides under catalyst-free conditions was reported. Various products were obtained in good to high yields. The model reaction could be scaled up to the gramscale level. A reaction mechanism was proposed based on control experiments and relevant literatures.

Keywords: Amides, benzoic acid, dicarbodiimide, catalyst-free conditions, reaction mechanism

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