Generic placeholder image

Current Alzheimer Research

Author(s): Toba Kazemi, Mitra Moodi, Shahnaz Rajabi, Farshad Sharifi, Saeed Samarghandian, Masoumeh Khorashadizadeh and Tahereh Farkhondeh*

DOI: 10.2174/1567205019666220913114154

DownloadDownload PDF Flyer Cite As
Trace Element Concentration and Cognitive Dysfunction in Elderly Residents in Birjand

Page: [674 - 680] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Background: Trace elements were suggested to have a main role in modulating cognitive function. However, there are several controversial findings regarding the association between serum trace element concentration and cognitive function in patients with cognitive disorders.

Methods: Thus, this study aimed to evaluate the changes in serum trace element concentrations in elderly with cognitive dysfunction versus the participants with normal cognitive function. This crosssectional study included 191 older adults over 60 years from Birjand County, Iran. Participants were assessed for cognitive performance and serum trace elements concentration, including aluminum (AL), cobalt (Co), cadmium (Cd), Chrome (Cr), copper (Cu), Iron (Fe), magnesium (Mg), manganese (Mn), selenium (Se) and zinc (Zn). Our findings showed no significant difference in the serum concentration of AL, Co, Cr, Zn, Fe, Mg, Mn, and Se of elderly with cognitive dysfunction versus the subjects with normal cognitive function.

Results: However, the concentration of Cu significantly increased in the serum of the elderly with cognitive dysfunction versus participants with normal function. In conclusion, our study indicated an increase in the serum concentration of Cu in the elderly with cognitive dysfunction in the sample of the Birjand Longitudinal Aging Study.

Conclusion: However, due to the main limitations of our study, including low sample size and crosssection design, these findings should be interpreted with caution.

Keywords: cognition, dementia, cognitive dysfunction, trace element, elderly

[1]
Réus GZ, Titus SE, Abelaira HM, et al. Neurochemical correlation between major depressive disorder and neurodegenerative diseases. Life Sci 2016; 158: 121-9.
[http://dx.doi.org/10.1016/j.lfs.2016.06.027] [PMID: 27370938]
[2]
Di Benedetto S, Müller L, Wenger E, Düzel S, Pawelec G. Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neurosci Biobehav Rev 2017; 75: 114-28.
[http://dx.doi.org/10.1016/j.neubiorev.2017.01.044] [PMID: 28161508]
[3]
Bell RD, Zlokovic BV. Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease. Acta Neuropathol 2009; 118(1): 103-13.
[http://dx.doi.org/10.1007/s00401-009-0522-3] [PMID: 19319544]
[4]
Wang J, Song Y, Chen Z, Leng SX. Connection between systemic inflammation and neuroinflammation underlies neuroprotective mechanism of several phytochemicals in neurodegenerative diseases. Oxid Med Cell Longev 2018; 2018: 1972714.
[http://dx.doi.org/10.1155/2018/1972714]
[5]
Smorgon C, Mari E, Atti AR, et al. Trace elements and cognitive impairment: An elderly cohort study. Arch Gerontol Geriatr 2004; 38(9): 393-402.
[http://dx.doi.org/10.1016/j.archger.2004.04.050] [PMID: 15207438]
[6]
Ott M, Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria, oxidative stress and cell death. Apoptosis 2007; 12(5): 913-22.
[http://dx.doi.org/10.1007/s10495-007-0756-2] [PMID: 17453160]
[7]
Mattson MP. Calcium and neurodegeneration. Aging Cell 2007; 6(3): 337-50.
[http://dx.doi.org/10.1111/j.1474-9726.2007.00275.x] [PMID: 17328689]
[8]
Bowling AC, Beal MF. Bioenergetic and oxidative stress in neurodegenerative diseases. Life Sci 1995; 56(14): 1151-71.
[http://dx.doi.org/10.1016/0024-3205(95)00055-B] [PMID: 7475893]
[9]
Bourre J-M. Effects of nutrients (in food) on the structure and function of the nervous system: Update on dietary requirements for brain. Part 1: Micronutrients. J Nutr Health Aging 2006; 10(5): 377-85.
[PMID: 17066209]
[10]
Moodi M, Firoozabadi MD, Kazemi T, et al. Birjand longitudinal aging study (BLAS): The objectives, study protocol and design (wave I: Baseline data gathering). J Diabetes Metab Disord 2020; 19(1): 551-9.
[http://dx.doi.org/10.1007/s40200-020-00504-5] [PMID: 32550207]
[11]
Squitti R, Simonelli I, Ventriglia M, et al. Meta-analysis of serum non-ceruloplasmin copper in Alzheimer’s disease. J Alzheimers Dis 2013; 38(4): 809-22.
[http://dx.doi.org/10.3233/JAD-131247] [PMID: 24072069]
[12]
Li DD, Zhang W, Wang ZY, Zhao P. Serum copper, zinc, and iron levels in patients with Alzheimer’s disease: A meta-analysis of case-control studies. Front Aging Neurosci 2017; 9: 300.
[http://dx.doi.org/10.3389/fnagi.2017.00300] [PMID: 28966592]
[13]
Ventriglia M, Bucossi S, Panetta V, Squitti R. Copper in Alzheimer’s disease: A meta-analysis of serum, plasma, and cerebrospinal fluid studies. J Alzheimers Dis 2012; 30(4): 981-4.
[http://dx.doi.org/10.3233/JAD-2012-120244] [PMID: 22475798]
[14]
Loef M, Walach H. Copper and iron in Alzheimer’s disease: A systematic review and its dietary implications. Br J Nutr 2012; 107(1): 7-19.
[http://dx.doi.org/10.1017/S000711451100376X] [PMID: 21767446]
[15]
Gao S, Jin Y, Unverzagt FW, et al. Trace element levels and cognitive function in rural elderly Chinese. J Gerontol A Biol Sci Med Sci 2008; 63(6): 635-41.
[http://dx.doi.org/10.1093/gerona/63.6.635] [PMID: 18559640]
[16]
Huang X, Cuajungco MP, Atwood CS, et al. Cu(II) potentiation of Alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 1999; 274(52): 37111-6.
[http://dx.doi.org/10.1074/jbc.274.52.37111] [PMID: 10601271]
[17]
Shen XL, Yu JH, Zhang DF, Xie JX, Jiang H. Positive relationship between mortality from Alzheimer’s disease and soil metal concentration in mainland China. J Alzheimers Dis 2014; 42(3): 893-900.
[http://dx.doi.org/10.3233/JAD-140153] [PMID: 25024310]
[18]
Jean H, Emard JF, Thouez JP, et al. Alzheimer’s disease: Preliminary study of spatial distribution at birth place. Soc Sci Med 1996; 42(6): 871-8.
[http://dx.doi.org/10.1016/0277-9536(95)00185-9] [PMID: 8778999]
[19]
Martyn CN, Coggon DN, Inskip H, Lacey RF, Young WF. Aluminum concentrations in drinking water and risk of Alzheimer’s disease. Epidemiology 1997; 8(3): 281-6.
[http://dx.doi.org/10.1097/00001648-199705000-00009] [PMID: 9115023]
[20]
Forster DP, Newens AJ, Kay DW, Edwardson JA. Risk factors in clinically diagnosed presenile dementia of the Alzheimer type: A case-control study in northern England. J Epidemiol Community Health 1995; 49(3): 253-8.
[http://dx.doi.org/10.1136/jech.49.3.253] [PMID: 7629459]
[21]
Dartigues JF, Gagnon M, Michel P, et al. The Paquid research program on the epidemiology of dementia. Methods and initial results. Rev Neurol (Paris) 1991; 147(3): 225-30.
[PMID: 2063070]
[22]
Rondeau V, Jacqmin-Gadda H, Commenges D, Helmer C, Dartigues JF. Aluminum and silica in drinking water and the risk of Alzheimer’s disease or cognitive decline: Findings from 15-year follow-up of the PAQUID cohort. Am J Epidemiol 2008; 169(4): 489-96.
[http://dx.doi.org/10.1093/aje/kwn348] [PMID: 19064650]
[23]
Gu L, Yu J, Fan Y, et al. The association between trace elements exposure and the cognition in the elderly in China. Biol Trace Elem Res 2021; 199(2): 403-12.
[http://dx.doi.org/10.1007/s12011-020-02154-3] [PMID: 32323131]
[24]
Socha K, Klimiuk K, Naliwajko SK, et al. Dietary habits, selenium, copper, zinc and total antioxidant status in serum in relation to cognitive functions of patients with Alzheimer’s disease. Nutrients 2021; 13(2): 287.
[http://dx.doi.org/10.3390/nu13020287] [PMID: 33498452]
[25]
Ji X, Cui N, Liu J. Neurocognitive function is associated with serum iron status in early adolescents. Biol Res Nurs 2017; 19(3): 269-77.
[http://dx.doi.org/10.1177/1099800417690828] [PMID: 28196427]
[26]
Horning KJ, Caito SW, Tipps KG, Bowman AB, Aschner M. Manganese is essential for neuronal health. Annu Rev Nutr 2015; 35(1): 71-108.
[http://dx.doi.org/10.1146/annurev-nutr-071714-034419] [PMID: 25974698]