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New Emirates Medical Journal

Author(s): Nahla Kharraz, Hebah Al Jaghoub, Hamzeh Alsubbah, Dhanya Mohan*, Fakhriya Alalawi and Amna Alhadari

DOI: 10.2174/03666220909092340

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Baclofen-induced Encephalopathy in Patients with End-stage Kidney Disease – A Case Series

Article ID: e090922208698 Pages: 4

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Abstract

Introduction/Background: Baclofen is a centrally acting GABA B receptor agonist, widely used for the treatment of neurological diseases ranging from hiccups to multiple sclerosis. As the drug is renally excreted, intoxication can rapidly develop in those patients with a reduced glomerular filtration rate. A strong index of clinical suspicion is essential to correctly diagnose the condition.

Case Presentation: We report a case series of patients with advanced kidney disease and baclofen-induced encephalopathy that settled with discontinuation of the drug and hemodialysis sessions.

Conclusion: We report this cluster of patients with baclofen toxicity to highlight the common occurrence of neurotoxicity after its use in patients with end-stage renal disease and its resolution after cessation of the drug and hemodialysis sessions.

Keywords: Baclofen, Encephalopathy, Hemodialysis, ESKD, Kidney Disease, Neurotoxicity.

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