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Current Topics in Medicinal Chemistry

Author(s): Ana Ediléia Barbosa Pereira Leal, Érica Martins de Lavor, Jackson de Menezes Barbosa, Maria Taís de Moura Fontes Araújo, Cristiane dos Santos Cerqueira Alves, Raimundo Gonçalves de Oliveira Júnior, Ádley Antonini Neves de Lima and Jackson Roberto Guedes da Silva Almeida*

DOI: 10.2174/1568026622666220819160923

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Pharmacological Activities of the Genus Passiflora (Passifloraceae): A Patent Review

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Abstract

Background: Passiflora L. is a genus belonging to the Passifloraceae family, with many species widely used in folk medicine and several pharmacological activities described in the scientific literature, being a major target for the development of new therapeutic products. Studies have identified several bioactive compounds in their composition as responsible for these activities, mainly C-glycoside flavonoids.

Objective: The aim of this study was to carry out a review of patents related to the genus and its application in several pharmacological activities, important for the development of new drugs and formulations.

Methods: The search was carried out in 5 specialized databases, INPI, EPO, WIPO, Latipat and Derwent, using the term ‘Passiflora’ combined with ‘A61K and A61P', subclasses of section A of the International Patent Classification (IPC), which are destined to medical, dental or hygienic purposes, and therapeutic activity of chemical compounds or medicinal preparation, respectively.

Results: 1,198 patents citing the genus in the title or abstract have been found, 508 being duplicates. After exclusion and inclusion criteria, 23 patents written in English, Portuguese and Spanish were selected, which demonstrated biological assays in vivo with species of Passiflora as the only active constituent or incorporated in formulations with other compounds.

Conclusion: The findings of this search showed growing interest in research and industrial areas in the pharmaceutical development with species of Passiflora, suggesting that the different bioactive compounds present in the genus can be considered as an important tool for the development of new effective and safe products with pharmacological potential.

Keywords: Bioactive compounds, C-glycoside flavonoids, Medicinal plants, Passiflora, Patents, Pharmacological activity.

Graphical Abstract

[1]
Devanesan, A.A.; Zipora, T.G.; Smilin, B.A.; Deviram, G.; Thilagar, S. Phytochemical and pharmacological status of indigenous medicinal plant Pedalium murex L.-A review. Biomed. Pharmacother., 2018, 103(8), 1456-1463.
[http://dx.doi.org/10.1016/j.biopha.2018.04.177] [PMID: 29864930]
[2]
Palanichamy, P.; Krishnamoorthy, G.; Kannan, S.; Marudhmuthu, M. Bioactive potential of secondary metabolites derived from medicinal plant endophytes. Egypt. J. Basic Appl. Sci., 2018, 5(4), 303-312.
[http://dx.doi.org/10.1016/j.ejbas.2018.07.002]
[3]
World health organization. Traditional medicines: Global situation, issues and challenges. Available from: http://digicollection.org/hss/en/m/abstract/Js18063en/ (Accessed on: December 15, 2020).
[4]
Dutra, R.C.; Campos, M.M.; Santos, A.R.S.; Calixto, J.B. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives. Pharmacol. Res., 2016, 112, 4-29.
[http://dx.doi.org/10.1016/j.phrs.2016.01.021] [PMID: 26812486]
[5]
Pacheco, G.; Simão, M.J.; Vianna, M.G.; Garcia, R.O.; Vieira, M.L.C.; Mansur, E. In vitro conservation of Passiflora-A review. Sci. Hortic. (Amsterdam), 2016, 211, 305-311.
[http://dx.doi.org/10.1016/j.scienta.2016.09.004]
[6]
Wosch, L.; Imig, D.C.; Cervi, A.C.; Moura, B.B.; Budel, J.M.; Santos, C.A.M. Comparative study of Passiflora taxa leaves: I. A morpho-anatomic profile. Rev. Bras. Farmacogn., 2015, 25(4), 328-343.
[http://dx.doi.org/10.1016/j.bjp.2015.06.004]
[7]
Costa, E.C.S.; Nunes, T.S.; Melo, J.I.M. Flora da Paraíba, Brasil: Passifloraceae sensu stricto. Rodriguésia, 2015, 66(1), 271-284.
[http://dx.doi.org/10.1590/2175-7860201566117]
[8]
Costa, G.M.; Gazola, A.C.; Zucolotto, S.M.; Castellanos, L.; Ramos, F.A.; Reginatto, F.H.; Schenkel, E.P. Chemical profiles of traditional preparations of four South American Passiflora species by chromatographic and capillary electrophoretic techniques. Rev. Bras. Farmacogn., 2016, 26(4), 451-458.
[http://dx.doi.org/10.1016/j.bjp.2016.02.005]
[9]
Dhawan, K.; Dhawan, S.; Sharma, A. Passiflora: A review update. J. Ethnopharmacol., 2004, 94(1), 1-23.
[http://dx.doi.org/10.1016/j.jep.2004.02.023] [PMID: 15261959]
[10]
de Lavor, É.M.; Leal, A.E.B.P.; Fernandes, A.W.C.; Ribeiro, F.P.R.A.; Barbosa, J.M.; Gama, E. Silva, M.; Teles, R.B.A.; Oliveira, L.F.D.S.; Silva, J.C.; Rolim, L.A.; de Menezes, I.R.A.; Almeida, J.R.G.D.S. Ethanolic extract of the aerial parts of Passiflora cincinnata Mast. (Passifloraceae) reduces nociceptive and inflammatory events in mice. Phytomedicine, 2018, 47, 58-68.
[http://dx.doi.org/10.1016/j.phymed.2018.04.052] [PMID: 30166109]
[11]
Elsas, S.M.; Rossi, D.J.; Raber, J.; White, G.; Seeley, C.A.; Gregory, W.L.; Mohr, C.; Pfankuch, T.; Soumyanath, A. Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. Phytomed, 2010, 940-949.
[http://dx.doi.org/10.1016/j.phymed.2010.03.002]
[12]
Chandrasekhar, D.; Pradeep, A.; Geoji, A.S.; Jose, S.M.; Jomy, A.; Joseph, A. Antiglycation property of Passiflora edulis f. flavicarpa deg. Foliage in type 2 diabetic Patients. Clin. Epidemiol. Glob. Health, 2018, 1-13.
[http://dx.doi.org/10.1016/j.cegh.2018.07.002]
[13]
Gazola, A.C.; Costa, G.M.; Zucolotto, S.M.; Castellanos, L.; Ramos, F.A.; de Lima, T.C.M.; Schenkel, E.P. The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway. Biomed. Pharmacother., 2018, 100, 388-393.
[http://dx.doi.org/10.1016/j.biopha.2018.02.002] [PMID: 29454287]
[14]
Siebra, A.L.A.; Oliveira, L.R.; Martins, A.O.B.P.B.; Siebra, D.C.; Albuquerque, R.S.; Lemos, I.C.S.; Delmondes, G.A.; Tintino, S.R.; Figueredo, F.G.; da Costa, J.G.M.; Coutinho, H.D.M.; Menezes, I.R.A.; Felipe, C.F.B.; Kerntopf, M.R. Potentiation of antibiotic activity by Passiflora cincinnata Mast. front of strains Staphylococcus aureus and Escherichia coli. Saudi J. Biol. Sci., 2018, 25(1), 37-43.
[http://dx.doi.org/10.1016/j.sjbs.2016.01.019] [PMID: 29379354]
[15]
Bravo, K.; Duque, L.; Ferreres, F.; Moreno, D.A.; Osorio, E. Passiflora tarminiana fruits reduce UVB-induced photoaging in human skin fibroblasts. J. Photochem. Photobiol. B, 2017, 168, 78-88.
[http://dx.doi.org/10.1016/j.jphotobiol.2017.01.023] [PMID: 28189068]
[16]
Ozarowski, M.; Piasecka, A.; Paszel-Jaworska, A.; Chaves, D.S.A.; Romaniuk, A.; Rybcynska, M.; Gryszczynska, A.; Sawikowska, A.; Kachlicki, P.; Mikolajczak, P.L.; Seremak-Mrozikiewicz, A.; Klejewski, A.; Thiem, B. Comparison of bioactive compounds content in leaf extracts of Passiflora incarnata, P. caerulea and P. alata and in vitro cytotoxic potential on leukemia cell lines. Rev. Bras. Farmacogn., 2018, 28(2), 179-191.
[http://dx.doi.org/10.1016/j.bjp.2018.01.006]
[17]
Figueiredo, D.A.F.; Pordeus, L.C.M.; Paulo, L.L.; Braga, R.M.; Fonsêca, D.V.; Sousa, B.S.; Costa, M.J.C.; Gonçalves, M.C.R.; Oliveira, K. Effects of bark flour of Passiflora edulis on food intake, body weight and behavioral response of rats. Rev. Bras. Farmacogn., 2016, 26(5), 595-600.
[http://dx.doi.org/10.1016/j.bjp.2016.02.010]
[18]
Anzoise, M.L.; Marrassini, C.; Bach, H.; Gorzalczany, S. Beneficial properties of Passiflora caerulea on experimental colitis. J. Ethnopharmacol., 2016, 194, 137-145.
[http://dx.doi.org/10.1016/j.jep.2016.09.002] [PMID: 27596328]
[19]
Wasicky, A.; Hernandes, L.S.; Vetore-Neto, A.; Moreno, P.R.H.; Bacchi, E.M.; Kato, E.T.M.; Yoshida, M. Evaluation of gastroprotective activity of Passiflora alata. Rev. Bras. Farmacogn., 2015, 25(4), 407-412.
[http://dx.doi.org/10.1016/j.bjp.2015.07.011]
[20]
Zeraik, M.L.; Serteyn, D.; Deby-Dupont, G.; Wauters, J.N.; Tits, M.; Yariwake, J.H.; Angenot, L.; Franck, T. Evaluation of the antioxidant activity of passion fruit (Passiflora edulis and Passiflora alata) extracts on stimulated neutrophils and myeloperoxidase activity assays. Food Chem., 2011, 128(2), 259-265.
[http://dx.doi.org/10.1016/j.foodchem.2011.03.001] [PMID: 25212130]
[21]
Teixeira, L.S.; Lima, A.S.; Boleti, A.P.A.; Lima, A.A.N.; Libório, S.T.; de Paula, L.; Oliveira, M.I.B.; Lima, E.F.; Costa, G.M.; Reginatto, F.H.; Lima, E.S. Effects of Passiflora nitida Kunth leaf extract on digestive enzymes and high caloric diet in rats. J. Nat. Med., 2014, 68(2), 316-325.
[http://dx.doi.org/10.1007/s11418-013-0800-1] [PMID: 24078292]
[22]
Corrêa, R.C.G.; Peralta, R.M.; Haminiuk, C.W.I.; Maciel, G.M.; Bracht, A.; Ferreira, I.C.F.R. The past decade findings related with nutritional composition, bioactive molecules and biotechnological applications of Passiflora spp. (Passion fruit). Trends Food Sci. Technol., 2016, 58, 79-95.
[http://dx.doi.org/10.1016/j.tifs.2016.10.006]
[23]
Farid, R.; Rezaieyazdi, Z.; Mirfeizi, Z.; Hatef, M.R.; Mirheidari, M.; Mansouri, H.; Esmaelli, H.; Bentley, G.; Lu, Y.; Foo, Y.; Watson, R.R. Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis. Nutr. Res., 2010, 30(9), 601-606.
[http://dx.doi.org/10.1016/j.nutres.2010.08.010] [PMID: 20934601]
[24]
Ozturk, Z.; Kalayci, C.C. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement. Ther. Med., 2018, 36, 30-32.
[http://dx.doi.org/10.1016/j.ctim.2017.11.008] [PMID: 29458926]
[25]
Rey, D.; Fernandes, T.A.; Sulis, P.M.; Gonçalves, R.; Sepúlveda, R. M.; Silva Frederico, M.J.; Aragon, M.; Ospina, L.F.; Costa, G.M.; Silva, F.R.M.B. Cellular target of isoquercetin from Passiflora ligularis Juss for glucose uptake in rat soleus muscle. Chem. Biol. Interact., 2020, 330(1), 109198.
[http://dx.doi.org/10.1016/j.cbi.2020.109198] [PMID: 32692981]
[26]
Sandupatla, R.; Dongamanti, A.; Koyyati, R. Antimicrobial and antioxidant activities of phytosynthesized Ag, Fe and bimetallic Fe-Ag nanoparticles using Passiflora edulis: A comparative study. Mater. Today Proc., 2021, 44(1), 2665-2673.
[http://dx.doi.org/10.1016/j.matpr.2020.12.679]
[27]
Carlini, E.A. Plants and the central nervous system. Pharmacol. Biochem. Behav., 2003, 75(3), 501-512.
[http://dx.doi.org/10.1016/S0091-3057(03)00112-6] [PMID: 12895668]
[28]
Miyasaka, L.S.; Atallah, A.N.; Soares, B.G.O. Passiflora for anxiety disorder. Cochrane Database Syst. Rev., 2007, 24(1), CD004518.
[http://dx.doi.org/10.1002/14651858] [PMID: 17253512]
[29]
Miroddi, M.; Calapai, G.; Navarra, M.; Minciullo, P.L.; Gangemi, S. Passiflora incarnata L.: Ethnopharmacology, clinical application, safety and evaluation of clinical trials. J. Ethnopharmacol., 2013, 150(3), 791-804.
[http://dx.doi.org/10.1016/j.jep.2013.09.047] [PMID: 24140586]
[30]
Kim, M.; Lim, H.S.; Lee, H.H.; Kim, T.H. Role identification of Passiflora Incarnata Linnaeus: A mini review. J. Menopausal Med., 2017, 23(3), 156-159.
[http://dx.doi.org/10.6118/jmm.2017.23.3.156] [PMID: 29354614]
[31]
Muschner, V.C.; Zamberlan, P.M.; Bonatto, S.L.; Freitas, L.B. Phylogeny, biogeography and divergence times in Passiflora (Passifloraceae). Genet. Mol. Biol., 2012, 35(4)(Suppl.), 1036-1043.
[http://dx.doi.org/10.1590/S1415-47572012000600019] [PMID: 23412994]
[32]
Diniz, T.C.; Pinto, T.C.C.; Menezes, P.D.P.; Silva, J.C.; Teles, R.B.A.; Ximenes, R.C.C.; Guimarães, A.G.; Serafini, M.R.; Araújo, A.A.S.; Quintans Júnior, L.J.; Almeida, J.R.G.D.S. Cyclodextrins improving the physicochemical and pharmacological properties of antidepressant drugs: A patent review. Expert Opin. Ther. Pat., 2018, 28(1), 81-92.
[http://dx.doi.org/10.1080/13543776.2017.1384816] [PMID: 28965471]
[33]
Sau, A.; Bhakta, I. Screening of anxiety and depression among the seafarers using machine learning technology. Inform. Med. Unlocked, 2019, 16, 100149.
[http://dx.doi.org/10.1016/j.imu.2018.12.004]
[34]
Hirschfeld, R.M. The comorbidity of major depression and anxiety disorders: Recognition and management in primary care. Prim. Care Companion J. Clin. Psychiatry, 2001, 3(6), 244-254.
[http://dx.doi.org/10.4088/PCC.v03n0609] [PMID: 15014592]
[35]
Fiebich, B.L.; Knörle, R.; Appel, K.; Kammler, T.; Weiss, G. Pharmacological studies in an herbal drug combination of St. John’s Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): In vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models. Fitoterapia, 2011, 82(3), 474-480.
[http://dx.doi.org/10.1016/j.fitote.2010.12.006] [PMID: 21185920]
[36]
Ayres, A.S.; de Araújo, L.L.S.; Soares, T.C.; Costa, G.M.; Reginatto, F.H.; Ramos, F.A.; Castellanos, L.; Schenkel, E.P.; Soares-Rachetti, V.P.; Zucolotto, S.M.; Gavioli, E.C. Comparative central effects of the aqueous leaf extract of two populations of Passiflora edulis. Rev. Bras. Farmacogn., 2015, 25(5), 499-505.
[http://dx.doi.org/10.1016/j.bjp.2015.06.007]
[37]
Li, H.; Zhou, P.; Yang, Q.; Shen, Y.; Deng, J.; Li, L.; Zhao, D. Comparative studies on anxiolytic activities and flavonoid compositions of Passiflora edulis ‘edulis’ and Passiflora edulis ‘flavicarpa’. J. Ethnopharmacol., 2011, 133(3), 1085-1090.
[http://dx.doi.org/10.1016/j.jep.2010.11.039] [PMID: 21111038]
[38]
Mickymaray, S.; Aboody, M.S.S.; Rath, P.K.; Annamalai, P.; Nooruddin, T. Screening and antibacterial efficacy of selected Indian medicinal plants. Asian Pac. J. Trop. Biomed., 2016, 6(3), 185-191.
[http://dx.doi.org/10.1016/j.apjtb.2015.12.005]
[39]
Veras, H.N.C.; Rodrigues, F.F.G.; Botelho, M.A.; Menezes, I.R.A.; Coutinho, H.D.M.; Costa, J.G.M. Enhancement of aminoglycosides and β-lactams antibiotic activity by essential oil of Lippia sidoides Cham. and the Thymol. Arab. J. Chem., 2017, 10, S2790-S2795.
[http://dx.doi.org/10.1016/j.arabjc.2013.10.030]
[40]
Siebra, A.L.A.; Lemos, I.C.S.; Delmondes, G.A.; Oliveira, L.R.; Martins, A.O.B.P.B.; Siebra, D.C.; Coutinho, H.; Albuquerque, R.S.; Leite, N.F.; Costa, J.G.M.; Menezes, I.R.A.; Kerntopf, R. Antimicrobial activity and phytochemical characterization of hydroalcoholic extracts of Passiflora cincinnata Mast. (maracujá-do-mato). Rev. Cuba. Plantas Med., 2014, 19(4), 319-328.
[41]
Saravanan, S.; Parimelazhagan, T. In vitro antioxidant, antimicrobial and anti-diabetic properties of polyphenols of Passiflora ligularis Juss. fruit pulp. Food Sci. Hum. Wellness, 2014, 3(2), 56-64.
[http://dx.doi.org/10.1016/j.fshw.2014.05.001]
[42]
Florentino, I.F.; Silva, D.P.B.; Galdino, P.M.; Lino, R.C.; Martins, J.L.R.; Silva, D.M.; de Paula, J.R.; Tresvenzol, L.M.F.; Costa, E.A. Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice. J. Ethnopharmacol., 2016, 186, 298-304.
[http://dx.doi.org/10.1016/j.jep.2016.04.010] [PMID: 27079223]
[43]
Onoja, S.O.; Ezeja, M.I.; Omeh, Y.N.; Onwukwe, B.C. Antioxidant, anti-inflammatory and antinociceptive activities of methanolic extract of Justicia secunda Vahl leaf. Alex. J. Med., 2017, 53(3), 207-213.
[http://dx.doi.org/10.1016/j.ajme.2016.06.001]
[44]
Montanher, A.B.; Zucolotto, S.M.; Schenkel, E.P.; Fröde, T.S. Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model. J. Ethnopharmacol., 2007, 109(2), 281-288.
[http://dx.doi.org/10.1016/j.jep.2006.07.031] [PMID: 16949230]
[45]
Sasikala, V.; Saravanan, S.; Parimelazhagan, T. Analgesic and anti-inflammatory activities of Passiflora foetida L. Asian Pac. J. Trop. Med., 2011, 4(8), 600-603.
[http://dx.doi.org/10.1016/S1995-7645(11)60155-7] [PMID: 21914535]
[46]
Quadan, F. Composition comprising Raphanus, Theobroma and Passiflora for treating opioid and alcohol abuse. US Patent US20150320815A1,
[47]
Bech, S.F. Natural composition. DK Patent WO02066041A1, 2002.
[48]
Jamerson, B.D.; Breivogel, C.S. Treatment of withdrawal symptoms to aid in nicotine use cessation with Passiflora incarnata. US Patent US2016271194A1, 2016.
[49]
Golz-Berner, K.; Zastrow, L.; Doucet, O. Producto cosmético antiarrugas. US Patent US20070134189, 2007.
[50]
Smith, W.P. Methods and compositions for reducing the appearance of dynamic facial wrinkles. US Patent US2009104174A1, 2009.
[51]
Pianowski, L.F. Processo para preparação de um produto à base de Passiflora incarnata L., produto farmacêutico, composição farmacêutica, usos e método de tratamento de ansiedade e insônia. BR. Patent BRPI0602106A, 2007.
[52]
Farrington, D.; Farrington, T. A homeopathic complex. IE Patent WO2009047004A1, 2009.
[53]
Yusubov, N. A novel combination containing passiflora, glycine, metylfolate and magnesium threonate and production method thereof. TR Patent WO2020162859, 2020.
[54]
Harvey, C.G. Orchid essence containing for treatment of stress. GB Patent GB2381195-A, 2003.
[55]
Carneiro, R.S.; Morais, V.S. Modified-release composition for readjusting the human biological clock and use of a modifiedrelease composition for readjusting the human biological clock. BR Patent WO2018132886-A1, 2018.
[56]
Hatipoglu, B.; Margrave, R. Herbal-based compositions for alleviating symptoms associated with autism. US Patent, US2011268717-A1, 2011.
[57]
Lorente, R.R.; Fernandez, O.S.L.; Sánches, G.M.; Jure, M.M. Pharmaceutical composition based on plant extracts for the treatment and/or prevention of migraines. CU Patent WO2007048356A1, 2007.
[58]
Gesztesi, J.L.; Moreira, P.L.; Lorencini, M.; Manfio, G.P.; Delarcina, S.J.; Esteves, S.S.; Calixto, J.B.; Ferrari, C.R.; Braz, T.; Romanhole, R.C.; De Oliveira, A.P.P.; Oliveira, E.C.; Medina, S.P.H. Processo para a preparação de um extrato de planta Passiflora alata e uso no dito extrato em composições cosméticas e farmacêuticas. BR Patent BRPI0816292, 2015.
[59]
Gonen, S. Methods and compositions for treating hair and skin afflictions. US Patent US2007116664A1, 2007.
[60]
Foo, L.Y.; Lu, Y.; Watson, R. Extracts of passion fruit and uses thereof. NZ Patent WO2005097153A2, 2005.
[61]
Almeida, J.R.G.S.; Lima, J.T.; Leal, A.E.B.P.; Rolim, L.A.; Queiroz, M.A.A.; Lima, R.S.; Lavôr, E.M.; Santos, R.F.; Oliveira, A.P.; Oliveira-Júnior, R.G.; Ribeiro, F.P.R.A.; Teles, R.B.; Barbosa, J.M. Extrato e farinha da casca do fruto de Passiflora cincinnata Mast. (Passifloraceae) para uso como agente hipolipemiante. BR Patent BR102017027632A2, 2019.
[62]
Bortolin, R.H.; Rezende, A.A.; Cabral, B.; Langassner, S.M.Z. Composições farmacêuticas contendo insumo ativo do pericarpo de Passiflora edulis forma flavicarpa Degener. BR Patent BR1020190185104, 2021.
[63]
Healy, C.J. Compositions and methods for the prophylaxis or treatment of a condition associated with alcohol consumption. AU Patent WO2019140479A1, 2019.
[64]
Leclere-Bienfaint, S.; Bredif, S. Passionflower seed extract, and cosmetic, pharmaceutic or dermatological compositions containing same. FR Patent US2019000902A1, 2017.
[65]
Shin, Y.S.; Kim, G.H.; Lim, K.H. A composition for improving, preventing and treating of cognitive and failure of one’s memory comprising Passiflora incarnata L. extract. KR Patent KR1020200001977, 2020.
[66]
Foo, L.Y.; Lu, Y.; Watson, R. Method of treating inflammation disorders using extracts of passion fruit. NZ Patent NZ554762, 2008.
[67]
Aubert, L.; Anthoine, P. Vegetable extract-based cosmetic or pharmaceutic composition wich acts on capillary brittleness. FR Patent US4942033, 1990.
[68]
Hegenauer, J.C.; Yamaguchi, H.; Chan, W.W.Y.; Bagwell, E.L.; Latham, C.; Avila, J.M. Compositions, methods, and kits publication classification for weight loss and inhibiting the loss of lean body mass. US Patent US2004166181, 2004.
[69]
Leite, M.F.; Carvalho, L.S.; Garcia, L.B. Formulações de uso tópico para fotoproteção contendo Passiflora cincinnata. BR Patent BR102015032464-A2, 2017.
[70]
Bacchi, E.M.; Chacra, N.A.B.; Salazar, P.M.N. Nanopartícula. BR Patent BR102012021728-A2, 2014.
[71]
Msika, P.; Lecleire-Bienfait, S.; Bredif, S.; Sébastien, G. Extracto de semillas de Pasiflora y composiciones cosméticas, farmacéuticas, dermatológicas o nutracéuticas que lo comprenden. FR Patent ES2665313-T3, 2018.
[72]
Figueiredo, P.M.S.; Costa, N.C.; Alencar, P.M.F.A.; Mota, R.D.; Monteiro, S.G. Produção de antibiótico a partir do extrato de Passiflora Edulis Sims e seu uso. BR Patent BR102015002897-A2, 2016.
[73]
Matsui, Y.; Kamei, M.; Sugiyama, K. Composición que contiene piceatannol y procedimiento para producir la composición que contiene piceatannol. JP Patent ES2545975-T3, 2015.
[74]
Leclere-Bienfait, S.; Bredif, S.; Debrock, S.; Garnier, S. Lipid extract from Passiflora seeds. FR. Patent US2016235794-A2, 2016.
[75]
Yamauchi, R.H. Cápsulas com aromatizante para diminuição da absorção de lipídes e carbohidratos. BR Patent BRPI0800705-A2, 2011.
[76]
Leclere, J. Asociación de extractos de pasionaria y de anchusa utilizable en cosmetica. FR Patent ES2608714-T3, 2017.
[77]
Echeverry, S.M.; Medina, H.I.; Costa, G.M.; Aragón, D.M. Optimization of flavonoid extraction from Passiflora quadrangularis leaves with sedative activity and evaluation of its stability under stress conditions. Rev. Bras. Farmacogn., 2018, 28(5), 610-617.
[http://dx.doi.org/10.1016/j.bjp.2018.06.005]
[78]
Araujo, M.H.; da Silva, I.C.V.; de Oliveira, P.F.; Barreto, A.R.R.; Konno, T.U.P.; Esteves, F.A.; Barth, T.; Aguiar, F.A.; Lopes, N.P.; Demenjian, R.K.; Guimarães, D.O.; Leal, I.C.R.; Lasunskaia, E.B.; Muzitano, M.F. Biological activities and phytochemical profile of Passiflora mucronata from the Brazilian restinga. Rev. Bras. Farmacogn., 2017, 27(6), 702-710.
[http://dx.doi.org/10.1016/j.bjp.2017.07.005]
[79]
Ribeiro, T.H.S.; Bolanho, B.C.; Montanuci, F.D.; Ruiz, S.P. Physicochemical and sensory characterization of gluten-free fresh pasta with addition of passion fruit peel flour. Cienc. Rural, 2018, 48(12), 1-9.
[http://dx.doi.org/10.1590/0103-8478cr20180508]
[80]
Oliveira, C.F.; Gurak, P.D.; Cladera-Oliveira, F.; Marczak, L.D.F. Evaluation of physicochemical, technological and morphological characteristics of powdered yellow passion fruit peel. Int. Food Res. J., 2016, 23(4), 1653-1662.
[81]
Patel, K.; Patel, D.K. Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report. J. Tradit. Complement. Med., 2016, 7(3), 360-366.
[http://dx.doi.org/10.1016/j.jtcme.2016.11.003] [PMID: 28725632]
[82]
Leal, A.E.B.P.; Oliveira-Júnior, R.G.; Oliveira, A.P.; Almeida, J.R.G.S.; Lima, J.T. Atividade ansiolítica e sedativa de espécies do gênero Passiflora – um mapeamento científico e tecnológico. Cad. Prospec., 2016, 9(3), 323-336.
[http://dx.doi.org/10.9771/cp.v9i3.16424]