Pharmaceutical Potential of Constituents from Azadirachta indica and
their Specific Role as Anti-cancer Agents

Ishtiaq      Jeelani; Mrinalini      Bhosale; Tanzeela      Qadir; Praveen   Kumar   Sharma; Allah      Nawaz; Aamir      Sharif; Andleeb      Amin; Alisha      Sheikh; Saeed      Ahmad; Vinita      Kukreja; Snehal      Kulkarni; Subhash      Padhye
Abstract

Neem (Azadirachta indica), a Meliaceae family member, is a rapidly growing tropical evergreen tree with a thick, branching trunk. It has been used for hundreds of years in traditional Indian medicine as a home cure against numerous human illnesses in the Indian and African continents. Different components of the plant, including the flowers, leaves, seeds, and bark, have been used to treat both acute and chronic human illnesses, as well as an insecticide, antibiotic, larvicidal, antimalarial, antibacterial, antiviral, and spermicidal. The plant's anticancer qualities have been extensively researched in terms of its preventative, protective, tumor-suppressive, immunomodulatory, and apoptotic actions against different cancers and their molecular processes. Triple-negative breast cancer (TNBC), which lacks the expression of progesterone and estrogen receptors, has a dismal prognosis and no viable therapeutic options. Gedunin compound isolated from Azadirachta indica's seed oil shows potential anticancer effect against triple-negative breast cancer (TNBC) cancer cells, which acts as heat shock protein 90 (Hsp90) inhibitor.
Keywords: : Neem, India, tree, Azadirachta indica, TNBC, anticancer.
Graphical Abstract

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Cite As
Current Bioactive Compounds

Pharmaceutical Potential of Constituents from Azadirachta indica and their Specific Role as Anti-cancer Agents

Abstract

Graphical Abstract
