Current Trends, Advances, and Challenges of Tissue Engineering-Based
Approaches of Tooth Regeneration: A Review of the Literature

Parham      Hazrati; Mohammad   Hassan   Mirtaleb; Helia   Sadat Haeri   Boroojeni; Amir   Ali Yousefi   Koma; Hanieh      Nokhbatolfoghahaei
Abstract

Introduction: Tooth loss is a significant health issue. Currently, this situation is often treated with the use of synthetic materials such as implants and prostheses. However, these treatment modalities do not fully meet patients' biological and mechanical needs and have limited longevity. Regenerative medicine focuses on the restoration of patients' natural tissues via tissue engineering techniques instead of rehabilitating with artificial appliances. Therefore, a tissue-engineered tooth regeneration strategy seems like a promising option to treat tooth loss.
Objective: This review aims to demonstrate recent advances in tooth regeneration strategies and discoveries about underlying mechanisms and pathways of tooth formation.
Results and Discussion: Whole tooth regeneration, tooth root formation, and dentin-pulp organoid generation have been achieved by using different seed cells and various materials for scaffold production. Bioactive agents are critical elements for the induction of cells into odontoblast or ameloblast lineage. Some substantial pathways enrolled in tooth development have been figured out, helping researchers design their experiments more effectively and aligned with the natural process of tooth formation.
Conclusion: According to current knowledge, tooth regeneration is possible in case of proper selection of stem cells, appropriate design and manufacturing of a biocompatible scaffold, and meticulous application of bioactive agents for odontogenic induction. Understanding innate odontogenesis pathways play a crucial role in accurately planning regenerative therapeutic interventions in order to reproduce teeth.
Keywords: Tooth regeneration, stem cell, scaffold, tissue engineering, regenerative therapy, odontogenesis.
Graphical Abstract

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Cite As
Current Stem Cell Research & Therapy

Current Trends, Advances, and Challenges of Tissue Engineering-Based Approaches of Tooth Regeneration: A Review of the Literature

Abstract

Graphical Abstract
