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Letters in Organic Chemistry

Author(s): Gülay Akyüz* and Emre Menteşe

DOI: 10.2174/1570178619666220816121312

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Synthesis and Characterization of New Bistriazole Quinazolinediones and their Urease Inhibition Activities

Page: [258 - 264] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

A new series of bisthiosemicarbazide and bistriazole molecules bridged quinazolinedione was synthesized and characterized by FT-IR, 1H and 13C-NMR spectral data. Antiurease activities of all new compounds were tested according to the phenol-hypochlorite method by Weatherburn. All compounds have effective urease inhibition activities compared to the standard inhibitor thiourea and previously synthesized quinazolinones as potential inhibitors. Bistriazoles containing quinazolinedione have the best inhibition results. 1,3-Bis[(4-ethyl-5-mercapto-4H-1,2,4-triazol-3-yl)methyl]quinazoline- 2,4(1H,3H)-dione (5b) has the best inhibitory activity with 1.25 ± 0.45 μg/mL IC50 value.

Keywords: Quinazolinedione, bisthiosemicarbazide, bistriazole, antiurease, Weatherburn

Graphical Abstract

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