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The Natural Products Journal

Author(s): Vanktesh Kumar*, Navjot Kaur, Arvinder Kaur and Pankaj Wadhwa

DOI: 10.2174/2210315512666220811153919

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Phytochemistry and Pharmacology of Indian Traditional Plant Hyssop (Hyssopus officinalis L.): A Review

Article ID: e110822207418 Pages: 31

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Abstract

Hyssopus officinalis is a traditional medicinal plant that belongs to the family Lamiaceae, which has been used for centuries for various purposes like carminative, expectorant, and cough reliever. It has been used for the treatment of numerous diseases in patients such as ulcers, asthma, jaundice, leprosy, dropsy, bronchitis, COPD, diabetes, AIDS, bacterial and fungal infections as an herbal remedy due to its fewer side effects and is more efficacies than other traditional medicine. Major classes of chemical compounds found in H. officinalis essential oil are bicyclic monoterpenes, monoterpenoids, acyclic monoterpenes, phenolic monoterpenoids, monocyclic monoterpenes, monocyclic sesquiterpenes, tricyclic sesquiterpenes, bicyclic sesquiterpenes, tricyclic sesquiterpenoids, straight chain saturated hydrocarbons. Some of the major chemical constituents present in the H. officinalis are β-pinene, α-pinene, 1, 8-cineole, apigenin, diosmin, caffeic acid, rosmarinic acid, cis-pinocamphone, trans-pinocamphone, iso-pinocamphone, pinocarvone, which are responsible for its various pharmacological activity. Various studies have been performed on the pharmacological activity of its extract, such as antioxidant, antimicrobial, anti-diabetic, anticancer, antiviral, antiinflammatory, analgesic, anti-leishmanial, anthelmintic, anti-protozoal, and anti-anxiety. Recently, it is used as an anticancer agent and has been demonstrated by studying its cytotoxic and apoptotic effects on breast cancer and colon cancer cells. It is used as a potent antibacterial and antifungal agent being studied on the antibiotic-resistant bacterial and fungal strains recently, which can be further useful in developing herbal medicine against AMR. It is an excellent natural antioxidant due to the presence of polyphenolic compounds, and H. officinalis is used in various food industries as a source of natural antioxidants, which has minimum side effects as compared to artificial antioxidants. Furthermore, the pharmacological activity of these individual chemical constituents in H. officinalis extract still needs to be investigated for identifying the effectiveness of this plant in the natural treatment of various diseases. This review aims to collect various data regarding the traditional herbal plant hyssop (Hyssopus officinalis), including its photochemistry, chemical structures of the phyto-constituents and pharmacological profile, along with all the pharmacological models. This plant has significant importance in the health industry, so further studies are required on its effective usage against various emerging health problems, including COVID-19, cancer, diabetes, AMR.

Keywords: Hyssopus officinalis, Anti-Anxiety, Anti-fungal, Anti-microbial, Anti-diabetic, Phytochemistry

Graphical Abstract

[1]
Samal, J. Medicinal plants and related developments in India: A peep into 5-year plans of India. Indian J. Health Sci. Biomed. Res., 2016, 9(1), 14.
[http://dx.doi.org/10.4103/2349-5006.183698]
[2]
Ravishankar, B.; Shukla, V.J. Indian systems of medicine: A brief profile. Afr. J. Tradit. Complement. Altern. Med., 2007, 4(3), 319-337.
[http://dx.doi.org/10.4314/ajtcam.v4i3.31226] [PMID: 20161896]
[3]
Tripathi, Y.C.; Prabhu, V.V.; Pal, R.S.; Mishra, R.N. Medicinal plants of Rajasthan in Indian system of medicine. Anc. Sci. Life, 1996, 15(3), 190-212.
[PMID: 22556743]
[4]
Weisany, W.; Rahimzadeh, S.; Sohrabi, Y. Effect of biofertilizers on morphological, physiological characteristic and essential oil content in basil (Ocimumbasilicum L.). Tahqiqat-i Giyahan-i Daruyi va Muattar-i Iran, 2012, 28(1), 73-87.
[5]
AghaAlikhani, M.; Iranpour, A.; Naghdi Badi, H. Changes in agronomical and phytochemical yield of purple coneflower (Echinaceae purpurea (L.) Moench) under urea and three biofertilizers application. Faslnamah-i Giyahan-i Daruyi, 2013, 2(46), 121-136.
[6]
Bakkali, F.; Averbeck, S.; Averbeck, D.; Idaomar, M. Biological effects of essential oils-a review. Food Chem. Toxicol., 2008, 46(2), 446-475.
[http://dx.doi.org/10.1016/j.fct.2007.09.106] [PMID: 17996351]
[7]
Carović-StanKo, K.; Pete, K.M.; Martina, G.; Pintar, J.; Bedeković, D.; Ćustić, M.H.; Šatović, Z. Medicinal plants of the family Lamiaceaeas functional foods-A review. Czech J. Food Sci., 2016, 34(5), 377-390.
[http://dx.doi.org/10.17221/504/2015-CJFS]
[8]
Fathiazad, F.; Mazandarani, M.; Hamedeyazdan, S. Phytochemical analysis and antioxidant activity of Hyssopus officinalis L. from Iran. Adv. Pharm. Bull., 2011, 1(2), 63-67.
[PMID: 24312758]
[9]
Venditti, A.; Bianco, A.; Frezza, C.; Conti, F.; Bini, L.M.; Giuliani, C.; Bramucci, M.; Quassinti, L.; Damiano, S.; Lupidi, G.; Beghelli, D.; Caterbi, S.; Petrelli, D.; Vitali, L.A.; Papa, F.; Caprioli, G.; Maggi, F. Essential oil composition, polar compounds, glandular trichomes and biological activity of Hyssopus officinalis subsp. aristatus (Godr.) Nyman from central Italy. Ind. Crops Prod., 2015, 77, 353-363.
[http://dx.doi.org/10.1016/j.indcrop.2015.09.002]
[10]
Pandey, V.; Verma, R.S.; Chauhan, A.; Tiwari, R. Compositional variation in the leaf, flower and stem essential oils of Hyssop (Hyssopus officinalis L.) from Western-Himalaya. J. Herb. Med., 2014, 4(2), 89-95.
[http://dx.doi.org/10.1016/j.hermed.2013.12.001]
[11]
ZawiĞlak, G. The chemical composition of essential hyssop oil depending on plant growth stage. Acta Sci. Pol. Hortorum Cultus, 2013, 12(3), 161-170.
[12]
Chopra, R.N.; Nayar, S.L.; Chopra, I.C. Glossary of Indian medicinal plants; council of scientific & industrial research: New Delhi. , 1956, Vol. 1, pp. 138-139.
[13]
Khoshnood-Mansoorkhani, M.J.; Moein, M.R.; Oveisi, N. Anticonvulsant activity of Teucrium polium against seizure induced by PTZ and MES in mice. Iran. J. Pharm. Res., 2010, 9(4), 395-401.
[PMID: 24381604]
[14]
Azizi, H.; Keshavarzi, M. Ethnobotanical study of medicinal plants of Sardasht, Western Azerbaijan, Iran. J. Herb. Drugs, 2015, 6(2), 113-119.
[15]
Chalchat, J.C.; Adamovic, D.; Gorunovic, M.S. Composition of oils of three cultivated forms of Hyssopus officinalis Endemic in Yugoslavia: F. albus Alef., F. cyaneus Alef. and F. ruber Mill. J. Essent. Oil Res., 2001, 13(6), 419-421.
[http://dx.doi.org/10.1080/10412905.2001.9699712]
[16]
Munz, PA California mountain wildflowers. In: California Mountain Wildflowers; University of California Press, 2020.
[17]
Judžentienė, A. Hyssop (Hyssopus officinalis L.) oils In: Essential Oils in Food Preservation, Flavor and Safety; Academic Press, 2016; pp. 471-479.
[18]
Mijani, S.; Eskandari Nasrabadi, S.; Zarghani, H.; Ghias Abadi, M. Seed germination and early growth responses of hyssop, sweet basil and oregano to temperature levels. Not. Sci. Biol., 2013, 5(4), 462-467.
[http://dx.doi.org/10.15835/nsb549164]
[19]
Fathiazad, F.; Hamedeyazdan, S. A review on Hyssopus officinalis L.: Composition and biological activities. Afr. J. Pharm. Pharmacol., 2011, 5(17), 1959-1966.
[20]
Özer, H.; Sökmen, M.; Güllüce, M.; Adigüzel, A.; Kilic, H.; Şahin, F. In vitro antimicrobial and antioxidant activities of the essential oils and methanol extracts of Hyssopus officinalis L. SSP. Angustifolius. Ital. J. Food Sci., 2006, 18(1), 73-84.
[21]
Džamić, A.M.; Soković, M.D.; Novaković, M.; Jadranin, M.; Ristić, M.S.; Tešević, V.; Marin, P.D. Composition, antifungal and antioxidant properties of Hyssopus officinalis L. subsp. pilifer (Pant.) Murb. essential oil and deodorized extracts. Ind. Crops Prod., 2013, 51, 401-407.
[http://dx.doi.org/10.1016/j.indcrop.2013.09.038]
[22]
Ardestani, A.; Yazdanparast, R. Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. Food Chem. Toxicol., 2007, 45(12), 2402-2411.
[http://dx.doi.org/10.1016/j.fct.2007.06.020] [PMID: 17673348]
[23]
Colceru-Mihul, S.; Nita, S.; Grigore, A.; Bubueanu, C.; Draghici, E.; Vamanu, E.; Rughinis, D. Selective fractions with antioxidant activity from Romanian cultivated Cynara scolymus L. Sci. Bull. Ser. F Biotechnol., 2016, 20, 347-351.
[24]
Colceru-Mihul, S.; Bubueanu, C.; Serban, E.A.; Grigore, A.; Rughinis, D.; Bazdoaca, C.; Nita, S. Selective fractions obtained from plant species cultivated in Romania with potential effect on counteracting diseases associated with aging processes. Sci. Bull. Ser. F Biotechnol., 2017, XXI, 325-329.
[25]
Letessier, M.P.; Svoboda, K.P.; Walters, D.R. Antifungal activity of the essential oil of hyssop (Hyssopus officinalis). J. Phytopathol., 2001, 149(11-12), 673-678.
[http://dx.doi.org/10.1046/j.1439-0434.2001.00692.x]
[26]
Lawless, J. The Encyclopedia of Essential Oils.The Complete Guide to the Use of Aromatic Oils in Aromatherapy, Herbalism, Health and Well-Being. 2002; Thorsons Harper, Ontario, 2002, PP. 256.
[27]
Lu, M.; Battinelli, L.; Daniele, C.; Melchioni, C.; Salvatore, G.; Mazzanti, G. Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparations. Planta Med., 2002, 68(3), 213-216.
[http://dx.doi.org/10.1055/s-2002-23139] [PMID: 11914956]
[28]
Hassanshahian, M.; Saadatfar, A.; Masoumi, F. Antimicrobial properties of Hyssopus officinalis extract against antibiotic-resistant bacteria in planktonic and biofilm form. Biol. J. Microorg., 2019, 7(28), 91-101.
[29]
Dehghanzadeh, N.; Ketabchi, S.; Alizadeh, A. Essential oil composition and antibacterial activity of Hyssopus officinalis L. grown in Iran. Asian J. Exp. Biol. Sci., 2012, 3(4), 767-771.
[30]
Baytop, T. Dictionary of Plant Names; Istanbul University Publication: Istanbul, 1997.
[31]
Simon, J.E.; Chadwick, A.F.; Craker, L.E. Herbs, an indexed bibliography,1971-1980, Elsevier, Hander.. 1984.
[32]
Tyler, V.E. Pharmaceutical Products, Haworth Press: USDA, Binghampton, NY, 1993, The Honest Herbal, 3rd ed; p. 357.
[33]
Bown, D. The Royal Horticultural Society encyclopedia of herbs & their uses; Dorling Kindersley Limited, 1995.
[34]
Khazaie, H.R.; Nadjafi, F.; Bannayan, M. Effect of irrigation frequency and planting density on herbage biomass and oil production of thyme (Thymus vulgaris) and hyssop (Hyssopus officinalis). Ind. Crops Prod., 2008, 27(3), 315-321.
[http://dx.doi.org/10.1016/j.indcrop.2007.11.007]
[35]
Small, E.; Deutsch, G. Culinary herbs for short-season gardeners. NRC Research Press, 2001, 181.
[http://dx.doi.org/10.1139/9780660177854]
[36]
Khan, I.A.; Abourashed, E.A. Leung’s encyclopedia of common natural ingredients: Used in food, drugs and cosmetics; John Wiley & Sons: Toronto, 2011, p. 848.
[37]
Pirbaloutl, A.G. Medicinal plants used in Chaharmahal and Bakhtyari districts of Iran. Herba Pol., 2009, 55(2), 69-77.
[38]
Kizil, S.; Toncer, O.; Ipek, A.; Arslan, N.; Saglam, S.; Mahmood Khawar, K. Blooming stages of Turkish hyssop (Hyssopus officinalis L.) affect essential oil composition. Acta Agric. Scand. B Soil Plant Sci., 2008, 58(3), 273-279.
[http://dx.doi.org/10.1080/09064710701647297]
[39]
Kreis, W.; Kaplan, M.H.; Freeman, J.; Sun, D.K.; Sarin, P.S. Inhibition of HIV replication by Hyssop officinalis extracts. Antiviral Res., 1990, 14(6), 323-337.
[http://dx.doi.org/10.1016/0166-3542(90)90051-8] [PMID: 1708226]
[40]
Bernotiene, G.; Butkiene, R. Essential oils of Hyssopus officinalis L. cultivated in East Lithuania. Chemija, 2010, 21(2-4), 135-138.
[41]
Kizil, S.; Haşı̇mı, N.; Tolan, V.; Kilinc, E.; Karataş, H. Chemical composition, antimicrobial, and antioxidant activities of hyssop (Hyssopus officinalis L.) essential oil. Not. Bot. Horti Agrobot. Cluj-Napoca, 2010, 38(3), 99-103.
[42]
Michalczyk, M.; Macura, R.; Tesarowicz, I.; Banaś, J. Effect of adding essential oils of coriander (Coriandrum sativum L.) and hyssop (Hyssopus officinalis L.) on the shelf life of ground beef. Meat Sci., 2012, 90(3), 842-850.
[http://dx.doi.org/10.1016/j.meatsci.2011.11.026] [PMID: 22153611]
[43]
Dragland, S.; Senoo, H.; Wake, K.; Holte, K.; Blomhoff, R. Several culinary and medicinal herbs are important sources of dietary antioxidants. J. Nutr., 2003, 133(5), 1286-1290.
[http://dx.doi.org/10.1093/jn/133.5.1286] [PMID: 12730411]
[44]
Pavela, R. Insecticidal activity of certain medicinal plants. Fitoterapia, 2004, 75(7-8), 745-749.
[http://dx.doi.org/10.1016/j.fitote.2004.08.005] [PMID: 15567255]
[45]
Fraternale, D.; Ricci, D.; Epifano, F.; Curini, M. Composition and antifungal activity of two essential oils of hyssop (Hyssopus officinalis L.). J. Essent. Oil Res., 2004, 16(6), 617-622.
[http://dx.doi.org/10.1080/10412905.2004.9698810]
[46]
Fernández-López, J.; Sevilla, L.; Sayas-Barberá, E.; Navarro, C.; Marin, F.; Pérez-Alvarez, J.A. Evaluation of the antioxidant potential of hyssop (Hyssopus officinalis L.) and rosemary (Rosmarinus officinalis L.) extracts in cooked pork meat. J. Food Sci., 2003, 68(2), 660-664.
[http://dx.doi.org/10.1111/j.1365-2621.2003.tb05727.x]
[47]
Composition and antioxidant activity of Hyssopus officinalis L. selective fractions obtained by different methods. In: Scientific Bulletin. Series F. Biotechnologies 2019, Vol, XXIII.
[48]
Ortiz de Elguea-Culebras, G.; Sánchez-Vioque, R.; Berruga, M.I.; Herraiz-Peñalver, D.; González-Coloma, A.; Andrés, M.F.; Santana-Méridas, O. Biocidal potential and chemical composition of industrial essential oils from Hyssopus officinalis, Lavandula× intermedia var. Super, and Santolina chamaecyparissus. Chem. Biodivers., 2018, 15(1), e1700313.
[http://dx.doi.org/10.1002/cbdv.201700313] [PMID: 28801935]
[49]
Pirbalouti, A.G.; Mohamadpoor, H.; Bajalan, I.; Malekpoor, F. Chemical compositions and antioxidant activity of essential oils from inflorescences of two Landraces of Hyssop [Hyssopus officinalis L. subsp. angustifolius (Bieb.)] Cultivated in Southwestern, Iran. J. Essent. Oil-Bear. Plants, 2019, 22(4), 1074-1081.
[http://dx.doi.org/10.1080/0972060X.2019.1641431]
[50]
Aćimović, M.; Todosijević, M.; Varga, A.; Kiprovski, B.; Tešević, V.; Čabarkapa, I.; Sikora, V. Bioactivity of essential oils from cultivated winter savory, sage and hyssop. Lekovitesirovine, 2019, 39, 11-17.
[51]
Salamon, I.; Kryvtsova, M.; Bucko, D.; Tarawneh, A.H. Chemical characterization and antimicrobial activity of some essential oils after their industrial large-scale distillation. J. Microbiol. Biotechnol. Food Sci., 2019, 8(3), 965-969.
[http://dx.doi.org/10.15414/jmbfs.2019.8.4.984-988]
[52]
Srivastava, A.; Awasthi, K.; Kumar, B.; Misra, A.; Srivastava, S. Pharmacognostic and pharmacological evaluation of Hyssopus officinalis L. (Lamiaceae) Collected from Kashmir Himalayas, India. Pharmacogn. J., 2018, 10(4), 690-693.
[http://dx.doi.org/10.5530/pj.2018.4.114]
[53]
Baj, T.; Korona-Głowniak, I.; Kowalski, R.; Malm, A. Chemical composition and microbiological evaluation of essential oil from Hyssopus officinalis L. with white and pink flowers. Open Chem., 2018, 16(1), 317-323.
[http://dx.doi.org/10.1515/chem-2018-0032]
[54]
Váradyová, Z.; Pisarčíková, J.; Babják, M.; Hodges, A.; Mravčáková, D.; Kišidayová, S.; Königová, A.; Vadlejch, J.; Várady, M. Ovicidal and larvicidal activity of extracts from medicinal-plants against Haemonchus contortus. Exp. Parasitol., 2018, 195, 71-77.
[http://dx.doi.org/10.1016/j.exppara.2018.10.009] [PMID: 30389531]
[55]
Hristova, Y.; Wanner, J.; Jirovetz, L.; Stappen, I.; Iliev, I.; Gochev, V. Chemical composition and antifungal activity of essential oil of Hyssopus officinalis L. from Bulgaria against clinical isolates of Candida species. Biotechnol. Biotechnol. Equip., 2015, 29(3), 592-601.
[http://dx.doi.org/10.1080/13102818.2015.1020341]
[56]
Nile, S. H.; Nile, A. S.; Keum, Y. S. Total phenolics, antioxidant, antitumor, and enzyme inhibitory activity of Indian medicinal and aromatic plants extracted with different extraction methods. 3 Biotech., 2017, 7(1), 76.
[57]
Benelli, G.; Pavela, R.; Canale, A.; Cianfaglione, K.; Ciaschetti, G.; Conti, F.; Nicoletti, M.; Senthil-Nathan, S.; Mehlhorn, H.; Maggi, F. Acute larvicidal toxicity of five essential oils (Pinus nigra, Hyssopus officinalis, Satureja montana, Aloysia citrodora and Pelargonium graveolens) against the filariasis vector Culex quinquefasciatus: Synergistic and antagonistic effects. Parasitol. Int., 2017, 66(2), 166-171.
[http://dx.doi.org/10.1016/j.parint.2017.01.012] [PMID: 28110082]
[58]
Alinezhad, H.; Azimi, R.; Zare, M.; Ebrahimzadeh, M.A.; Eslami, S.; Nabavi, S.F.; Nabavi, S.M. Antioxidant and antihemolytic activities of ethanolic extract of flowers, leaves, and stems of Hyssopus officinalis L. Var. angustifolius. Int. J. Food Prop., 2013, 16(5), 1169-1178.
[http://dx.doi.org/10.1080/10942912.2011.578319]
[59]
Moghtader, M. Comparative evaluation of the essential oil composition from the leaves and flowers of Hyssopus officinalis L. J. Hortic. For., 2014, 6(1), 1-5.
[http://dx.doi.org/10.5897/JHF2013.0318]
[60]
Tsankova, E.T.; Konaktchiev, A.N.; Genova, E.M. Chemical composition of the essential oils of two Hyssopus officinalis taxa. J. Essent. Oil Res., 1993, 5(6), 609-611.
[http://dx.doi.org/10.1080/10412905.1993.9698292]
[61]
Salma, A. El Sawi, Azza A. Ezz El Din, Chemical and physiological studies on Anise hyssop [Agastache foeniculumpursh] and hyssop [Hyssopus officinalis L]., plants grown in Egypt as new spices. Bull. Natl. Res. Cent., 2002, 27(1), 25-35.
[62]
Salvatore, G.; Nicoletti, M.; Di Gioia, V.; Ciccoli, R.; D’Andrea, A. Chemical characterization of essential oil of Hyssop (Hyssopus officinalis L. var. decumbens) from the High-Provence Alps; RivistaItaliana EPPOS: Banon, France, 1997, pp. 673-681.
[63]
Schulz, G.; Stahl-Biskup, E. Essential oils and glycosidic bound volatiles from leaves, stems, flowers and roots of Hyssopus officinalis L. (Lamiaceae). Flavour Fragrance J., 1991, 6(1), 69-73.
[http://dx.doi.org/10.1002/ffj.2730060109]
[64]
Shah, N.C. Chemical constituents of Hyssopus officinalis L.: ' ZufahYabis’ A Unani drug from UP Himalaya, India. Indian Perfumer, 1991, 35, 49-52.
[65]
Garg, S.N.; Naqvi, A.A.; Singh, A.; Ram, G.; Kumar, S. Composition of essential oil from an annual crop of Hyssopus officinalis grown in Indian plains. Flavour Fragrance J., 1999, 14(3), 170-172.
[http://dx.doi.org/10.1002/(SICI)1099-1026(199905/06)14:3<170:AID-FFJ808>3.0.CO;2-Q]
[66]
Khan, R.; Shawl, A.S.; Tantry, M.A. Determination and seasonal variation of chemical constituents of essential oil of Hyssopus officinalis growing in Kashmir valley as incorporated species of Western Himalaya. Chem. Nat. Compd., 2012, 48(3), 502-505.
[http://dx.doi.org/10.1007/s10600-012-0290-5]
[67]
Salvatore, G.; D’Andrea, A.; Nicoletti, M. A pinocamphone poor oil of Hyssopus officinalis L. var. decumbens from France (Barton). J. Essent. Oil Res., 1998, 10(5), 563-567.
[http://dx.doi.org/10.1080/10412905.1998.9700972]
[68]
Gorunovic, M.S.; Bogavac, P.M.; Chalchat, J.C.; Chabard, J.L. Essential oil of Hyssopus officinalis L., Lamiaceae of Montenegro origin. J. Essent. Oil Res., 1995, 7(1), 39-43.
[http://dx.doi.org/10.1080/10412905.1995.9698459]
[69]
Wesolowska, A.; Jadczak, D.; Grzeszczuk, M. Essential oil composition of hyssop [Hyssopus officinalis L. cultivated in north-western Poland. Herba Pol., 2010, 56(1), 57-65.
[70]
Cvijovic, M.; Djukic, D.; Mandic, L.; Acamovic-Djokovic, G.; Pesakovic, M. Composition and antimicrobial activity of essential oils of some medicinal and spice plants. Chem. Nat. Compd., 2010, 46(3), 481-483.
[http://dx.doi.org/10.1007/s10600-010-9652-z]
[71]
Vallejo, M.C.G.; Herraiz, J.G.; Pérez-Alonso, M.J.; Velasco-Negueruela, A. Volatile oil of Hyssopus officinalis L. from Spain. J. Essent. Oil Res., 1995, 7(5), 567-568.
[http://dx.doi.org/10.1080/10412905.1995.9698590]
[72]
Özer, H.; Şahin, F.; Kılıç, H.; Güllüce, M. Essential oil composition of Hyssopus officinalis L. subsp. angustifolius (Bieb.) Arcangeli from Turkey. Flavour Fragrance J., 2005, 20(1), 42-44.
[http://dx.doi.org/10.1002/ffj.1421]
[73]
Tampieri, M.P.; Galuppi, R.; Macchioni, F.; Carelle, M.S.; Falcioni, L.; Cioni, P.L.; Morelli, I. The inhibition of Candida albicans by selected essential oils and their major components. Mycopathologia, 2005, 159(3), 339-345.
[http://dx.doi.org/10.1007/s11046-003-4790-5] [PMID: 15883716]
[74]
De Martino, L.; De Feo, V.; Nazzaro, F. Chemical composition and in vitro antimicrobial and mutagenic activities of seven Lamiaceae essential oils. Molecules, 2009, 14(10), 4213-4230.
[http://dx.doi.org/10.3390/molecules14104213] [PMID: 19924059]
[75]
de Almeida, L.F.R.; Frei, F.; Mancini, E.; De Martino, L.; De Feo, V. Phytotoxic activities of Mediterranean essential oils. Molecules, 2010, 15(6), 4309-4323.
[http://dx.doi.org/10.3390/molecules15064309] [PMID: 20657443]
[76]
Moro, A.; Zalacain, A.; Hurtado de Mendoza, J.; Carmona, M. Effects of agronomic practices on volatile composition of Hyssopus officinalis L. essential oils. Molecules, 2011, 16(5), 4131-4139.
[http://dx.doi.org/10.3390/molecules16054131]
[77]
Andrés, M.F.; González-Coloma, A.; Sanz, J.; Burillo, J.; Sainz, P. Nematicidal activity of essential oils: A review. Phytochem. Rev., 2012, 11(4), 371-390.
[http://dx.doi.org/10.1007/s11101-012-9263-3]
[78]
Baj, T.; Kowalski, R.; Swiatek, L.; Modzelewska, M.; Wolski, T. Chemical composition and antioxidant activity of the essentials oil of hyssop (Hyssopus officinalis L. ssp. officinalis). Ann. Univ. Mariae Curie-Skłodowska, 2010, 23(3), 55-62.
[79]
Moro, A.; Librán, C.M.; Berruga, M.I.; Zalacain, A.; Carmona, M. Mycotoxicogenic fungal inhibition by innovative cheese cover with aromatic plants. J. Sci. Food Agric., 2013, 93(5), 1112-1118.
[http://dx.doi.org/10.1002/jsfa.5859] [PMID: 22936395]
[80]
Sayyahi, J.; Mobaiyen, H.; Jafari, B.; Jafari-Sales, A. Antibacterial effects of methanolic extracts of Reumribes L. and Hyssopus officinalis on some standard pathogenic bacteria. Jorjani Biomedicine J., 2019, 7(3), 34-44.
[http://dx.doi.org/10.29252/jorjanibiomedj.7.3.34]
[81]
Rahimi Kalateh Shah Mohammad, G.; Karimi, E.; Oskoueian, E.; Homayouni-Tabrizi, M. Anticancer properties of green-synthesised zinc oxide nanoparticles using Hyssopus officinalis extract on prostate carcinoma cells and its effects on testicular damage and spermatogenesis in Balb/C mice. Andrologia, 2020, 52(1), e13450.
[http://dx.doi.org/10.1111/and.13450] [PMID: 31692026]
[82]
Tahir, M.; Rahman, M.A.; Khushtar, M. Gastroprotective effect of Hyssopus officinalis L. leaves via reduction of oxidative stress in indomethacin-induced gastric ulcer in experimental rats. Drug Chem. Toxicol., 2019, 45(1), 1-10.
[PMID: 31694395]
[83]
Kermanjani, A.; Jalalizadegan, B.; Tabatabaie, F. Comparison of Hyssopus officinalis, tussilagefarfara, carum copticum extracts versus systemic glucantime in the treatment of cutaneous leishmaniasis in Balb/c mice. Adv. Stud. Biol., 2015, 7(2), 49-54.
[http://dx.doi.org/10.12988/asb.2015.41054]
[84]
Vlase, L.; Benedec, D.; Hanganu, D.; Damian, G.; Csillag, I.; Sevastre, B.; Mot, A.C.; Silaghi-Dumitrescu, R.; Tilea, I. Evaluation of antioxidant and antimicrobial activities and phenolic profile for Hyssopus officinalis, Ocimum basilicum and Teucrium chamaedrys. Molecules, 2014, 19(5), 5490-5507.
[http://dx.doi.org/10.3390/molecules19055490] [PMID: 24786688]
[85]
Wang, N.; Yang, X.W. Two new flavonoid glycosides from the whole herbs of Hyssopus officinalis. J. Asian Nat. Prod. Res., 2010, 12(12), 1044-1050.
[http://dx.doi.org/10.1080/10286020.2010.533120] [PMID: 21128145]
[86]
Semerdjieva, I.B.; Burducea, M.; Astatkie, T.; Zheljazkov, V.D.; Dincheva, I. Essential oil composition of Ruta graveolens L. Fruits and Hyssopus officinalis subsp. aristatus (Godr.) Nyman biomass as a function of hydrodistillation time. Molecules, 2019, 24(22), 4047.
[http://dx.doi.org/10.3390/molecules24224047] [PMID: 31717325]
[87]
Gholami, M.; Jafari, F.; Baradaran, Z.; Amri, J.; Azhdari-Zarmehri, H.; Sadegh, M. Effects of aqueous extract of Hyssopus officinalis on seizures induced by pentylenetetrazole and hippocampus mRNA level of iNOS in rats. Avicenna J. Phytomed., 2020, 10(3), 213-221.
[PMID: 32523876]
[88]
Bergendorff, O.; Franzen, C.; Jeppsson, A.B.; Sterner, O.; Waldeck, B. Screening of some European medicinal plants for spasmolytic activity on isolated guinea-pig trachea. Inter. J. Pharmacog., 1995, 33(4), 356-358.
[89]
Mazzanti, G.; Lu, M.; Salvatore, G. Spasmolytic action of the essential oil from Hyssopus officinalis L. var. decumbens and its major components. Phytother. Res., 1998, 12(S1), S92-S94.
[http://dx.doi.org/10.1002/(SICI)1099-1573(1998)12:1+<S92:AIDPTR261>3.0.CO;2-9]
[90]
Salehi, A.; Setorki, M. Analgesic and anti-inflammatory effects of ethanolic extract of Hyssopus officinalis in mice. Majallah-i Danishgah-i Ulum-i Pizishki-i Gurgan, 2018, 20(2), 42-47.
[91]
Behbahani, M. Anti-viral activity of the methanolic leaf extract of an Iranian medicinal plant “Hyssopus officinalis” against herpes simplex virus. JMPR, 2009, 3, 1118-1125.
[92]
Gollapudi, S.; Sharma, H.A.; Aggarwal, S.; Byers, L.D.; Ensley, H.E.; Gupta, S. Isolation of a previously unidentified polysaccharide (MAR-10) from Hyssop officinalis that exhibits strong activity against human immunodeficiency virus type 1. Biochem. Biophys. Res. Commun., 1995, 210(1), 145-151.
[http://dx.doi.org/10.1006/bbrc.1995.1639] [PMID: 7741735]
[93]
Min, J.; Ge, T.; Jing, W.; Hongping, Z.; Aishan, B.; Fengsen, L. Effects of Uygur Medicine Hyssopus officinalis L. on Balance of Th1/Th2 and Th17/Treg of COPD Mice. Moderniz. Trad. Chinese Med. Materia Materia-World Sci. Technol., 2013, , 3.
[94]
Lelešius, R.; Karpovaitė, A.; Mickienė, R.; Drevinskas, T.; Tiso, N.; Ragažinskienė, O.; Kubilienė, L.; Maruška, A.; Šalomskas, A. in vitro antiviral activity of fifteen plant extracts against avian infectious bronchitis virus. BMC Vet. Res., 2019, 15(1), 178.
[http://dx.doi.org/10.1186/s12917-019-1925-6] [PMID: 31142304]
[95]
Yanan, W.; Jun, M.; Xiumin, M. Effects of uigur herb Hyssopus officinalis L. on cytokines in allergic asthma mice. Acta Universitatis TraditionisMedicalis Sinensis Pharmacologiaeque Shanghai, 2008, 22(3), 58-60.
[96]
Wang, H-Y.; Ding, J-B.; Halmurat, U.; Hou, M.; Xue, Z.Q.; Zhu, M.; Tian, S.G.; Ma, X.M. [The effect of Uygur medicine Hyssopus officinalis L on expression of T-bet, GATA-3 and STAT-3 mRNA in lung tissue of asthma rats]. Xibao Yu Fenzi Mianyixue Zazhi, 2011, 27(8), 876-879.
[PMID: 21806885]
[97]
Hou, M.; Ma, X.; Ding, J. Effect of Uygur medicine Hyssopus officinalis L. on serum eotaxin-2, eotaxin-3 and sPselectin level of asthma rats. Sci. Technol. Rev., 2009, 28(19), 90-93.
[98]
Ma, X.; Ma, X.; Ding, J. Extraction process of polysaccharide from Hyssopus offcinalis. Chinese J. Mod. Appl. Pharm., 2011, 28(5), 437-439.
[99]
Andrew, C. Encyclopedia of herbal medicine; DK publishing (Division of Penguin Random House): canada, 2016, p. 336.
[100]
Nabavi, S.F.; Ebrahimzadeh, M.A.; Nabavi, S.M.; Eslami, B. Antioxidant activity of flower, stem and leaf extracts of Ferulagummosa Boiss. Grasas Aceites, 2010, 61(3), 244-250.
[http://dx.doi.org/10.3989/gya.110809]
[101]
Koch, C.; Reichling, J.; Schnitzler, P. Essential oils inhibit the replication of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). In: Botanical Medicine in Clinical Practice; , 2008; pp. 192-197.
[102]
Silva, M.; da Camara, C.A.; Moraes, M.M.D.; de Melo, J.P.; Santos, R.B.D.; Neves, R. Insecticidal and acaricidal activity of essential oils rich in (E)-nerolidol from Melaleuca leucadendra occurring in the state of Pernambuco (Brazil) and effects on two important agricultural pests. J. Braz. Chem. Soc., 2020, 31(4), 813-820.
[http://dx.doi.org/10.21577/0103-5053.20190245]
[103]
Seo, S.M.; Park, H.M.; Park, I.K. Larvicidal activity of ajowan (Trachyspermum ammi) and Peru balsam (Myroxylon pereira) oils and blends of their constituents against mosquito, Aedes aegypti, acute toxicity on water flea, Daphnia magna, and aqueous residue. J. Agric. Food Chem., 2012, 60(23), 5909-5914.
[http://dx.doi.org/10.1021/jf301296d] [PMID: 22620984]
[104]
Ma, Q.; Zhang, X.M.; Jiang, J.G.; Zhu, W. Apigenin-7-O-β-Dglucuronide inhibits modified low-density lipoprotein uptake and foam cell formation in macrophages. J. Funct. Foods, 2017, 35, 615-621.
[http://dx.doi.org/10.1016/j.jff.2017.06.026]
[105]
Hu, W.; Wang, X.; Wu, L.; Shen, T.; Ji, L.; Zhao, X.; Si, C.L.; Jiang, Y.; Wang, G. Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock. Food Funct., 2016, 7(2), 1002-1013.
[http://dx.doi.org/10.1039/C5FO01212K] [PMID: 26750400]
[106]
Dragomanova, S.; Tancheva, L.; Georgieva, M.; Klisurov, R. Analgesic and anti-inflammatory activity of monoterpenoid Myrtenal in rodents. J. IMAB-Annual Proceeding (Scientific Papers), 2019, 25(1), 2406-2413.
[http://dx.doi.org/10.5272/jimab.2019251.2406]
[107]
Safayhi, H.; Sabieraj, J.; Sailer, E.R.; Ammon, H.P.T. Chamazulene: An antioxidant-type inhibitor of leukotriene B4 formation. Planta Med., 1994, 60(5), 410-413.
[http://dx.doi.org/10.1055/s-2006-959520] [PMID: 7997466]
[108]
Sul ‘ain, M.D.; Zakaria, F.; Johan, M.F. Anti-proliferative effects of methanol and water extracts of Pyrrosia piloselloides on the hela human cervical carcinoma cell line. Asian Pacific Journal of Cancer Prevention: APJCP, 2019, 20(1), 185-192.
[http://dx.doi.org/10.31557/APJCP.2019.20.1.185] [PMID: 30678430]
[109]
Tisserand, R.; Young, R. Essential oil safety: A guide for health care professionals, 2nd ed; Elsevier: New York: Churchill Livingstone, 2014.
[110]
Rudbäck, J.; Bergström, M.A.; Börje, A.; Nilsson, U.; Karlberg, A.T. α-Terpinene, an antioxidant in tea tree oil, autoxidizes rapidly to skin allergens on air exposure. Chem. Res. Toxicol., 2012, 25(3), 713-721.
[http://dx.doi.org/10.1021/tx200486f] [PMID: 22250748]