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Current Pharmaceutical Biotechnology

Author(s): Melisa Çetinkaya and Yusuf Baran*

DOI: 10.2174/1389201023666220803150431

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MicroRNAs and Long Non-coding RNAs as Novel Targets in Anti-cancer Drug Development

Page: [913 - 925] Pages: 13

  • * (Excluding Mailing and Handling)

Abstract

Non-coding RNAs comprise the majority of RNAs that have been transcribed from the human genome, and these non-coding RNAs have essential regulatory roles in the cellular processes. They have been discovered to influence the expression of the genes, including tumorsuppressive and oncogenes, that establish the non-coding RNAs as novel targets for anti-cancer drug development. Among non-coding RNAs, microRNAs have been extensively studied in terms of cancer biology, and some microRNA-based therapeutics have been reached in clinical studies. Even though most of the research regarding targeting non-coding RNAs for anti-cancer drug development focused on microRNAs, long non-coding RNAs have also started to gain importance as potential therapeutic targets for cancer therapy. In this chapter, the strategies and importance of targeting microRNAs and long non-coding RNAs will be described, along with the clinical studies that involve microRNA-based cancer therapeutics and preclinical studies that involve long noncoding RNA-based therapeutics. Finally, the delivery strategies that have great importance in the effective delivery of the non-coding RNA-based cancer therapeutics, hence the therapy's effectiveness, will be described.

Keywords: miRNA-based cancer therapeutics, miRNA mimics, antagomiRs, MRX34, lncRNA-based cancer therapeutics, and drug delivery strategies

Graphical Abstract

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