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CNS & Neurological Disorders - Drug Targets

Author(s): Anastasia Babina, Iryna Sokolova* and Mykhailo Vysotskyi

DOI: 10.2174/1871527321666220726141936

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Characteristics of Amphetamine Psychosis with Respect to the Length of Drug Exposure

Page: [599 - 606] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

Background: Over the past decade, the number of individuals requiring medical care for amphetamine-related psychosis has increased.

Objective: This study aims to examine the psychological characteristics of amphetamine psychosis in drug-addicted patients depending on the length of drug exposure and compared to patients diagnosed with paranoid schizophrenia.

Methods: The study was carried out in psychiatric clinic No. 1 in Kyiv (Ukraine) in 2019, involving 107 patients. Of all the participants, 50 were included in Group 1 (methamphetamine psychosis) and 57 - in Group 2 (paranoid schizophrenia). All patients were treated with medication to relieve exacerbating symptoms. They underwent extensive testing to determine the impairment severity of cognitive function, attention, and task performance during remission.

Results: In Group 1, the timing of onset for paranoid symptoms depends on the length of amphetamine exposure (Spearman correlation coefficient = 0.89). The efficacy and dynamics of drug treatment in Group 2 were similar to patients in Group 1. However, the effect of reduction in Group 2 was achieved only in 4 months. Delusions, emotional disturbances, hallucinations in patients of Group 1 occurred 2.3 times more frequently than in Group 2 (p ≤ 0.05). The patients of Group 1 are characterized by the presence of disorders related to the affective and behavioral components.

Conclusion. All reported exacerbations are related to amphetamine use. Patients in Group 1 learned a smaller number of words compared to those in Group 2. Besides, a large number of errors and difficulties with shifting focus were recorded.

Keywords: Amphetamine, schizophrenia, cognitive function, delusions, hallucinations, amphetamine psychosis.

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