Generic placeholder image

Current Traditional Medicine

Author(s): Ratna Jyoti Das*, Kalyani Pathak, Smita Bordoloi, Riya Saikia, Saif Aboud Alqahtani, Jon Saharia, Mary Devi and Bhaskar Mazumder

DOI: 10.2174/2215083808666220623112606

DownloadDownload PDF Flyer Cite As
Clerodendrum colebrookianum Walp: An Insight into its Pharmacology, Expository Traditional Uses and Extensive Phytochemistry

Article ID: e230622206326 Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

Introduction: Clerodendrum colebrookianum Walp (Family, Verbenaceae) is one of the beneficial medicinal plants, used by the traditional people of this Northeast region of India due to its cardioprotective action and most widely known as “Nefafu” in Assam, “Arun” in Nagaland and “Phuinum” in Mizoram. Clerodendrum colebrookianum is found extensively in the South as well as Southeast Asia. The Mizo natives of the Northeast, India expanse of India claim that the hypertensive populace's minor occurrence in the middle of their society member is because of the habitual ingestion of this medicinal plant as vegetables.

Aim: This review summarizes the ethnopharmacology, selected scientific evidence on the pharmacological properties and phytochemistry of Clerodendrum colebrookianum Walp. This plant is generally considered the most significant herbal variety practiced in the therapy of hypertension by various communities of Northeast India.

Methods: The review covers literature about the evidence-based ethnopharmacology, therapeutic potential, and phytochemistry of Clerodendrum colebrookianum Walp. Literature was collected from non-English journals and English scientific databases via electronic search (Elsevier, Google Scholar, PubMed, Scopus, Springer, Web of Science, Wiley online library) and Ph.D. thesis databases.

Results: Evidence suggests that the extracts and some compounds from. Clerodendrum colebrookianum Walp cause abdominal pain, anthelmintic, antidote, blood purifier, colics in infants, cough, diabetes, diarrhea, and dysentery, gastric disorders. It also has cardioprotective potential, which is a valid scientific basis for consuming it for health benefits in the northeast region of India.

Conclusion: Scientific evidence suggests Clerodendrum colebrookianum Walp's immense potential to treat diabetes, hypertension, and other chronic diseases.

Keywords: Ethnopharmacology, phytochemistry, hypertension, ethnomedicine, tribal community

[1]
Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002; 81(1): 81-100.
[http://dx.doi.org/10.1016/S0378-8741(02)00059-4] [PMID: 12020931]
[2]
Pal SK, Shukla Y. Herbal medicine: Current status and the future. Asian Pac J Cancer Prev 2003; 4(4): 281-8.
[PMID: 14728584]
[3]
Arya H, Syed SB, Singh SS, Ampasala DR, Coumar MS. In silico investigations of chemical constituents of Clerodendrum colebrookianum in the anti-hypertensive drug targets: ROCK, ACE, and PDE5. Interdiscip Sci 2018; 10(4): 792-804.
[http://dx.doi.org/10.1007/s12539-017-0243-6] [PMID: 28623462]
[4]
Goswami P, Kotoky J, Chen ZN, Lu Y. A sterol glycoside from leaves of Clerodendron colebrookianum. Phytochemistry 1996; 41(1): 279-81.
[http://dx.doi.org/10.1016/0031-9422(95)00557-9]
[5]
Yang H, Mei SX, Jiang B, Lin ZW, Sun HD. Two new C~ 2~ 9 sterols from Clerodendrum colebrookianum. Chin Chem Lett 2000; 11(1): 57-60.
[6]
Srivastava RC, Choudhary RK. Species diversity and Economic importance of the family Verbenaceae in Arunachal Pradesh. Bull Arunachal Forest Res 2008; 24(1&2): 1-21.
[7]
Kotoky J, Dasgupta B, Deka N. Pharmacological studies of Clerodendron colebrookianum Walp, a potent hypotensive plant. Indian J Physiol Pharmacol 2005; 49(3): 289-96.
[PMID: 16440846]
[8]
Kalita J, Singh SS, Khan ML. Clerodendrum colebrookianum Walp.: A potential folk medicinal plant of North East India. Asian J Pharm Biol Res 2012; 2(4): 256-61.
[9]
Hooker JD. The Flora of British India. London: Reeve and Co. Ltd 1875; pp. 78-9.
[10]
Jadeja RN, Thounaojam MC, Ramani UV, Devkar RV, Ramachandran AV. Anti-obesity potential of Clerodendron glandulosum. Coleb leaf aqueous extract. J Ethnopharmacol 2011; 135(2): 338-43.
[http://dx.doi.org/10.1016/j.jep.2011.03.020] [PMID: 21397678]
[11]
Nath SC, Bordoloi DN. Clerodendrum colebrookianum, a folk remedy for the treatment of hypertension in Northeastern India. Int J Pharmacogn 1991; 29(2): 127-9.
[12]
Shrivastava N, Patel T. Clerodendrum and healthcare: An overview. Med Aromat Plant Sci Biotechnol 2007; 1(1): 142-50.
[13]
Inta A, Shengji P, Balslev H, Wangpakapattanawong P, Trisonthi C. A comparative study on medicinal plants used in Akha’s traditional medicine in China and Thailand, cultural coherence or ecological divergence? J Ethnopharmacol 2008; 116(3): 508-17.
[http://dx.doi.org/10.1016/j.jep.2007.12.015] [PMID: 18280071]
[14]
Rajbongshi P. Clerodendrum colebrookianum Walp: A phytopharmacological review. World J Pharm Res 2014; 3 (Suppl. 7): 305-17.
[15]
Payum T, Taggu T, Taro K. Pharmacognostic study of Clerodendrum colebrookianum Walp. plant used for medicinal food by Adi tribe of Arunachal Pradesh, India. AAES 2020; 5(3): 363-7.
[http://dx.doi.org/10.26832/24566632.2020.0503018]
[16]
Rajlakshmi D, Sharma DK. Effect of fresh juice and ethyl acetate extract of Clerodendron colebrookianum leaves on serum and liver transaminase activity in rats. Indian J Pharmacol 1999; 31(5): 373.
[17]
Mishra TN, Singh RS, Pandey HS, Kohli YP. Antibacterial and antifungal activity of three volatile hexane eluates extracted from the leaves of Clerodendrum colebrookianum. Acta Cienc Indica Chem 1998; 24: 1-4.
[18]
Yadav A, Verma PK, Chand T, Bora HR. Ethno-medicinal knowledge of Clerodendrum L. among different tribes of Nambor reserve forest, Assam, India. J Pharmacogn Phytochem 2018; 7(5): 1567-70.
[19]
Namsa ND, Mandal M, Tangjang S, Mandal SC. Ethnobotany of the Monpa ethnic group at Arunachal Pradesh, India. J Ethnobiol Ethnomed 2011; 7(1): 31.
[http://dx.doi.org/10.1186/1746-4269-7-31] [PMID: 21995750]
[20]
Das AK, Dutta BK, Sharma GD. Medicinal plants used by different tribes of Cachar district, Assam. Indian J Tradit Knowl 2004; 7(3): 446-54.
[21]
Sajem AL, Gosai K. Traditional use of medicinal plants by the Jaintia tribes in North Cachar Hills district of Assam, northeast India. J Ethnobiol Ethnomed 2006; 2(1): 33.
[http://dx.doi.org/10.1186/1746-4269-2-33] [PMID: 16899114]
[22]
Das AK, Sharma GD. Ethno-medicinal uses of plants by Manipuri and Barman communities of Cachar district, Assam. J Econ Taxon Bot 2003; 27(2): 421-9.
[23]
Tamuli P, Saikia R. Ethno-medico-botany of the Zeme tribe of North Cachar Hills district of Assam. Indian J Tradit Knowl 2004; 3(4): 430-6.
[24]
Gupta VI. Traditional medicinal plants of the Bangnis of East Kameng district, Arunachal Pradesh. J Econ Taxon Bot 2006; 30: 310-9.
[25]
Gupta M, Mazumder UK, Das S. Effect of leaf extract from Clerodendron colebrookianum on CNS function in mice. Indian J Exp Biol 1998; 36(2): 171-4.
[PMID: 9754047]
[26]
Yang H, Wang J, Hou AJ, Guo YP, Lin ZW, Sun HD. New steroids from Clerodendrum colebrookianum. Fitoterapia 2000; 71(6): 641-8.
[http://dx.doi.org/10.1016/S0367-326X(00)00223-9] [PMID: 11077170]
[27]
Al-Attar AM. Physiological and biochemical alterations in Sprague-Dawley female rats subjected to high fat diet and intermittent fasting. J Appl Sci Res 2010; (December): 2096-104.
[28]
Mukherjee PK. Plant products with hypocholesterolemic potentials. Adv Food Nutr Res 2003; 47: 277-338.
[http://dx.doi.org/10.1016/S1043-4526(03)47005-8] [PMID: 14639785]
[29]
Richard NF. Statin Drugs. Available from: http://heartdisease. about.com/b/2008/01/14/enhance-at-best-nobenefit-from-vytorinor-zetia.htm (Accessed on 2008).
[30]
Wilson PW. High-density lipoprotein, low-density lipoprotein and coronary artery disease. Am J Cardiol 1990; 66(6): 7A-10A.
[http://dx.doi.org/10.1016/0002-9149(90)90562-F] [PMID: 2203248]
[31]
Naik GH, Priyadarsini KI, Satav JG, et al. Comparative antioxidant activity of individual herbal components used in Ayurvedic medicine. Phytochemistry 2003; 63(1): 97-104.
[http://dx.doi.org/10.1016/S0031-9422(02)00754-9] [PMID: 12657303]
[32]
Sultana B, Anwar F, Przybylski R. Antioxidant activity of phenolic components present in barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam. trees. Food Chem 2007; 104(3): 1106-14.
[http://dx.doi.org/10.1016/j.foodchem.2007.01.019] [PMID: 26065778]
[33]
Choi Y, Jeong HS, Lee J. Antioxidant activity of methanolic extracts from some grains consumed in Korea. Food Chem 2007; 103(1): 130-8.
[http://dx.doi.org/10.1016/j.foodchem.2006.08.004]
[34]
Shrestha S, Subaramaihha SR, Subbaiah SG, Eshwarappa RS, Lakkappa DB. Evaluating the antimicrobial activity of methonolic extract of Rhus succedanea leaf gall. Bioimpacts 2013; 3(4): 195-8.
[PMID: 24455483]
[35]
Decker EA. Phenolics: Prooxidants or antioxidants? Nutr Rev 1997; 55(11 Pt 1): 396-8.
[PMID: 9420450]
[36]
Rice-Evans CA, Miller NJ, Bolwell PG, Bramley PM, Pridham JB. The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic Res 1995; 22(4): 375-83.
[http://dx.doi.org/10.3109/10715769509145649] [PMID: 7633567]
[37]
Tschesche R. Advances in the chemistry of antibiotic substances from higher plants. In: Wagner H, Hörhammer, L, Eds. Pharmacognosy and Phytochemistry. Berlin, Heidelberg: Springer. 1971; pp. 274-89.
[http://dx.doi.org/10.1007/978-3-642-65136-6_12]
[38]
Mabberley DJ. Mabberley’s Plant-Book: A Portable Dictionary of Plants, their Classifications and Uses. Cambridge, UK: Cambridge University Press 2008.
[39]
Subramanian SS, Nair AG, Vedantham TN. (24s)-ethylcholesta-5, 22, 25-triene-3-beta-ol from four Clerodendron species. Phytochemistry 1973; 12(8): 2078-9.
[http://dx.doi.org/10.1016/S0031-9422(00)91554-1]
[40]
Deb L, Dey A, Sakthivel G, Bhattamishra SK, Dutta A. Protective effect of Clerodendrum colebrookianum Walp., on acute and chronic inflammation in rats. Indian J Pharmacol 2013; 45(4): 376-80.
[http://dx.doi.org/10.4103/0253-7613.115021] [PMID: 24014914]
[41]
Jacke G, Rimpler H. Distribution of iridoid glycosides in Clerodendrum species. Phytochemistry 1983; 22(8): 1729-34.
[http://dx.doi.org/10.1016/S0031-9422(00)80260-5]
[42]
Deb L, Singh KR, Singh KB, Thongam B. Some ethnomedicinal plants used by the native practitioners of Chandel district, Manipur, India. Int Res J Pharm 2011; 2(12): 199-200.
[43]
Lokesh D, Amitsankar D. Evaluation of mechanism for antihypertensive action of Clerodendrum colebrookianum Walp., used by folklore healers in north-east India. J Ethnopharmacol 2012; 143(1): 207-12.
[http://dx.doi.org/10.1016/j.jep.2012.06.025] [PMID: 22732729]
[44]
Phone NL, Kumar Y, Myrboh B. Survey and assessment of ethnomedicinal plants used in Senapati District of Manipur State, Northeast India. Phytopharmacology 2012; 2(2): 285-311.
[45]
Jain SK, Saklani A. Cross-cultural ethnobotanical studies in Northeast India. Ethnobotany 1992; 4(1-2): 25-38.
[46]
Verma S, Singh SP. Current and future status of herbal medicines. Vet World 2008; 1(11): 347.
[http://dx.doi.org/10.5455/vetworld.2008.347-350]
[47]
Kar P, Dutta S, Chakraborty AK, et al. The antioxidant rich active principles of Clerodendrum sp. controls haloalkane xenobiotic induced hepatic damage in murine model. Saudi J Biol Sci 2019; 26(7): 1539-47.
[http://dx.doi.org/10.1016/j.sjbs.2018.12.006] [PMID: 31762623]
[48]
Deb L, Dutta A. Comparative toxicological evaluation of two medicinal plants used by folklore practitioners of northeast India for treatment of hypertension. Toxicol Environ Chem 2013; 95(5): 846-52.
[http://dx.doi.org/10.1080/13607863.2013.821821]
[49]
Jadeja RN, Thounaojam MC. Ansarullah, et al. Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum. Caleb leaf extract. Hum Exp Toxicol 2011; 30(1): 63-70.
[http://dx.doi.org/10.1177/0960327110368420] [PMID: 21148599]