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Current Stem Cell Research & Therapy

Author(s): Sanaa EL Marsafy* and Jérôme Larghero

DOI: 10.2174/1574888X17666220608101852

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Cancer Cell De-Differentiation: Plasticity-Driven Stratagem For Tumor Metastasis and Recurrence

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Abstract

Tumor recurrence is a colossal challenge in clinical oncology. This multifactorial problem is attributed to the emergence of additional genetic mutations and the presence of dormant cancer cells. However, the plasticity of non-stem cancer cells and the acquisition of cancer stem cell (CSC) functionality is another contributing factor to tumor recurrence. Herein, I focus attention on the mechanisms that fuel cancer cell de-differentiation and the interplay between intra-cellular regulators and tumor microenvironment (TME) landscape that promotes cancer cell stemness. Our understanding of the mechanisms underlying tumor cell de-differentiation is crucial for developing innovative therapeutic strategies that prevent cancer from ever recurring.

Keywords: Cancer stem cells, cancer cell plasticity, de-differentiation, epithelial-mesenchymal transition, cancer cell immune evasion, cancer cell dormancy.

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