Current Women`s Health Reviews

Author(s): John Yeh

DOI: 10.2174/157340481804220526155112

Obesity and a Higher Rate of Miscarriages: Associations and Possible Mechanisms

Article ID: e260522205308 Pages: 2

  • * (Excluding Mailing and Handling)

[1]
Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol 2018; Mar 9;16(1): 22.
[http://dx.doi.org/10.1186/s12958-018-0336-z] [PMID: 29523133] [PMCID: PMC5845358]
[2]
Jungheim ES, Travieso JL, Hopeman MM. Weighing the impact of obesity on female reproductive function and fertility. Nutr Rev 2013; Oct;71 Suppl 1(0 1): S3-8.
[http://dx.doi.org/10.1111/nure.12056] [PMID: 24147921] [PMCID: PMC3813308]
[3]
Lee JC, Bernardi LA, Boots CE. The association of euploid miscarriage with obesity. F S Rep 2020; 1(2): 142-8. Published 2020 Sep 28.
[http://dx.doi.org/10.1016/j.xfre.2020.05.011]
[4]
Wang L, Xu J, Niu W, et al. Genetic testing on products of conception and its relationship with body mass index. J Assist Reprod Genet 2020; 37: 1853-60.
[http://dx.doi.org/10.1007/s10815-020-01849-9]
[5]
Tremellen K, Pearce K, Zander-Fox D. Increased miscarriage of euploid pregnancies in obese women undergoing cryopreserved embryo transfer. Reprod Biomed Online 2017; Jan;34(1): 90-7. Epub 2016 Oct 17.
[http://dx.doi.org/10.1016/j.rbmo.2016.09.011] [PMID: 27789185]
[6]
Qu P, Yan M, Zhao D, Wang D, Dang S, Shi W, Shi J and Zhang C (2021) Association Between Pre-Pregnancy Body Mass Index and Miscarriage in an Assisted Reproductive Technology Population: A 10-Year Cohort Study. Front Endocrinol 12: 646162.
[http://dx.doi.org/10.3389/fendo.2021.646162]
[7]
Boots CE, Bernardi LA, Stephenson MD. Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss. Fertil Steril 2014; Aug;102(2): 455-9. Epub 2014 Jun 4.
[http://dx.doi.org/10.1016/j.fertnstert.2014.05.005] [PMID: 24907916]
[8]
Ng, K.Y.B., Cherian, G., Kermack, A.J. et al. Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss. Sci Rep 2021; 11: 7081.
[http://dx.doi.org/10.1038/s41598-021-86445-2]
[9]
Eapen A, Hayes ET, McQueen DB, Beestrum M, Eyck PT, Boots C. Mean differences in maternal body mass index and recurrent pregnancy loss: a systematic review and meta-analysis of observational studies. Fertil Steril 2021; Nov;116(5): 1341-8. Epub 2021 Aug 17.
[http://dx.doi.org/10.1016/j.fertnstert.2021.06.019] [PMID: 34412893] [PMCID: PMC8608000]
[10]
Dendana M, Bahia W, Finan RR, et al. Association of adiponectin gene variants with idiopathic recurrent miscarriage according to obesity status: a case–control study. J Transl Med 2018; 16: 76.
[http://dx.doi.org/10.1186/s12967-018-1453-3]
[11]
Chen Z, Yu HJ, Shi X, Warren CR, Lotta LA, Friesen M, Meissner TB, Langenberg C, Wabitsch M, Wareham N, et al. Functional screening of candidate causal genes for insulin resistance in human preadipocytes and adipocytes. Circ Res 2020; 126: 330-46. doi: 10.1161CIRCRESAHA.119.315246
[12]
Fullerton PT Jr, Monsivais D, Kommagani R, Matzuk MM. Follistatin is critical for mouse uterine receptivity and decidualization. Proc Natl Acad Sci U S A 2017; Jun 13;114(24): E4772-81. Epub 2017 May 30.
[http://dx.doi.org/10.1073/pnas.1620903114] [PMID: 28559342] [PMCID: PMC5474784]
[13]
Machtinger R, Combelles CM, Missmer SA, Correia KF, Fox JH, Racowsky C. The association between severe obesity and characteristics of failed fertilized oocytes. Hum Reprod 2012; Nov;27(11): 3198-207. Epub 2012 Sep 11.
[http://dx.doi.org/10.1093/humrep/des308] [PMID: 22968161]
[14]
Provost MP, Acharya KS, Acharya CR, Yeh JS, Steward RG, Eaton JL, Goldfarb JM, Muasher SJ. Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008-2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry. Fertil Steril 2016; Feb;105(2): 364-8. Epub 2015 Oct 30.
[http://dx.doi.org/10.1016/j.fertnstert.2015.10.015] [PMID: 26523329]
[15]
Metwally M, Preece R, Thomas J, et al. A proteomic analysis of the endometrium in obese and overweight women with recurrent miscarriage: preliminary evidence for an endometrial defect. Reprod Biol Endocrinol 2014; 12: 75.
[http://dx.doi.org/10.1186/1477-7827-12-75]
[16]
Rhee JS, Saben JL, Mayer AL, Schulte MB, Asghar Z, Stephens C, Chi MM, Moley KH. Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy. Hum Reprod 2016; Jun;31(6): 1315-26. Epub 2016 Apr 6.
[http://dx.doi.org/10.1093/humrep/dew048] [PMID: 27052498] [PMCID: PMC4871191]
[17]
Govindasamy N, Long H, Jeong HW, Raman R, Özcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH, Trappmann B, Bedzhov I. 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels. Dev Cell 2021 Dec 6; 56(23): 3276-3287.e8. Epub 2021 Nov 5.
[http://dx.doi.org/10.1016/j.devcel.2021.10.014] [PMID: 34741805]
[18]
Maruvada P, Leone V, Kaplan LM, Chang EB. The Human Microbiome and Obesity: Moving beyond Associations. Cell Host Microbe 2017 Nov 8; 22(5): 589-99.
[http://dx.doi.org/10.1016/j.chom.2017.10.005] [PMID: 29120742]
[19]
Liu, Yongjie, et al. "Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage." NPJ biofilms and microbiomes 2021; 7.1: 1-12.
[http://dx.doi.org/10.1038/s41522-021-00199-3]
[20]
Al-Memar M, Bobdiwala S, Fourie H, Mannino R, Lee YS, Smith A, Marchesi JR, Timmerman D, Bourne T, Bennett PR, MacIntyre DA. The association between vaginal bacterial composition and miscarriage: a nested case-control study. BJOG 2020; Jan;127(2): 264-74. Epub 2019 Oct 31.
[http://dx.doi.org/10.1111/1471-0528.15972] [PMID: 31573753] [PMCID: PMC6972675]
[21]
Xu, Linfen & Huang, Lingna & Lian, Chengying & Xue, Huili & Lu, Yanfang & Chen, Xiujuan & Xia, Yong. (2020). Vaginal Microbiota Diversity of Patients with Embryonic Miscarriage by Using 16S rDNA High-Throughput Sequencing. International Journal of Genomics 2020; 1-12.
[http://dx.doi.org/10.1155/2020/1764959]
[22]
Ouni M, Schürmann A. Epigenetic contribution to obesity. Mamm Genome 2020; Jun;31(5-6): 134-45. Epub 2020 Apr 11.
[http://dx.doi.org/10.1007/s00335-020-09835-3] [PMID: 32279091] [PMCID: PMC7368865]
[23]
Sarah Meister, Isabel Kellner, Susanne Beyer, Stefanie Corradini, Christian Schulz, Nina Rogenhofer, Lucia Keilmann, Theresa Maria Kolben, Sven Mahner, Mirjana Kessler, Udo Jeschke, Thomas Kolben, Epigenetic changes occur in placentas of spontaneous and recurrent miscarriages, Journal of Reproductive Immunology, Volume 149, 2022; 103466. ISSN 0165-0378,
[http://dx.doi.org/10.1016/j.jri.2021.103466]
[24]
Zhou Q, Xiong Y, Qu B, Bao A and Zhang Y (2021) DNA Methylation and Recurrent Pregnancy Loss: A Mysterious Compass? Front Immunol 12: 738962.
[http://dx.doi.org/10.3389/fimmu.2021.738962]
[25]
Wang Z, Groen H, Van Zomeren KC, Cantineau AEP, Van Oers A, Van Montfoort APA, Kuchenbecker WKH, Pelinck MJ, Broekmans FJM, Klijn NF, Kaaijk EM, Mol BWJ, Hoek A, Van Echten-Arends J. Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort study. Hum Reprod Open 2021; Aug 7;2021(4): hoab032.
[http://dx.doi.org/10.1093/hropen/hoab032] [PMID: 34557597] [PMCID: PMC8452483]